한옥의 특징기반 형상모델링 및 매개변수형 BIM 라이브러리 브라우저 개발에 관한 연구

김인한(Kim In-Han),박승화(Park Seung-Hwa),이지아(Lee Ji-Ah) 대한건축학회 2012 대한건축학회논문집 Vol.28 No.5

Since Han-ok, the traditional Korean-style house, is composed with combinations of complex components in various shapes and sizes, it is essential to categorize the components into several types for digitalization of Han-ok information. This study applied feature-based classification using BIM parametric modelling methods. After investigating ‘Parameter and Formula relations’, ‘Parametric description’ and ‘Instance diagram’ of Han-ok components, the study established XML libraries for the parametric modelling of open BIM. The IFC-XML libraries include parametric and properties information as well as the geometric information of Han-ok. For the combination of parametric and non-parametric geometry, the study also suggested a new methodology of using ‘comments’ inside IFC, which enabled interworking between IFC and XML. A prototype of BIM browsing module was developed in the last phase of this study to validate the conformance of the IFC-XML libraries. This integrated browser for Han-ok allows the users, both experts and non-experts, to check and manipulate Han-ok component fabrication by changing specific parameters promptly. The browser successfully showed automatic changes of all related Han-ok elements in accordance with the parameters, relationships and formulas of components.

신장기증자들의 심리적 특성

정승아,김재환,강종명,이장한,김경욱 漢陽大學校 精神健康硏究 1998 精神健康硏究 Vol.17 No.-

인체 간 Microsome에서의 우슬 추출물의 Cytochrome P450 약물 대사효소에 대한 억제작용

김경아,이지숙,박히준,김진우,김창주,심인섭,한승무,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective : Achyranthes bidentata radix (Usul) has been used as anti-arthritic, antiallergic, antidiuretic and so on Recently extracts of Achyranthes bidentata radix have shown anti-inflammatory and cancer preventive effects in vitro and in vivo. Methods : We therefore evaluated the inhibitory potential of ehtanol extracts of Achyranthes bidentata radix on cytochrome P450(CYP) isoforms-catalyzecd reactions, which relate to causes of cancer and inflammation, including CYP1A2, CYP2C9, CYP2C19, CYP2E1, CYP2D6, CYP2C8, and CYP3A4, using human liver microsomal preparations. Results : The extracts showed weak or negligible inhibitory effects on CYP2C9-catalyzed (S)-warfarin 7-hydroxylation, CYP2C19-catalyzed S-mephenytoin 4-hydroxylation, and CYP2D6-catalyzed dextromethorphan O-demethylation with each IC50 over 1750 g/㎖, respectively. However, it showed relatively significant inhibitory effect on CYP1A2-catalyzed phenacetin O-deethylation and CYP2E1-catalyzed chloizoxazone 6-hydroxylation with IC50s of 970.5 g/㎖ and 821.4 g/㎖, respectively. Conclusions : These results suggest that extracts of Achyranthes bidentata radix have inhibitory effects on CYP-catalyzed reactions, expeciallyCYP1A2 and CYP2E1, in human liver microsomes. These effects appear to relate to anti-inflammatory and cancer prevention following decrease of reactive oxygen species formed by CYP, especially CYP1A2 and CYP2E1, by Achyranthes bidentata radix. However, further evaluation is necessary to demonstrate and to confirm its effects in human.

진달래 꽃에 의한 Grayanotoxin 중독 3 례

김아진,김준식,신동운,백광제,한승백,이용주 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Traditionally, the Rhododendron species has been used in gastrointestinal disorder or hypertension. Grayanotoxin exists in honey, flowers, pollen, and the nectar of the Rhododenron species. We experienced 3 cases of Grayanotoxin intoxication. The symptoms of intoxication were nausea, vomiting, hypotension, bradycardia, diplopia, dizziness, and chest discomfort. Generally, the treatment for Grayanotoxin intoxication is fluid resuscitation and injection of atropine sulfate. The patients who were intoxicated with Grayanotoxin were discharged without complication after supportive care.

