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      • KCI등재SCOPUS

        SpectrophotometricBrothMicrodilution법을 이용한AspergillusSpecies의 항진균제 감수성 검사

        박미라,신종희,송정원,박영규,조덕,기승정,신명근,서순팔,양동욱 대한진단검사의학회 2004 Annals of Laboratory Medicine Vol.24 No.5

        Background : A spectrophotometric approach to minimum inhibitory concentration (MIC) determination for filamentous fungi may provide an objective and rapid MIC reading, and quantify the hyphal growth of molds. In this study, we evaluated two spectrophotometric broth microdilution methods (SBM) to determine amphotericin B and itraconazole MICs for Aspergillus species isolated from clinical specimens. Methods : A total of 80 clinical isolates (20 A. fumigatus, 20 A. flavus, 18 A. niger, 20 A. terreus, and 2 A. nidulans) were tested for amphotericin B and itraconazole susceptibility by the broth microdilution method. The MIC endpoint was calculated by the spectrophotometer with microplate reader (SBM-Spec method) or colorimetric XTT (tetrazolium dye) method (SBM-XTT method). The results of the SBM method were compared with those of NCCLS M38-A broth microdilution method. Results : The MICs of amphotericin B by the NCCLS M38-A method ranged from 0.125 to 8 g/ mL, and those of itraconazole ranged from 0.25 to 2 g/mL. The agreement of SBM-Spec and SBMXTT methods within one dilution of the NCCLS M38 reference were 98.8% and 96.3% for the amphotericin B, and 98.8% and 100% for itraconazole, respectively. The agreements between SBM-Spec and SBM-XTT methods were 97.5% for amphotericin B and 98.8% for itraconazole. Conclusions : In antifungal susceptibility testing of Aspergillus species, the SBM method including SBM-Spec and SBM-XTT methods showed high levels of agreements with the NCCLS M38-A method. The SBM methods can be useful in the clinical laboratory. (Korean J Lab Med 2004; 24: 301-7) 배경 : 항진균제 감수성 검사에 있어 분광광도계를 이용하여minimum inhibitory concentration (MIC)을 판정할 경우 육안관찰보다 객관적이고 빠르며, 균사의 성장을 더 정확하게 정량할수 있다고 알려져 있다. 본 연구는 임상 검체에서 분리된Asper-gillusspecies에 대한항진균제 감수성 검사를 분광광도계를 이용하여 MIC를 판정하는 spectrophotometric broth microdilution(SBM)법으로 시행하고, 이를 National Committee for ClinicalLaboratory Standards (NCCLS) M38-A법과 비교하였다. 방법 :임상 검체로부터 분리된 80주의 Aspergillus species (A.fumigatus 20주, A. flavus 20주, A. niger 18주, A. terreus20주 및 A. nidulans 2주)를 대상으로 amphotericin B와 itracona-zole에 대한 감수성 검사를 broth microdilution법으로실시하였다.SBM법은 48시간 배양한 후 마이크로플레이트를 그대로(SBM-Spec법) 혹은 XTT를 첨가한 후(SBM-XTT법) 분광도계를이용하여 MIC를 판정하는 2가지 법으로 실시하였다. SBM 검사성적은 동시에 실시한 NCCLS M38-A법( 육안판정) 성적과 비306 박미라신종희송정원 외 6인교하였다.결과 :NCCLS M38-A법에 의한 amphotericin B에 대한 MIC는 0.125-8 g/mL이었고, itraconazole에 대한 MIC는 0.25-2.0g/mL 사이의 범위였다. SBM법과 NCCLS M38-A법과의 일치율(1배 희석배수 내)은 amphotericin B의 경우 SBM-Spec법은 98.8%, SBM-XTT법은 96.3%이었고, itraconazole의 경우SBM-Spec법은 98.8%, SBM-XTT법은 100% 이었다. SBM-Spec법과 SBM-XTT법의 두 방법간의 일치율은 amphotericinB 97.5% 및 itraconazole 98.8%이었다.

      • KCI등재
      • KCI등재

        기독교교육현장인 청소년 수련회에서 가정사역 프로그램과 예배만족의 효과분석

        박미라 한국기독교교육정보학회 2009 기독교교육정보 Vol.0 No.24

        The youth retreat is an essential program for developing membership and teamwork for youth. It is also a chance for spiritual experience and healing the scars. This research defines the meaning of youth, youth retreat, and its needs and purposes. Also, it examined adolescent's problems and what they need in the youth retreat setting. In addition, it checked the relationship between various family ministry programs for youth and the satisfaction of the worship in the retreat. This research proved that youth retreats need to provide specialized and diverse educational programs. Worship at the youth retreat provides an opportunity for curing personal scars in their lives. Also, they could solve their problems through programs about occupational and personality problems. This research proved that the healing of their scars is related to having confidence for salvation. This research provided very important data for planning future youth retreats and programs. The results of this research showed requirements for educational and training programs in the area of family ministry which focus on youth retreats that give opportunities for spiritual experiences, to deal with the stress of studying, solve occupational issues, deal with personality problems, and heal personal scars.

