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경계성 상피성 난소종양 환자에서 혈청 CA-125농도 측정의 임상적 효용성
김병기,박상윤,이제호,김종훈,박기복,이경희,이의돈,배재호,고재환,한현신 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.10
1987년 1월부터 1992년 12월까지의 본원 산부인과에서 수술하고 수술 후 경계성 난소종양으로 진단받고 치료받은 환자 29명을 대상으로, 임상병리학적 소견과 혈청 CA-125의 추적조사를 통하여 다음과 같은 결론을 얻었다. 1. 조직학적 유형으로는 44.8%는 장액성이었고, 나머지는 점액성이었다. 2. FIGO 병기분류는 I기가 86.2%인 25명으로 대부분이었다. 3. 수술시 전체 난소종양의 크기는 6.0 cm에서 40.0 cm까지 였으며, 중앙값은 18.0 cm였다. 수술전 혈청 CA-125치는 정상군에서 18.3+-1.8 cm, 상승군에서는 17.4+-3.0 cm로 유의한 차이는 없었다. 4. 조직학적 유형에 따른 수술 전 혈청 CA-125상승 양성율을 비교하여 보면, 장액성은 13명에서 5명, 점액성은 16명에서 8명으로 유의한 차이는 없었다. 5. FIGO병기에 따른 수술전 혈청 CA-125상승양성율을 보면, I기 환자 25명중 9명에서 양성율을 보여 36%가 양성이었으며, II기 이상 환자의 경우는 4명 모두에서 수술 전 혈청 CA-125치가 상승을 보여 100%양성율을 나타내었다. 6. 치료 전 및 치료 후 혈청 CA-125치 변화를 조직학적 유형에 따라 비교하여 보면, 장액성에서는 수술 전 혈청 CA-125치가 257.1+-211.3 U/ml에서 수술후 7.3+-1.7 U/ml로 유의한 감소를 보였으며, 점액성에서도 수술 전 55.9+-11.3 U/ml에서 수술후 9.4+-3.4 U/ml로 유의한 감소를 보였다. 7. 수술 전 혈청 CA-125역가에 따른 수술 전후의 혈청 CA-125치의 변화를 비교하여 보면, 수술 전 혈청 CA-125치 상승군 10명에서는 혈청 CA-125치가 349.6+-247.5 U/ml에서 9.4+-3.4 U/ml로 유의하게 감소하였고, 수술 전 혈청 CA-125치가 정상이었던 환자 14명에서도 혈청 CA-125치가 18.6+-2.5 U/ml에서 7.6+-1.5 U/ml로 유의한 감소를 보였다. The measurement of serum CA-125 levels has been demonstrated to be useful in monitoring the disease status of patients with invasive epithelial ovarian malignancies. However, the role of serum CA-125 in the diagnosis and management of patients with borderline ovarian tumors has not been established. Retrospective analysis of serum CA-125 levels was performed in 29 patients before operation and after treatment for borderline epithelial ovarian tumors at the Korea Cancer Center Hospital between 1987 and 1992. 14(87.5%), 2(12.5%) of 16 patients with mucinous tumor were stage I and III, while 11 (84.6%), 1(7.7%), 1(7.7%) of 13 aptients with serous tumors were stage I, II, III$lt; respectively on surgical staging. The tumor sizes between patients with normal (less than 35 U/ml) and elevated level(over than 35 U/ml) of serum CA-125 were 18.3+-1.8 and 17.4+-3.0 cm, respectively, and there was no statistical difference between the two groups(p=0.689). 38.5% of serous and 50.0% of mucinous tumors ahd elevated CA-125 levels, and there was no statistical difference between the two groups(p=0.806). Combining both cell types, 9(36.0%) of 25 patients with stage I desease and 4(100.0%) of 4 patients with Stage II and III disease had elevated preoperative levels. Serum CA-125 was statically significnatly increased according to upstaging(p=0.001). Serum CA-125 levels in patients with serous tumors(N=12) were decreased after surgery from 257.1+-211.3U/ml to 7.3+-1.7 U/ml(p=0.0049), and with mucinous tumors(N=12) from 55.9+-11.3U/ml to 9.4+-2.8 U/ml(p=0.0005). CA-125 levels in patients with elevated CA-125 level(N=10) were decreased after surgery from 349.6+-247.5 U/ml to 9.4+-3.4 U/ml(p=0.002) and with normal CA-125 level(N-14) from 18.6+-2.5 U/ml to 7.6+-1.5 U/ml(p=0.0038). These data suggest that preoperative serum CA-125 level correlates with stage of disease and serum CA-125 levels decrease after sugery regardless the initial level before treatment.
박정희,조태일,이준형,박종두,강유미 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.8
저자들은 1998년 1월 본원 산부인과에서 극히 희귀한 49세 여성의 우측 난소에서 발생한 평활근육종 1예를 경험하였기에 간단한 문헌 고찰과 함께 이를 보고하는 바이다. A diagnosis of leiomyosarcoma of the ovary was made in a 49 year old female presenting with abdominal pain and palpable mass. On clinical examination, a hard, large mass was found occupying the pelvic cavity. We experienced this infrequent malignant tumor. The authors report this case with the clinicopathologic findings and brief review of literature.
박상윤,이제호,박기복,이경희,이의돈,조경자,김민경,박영양,김해숙,명나혜 대한산부인과학회 1992 Obstetrics & Gynecology Science Vol.35 No.3
The reported cases of adenoid cystic carcinoma of Bartholins gland are extremely rare. We experienced two cases of adenoid cystic carcinoma of Bartholins gland. Authors presented two cases with a brief review o literatures.
Park, E-K,Lee, EJ,Lee, S-H,Koo, KH,Sung, JY,Hwang, EH,Park, JH,Kim, C-W,Jeong, K-C,Park, B-K,Kim, Y-N Wiley (Blackwell Publishing) 2010 British journal of pharmacology Vol.160 No.5
<P>Background and purpose: Lipid rafts and caveolae are membrane microdomains with important roles in cell survival signalling involving the Akt pathway. Cholesterol is important for the structure and function of these microdomains. The ginsenoside Rh2 exhibits anti-tumour activity. Because Rh2 is structurally similar to cholesterol, we investigated the possibility that Rh2 exerted its anti-tumour effect by modulating rafts and caveolae. Experimental approach: A431 cells (human epidermoid carcinoma cell line) were treated with Rh2 and the effects on cell apoptosis, raft localization and Akt activation measured. We also examined the effects of over-expression of Akt and active-Akt on Rh2-induced cell death. Key results: Rh2 induced apoptosis concentration- and time-dependently. Rh2 reduced the levels of rafts and caveolae in the plasma membrane and increased their internalization. Furthermore, Akt activity was decreased and consequently, Akt-dependent phosphorylation of Bad, a pro-survival protein, was decreased whereas the pro-apoptotic proteins, Bim and Bax, were increased upon Rh2 treatment. Unlike microdomain internalization induce by cholesterol depletion, Rh2-mediated internalization of rafts and caveolae was not reversed by cholesterol addition. Also, cholesterol addition did not restore Akt activation or rescue cells from Rh2-induced cell death. Rh2-induced cell death was attenuated in MDA-MB-231 cells over-expressing either wild-type or dominant-active Akt. Conclusions and implications: Rh2 induced internalization of rafts and caveolae, leading to Akt inactivation, and ultimately apoptosis. Because elevated levels of membrane rafts and caveolae, and Akt activation have been correlated with cancer development, internalization of these microdomains by Rh2 could potentially be used as an anti-cancer therapy.</P>