특수건강진단의 건강관리구분과 그 개선방안에 관한 연구

이승한,이원철,김형아,장성실 大韓産業醫學會 1994 대한직업환경의학회지 Vol.6 No.2

The findings of special medical examinations are not infrequently summarized in the form of health classification. This procedure seems valuable for the protection of workers' health from personal health as well as public health point of view, because health classification of workers provides occupational health workers with birds eye view informations in terms of medical, placement and educational procedures, which are to be followed after medical examinations. In this study, the authors have reviews the existing systems of special medical examinations and health classifications in different countries and those recommended by international organizations for the purpose of improving the current system in Korea. The important issues covered in this review in relation to health classification of workers included the categories of diseases, the examination and laboratory tests, the criteria for health level classification and the health instructions to be given at each health levels. It was found that the current health classification system in Korea could be featured as follows: 1. Special medical examinations are always carried out in combination with general medical examinations, contributing to the detection of risk factors of occupational diseases. 2. The selection of examinees is always made on the basis of work environment monitoring, often resulting in the underdetection of exposed workers. 3. Even if the test items are properly selected according to the principles of occupational medicine, further review is required in the light of recent advances in the pathogenesis as well as early changes of occupational diseases and epidemiologic principles. 4. The criteria for the classification of health levels are to be reviewed on the basis of clinical eqidemiology. 5. The health instructions covered only medical and placement aspects, failing to introduce the concept of health promotion.

랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구

김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.

침 시술로 발생한 Non-O1, Non-O139 Vibrio cholerae에 의한 패혈증

임태섭,지아영,이중희,장수연,김인수,김영주,김범경,김승업,박준용,안상훈,한광협,김도영 Ewha Womans University School of Medicine 2013 EMJ (Ewha medical journal) Vol.36 No.S

Vibrio cholerae is mainly known to cause gastrointestinal infection after seawater exposure or raw seafood intake. It is rarely reported to cause cellulitis or sepsis, but threre has been no known case after acupuncture. Herein, We report a 56-year-old cirrhotic patient of non-O1, non-O139 Vibrio cholerae septicemia caused by cellulitis of both lower extremities after acupuncture.

Amino-Functionalized Mesoporous Silica Particles for Ocular Delivery of Brimonidine

Kim, Se-Na,Ko, Song Ah,Park, Chun Gwon,Lee, Seung Ho,Huh, Beom Kang,Park, Yoh Han,Kim, Young Kook,Ha, Ahnul,Park, Ki Ho,Choy, Young Bin American Chemical Society 2018 MOLECULAR PHARMACEUTICS Vol.15 No.8

<P>To treat glaucoma, conventional eye drops are often prescribed. However, the eye drops have limited effectiveness as a result of low drug bioavailability due to their rapid clearance from the preocular space. To resolve this, we proposed amino-functionalized mesoporous silica (AMS) particles as delivery carriers of the glaucoma drug, brimonidine. Because of the presence of mesopores, brimonidine (BMD) could be encapsulated in the AMS with a loading amount of 41.73 μg/mg (i.e., drug loading capacity of about 4.17%) to give the BMD-AMS, which could release the drug in a sustained manner over 8 h. BMD-AMS was also shown to be mucoadhesive due to the presence of both hydroxyl and amino groups in the surface, allowing for formation of hydrogen bonds and an ionic complex with the mucin, respectively. Therefore, when topically administered to rabbit eyes in vivo, BMD-AMS could reside in the preocular space for up to 12 h because of its adherence to the mucous layer. To assess in vivo efficacy, we examined the variance in intraocular pressure (IOP) and brimonidine concentration in the aqueous humor (AH) after applying BMD-AMS to the eye, which was compared with that induced by Alphagan P, the marketed brimonidine eye drops. For BMD-AMS, the duration in the decrease in IOP and the area under the drug concentration in the AH-time curve (AUC) were 12 h and 2.68 μg·h/mL, respectively, which were about twice as large as those obtained with Alphagan P; this finding indicated enhanced ocular bioavailability of brimonidine with BMD-AMS.</P> [FIG OMISSION]</BR>

