흰쥐 하부뇌간에서의 Cholecystokinin octapeptide의 분포

오석희,박매자,조희중,주강 慶北大學校 醫科大學 1990 慶北醫大誌 Vol.31 No.3

흰쥐의 하부뇌간에서 cholecystokinin-octapeptide(CCK-8)의 분포를 관찰하기 위하여 Peroxidase-Antiperoxidase법으로 염색하여 관찰해 본 결과 다음의 많은 부위에서 CCK-8양성세포 및 양성섬유를 관찰할 수 있었다. 중뇌: 흑질, 복측피개야, n. linea rostralis, 중심회백질, n. parabrachialis colliculi posterioris, 하구 및 외측모대핵에서 CCK-8양성세포가 관찰되었고 양성섬유의 경우 각간핵, n. parabrachialis co lliculi posterioris, parabigeminal n., 하구, 외측모대핵 및 배측 봉선핵에서 관찰되었다. 후뇌: CCK-8양성세포는 n. parabrachialis lateralis, n. of group O, 고속핵, 최후야 및 삼차신경 척수로핵에서 분포하였고, 양성섬유는 교봉선핵, 교핵, n. parabrachialis lateralis, 청반핵, n. parolivaris superior, 와우신경핵, 고속핵, 미주신경배측핵, inferior olivary complex, 박속핵, 설상속핵, 삼차신경척수로핵 및 망양체의 일부등에서 존재하였다. In order to investigate the distribution of immunoreactive cholecystokinin octapeptide(CCK-8)-containing neurons in the lower brain stem of the rat, brains of the rats perfused with fixative were extirpated, fronzen sectioned and processed for Peroxidase method. The results obtained were as follows. Mid brain; CCK-8-containing cells were found in the ventral tegmental area, substantia nigra, nucleus(=n.) linea rostralis, substatia grisea centralis, n. parabrachialis lateralis, inferior colliculus and lateral lemniscus and fibers were distributed in the interpeduncular n., n. linea rostralis, ventral tegmental area, substantia nigra, superior colliculus, substantia gricea centralis, n. parabrachialis, lateralis parabigeminal n., inferior colliculus, lateral lemniscus and n. raphe dorsalis. Pons and Medulla oblongata; CCK-8-containing cells were detected in the n. parabrachialis lateralis, n. of group O, n. tractus solitarii, area postrema and n. tractus spinalis nervi trigemini, and fibers were found in n. centralis superior, pontine n., n. parabrachialis lateralis, locus coeruleus, n. parolivaris superioris, cochlea n., n. tractus solitarii, dorsal n. of vagus nerve, inferior olivary compex, n. gracilis, n. cuneatus, n. tractus spinalis nervi trigemini and reticular formation.

Constipation in Children

오석희 대한소아청소년정신의학회 2018 대한소아청소년정신의학회 학술대회논문집 Vol.2018 No.11

Principles of Nutritional Support in PICU

오석희 한국정맥경장영양학회 2014 한국정맥경장영양학회 학술대회집 Vol.2014 No.-

Long-term outcomes of infantile spasms

오석희,이은혜,정민희,염미선,고태성 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.1

Purpose:The aims of this study were to investigate the long-term outcomes in children with infantile spasms (IS) and to identify the prognostic factors influencing their neurodevelopment. Methods:We retrospectively evaluated seventy two children over five years old who were treated for IS at Asan Medical Center, Seoul, Korea, between 1994 and 2007. Forty-three children were contacted by telephone or medical follow-up to assess their current neurodevelopmental status. Multiple logistic regression was used to calculate odds ratios (ORs) and 95% confidence interval (95% CIs) of risk factors for unfavorable outcomes. Results:The mean follow-up duration for these 43 children was 7.2±1.5 years (range, 4.5 to 13.0 years). Of these, 13 (30.2%) had cryptogenic and 30 (69.8%) had symptomatic IS. Eleven (25.6%) children were initially treated with adrenocorticotrophic hormone (ACTH) therapy, with a mean treatment lag of 1.3±1.9 months (range; 0.1 to 7.0 months). Eighteen (41.8%) children clinically responded to initial treatment, as shown by EEG response. Overall, 22 (51.2%) children had at least moderate neurodevelopmental disorders and 2 (4.8%) died. In univariate analysis, etiology (symptomatic) and poor electroclinical response to initial treatment were related to long-term unfavorable outcomes. In multivariate analysis, response to primary treatment was the sole significant independent risk factor with a high OR. Conclusion:Overall prognosis of children with IS was poor. Electroclinical non-responsiveness to initial treatment was related to unfavorable long-term outcomes, indicating that initial control of seizures may be important in reducing the likelihood of poor neurodevelopment.

