Alcohol extract of Geum Chung Cho alleviates alcohol-induced short-term memory impairment in gerbils

Han-Sam Cho,Tae-Woon Kim,Sang-Seo Park,Mal-Soon Shin,Jae-Min Lee,Eun-Sang Ji,Chang-Ju Kim 한국운동재활학회 2015 한국운동재활학회 학술대회 Vol.2015 No.10

Chronic ethanol consumption leads to memory impairment and also induces brain damage. The hippocampus has been particularly regarded as a possible target organ of alcoholic intoxication, since this structure plays a prominent function in memory processes. Cordyceps has been used as a traditional medicine in Asian countries for a long time. Different types of Cordyceps extract were reported to have various pharmacological activities including anti-tumor, anti-inflammatory, anti-viral, and immune modulatory effects. Guem Chung Cho is an artificial cultivated Cordyceps, and was supplied from GCordy (Seoul, Korea). Ethanol extract of Cordycep (50 g) was made by rotary evaporate, and resulting powder 8.29 g was obtained (yield 17%). In the present study, we investigated the effects of ethanol extract of Geum Chung Cho on short-term memory, cell proliferation and apoptosis in the hippocampus of ethanol-treated gerbils. The gerbils were divided into 5 groups (n = 10 in each group): Control group, alcohol-treated group, alcohol-treated and 0.001 mg/kg Geum Chung Cho-applied group, alcohol-treated and 0.01 mg/kg Geum Chung Cho-applied group, and alcohol-treated and 0.1 mg/kg Geum Chung Cho-applied group. Gerbils in the alcohol-treated groups were orally administered ethanol (1 g/kg) once a day for 2 weeks. Gerbils in the Guem Chung Cho-applied groups were orally administered Guem Chung Cho extract at each dosage 1 hour before ethanol consumption. Our results revealed that consumption of alcohol for 2 weeks deteriorated short-term memory, induced apoptosis, and inhibited cell proliferation, and reduced expressions of brain-derived neurotrophic (BDNF) and tyrosine kinase B (TrkB). However, Guem Chung Cho treatment alleviated alcohol-induced short-term memory impairment through enhancing cell proliferation and BDNF expression with inhibiting apoptosis in the hippocampus. Guem Chung Cho showed maximum effects at 0.1 mg/kg. Based on these results, alcohol extract of Guem Chung Cho may provide therapeutic value for the treatment of chronic alcohol-inducted brain injury. This study was supported by GCordy company.

폴리에스테르아마이드에 관한 연구

趙淳彩,姜濚義,崔在炅 全北大學校 1985 論文集 Vol.27 No.-

Polyesteramide(PEA) was prepared by the polymerization of caprolactam and 6-amino-caproic acid with oligomer of polyethylene terephthalate, which was prepared by the reaction of terephthalic acid with ethylene glycol, and characterized by melting point, molecular weight and whiteness. The results are summarized as follows. (1) Molecular weight has no relation to melting point of PEA. (2) Molar fraction of caprolactam of stoichemistry has no relation to molecular weight of PEA. (3) Melting point of PEA decreased with the molar fraction of oligoester of stoichiometry and was still lower than that of polyethylene terephthalate. (4) Whiteness of PEA decreased with the molar fraction of oligoester of stoichiometry and superior to that of PEA from hexamethylenediamine and oligoester, in respect of whiteness.

일본의 워트프런트 개발 현상과 관광상품화 전략

조재기,김순금 東亞大學校附設스포츠科學硏究所 2003 스포츠科學硏究論文集 Vol.21 No.-

This study aims to Waterfront Development the present condition and its strategy of tourism merchandise in Japan In order to obtain objective material, the Waterfront Development the present condition and descriptive analysis as its primary method of analysis. In order to draw an inductive reasoning to understand the present situation, the study chose the method of case study as the secondary method of analysis through the field survey in the advanced countries of tourism. 1. It is necessary to establish a sustainable and organized policy and system through "periodic public hearings" in which local governments and universities cooperate. 2. An index for sustainable Waterfront Development should be developed by research institutions such as universities. 3. In order to construct a competitive theme park or the waterfront, which would require considerable time, technology and financial resources, the central government or local governments should seek foreign investment or make policies for tax cut down. 4. The direction for developing Waterfront Development tourism should be divided into tourism product development and tourism attraction development. 5. In order to actively confront the environmental change and establish an efficient marine tourism information system, a new program consisting of 3Cs of commerce, contents, and community should be developed. 6. Waterfront Development should take root in the social system and be standardized. 7. A gradual and systematic policy should be made by the local government in order to develop marine-leisure sports into lucrative regional business.

