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Human Papilloma Virus Type 16 양성 유무에 따른 자궁경부암의 임상양상 및 예후인자에 관한 연구
강순범,이효표,박만철,이경희,장윤석,송계용,박상철,박재갑,안기범 대한산부인과학회 1990 Obstetrics & Gynecology Science Vol.33 No.7
서울대학교병원 산부인과를 내원하여 조직 생검상 자궁경부암으로 진단받은 51예와, 그외의 여성 생식기 암 10예 및 이상소견이 없었던 12예에서 자궁경부조직을 채취하여 HPV 16의 검출을 위한 southern blot 핵산교잡법과 단백질 분해효소의 측정을 통해 다음과 같은 결론을 얻었다. 1. HPV16 DNA는 자궁경부암에서 35.3%(18예)의 양성율을 보였으나 기타의 여성생식기암과 정상자궁경부 조직 소견을 보인 군에서는 전혀 발견되지 않았다. 2. HPV 16 DNA 양성율은 종양의 크기, 세포의 형태, 자궁경부조직 및 자궁방결합 조직의 침윤 정도 및 임파혈관의 침윤과는 유의한 상관관계가 없었으나, 골반내 임파절 전이가 된 군에서 유의하게 증가하였다(p$lt;0.05). 3. 자궁경부암이 있었던 경우에서는 HPV 16 DNA양성군에서 serine protease와 metalloprotease의 활성도가 유의하게 증가하였다(p$lt;0.001). 이상의 결과에서 HPV 16 DNA 양성군에서는 조직침윤성이 높은 것으로 추측이 되는 반면, 자궁경부암의 유발인자로서의 HPV 16의 역할에 대하여는 추후 장기적이고 더 많은 역학적, 분자생물학적 연구가 필요하리라고 사료된다. It is suspected that HPV infections, especially type 16 and 18, influence the biologic behavior of the cervical cancer. This study included 51 cases of biopsy-proven cervical cancer, 10 cases of other genital cancer, and twelve cases of negative biopsy. We have analysed for the presence of HPV deoxyribonucleic acid(DNA)by Southern blot analysis and measured the proteolytic activities of the cervical cancer tissues. Human papilloma virus DNAs were found in 18 of 51(35.3%)women with cervical cancer, but none of women with other genital cancer and negative biopsy. Human papilloma virus 16 positive rate was significantly elevated in group of positive pelvic lymph node metastasis(p$lt;0.05). In cervical tissues of HPV 16 DNA positive cervical cancer group, the activities of serine protease and metalloprotease were increased with statistical significance(p$lt;0.001). The results of this study suggest that the ability of tissue invasion may be high in HPV DNA positives group. But further epidemiological & biological study will be needed to clarify the role of HPV 16 in cervical cancer.
질내강으로 탈출한 악성 혼합 Muller 종양의 자기공명영상
박성진,이혜경,김대호,박재성,홍현숙,조준희,차장규,백상현 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Malignant mixed Mullerian tumor is a rare uterine malignancy and prolapse of MMMT into the vagina is an extremely rare condition. In this case, MR findings showed a well circumscribed mass in vaginal canal with stalk arising from uterine wall. The mass showed heterogeneous high signal intensity on T2-weighted image and heterogeneous enhancement in mass and stalk on enhanced T1-weighted image.
Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition
Park SY,Kim HS,Kim NH,Ji S,Cha SY,Kang JG,Seo HK,Ota I,Shimada K,Konishi N,Nam HW,Hong SW,Yang WH,Roth J,Yook JI,Cho JW 한국당과학회 2011 한국당과학회 학술대회 Vol.2011 No.1
Protein O-phosphorylation often occurs reciprocally with O-GlcNAc modification and represents a regulatory principle for proteins. O-phosphorylation of serine by glycogen synthase kinase-3β on Snail1, a transcriptional repressor of E-cadherin and a key regulator of the epithelial-mesenchymal transition (EMT) programme, results in its proteasomal degradation. We show that by suppressing O-phosphorylation-mediated degradation, O-GlcNAc at serine112 stabilizes Snail1 and thus increases its repressor function, which in turn attenuates E-cadherin mRNA expression. Hyperglycaemic condition enhances O-GlcNAc modification and initiates EMT by transcriptional suppression of E-cadherin through Snail1. Thus, dynamic reciprocal O-phosphorylation and O-GlcNAc modification of Snail1 constitute a molecular link between cellular glucose metabolism and the control of EMT.
