진행된 HIV 감염 환자에서 십이지장의 미란성 병변으로 발현한 Mycobacterium genavense 감염 1예

진상만,박종선,김홍빈,오명돈,최강원,김희연,국윤호,김남중 대한감염학회 2007 감염과 화학요법 Vol.39 No.4

Mycobacterium genauense는 최근에 알려진 미코박테륨으로서, 식욕 부진, 체중 감소, 설사, 림프절 병증 등 파종성 Myocobacterium avium-intracellulare complex 감염과 유사한 임상상을 보이며, 위장관 침범을 잘 하는 것으로 알려져 있으나 아직 국내에서 증례는 보고된 바가 없다. 저자들은 진행된 HIV 감염 환자에서 십이지장의 미란성 병변으로 발현한 Mycobacterium genavense 감염 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. 환자는 상복부 동통과 발열, 설사로 내원하였다. 십이지장의 미란성 병변에서 시행한 조직검사에서 항산균이 가득 차있는 거품세포가 관찰되었으며, 이 검체에서 16S rRNA 유전자의 중합연쇄반응 검사를 시행하여 Mycobacterium genavense를 확인하였다. Mycobacterium genavense, first identified in 1990, is known as a pathogen that mimics disseminated Myocobacterium avium-intracellulare complex (MAC) infection with particular propensity for the gastrointestinal tract. In Korea, no case with the organism has been reported. Herein we report a case of Mycobacterium genavense infection that manifested with erosive lesion of duodenum in a patient with acquired immune deficiency syndrome. The patient presented with epigastric pain and fever, diarrhea. Duodenal biopsy showed histiocytic infiltration with numerous acid-fast bacilli. Identification of the mycobacterial isolate by the polymerase chain reaction restriction analysis of 16S rRNA gene revealed Mycobacterium genavense.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

절단된 안면신경의 일차문합술

강진성,한기환,송중원,오재훈 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.4

Because the facial nerve innervates the muscles of facial expression, injury to this nerve may cause social, psychological, and functional disability. For this reason, a transected facial nerve must be restored appropriately by any one of a variety of approaches. The choice of anastomosis should be based upon the cause, location of transection and the length of time since paralysis was first noted. Although there are numerous methods of anastomosis, none will result in complete recovery. And thus, the method must be carefully selected and tailored to suit each patient. During the 20 months between July 1988 and February 1990. We have been operated (immediate end to were epineurial repair) in 20 patients. 15 of 20 aged 23 to 60. There were 13 males and 2 females. The nerve injury was unilateral in all cases. One of 15 received a nerve graft harvested from the greater auricular nerve. 12 of 15 Stensen's duct injuries were associated with served zygomatic branch and/or buccal branch. So an end to end anastomosis of the duct was performed simultaneously with anastomosis of the nerve. Failure to repair the duct resulted in a salivary fistula in two cases. To show the success of the procedure, EMG(electromyogram) and NCV(nerve conduction velocity) were done at least 6 months following surgery. The findings have been considered good to excellent and the reinnervated muscles have showed symmetric movements in all cases.

SrO·nFe₂O₃의 磁氣特性에 미치는 La₂O₃의 影響

오응철,서강수,문현욱,신용진 明知大學校 産業技術硏究所 1992 産業技術硏究所論文集 Vol.11 No.-

This paper is studies the addition effects of La₂O₃ on the magnetic properties of Sr·ferrite The calcination temperature was 1250℃ for 1hr in air, and sintering temperature has been made at the temperature of 1225℃, 1250℃, 1275℃ and 13O0℃ respectively for 0.5hr. Compositions were chosen according to the formula ?? where n was varied between 5.8∼6.1 and x was varied between 0∼3 The composition of the best value ??= 1.48MG0e was n = 6(stoichiometric composition) and x = 2 at La₂0₃ addition. This value was higher than that of ordinary isotropic strontium ferrite.

소형 Gun Drill Machine 개발에 관한 연구

오진수,박광훈,남궁재관,우창기,강동명 한국공작기계학회 2006 한국공작기계학회 추계학술대회논문집 Vol.2006 No.-

This compact Gun Drilling Machine was developed to improve productivity and economical efficiency for small and midium enterprise tool makers. To produce specialize tools that gun drilling works should be required prior to making deep holes. Gun drill machines are so expensive and big burden for small tool makers so that works used to execute through outside orders but it was required lot of cost too. Most of gun drill machines are providing for high volume and large capacity enterprises. In order to support for small and medium enterprise purpose that compact gun drill machine was designed and developed. It could be improved products quality, productivity and saving manufacturing cost using this machine.

세 도시의 생활 쓰레기 발생량의 장래 추이 예측

오정화,강호,이진홍 忠南大學校 環境問題硏究所 1995 環境硏究 Vol.13 No.-

This study centers on a long-term prediction for the generation of municipal solid wastes for 3 cities such as Pusan, Taejon and Cheongju. For the long-term prediction several statistical models based on time or population were proposed and utilized. The MSW discharge per day from 3 cities predicted is in the range of 12,100~14,600 ton for Pusan, and 3,100~3,800 ton for Taejon, and 2,200~2,600 ton for Cheongju in the year of 2008, respectively. However, the volume-based charge system since January 1995 has made a great effect on the generation of MSWs. Unfortunately, there has been few data to consider this effect for the prediction. Therefore, there has been an urgent need to collect new baseline data for the more realistic long-term prediction.