만성 화농성 중이염의 세균학적 고찰

조남순,이영훈,강기훈,최제환,송태현,이병돈,장혁순,강주원,김연준 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Background and Objectives : Chronic suppurative otitis media is one of the frequent diseases in otolaryngologic field. It is important to choose of antibiotics in the management of infectious disease. But the organisms in infections have been changed and resistance to antibiotics has been grown as the development of antibiotics has been achieved. And so it has been necessary to recognize the changes of organisms and resistance in antibiotics. Our study was performed to identify the pathogens isolated from discharges in chronic otitis media and evaluate the antibiotic agents, to recognize the change of to resistance to·antibiotic agents and to use the appropriate anitiotics. Materials and Methods : Retrospectively, authors reviewed the backeriologic study of 114 cases of chronic suppurative otitis media who visited the Department of Otolaryngology, Soonchunhyang University in Seoul from Nov. 1996 to Oct. 1999 and analyzed 101 strains and its sensitivity test to various antibiotics. Result : In 93 cases in which pathogenic organism was isolated, single infection was 85 cases(91.4%) and mixed infection was 8 cases(8.6%). The most frequent pathogenic organism was Staphylococcus aureus(59.4%), Pseudomonas aeruginosa(13.9%), Providencia(4.8%), Alcaligenes(3.0%) and Streptococcus pneumoniae(2.9%) were the next. Methicilline-Resistance Staphylococcus aureus was 34 cases(57.6%) of Staphylococcus aureus. Staphylococcus aureus was sensitive to Vancomycin(96.7%), Trimethoprim-Sulfamethoxazole (57.6%), Cefuroxime(42.4%) and Ciprofloxacin(40.7%) but resistant to Penicillin(94.9%). Pseudomonas aeruginosa was sentitive Amikacin(100%), Ciprofloxacin(100%) and Gentamicin(67%). Conclusion : As MRSA recently was wide spread in community accquired infection as well as nosocomial infection, we must consider strict control of MRSA.

실험적으로 유발한 가토의 급성 상악동염에서 sialoglycoconjugates의 표현양상

조진학,황순재 고려대학교 의과대학 1996 고려대 의대 잡지 Vol.33 No.1

The present study was carried out in order to observe the changes in the expression of the sialoglycoconjugates of the rabbit sinus mucosa in the acute maxillary sinusitis model utilizing a biotin labeled lectins for light microscopy and lectin-gold complexes for eletron microscopy with three different lectins; Maackia amurensis (MAA), Wheat germ agglutinin (WGA) and Sambucus nigra (SNA). A comparison of the affinity of these lectins demonstrated the different distribution of sialoglycoconjugates in the ciliary layer and goblet cells. The normal sinus mucosa stained with three types of lectins showed that the sialoglycoconjugates were mainly distributed in the ciliary layer and goblet cells, and that their ultrastructural localization was restricted to the surface of the cilia, microvilli and secretory granules. Moreover, the main sugar residues of the sialoglycoconjugates were found to be consisted of Neu5Ac( 2,3)Gal, GlcNAc and Neu5Ac. Influenza A virus infection decreased the staining intensity of the mucosa with MAA, but not with WGA. In sinus mucosa infected with S. pneumoniae 7 days after Influenza A virus inoculation, however, these findings reverted to the staining intensity shown in the normal sinus mucosa. In addition, there was a hypersecretory activity of the hyperplastic and hypertrophic goblet cells which showed the intense reactivity with MAA and WGA. All of these changes in the staining intensity were also confirmed by the electron microscopic lectin-gold complexes. These results suggest that Neu5Ac(a2,3)Gal sugar residues may be required as protecting factor or modulator for Influenza A virus and s. pnumoinae infectivity.