Current issues of pediatric inflammatory bowel disease in Korea

오석희,김경모 대한소아청소년과학회 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.11

Inflammatory bowel disease (IBD) is a chronic relapsing disorder of unknown etiology, which is believed to be multifactorial. Recently, the incidence of pediatric IBD has steeply increased in Korea since 2000. Poorly controlled disease activity can result in complications such as intestinal fistulae, abscess, and stricture, as well as growth retardation and delayed puberty in children. Because of a lack of confirmative tests, various diagnostic modalities must be used to diagnose IBD. Onset age, location, behavior, and activity are important in selecting treatments. Monogenic IBD must be excluded among infantile and refractory very-early-onset IBD. Early aggressive therapy using biologics has recently been proposed for peripubertal children to prevent growth failure and malnutrition.

소아 장부전

오석희,김경모 대한의사협회 2014 대한의사협회지 Vol.57 No.6

Pediatric intestinal failure causes growth failure and mortalityin children due to the inability to maintain normal nutritionalbalance. Short bowel syndrome is the most common cause in pediatric cases,and the residual bowel length is importantforpredicting long-term dependence on parenteral nutrition. Based on the possibility that the process of intestinal adaptationin children can continuethroughoutthe first five years, enteral autonomy should be prioritized in the management ofintestinal failure. Despite the lack of well-established guidelines, careful advance of enteral feeding and a multidisciplinaryteam approach are critical foroptimizingsurvival outcomes.

연속영상의 특징점 자동추출기법 개발

오석희(Ochirbat SukHee),유환희(Yoo Hwan-Hee) 대한공간정보학회 2009 한국지형공간정보학회 학술대회 Vol.2009 No.4

UAV에서 촬영된 연속된 영상자료를 이용하여 실시간적 영상지도를 제작하기 위해 필요한 핵심기술로서, 연속된 영상에서 특징점을 자동추출 할 수 있는 기법을 KLT를 개량하여 개발하였다.

절골술을 이용한 안면교정

오석희,한기환,강진성 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.5

The most important factor in the beauty of the face is the harmony of the facial skeleton and soft tissue. The postoperative result is not always satisfying after only classic soft tissue surgery. The reason for dissatisfaction is disharmony of the facial skeleton. Recently, the development of maxillofacial surgical techniques enable disharmony of the facial skeleton to be successfully corrected. The authors have had experience with 33 cases of congenital and acquired facial deformities, from March of 1986 to February of 1989, and have followed them from 6 months to 2 years. We used an intraoral approach in most cases and got good results. There were four wound disruptions which were treated conservatively and resolved without sequelae.

Infections after Living Donor Liver Transplantation in Children

김정은,오석희,김경모,최보화,김대연,조형래,이연주,이강원,박성종,이영주,이성규 대한의학회 2010 Journal of Korean medical science Vol.25 No.4

The aim of this study was to evaluate the infectious complications after living donor liver transplantation (LDLT) in children. We enrolled 95 children (38 boys and 57girls) who underwent LDLT from 1994 to 2004. The median age was 22 months (range, 6 months to 15 yr). We retrospectively investigated the proven episodes of bacterial, viral, and fungal infection. There occurred 150 infections in 67 (70%) of 95 patients (1.49 infections/patient); 74 in 43 patients were bacterial, 2 in 2 were fungal, and 74 in 42 were viral. The most common sites of bacterial infection were the bloodstream (33%) and abdomen (25%). Most of the bacterial infections occurred within the first month after LDLT. Bacterial and fungal infections did not result in any deaths. The most common causes of viral infection were Epstein-Barr virus in 37patients and cytomegalovirus in 18. Seven of the 14 deaths after LDLT were associated with viral infection. Our study suggests that infection is one of the important causes of morbidity and mortality after LDLT. Especially careful monitoring and management of viral infections is crucial for improving the outcome of LDLT in children.

A case report of chronic granulomatous disease presenting with aspergillus pneumonia in a 2-month old girl

이은,오석희,권지원,김병주,유진호,박찬정,홍수종 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.6

Chronic granulomatous disease (CGD) is an uncommon inherited disorder caused by mutations in any of the genes encoding subunits of the superoxide-generating phagocyte NADPH oxidase system, which is essential for killing catalase producing bacteria and fungi, such as Aspergillus species, Staphylococcus aureus,Serratia marcescens, Nocardia species and Burkholderia cepacia . In case of a history of recurrent or persistent infections, immune deficiency should be investigated. Particularly, in the case of uncommon infections such as aspergillosis in early life, CGD should be considered. We describe here a case of CGD that presented with invasive pulmonary aspergillosis in a 2-month-old girl. We confirmed pulmonary aspergillosis noninvasively through a positive result from the culture of bronchial alveolar lavage fluid, positive serological test for Aspergillus antigen and radiology results. She was successfully treated with Amphotericin B and recombinant IFN-γ initially. Six weeks later after discharge, she was readmitted for pneumonia. Since there were infiltrates on the right lower lung,which were considered as residual lesions, voriconazole therapy was initiated. She showed a favorable response to the treatment and follow-up CT showed regression of the pulmonary infiltrates.