정신병리적 언어행위의 형식적 특징규명을 위한 기초연구

민형원,홍성기,정승아,이장한,양병환 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 정신분열병집단과 정상집단의 사고형태의 차이를 언어철학적으로 접근하여 이해하고 이를 바탕으로 사고형태를 측정하는 도구를 개발하고자 한다. 방 법 : 1997년의 예비실험에서 얻은 결과를 중심으로 새로운 작품사진(具象, 抽象의 彫刻과 繪畵)을 약 50장을 선정한 후 반응의 용이성과 다양성을 기준으로 최종 10개의 작품을 실험도구로 결정하였다. 피검자는 1999년 2월부터 동년11월까지 대학병원 신경정신과에 입원한 24명(정신분열병)과 정상대조군으로 19명의 일반인들이 실험에 참가하였다. 피검자들은 제시되는 작품의 제목을 붙이도록 요구받았으며, 피검자의 세 가지 반응측면 즉 반응의 방식, 반응이 지칭하는 작품의 범위, 그리고 반응이 지칭하는 대상의 구체성 혹은 추상성 여부로 구분하여 전체 7가지 양상으로 기호화하였고 각 반응를 직접과 간접으로 구분하였다. 피검자에게 실험을 실시한 후 기호화하여 집단간 빈도분석을 실시하였다. 결 과 : 1) 정신분열병집단이 정상집단보다 직접속성, 단순기술의 반응이 많은 반면에, 정상집단의 경우 투사가 결합된 직접속성, 간접속성, 간접연상, 그리고 개념의 형성에 필요한 일반화가 많았다. 2) 제목과 이 제목이 지칭하는 작품의 범위관계에 대한 정신분열병집단과 정상집단의 반응빈도는 의미 있는 차이를 보이지 않았으나 두 집단 모두 작품의 부분보다는 전체를 보고 제목을 정하는 경향이 높았고, 비교적 정신분열병집단이 제목을 작품전체를 보고 단순하게 반응하는 경향이 있는 반면에 정상집단은 작품의 일부분을 보고 이를 일반화하는 경향이 많았다. 3) 정신분열병집단과 정상집단 모두 제목의 추상성보다는 구체성이 우세한 경향을 보였으나, 정신분열병집단(95.3%)이 정상집단(71.4%)에 비해서 보다 더 제목의 구체성이 두드러졌으며 정상집단(28.6%)은 정신분열병집단(4.7%)에 비해서 전체 반응빈도에서 제목의 추상성이 더 우세하였다. 4) 정신분열병집단이 정상집단보다 사고의 직접성이 더 높았고(73.5%), 정상집단은 사고의 간접성이 더 높았다.(58.7%). 결 론: 1) 정신분열병집단이 정상집단에 비하여 추론과정과 사고의 단계성이 없는 직접적이고 단순한 형태의 사고형태나 언어표현이 확연히 드러났다. 또한 정신분열병집단이 사물을 지각하고 이를 표현하는데 있어서도 사물의 전체를 보고 단순하게 반응하거나, 구체적이고 직접적인 표현이 많은 것으로 보인다. 2) 본 연구를 통해 개발된 실험도구를 좀 더 넓은 범위의 대상자에게도 반복 적용하여 연구함으로써 지속적인 신뢰도와 타당성을 높일 수 있을 것이다. 또한 개별적 차이에 대한 연구를 병행함으로써 개인간의 혹은 동일한 인물의 시간경과에 따른 사고방식의 차이를 검사할 수 있는 방법으로 정착될 필요가 있다. 3) 비록 양집단 사이의 확연한 차이에도 불구하고 실험도구의 신뢰성을 객관적으로 확보하기 위하여 사고형태 및 언어적 표현에 영향을 미치는 것으로 추정되는 지적능력, 교육연한, 그리고 문화적 경험을 좀 더 고려한 추가연구가 필요할 것으로 생각된다. Objective : The purpose of this study was to identify differences in thinking between schizophrenic patients and healthy subjects with linguistic-philosophical approach and to develop a tool to measure pathological thinking. Methods : Approximately 50 cards(pictures of either representational or abstract sculptures and paintings) from the previous experiment(1997) were carefully examined and 10 cards were selected based on their variety and promptness of the response. Twenty-four schizophrenic patients and 19 healthy subjects participated in this experiment. Participants were required to give a title to each picture. Their responses were analysed based on the forms of thinking, abstractness(or concreteness) and the category of the title. Each response was also coded either direct of indirect. Results : 1) Schizophrenic patients emitted more direct and simple descriptive responses whereas healthy subjects showed projection-related direct traits, indirect traits, indirect association and generalization. 2) Both groups tended to utilize the whole rather than parts. Schizophrenic group depended more on the whole pictures than healthy group. Healthy subjects showed more generalization tendency with parts. 3)Both groups preferred concrete titles to abstract ones. Schizophrenic group(95.3%) used more concrete titles than healthy group(71.4%) and healthy group(28.65%) used more abstract titles than schizophrenic group(4.7%). 4) Schizophrenic patients(73.5%) showed more directness in thinking than healthy subjects, whereas healthy subjects(58.7%) more indirectness. Conclusions : 1) Schizophrenic patients clearly showed direct and simple forms of thinking and expressive language, lacking reasoning, and systematic processing. Additionally, schizophrenic patients simply responded to the whole and used concrete and direct expression. 2) Replication study is warranted to improve reliability and validity of the tool we developed. Research on individual differences needs to be conducted to measure differences among individuals and change over time in an individual. 3) Further study on the factors which might be related to forms of thinking and language expressions, such as intelligence is warranted.