제79회 전국체전 부산팀전력에 관한 고찰

조재기,성기환,안철순 東亞大學校附設스포츠科學硏究所 1998 스포츠科學硏究論文集 Vol.16 No.-

Focused on the performance of the Pusan team at this year's 79th National Sports Festival, this paper aims to analyze the results of the team by each event through the past 5 years from 1994 to 1998. This year Pusan stood at the 6th again in 8 years. This result is a crisis as the city is scheduled to host the 2000 National Sports Festival and the 2002 Asian Games. The following problems can be pointed out: First, slow development of school sports. From 1991 through 1994, elite-oriented school sports turned into club-associated sports for fun and play. Therefore, some relatively harder events became unpopular and it was more difficult recruiting excellent athletes. Tough financial conditions of schools also contributed to slowing the development of school sports. Second, budgetary lack. The budget of the Pusan Sports Association ranks the 10th among 16 domestic cities and provinces. In particular, the expenses for reinforced training amounting to 200,000 won per person (recording the 14th) leave much for improvement. It's getting harder and harder to purchase expensive equipment. So how to secure enough finance is the most urgent task. Third, tougher economic conditions of Pusan. Owing to the IMF crisis, a lot of companies in Pusan have gone bankrupt. As a result, some athletic associations go without their presidents. So missing are financially supporting athletes and properly collecting data. Henceforth, for the balanced development and high performance of Pusan sports at the National Sports Festival, the above problems should be solved. Let me suggest some guidelines: 1. School sports need to be activated above anything else. In fact, Pusan's high school teams reaped all but the lowest marks this year. We have to enlarge financial grants to high schools, invest in some specialized events, manage the representative reserve system, and expand the support of promising athletes. 2. A practical budget ought to be made, including the rise of reinforced training expenditure up to 300,000 to 400,000 won per athlete. For example, the interests of the sports promotion fund (about 4 billion won) held by the Pusan Sports Association might as well be used as special accounts. 3. Some concerned facilities (sports fields and public athletic parks) and equipment (especially for sea sports) have to be secured. 4. More vigorous support of and investment in college and industrial terms is needed for the bright picture of Pusan sports in the 2000s. 5. As sports administration also goes Seoul-oriented, fresh leaders are needed to run the otherwise weakening municipal sports organization.

주의력결핍과잉행동장애와 Alpha-1C-Adrenergic 수용체 유전자와의 연관성에 대한 연구

조수철,김재원,김붕년,황준원,박미라,김순애,조대연,유희정,정운선,손정우,박태원 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.1

Objectives : Neurobiological and pharmacological research has suggested that the dysregulation of the central noradrenergic systems might be involved in the pathophysiology of ADHD. The aim of this study was to examine the association of the alpha-1C-adrenergic receptor gene (ADRA1C) with ADHD in Korean subjects. Methods : In a case-control study, we assessed 186 DSM-IV ADHD probands and 150 normal controls. One hundred and eight trios were studied in a family-based association analysis. Psychiatric diagnoses were derived through structured diagnostic interviews. For the clinical evaluation of the ADHD subjects, the Child Behavior Checklist (CBCL), the ADHD Rating Scale-IV (ARS) and the Junior Temperament and Character Inventory (JTCI) were administered. A computerized continuous performance test (CPT) was used to measure the inattention and impulsivity of the ADHD children. Results : There were no significant differences in the genotype or allele frequencies of the ADRA1C PstI polymorphism between the ADHD and control group (p>0.05). The transmission disequilibrium test (TDT) analysis observed no evidence for biased transmission of any of the alleles of the PstI polymorphism. There were no significant differences in the CPT or JTCI profiles between those ADHD subjects with the CC genotype and those with the other (CT+TT) genotypes at the PstI polymorphism. Conclusion : The results of this study do not support the ADRA1C as a major genetic susceptibility factor in ADHD.

환경영향평가에 있어서 보건영향평가의 방법, 절차 및 적용에 관한 연구

조일형,박재홍,김임순,한상욱 한국환경영향평가학회 2003 환경영향평가 Vol.12 No.3

Most environmental impact assessment(EIA) programs around the world require the consideration of human health impacts. Yet relatively few EM documents adequately address those impacts. This article examines how, why, and to what extent health impacts are analyzed in environmental impact assessments. This article investigates these problems and provides recommendations to improve human health impact assessment(HIA), using methods, procedures and case study. Also, a comprehensive approach for the evaluation of possible health effects in an EIA is described, illustrated with the example of Amsterdam Airport Schiphol. Unlike many EIAs, we estimated quantitatively the impact of aircraft-related pollution in terms of the number of affected people for aircraft noise annoyance, odour annoyance and hypertension. In addition, an analysis of health registry data on cardiovascular and respiratory diseases and a short survey on annoyance and risk perception were carried out.