박정근,김준영,나상,정종기,장진석,박원곤,이형근 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.7
저자들은 1993년 9월부터 1995년 3월까지 본 병원 산부인과에서 110예의 골반경수술을 시행 한 결과 다음과 같은 결론을 얻을 수 있었다. 1. 골반경수술의 적응증은 총 110예중 자궁외임신이 43예(39%), 자궁근종이 26예(24%), 난소 종낭이 23예(21%)로서 대부분을 차지하였다. 2. 골반경수술의 방법은 총 110예중 난관절제술이 34예(32%), CISH LAVH operation 이 26예 (24%), 난소관절제술이 16예(15%), 난소절제술이 8예(7%) 및 난소낭종절제술의 8예(7%)순으 로 많았다. 3. 환자들의 연령분포는 21-40세가 78%였고 평균나이는 33.6세였다. 4. 환자들의 평균출산력은 1.52였다. 5. 입원기간은 수술후 1일에서 6일 사이였으며, 평균 입원기간은 3.57일이었다. 6. 수술시간은 30분에서 7시간까지 수술의 방법, 난이도에 따라 다양한 차이를 보였는데 근 래에 들어 많이 단축되었다. One hundred ten cases of pelviscopic operation were perfomed at Pusan Kwang-Hye General from September 1993 to March 1995. The common indication were ectopic pregnancy(39%) myoma uteri(24%) ovarian cyst(21%) and frequent types of surgery were salpingectomy(32%), CISH and LAVH operation (24%) , slapingoophorectomy(15%) oophorectomy(7%) and ovarian cystectomy(7%). The age of the patients ranged from 21 to 55 years and the mean age was 33.6 years and maen parity of the patients was 1.52 and mean duration of hospitalization was 3.57 days. The operation time was variable from 30 minutes to 7 hours because of operation method and difficulty, but was more shorter recently. In our conclusion, pelviscopic surgery makes minimal incision, minimal postoperative adhesion, and low morbidity rate, and early recovering brings short hospitalization, and reduction of medical cost. This pelviscopic surgery is simple and useful method of treatment in the community hospital.
이정기(JG Rhee),박경희(KH Park),강재화(JH Kang),김기진(KJ Kim) 대한산부인과학회 1968 Obstetrics & Gynecology Science Vol.11 No.11
A proper understanding of the characteristics of normal uterine contractility is necessary in order to appreciate the irregularities which exist in abnormal labors and to permit rational treatment. The auther was interested in trying to find out what the cause of this phenomenon might be, and if that were not possible, at least to learn more about the character of the uterine activity which takes place during pregnancy and labor. Uterine contractility has been studied in the past by different methods, each one of which brings into view some special aspect of the uterine function and contributes to a partial underrstanding of problems. An external method for recording simultaneously the activity by tocographic study of the uterus has been developed in the department of obstetrics, Catholic Medical College. The results obtained were summarized as follows: 1. AM & D type tocographic records were made of the uterine contraction patterns of 10 patients while they were experiencing normal pregnancy and labor. 2. As the term approaches, not only greater uterine contraction wave but also smaller one could be traced that were arisen by true and false labor pain. 3. Uterine contraction was observed with increasing frequency and tonus as pregnancy advanced, and it`s greatest increase taking place about the end of the last stage. 4. Characeteristic contraction pattern of each true labor pain presented while it was in 1st, 2nd and 3rd stage and could be understood the whole pergnancy and labor coures by it`s explanation. 5. The uterine contraction had great individual differences.