In vivo study for the hemostatic efficacy and foreign body reaction of a new powder-type polysaccharide hemostatic agent

Yoonhyeong Byun,Eun Jin Kim,Areum Lee,Young-Ah Suh,Hee Ju Sohn,Jung Min Lee,Jae Seung Kang,Yoo Jin Choi,Youngmin Han,Hongbeom Kim,Wooil Kwon,Jin-Young Jang 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.2

Purpose: Various hemostatic agents have been introduced in therapy as postoperative bleeding is a poor prognostic factor for postoperative outcomes. These products can be divided into those that directly promote the hemostatic cascade and those that physically form a barrier by absorbing blood. The latter, powder-type hemostatic agents have the advantages of being inexpensive and more absorbable with less foreign body reactions (FBRs) and are applicable to a relatively wide area. This study was conducted to verify the safety and efficacy of a newly invented polysaccharide product (OOZFIX, Theracion Biomedical), which improves blood absorption and hemostatic effects. Methods: Two separate animal experiments were performed. The first evaluated FBRs histologically at 3 days, 2 weeks, and 4 weeks, after implantation of OOZFIX in rats, and the second compared hemostatic performance of OOZFIX and Arista AH (Bard) in the porcine liver punch biopsy model. Results: We found minimal FBRs in the 3-day group and no reactions in both the 2-week and 4-week groups after implantation of hemostatic agents. The time to hemostasis of OOZFIX was not significantly different from that of Arista AH (median [interquartile range]: 9 [6–10] minutes vs. 8 [6–10] minutes, respectively; P = 0.522). When comparing the serial bleeding grade tendency, there was no statistical difference between OOZFIX and Arista AH (P = 0.656). Conclusion: OOZFIX caused a minimal FBR that disappeared within 2 weeks in vivo, and its hemostatic performance was comparable with that of an existing agent, Arista AH. Further clinical studies are required in the future.