초등학교 성교육 프로그램 개발 연구 : 초등학교 고학년을 중심으로 Focusing on the Upper Grades

조연순,김정효,이경순,우재경 한국초등교육학회 2001 초등교육연구 Vol.14 No.2

본 연구는 학교의 공식적인 교육과정을 통해 아동들이 성에 관한 과학적 지식을 습득하고, 건전하고 양성 평등한 태도를 형성하여 긍정적인 자아확립과 원만한 사회 생활을 영위할 수 있도록 하기 위한 성교육 프로그램을 개발하는 데에 목적을 두고 있다. 이를 위해 문헌 분석과 요구 조사를 바탕으로 성교육과정의 내용 체계를 구성하고 초등학교에서 별도의 성교육 시간이나 타 교과 시간 모두에서 활용 가능한 성교육 단원(교수-학습 활동)을 개발하였다. 이렇게 개발한 성교육 단원을 서울, 경기 지역의 8개 초등학교에 예비 적용해 본 후 프로그램을 수정·보완하였다. 이런 과정을 거쳐 9개 단원, 30개 차시안의 성교육 프로그램을 완성하였다. 본 프로그램의 수업방법은 문제 상황을 제시함으로써 성과 관련된 지식의 이해를 도모하며 이를 바탕으로 실생활 문제를 해결할 수 있는 능력을 기르고자 하는데 그 특징이 있다. The purpose of the study was to develop a sexuality education program for the upper graders of elementary schools to acquire scientific knowledge about sexuality, to have the healthy and positive attitude on their gender and to live harmoniously with opposite gender. The processes of program development were as follows; (1) reviewing related literatures, (2) investigating the needs of students, teachers and parents on the school-based sexuality program, (3) forming the framework of sexuality education program, (4) developing units and activities based on the framework of sexuality education program, (5) implementing the developed program to the eight elementary schools in Seoul and Kyung-gi-do, and (6) modifying the program according to the results of implementation. The above processes of the program development are described in detail, and one lesson is presented as an example among 39 lessons developed. Finally, some problems and thoughts of our society related to the sexuality education are discussed.

밝은社會를 指向하는 指導者 Leadership에 關한 硏究 : 새마을 指導者를 중심으로 With Reference to the Saemaeul Leadership

朴淳永,申大淳,趙萬濟,金旭卿,金種垠 慶熙大學校 1980 論文集 Vol.10 No.-

The Saemaeul Undong was launched in 1972 on the basis of the experimental model or Saemaeul pilot projects of the previous year. The Saemaeul Undong is now a nation-wide movement which is based on the fundamental spirits of diligence, self-help and cooperation. Much of the success of the Saemaeul Undong depends on its leaders, who play a pivot role in implementing Saemaeul projects for their community. Popularly elected by the village assembly according to their leadership and faith, the leaders render their services without remuneration, working in the spirit of self-sacrifice. Now, the Saemacul Undong enters upon its tenth year in 1981. If the movement is to continue with renewed momentum, effective training projects for Saemaeul leaders must be worked out. For this purpose, it is then recommended that the research works on the leadership training projects of the Bright Society Movement be referred to. Initially started as a community movement for better life on the campus of Kyung Hee University in 1960's, the Bright Society Movement is now gaining widespread support from national as well as international club members. The goals of the Bright Society Movement are to promote mutual understanding and friendship among members and to construct on earth a truly sound and civilized welfare society that is spiritually beautiful, materially affluent, and humanely rewarding. The main objectives of this study is to propose effective training projects for Saemeaul leaders as well as the Bright Society leaders. 1) Educational courses of leadership training should be offered through the school as well as through the training institution of the community. 2) Educational contents of leadership training should place greater emphasis not only on the spiritual education but also on the technical and practical education related to the welfare of the Community. 3) Public relations education should be strengthened because leaders must work in close cooperation with the community residents for the effective movement. 4) Long-term integrated projects for the community or village unit should be established and the movement should be developed according to them. 5) A special system of regional itinerant education should be established for the effective management of selective leaders. 6) For the welfare of leaders themselves, special favors such as the authorization of leadership careers, scholarships for their sons and daughters, discounts on public charges and the priority on public employment must be offer according to their respective performance.