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18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구
장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3
Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.
Ethylenediaminetetraacetic acid(EDTA)항응고제에 의한 Mean Corpuscular Volume(MCV)변화
홍승민,박영진,최하영,임진,정옥연,이호준,이호영,장숙진,문대수 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.2
It is essential that we put the anticoagulant into the blood specimen of the CBC test. However, the value of some parameters in the CBC test can be changed whenever using some anticoagulants. EDTA anticoagulant is mostly used these days. There are 3 kinds of EDTA, that is K_(2-), K_(3-), and Na_(2-) EDTA. The author studies how many effects each the EDTA gets into the true value of blood specimen for MCV of RBCs. Especially we compared the MCV effect of different concentrations of 3 EDTA anticoagulants on the bias with time and instrument. Some results are gotten. In our results, K_(3-)EDTA anticoagulant shows more satisfactory MCV value than K_(2) or Na_(2-)EDTA. On using concentration of EDTA, 1.5㎎ EDTA/㎖ of blood show more satisfactory MCV value than 7.5㎎ EDTA/㎖ of blood. However, the choice of anticoagulant may be dependant on the different instruments.
Ko, Il Gyu,Jeong, Jin Woo,Kim, Young Hoon,Jee, Yong Seok,Kim, Sung Eun,Kim, Sang Hoon,Jin, Jun Jang,Kim, Chang Ju,Chung, Kyung Jin Korean Continence Society 2014 International Neurourology Journal Vol.18 No.2
<P><B>Purpose</B></P><P>Aging-induced loss of muscle mass and subsequent reduction of strength is a fundamental cause of frailty, functional decline, and disability. And this may lead to muscular dysfunction, voiding dysfunction, or urinary incontinence due to pelvic muscle weakness induced by aging. Physical exercise has been recommended for the prevention and the treatment of these age-related frail states. We investigated the effects of treadmill exercise on muscle strength, myostatin mRNA and protein expression, and gastrocnemius myocytes proliferation in aged rats to investigate the possible antiaging effects of aerobic exercise on skeletal muscles such as pelvic floor muscles and urethral rhabdosphincter muscle.</P><P><B>Methods</B></P><P>In this study, 5-month-old male Sprague-Dawley rats were used as the young-age group (n=20) and 24-month-old rats were used as the old-age group (n=20). Each group was randomly divided into two groups (n=10 in each group): the sedentary and the treadmill exercise group. The rats in the exercise groups were forced to run on a motorized treadmill for 30 minutes, once a day, for 6 weeks. For this study, a weight load test, hematoxylin and eosin staining, real-time and reverse transcription polymerase chain reaction for myostatin mRNA, myostatin western blot, and 5-bromo-2'-deoxyuridine immunohistochemistry were performed in the gastrocnemius muscle.</P><P><B>Results</B></P><P>The age-induced reduction of muscle mass and strength was associated with a decrease in myocyte proliferation and an increase in myostatin mRNA and protein expression in the gastrocnemius. However, treadmill exercise improved muscle mass and strength through suppression of myostatin mRNA and protein expression, and myocyte proliferation increase in the gastrocnemius against the aging process.</P><P><B>Conclusions</B></P><P>Aerobic exercise is a useful strategy for enhancing muscle function against aging-induced loss of skeletal muscle mass and functions.</P>
Branch-Line Slit 을 갖는 이중 대역 PIFA의 설계 및 제작
장수영,윤진호,김보미,김석현,이영순 금오공과대학교 2005 論文集 Vol.26 No.-
A PIFA(Planar Inverted-F Antenna) which can be used in GSM/IXS dual band mobile phone has been designed and fabricated. In particular, in order to reduce the required top patch dimensions, the patch of the present PIFA has been designed as a type of an asymmetric branch line slit in which the excited patch surface currents can be meandered. By use of the HFSS, important design parameters such as the position of feed point and the length of slit were simulated and determined. In the present study, the design procedure by which the exact operating frequency and the proper band width can be obtained, are discussed. In order to check the validity of the present study, some simulated and measured results are presented.
Redundant Binary Booth Encoding을 이용한 FIR 필터 코어의 설계
장영진,이현수 경희-다반 ASIC 설계교육센터 2000 경희-다반 ASIC센터 논문집 Vol.1 No.-
In this paper, we propose the architecture of a fast programmable FIR filter core that can be used in digital signal processing demanding high-speed and high-order digital filtering. To reduce the complexity of multiplication and addition, we adopt a redundant binary representation. It can perform addition in a constant time independent on the word length of multiplicand. Since FIR computing needs addition proportion to the size of tap, fast addition and reduction method plays a key role in implementing a fast FIR filter. The proposed method results more than 100M/s. And it has a programmability and scalability for use a variety of signal processing.
GMDP 신경망 알고리즘과 PID 제어기를 이용한 효율적인 PLANT 제어에 관한 연구
장진청,설재훈,장종승,추연규,임영도 동아대학교 공과대학 부설 한국자원개발연구소 1995 硏究報告 Vol.19 No.2
Adapative control theory or parameter tuning of PID controller is mainly limited in linear systems. But in this paper, using a nonlinear mapping capability of NNS, we derive a realtime tuning method of PID controller based on a Back-Propagation method of single GMDP NN. A variety of neural models, especially higher-order networks, are known to computationlly powerful for complex application. While they have advantages over traditional multilayered perceptrons, the uniformity in their network structures, learning algorithms and loop time creates practical problems. Thus this paper evaluates the capability between MLP and GMDP for performing velocity control. Backpropagation is applied to the GMDP as learning rule.
혈청 감마지티(gamma glutamyl transferase)치와 대사증후군의 연관성
장미,유병욱,조용진,오정은,홍성호,조주연 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.1
Background: Serum gamma glutamyl transferase(GGT) level has been widely used as an index of liver dysfunction and a marker of alcohol intake. But, recently it is identified that the elevated GGT level was associated with insulin resistance. This study aimed to examine the association between metabolic syndrome and elevated GGT level in the women who had less alcoholic influence generally. Methods: From 585 women who received their annual health check-up, 577 women were selected for analysis except for 28 women who had hepatitis B surface antigen positive or antibody to hepatitis C virus positive, Categories of serum GGT were classified into four groups by quartile and then evaluated. Results: A abnormal GGT level(≥52U/L) was seen in 29(5.2%) of the 557 women. As GGT level increased, the prevalence rate of factors(body mass index≥25kg/m2, hypertension, hemoglobin≥14g/dL, total cholesterol≥220mg/dL, triglyceride≥150mg/dL, fasting plasma glucose≥110mg/dL, HDL-choles tero1<50mg/dL) except for hyperuhcemia was increased. The GGT level was correlated with age, body mass index, thglyceride and uric acid in women with fatty liver, but not in women without fatty liver. Factors independently contributing to elevated GGT level was diabetes, hyperthglycehdemia and obesity. Conclusion: The elevated, albeit normal, GGT level was strongly associated with the factors of metabolic syndrome in Korean women. Because measurement of serum GGT level is easy, reliable, and not expensive, it might have more important implication as predictive factor of metabolic syndrome.