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Kim Hee-Hoon,Shim Young-Ri,Choi Sung Eun,Kim Myung-Ho,Lee Giljae,You Hyun Ju,Choi Won-Mook,Keungmo Yang,Ryu Tom,Kim Kyurae,김민정,Woo Chaerin,Chung Katherine Po Sin,Hong Song Hwa,Eun Hyuk Soo,Kim Seok-Hw 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Chronic alcohol consumption often induces hepatic steatosis but rarely causes severe inflammation in Kupffer cells (KCs) despite the increased hepatic influx of lipopolysaccharide (LPS), suggesting the presence of a veiled tolerance mechanism. In addition to LPS, the liver is affected by several gut-derived neurotransmitters through the portal blood, but the effects of catecholamines on KCs have not been clearly explored in alcohol-associated liver disease (ALD). Hence, we investigated the regulatory roles of catecholamine on inflammatory KCs under chronic alcohol exposure. We discovered that catecholamine levels were significantly elevated in the cecum, portal blood, and liver tissues of chronic ethanol-fed mice. Increased catecholamines induced mitochondrial translocation of cytochrome P450 2E1 in perivenous hepatocytes expressing the β2-adrenergic receptor (ADRB2), leading to the enhanced production of growth differentiation factor 15 (GDF15). Subsequently, GDF15 profoundly increased ADRB2 expression in adjacent inflammatory KCs to facilitate catecholamine/ADRB2-mediated apoptosis. Single-cell RNA sequencing of KCs confirmed the elevated expression of Adrb2 and apoptotic genes after chronic ethanol intake. Genetic ablation of Adrb2 or hepatic Gdf15 robustly decreased the number of apoptotic KCs near perivenous areas, exacerbating alcohol-associated inflammation. Consistently, we found that blood and stool catecholamine levels and perivenous GDF15 expression were increased in patients with early-stage ALD along with an increase in apoptotic KCs. Our findings reveal a novel protective mechanism against ALD, in which the catecholamine/GDF15 axis plays a critical role in KC apoptosis, and identify a unique neuro-metabo-immune axis between the gut and liver that elicits hepatoprotection against alcohol-mediated pathogenic challenges.
송찬호,김재욱,김세광,조재성,김태윤,김행수,김경수,김현욱 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.8
This study was undertaken to determine both the prevalence of the red cell irregular antibodies and the clinical significance of such antibodies in pregnant women. Among 1.047 patients who received complete prenatal care at the Severance Hospital, Yonsei Medical Center, 22(2.1%) were found to have irregular antibodies. The encountered irregular antibodies in order of frequency were : anti-D(7), anti-Le^a(5), anti-E(2), anti-Le^b(2), anti-E+c(1), anti-Le^a+b(1), anti-Jr^3(1), warm auto(1), cold(1), and unidentified(1). The antecedent maternal risk factors for development of irreaular antibodies such as previous abortion, Cesarean birth, or blood transfusion were observed in 17 patients(77.3%). Seven of the 22(31.8% 0 patients with irregular antibodies delevered infants with hemolytic disease. Only one of these seven required an exchange transfusion. Of the remaining 15 pregnancies with irregular antibodies, they showed normal perinatal outcomes. Our data suggests that irregular antibody screening in all prenatal patients is clinically useful for predicting the likelihood of hemolytic disease of the newborn.