      • KCI등재
      • KCI등재

        생존함수의 비교연구를 위한 표본수의 결정

        박미라,김선우,이재원 한국통계학회 1998 응용통계연구 Vol.11 No.2

        임상시험연구의 설계에서 적절한 표본수의 결정은 매우 중요한 문제 중의 하나이다. 본 논문에서는 생존분포를 비교하기 위한 여러 가지 방법들을 소개하고, 각 방법에서의 가정들을 고찰하였다. 또한 다양한 상황에서의 표본수와 검정력 등을 비교제시하고 모의실험을 통해 각 방법들의 이론상의 검정력과 실제 검정력을 알아보았다. 그 결과로서 의학연구자들이 처한 여러 상황에 적합한 표본수의 결정방법을 제시하였다. One of the most important issues in the area of clinical trial research is the determination of the sample size required to insure a specified power in detecting a real or clinically relevant difference of a stated magnitude. Increasingly, medical journals are requiring authors to provide information on the sample size needed to detect a given difference. We restrict our attention to the designs for comparirng two survival distributions. These are concerned with the survival time which is defined as the interval from a baseline(e.g. randomization) to failure(e.g. death, recurrence of disease). Survival times are right censored when patients have not failed by the time of analysis or have been loss to follow-up during the trial. For different types of clinical trials for comparing surviavl distributions, there have been many research in sample size determination. We review the existing literature concerning commonly used sample size formulae in the design of randomized clinical trials, and compare the assumption, the power and the sample size calculation of these methods. We also compare by simulation the expected power and observed power of each method under various circumstances. As a result, guidelines in terms of practical usage are provided.

      • KCI등재

        다문화 기독교교육 관점에서 북한이탈주민 학생교육 -기독교 집단상담을 중심으로-

        박미라 한국기독교교육학회 2011 기독교교육논총 Vol.27 No.-

        본 논문은 새로운 시대를 맞이하여 기독교교육의 현실을 돌아보고, 평화공존의 미래지 향적인 교육과제를 발굴하여 새시대가 요청하는 기독교교육의 역할과 과제를 조명하는 것 에 있다. 본 논문에서는 북한을 탈출하여 한국에 귀순한 사람들 즉 북한이탈주민이라 명명한 사 람들이 한국사회의 편견과 이해 부족으로 어려움을 겪고 있는 실정에 초점을 두어 다문화 기독교교육관점에서의 기독교 상담접근으로 북한이탈주민 학생을 교육하는 것에 대해 논 하고자 한다. 연구문제는 다음과 같다. 첫째, 다문화교육의 개념 정리를 통해 기독교적 다문화교육의 범위를 설정하고 둘째, 한국 다문화교육과 기독교 다문화교육의 현실을 분석하며, 셋째, 다문화 교육 안에서 북한이탈주민 학생교육의 현실적 필요를 검증하며, 마지막으로 기독 교 상담학적 접근의 북한이탈주민 학생교육 방안을 구체적으로 모색하고자 하였다. 본 논문의 연구를 통해 북한이탈주민 학생을 위한 지속적이고 체계적인 지원 및 상담 이 필요함을 주장하였다. 현재 정부에서 의무적으로 시행하고 있는 하나원에서의 2-3개월 교육만으로는 부족하고 그 이후의 사회적 심리적 지지가 더 중요함을 지적하며 북한이탈 주민 학생들이 가지고 있는 심리적 문제를 파악하여 기독교상담 및 기독교 집단상담프로 그램을 통해 구체적인 치료를 제공해야 함은 물론이다. 더불어 본 논문을 통해 다문화 기 독교교육적 관점에서 북한이탈주민학생 교육은 통일의 당위성과 통일의식 및 통일교육을 위한 신학적 설명 해석 작 업을 중심으로 교회교육 커리큘럼에 통일이라는 주제를 포함해 야 할 것이다. The purpose of this research is to shed light on to the Christian education field with finding out new educational tasks in a new epoch. This research dealt with the difficulties of the North Korean defector students' settlement in South Korea with the lack of understanding of them. This research also focused on the Christian counseling approach to support the North Korean defector students' settlement in South Korea. This research has three research topics. First, the criteria of Christian multi-cultural education were constructed through the general multi-cultural education literature reviews. Second, The actualities of Korean multi-cultural education and Christian multi-cultural education were analyzed. Third, how multi-cultural education satisfies the needs of North Korean defector students. Finally, find out how to support North Korean defector students through the Christian counseling approach. The results of this research suggested several solutions to the research topics. The continuation of support and counseling to the North Korean defector students are indispensible to help their settlement in South Korea. The contemporary 2-3 months settlement program is insufficient to their safe settlement in South Korea. Korean churches should help the North Korean defector students through the Christian counseling and group counseling programs to solve the North Korean defector students' psychological problems. Through this research the subject of reunification should be included in the Christian educational curriculum.

      • KCI등재
      • KCI등재

        Analysis of Multivariate Phenotypes by Canonical Correlation Biplot in Genetic Association Study

        박미라,이재용,진서훈 한국자료분석학회 2014 Journal of the Korean Data Analysis Society Vol.16 No.6

        In the genetic association study of complex diseases, we may obtain several continuous phenotypes which are correlated to each other. The purpose of the analysis is to identify the relationship between genetic polymorphism and multiple phenotypes. Performing univariate analysis separately for each phenotype is common, but it has limitations in detecting pleiotropic genes. Its performance tends to deteriorate in the multiple testing problems. In this study, we suggest to employ a canonical correlation biplot (CCB) and a semi-partial canonical correlation biplot (SPCCB) as the multivariate approaches. The CCB summarizes the correlation between linear composites for phenotypes and genotypes. Also, it produces three kinds of graphs which are able to catch the relationship between genotypes, between phenotypes and ultimately between genotypes and phenotypes at a glance. SPCCB is an extension of the CCB by permitting covariates. We show the results of these methods by applying them to a sample genetic data as an illustration.

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