아리스토텔레스의 덕론에 의거한 도덕과 수업지도 방안

오진희,강두호 全北大學校 敎育大學院 1999 敎育論叢 Vol.19 No.-

The purpose of this study is to make an approach to the moral education based on Aritotle's theory of virtue. Aristotle accepts that people generally view happiness as the end of life. He says happiness must be an activity of virtue. In Aristotle virtue is particularly the activity of reason and of rationally ordered habits. Aristotle distinguishes the moral virtues and the intellectual virtues. Moral virtues are more directly concerned with good living. Intellectual virtues make the intellect a better instrument of knowledge. Virtue is a habit of choosing the mean between the extremes of excess and defect in action, and this mean is determined by reason guided by the intellectual virtue of prudence. We need take notice of common good, justice, and friendship as major virtues in the theory of Aristotle. As for Aristotle, the happiness of the individual and that of the community are identical. He also sees that justice tends to tends to produce and preserve happiness, and friendship refers to the truest form of justice. Keeping those in mind, this study constructs some instructional plans of moral studies in the primary school. Two themes in the textbooks of fourth and sixth grade, common good and justice, are extracted.

삭골(Bone shaving)한 골의 재생에 골막이 미치는 영향

강진성,권건영,송중원,오석희,한기환 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.5

Many orientals have a more prominent malar eminence and mandibular angle than westerners so their faces often look rough and unattracive. In recent years more people want to have a more attractive and beautiful face due to economic prosperity and westernization. Therefore people receiving bone shavings or osteotomies for cosmetic purposes are increasing. The effects of the periosteum on lay bone grafts were investigated but the effect of the periosteum after bone shaving or osteotomy is little known. The authors investigated the effect of the periosteum on the regeneration of bone in membranous and endochondral bone of rabbits. Bony defects each measuring about 5.0×5.0×1.5mm were made on the left and right sides of the parietal bones of 15 rabbits and femurs of 15 other rabbits respectively. The periosteum was preserved on the left and removed on the right. The following results were obtained: 1) The average thickness of the regenerated bones in groups 2 δ4 were thinner than those in groups 1 δ 3 at 4, 8 and 12 weeks postoperatively but the differences of thickness were statistically significant at onl 4weeks postoperatively(P<0.05). 2) The histological findings in groups 2 δ 4 showed lesser regeneration of the shaved bone than those in groups 1 δ 3 at 4, 8 and 12weeks postoperatively. 3) There was no significant increase in the thickness of the regenerated bone after 8 weeks postoperatively in all groups. 4) At 12 weeks postoperatively, the thickness of the regenerated bone in all groups was over 70% of the thickness of the resected bone. In summary, the authors found that it is important to perform overcorrection and resect the periosteum simultaneously in bone shaving to prevent the unwanted regeneration.

미학과 사회적 이슈를 연계한 전시디스플레이 작품 연구 -저출산에 대한 인식 개선 프로젝트 "나쁜 엄마, 최고의 아빠"의 전시디자인 프로세스를 중심으로-

강미선,박수빈,윤정원,오정은,이소원,이진민,신은별 숙명여자대학교 디자인연구소 2017 숙명디자인학 연구 Vol.23 No.-

본 연구는 전시디스플레이 디자인 분야에 미학을 기반으로 예술적, 사회적, 디자인적 측면으로 다각적으로 접근하여 전시 디자인 분야의 색다른 코딩 프로세스를 체계화하고, 동시에 기존의 전시와는 차별화되는 새로운 전시 공간 프로세스를 제안하는데 목적이 있다. 본 연구의 대상은 2016년 9월-12월까지 15주간 숙명여자대학교 미술대학 환경디자인학과<전시디스플레이 디자인>교과목에서 진행된 프로젝트 중 일부이다. 본 연구의 과정은 총 3과정으로 이루어져 있으며, 미학적 개념과 사회적 문제, 전시관련 학문에 대한 이론적 고찰을 한 뒤 이를 전시디자인에 코딩하는 작업을 선행하였다. 두 번째로는 코딩한 작업을 바탕으로 전략적 모티브를 빛으로 선정하고, 전시디자인 전략게획을 진행하였다. 마지막으로 자료를 바탕으로 만든 스토리텔링을 기반으로 전시전개구성을 하고 이를 통해 스토리가 있는 차별화된 공간구성을 하였다. 로고디자인, 포스터디자인, 리플렛디자인, 영상 디자인 등 전시디자인 E.I작업을 통해 전시를 표현하였다. 끝으로 본 연구는 '미학 + 사회문제 + 전시디자인의 코딩'이라는새로운 창의적 전시 디자인 프로세스를 제안하였고, 이는 미학과 사회문제의 이론적 고찰을 반영한 전시디스플레이 프로세스 개발에 있어 향후 기초 자료로 활용될 것으로 기대한다.

절골술을 이용한 안면교정

오석희,한기환,강진성 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.5

The most important factor in the beauty of the face is the harmony of the facial skeleton and soft tissue. The postoperative result is not always satisfying after only classic soft tissue surgery. The reason for dissatisfaction is disharmony of the facial skeleton. Recently, the development of maxillofacial surgical techniques enable disharmony of the facial skeleton to be successfully corrected. The authors have had experience with 33 cases of congenital and acquired facial deformities, from March of 1986 to February of 1989, and have followed them from 6 months to 2 years. We used an intraoral approach in most cases and got good results. There were four wound disruptions which were treated conservatively and resolved without sequelae.