의식이 명료한 일산화탄소 중독환자를 대상으로 응급실에서 시행한 간이정신상태검사의 임상적 의의
육현 ( Hyun Youk ),차용성 ( Yong Sung Cha ),김현 ( Hyun Kim ),김성훈 ( Sung Hoon Kim ),김지현 ( Ji Hyun Kim ),김오현 ( Oh Hyun Kim ),김형일 ( Hyung Il Kim ),차경철 ( Kyoung Chul Cha ),이강현 ( Kang Hyun Lee ),황성오 ( Sung Oh Hw 대한임상독성학회 2016 대한임상독성학회지 Vol.14 No.2
Purpose: Because carbon monoxide (CO)-intoxicated patients with an alert mental status and only mild cognitive dysfunction may be inadequately assessed by traditional bedside neurologic examination in the emergency department (ED), they may not receive appropriate treatment. Methods: We retrospectively investigated the incidence and features of cognitive dysfunction using the Korean version of the Mini-Mental State Examination (MMSE-K) in ED patients with CO poisoning with alert mental status. We conducted a retrospective review of 43 consecutive mild CO poisoned patients with a Glasgow Coma Scale score of 15 based on documentation by the treating emergency physician in the ED between July 2014 and August 2015. Results: Cognitive dysfunction, defined as a score of less than 24 in the MMSE-K, was diagnosed in six patients (14%) in the ED. In the MMSE-K, orientation to time, memory recall, and concentration/calculation showed greater impairments. The mean age was significantly older in the cognitive dysfunction group than the non-cognitive dysfunction group (45.3 yrs vs. 66.5 yrs, p<0.001). Among the initial symptoms, experience of a transient change in mental status before ED arrival was significantly more common in the cognitive dysfunction group (32.4% vs. 100%, p=0.003). Conclusion: Patients with CO poisoning and an alert mental status may experience cognitive dysfunction as assessed using the MMSE-K during the early stages of evaluation in the ED. In the MMSE-K, orientation to time, memory recall, and concentration/calculation showed the greatest impairment.
뇌수막종에 있어서 유세포 측정 양상과 임상적 형태와의 관계
김정훈,정영섭,김동규,정희원,김현집,최길수,한대희 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.6
Meningiomas have a wide range of biological potential and clinical behavior. Histological findings are helpful in recognizing the malignant potential of a given tumor, but often fail to correlat with clinical and biological behavior such as a gross feature, the liability of recurrence, and the extent of associated cerebral edema. To find alternate approaches to improve the correlation between clinical and biological behavoir, 18 meningiomas were studied by flow cytometry(FCM) using paraffin embedded tissues for deoxyribonucleic acid(DNA). The results are summarized as follows: 1) Fifteen cases were diploid and remaining three cases were aneuploid. The latter were two cases of an angioblastic meningioma, and one case of a malignant meningioma which recurred two years later. 2) No relationships were found between the results of ploidy analysis and the age, sex, the site of neoplasms, the size of neoplasms, the degree of peripheral edema, mitotic index, recurrence and the histological subtypes(p>0.1), but it was interesting to note that all three aneuploid cases were clinically and biologically aggressive meningiomas. 3) The proliferative index(PI : %S+%G₂M) between diploid and aneuploid cases had a statistically significant trend(0.05<P<0.1). 4) No significant differences were found between the age, sex, site, histological subtype, mitotic index, recurrence and the proliferative index value(p>0.1). 5) The PI value was relatively correlated with the size and the extent of associated cerebral edema(0.05<P<0.1). These data do not support the suggestion that flow cytometry in meningiomas may be of predictive value concerning the clinical behavior of these neoplasms, but the possible association between tumor aneuploidy, high PI value and poor clinical outcome in meningiomas merits further investigation.
자궁겨우암에 있어서 Nucleolar Organizer Regions과 예후인자로서의 효용성에 관한 연구
김병기,최영민,강순범,이효표,송용상,김우호,김종훈,박중신,전혜원 대한부인종양 콜포스코피학회 1993 Journal of Gynecologic Oncology Vol.4 No.1
We evaluated 17 women with normal cervix and 67 women with invasive cervical carcinoma to determine the relationship between the clinical variables of the cervical cancer(age, clinical stage, tumor size, depth of invasion, lymph node meatstasis, 5-year disease free survival rate) and nucleolar organizer regions by silver colloid technique with formalin fixed paraffin embedded tissues from January 1985 to December 1986 We calculated the mean number of AgNQRs per cell among 100 cells using an oil immersion lens and classified two groups according to the me number of AgNOR, 1.5(group I$lt;.l.5, group II1.5). There was significantly higher number of AgNORs in the invasive cervical carcinoma than in the normal cervix(Mean±SEN: 1.20±0.15, 1.65±0.06), The number of AgNORs was not significantly associated with age, tumor size, depth of invasion and clinical stage. And there was no significant difference in the 5-year disease free survival rates between the two groups in invasive cervical carcinoma. So we concluded that the number of AgNOR may be useful for the differential diagnosis between the normal and the malignancy but may not be useful as the prognostic factor of cervical carcinoma.