균류 분화과정의 유전적 조절기작

박범찬,이환희,박윤희,박희문 충남대학교 생물공학연구소 2003 생물공학연구지 Vol.9 No.1

Fungi are well suited for studying mechanism controlling development and cell differentiation in multicellular eukaryotes. The asexual and sexual reproductive cycles are tightly coordinated during the life cycle of Aspergillus nidulans. The asexual (mitotic) reproductive cycle involves the formation of a number of differentiated cell types. Successful formation of multicellular reproductive structures and spores (conidia) requires the establishment of spatiotemporal gradients in essential transcriptional regulators, such as brlA, abaA and wetA. Altered gene expression is coordinated with critical changes in the movement of nuclei and the regulation of the cell division cycle. Therefore, it has been proposed to define a central regulatory pathway. Several early regulatory genes involved in signal transduction pathway controlling asexual sporulation are also required for activating the central pathway. Sexual (meiotic) reproduction is more complex, requiring the differentiation of several specialized tissue types. Although technical difficulties have limited efforts to study the genetics of sexual fruiting-body formation directly, some recent progress has been made. With the recent availability of mutants blocked in sexual development, understanding the genetic interactions between genes that function primarily in determining sexual sporulation will be achieved in the near future.

Transmission ability of Zika virus with artificially infected Aedes albopictus in Korea

Yang Sung‐Chan,Lee Hee-Il,Kim Hyunwoo,Lee Wook‐Gyo 한국곤충학회 2021 Entomological Research Vol.51 No.8

Zika virus (ZIKV), a virus mainly occurring in South America, is now globally distributed. Understanding the pathogen transmission cycle in a vector is exceptionally important in developing disease control strategies. In this study, we performed ZIKV microinjection in Aedes albopictus (Skuese), to estimate its vertical and horizontal transmission ability. The virus infection rate was confirmed by real-time qPCR in the F1 generation derived from the ZIKV-injected Ae. albopictus. The minimum infection rate (MIR) of the F1 generation was highest when they were injected with the virus at 6–12 h (MIR: 16.1) and lowest at 12–24 h (MIR: 4.7) after feeding. In the developmental stage of the F1 progeny, MIR values were 1.0, 1.3, and 6.7 in each egg, larval, and adult stage, respectively, but ZIKV was not detected in the pupa stage. Virus transmission ability was not significantly different between the collection areas (Tongyeong and Jeju). Ae. albopictus demonstrated a high venereal transmission rate of ZIKV and was detected in males (6 pool/7 pool) and females (6 pool/7 pool), confirming that ZIKV can be transmitted from infected mosquitoes to uninfected mosquitoes via mating. This is the first study of the administration of a ZIKV microinjection to Ae. albopictus in Korea and suggests a possibility of a potential mechanism for the virus to survive during adverse conditions via vertical transmission.

프리미돈의 한국인에서의 생체이용율시험

권광일,윤민혁,윤희열,박희찬,권준택,심희옥,김동출 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-

A reversed phase HPLC method was developed and validated for the determination of primidone in human plasma. Propylthiouracil was used as an internal standard. Calibration curves were linear in the concentration range of 10-120 ng/㎖. The coefficient of variation of the intra- and inter-day precision were below 15%. The coefficient of variation of the accuracy were below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Twenty four healthy human male volunteers were orally administered 20 mg of primidone. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(LAST) was 85.0±17.7 ㎍ hr/㎖, C_(max) was 4.22±1.04 ㎍/㎖, T_(max) was 1.85±1.13 hr, t_(1/2) was 17.7±2.4 hr. The pharmacokinetic parameters and the HPLC method can be used for the desigm of bioequivalence study of primidone.

특수 언어발달 장애 환아의 임상 및음향음성학적 특성연구

김연희,박세훈,신용일,김찬양,김현기,김정수 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.1

흰쥐 뇌줄기에 분포하는 Nitric Oxide Synthase 신경세포에 관한 면역조직화학적 연구

나준희,허영범,박찬,김정혜,유진화,안희경,이원규 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.2

전시를 위한 토기와 청자의 복원 : 토기기대, 노형기대, 청자사이호를 중심으로

강희숙,안병찬 국립중앙박물관 1999 박물관보존과학 Vol.1 No.-

국립김해박물관 개관전시 유물인 가야시대 土器 器臺 2점과 중앙박물관의 특별전 “고대국가의 형성” 전시회 출품 유물인 靑磁四耳壺에 대한 보존처리를 수행하였다. 육안 및 실체현미경 관찰을 통하여 처리 전 상태, 文樣과 製作技法 등을 파악하였고 이를 토대로 각 유물의 특성에 맞는 보존처리를 실시하였다. 기대는 결실부분이 커 에폭시系 복원재료를 이용해 파손된 토기 面과 직접 접착시켜 형태를 복원하고 문양과 색, 질감을 類似하게 처리하였다. 청자는 토기와 같은 복원재를 이용했지만 파손된 청자 면과 分離시켜 형태를 복원하여 해체가 가능하도록 조치한 다음 색과 질감도 구분이 되도록 처리하였다. Conservation treatment was done for the pottery-stand of Gaya period which was to be exhibited in celebration of the opening of Gimhae National Museum and for the jar of Chinese celadon which was to be exhibited in Korea National Museums special exhibition "Formation of Ancient States". Through the examinations by naked eyes and under the microscope, condition before treatment, patterns and manufacturing techniques of the objects were observed. According to these examinations, conservation treatments, suitable for each object was finished. As the pottery-stand was damaged severely, the epoxy resin was pasted directly on the broken surface of the pottery to restore the original shape and pattern, color and feeling similar to original state were given to the restored area. Although same restoration material was applied on the celadon, it was not pasted directly on the broken surface of the celadon so that the restored area could be dismantled, and color and feeling were also treated somewhat differently.

農村地域(修倫面)에서의 主要精神疾患의 有病率

許瓚熙 大韓神經精神醫學會 1981 신경정신의학 Vol.20 No.1

The author investigated the prevalence rate and some related clinical aspects of the major mental disorders (schizophrenia, manic-depressive illness, epilepsy, general paresis, mental retardation, and others) by the census visit method from Jul. 1st, 1979 to Jul. 30th, 1979 in Su-Ryun Myun, Sung-Ju Gun, Gyung-Buk, Korea. The results were as follows. The prevalence rate was 0.29% for schizophrenia, 0.01% for manic-depressive illness, 0.09% for epilepsy, 0.13% for mental retardation, 0.02% for others, and 0.54% for all major mental disorders. The age of onset of each disorder was largely coincident with the known range of susceptibility. The corrected prevalence obtained from Weinberg's abridged method was 0.58% (the range of age of susceptibility 16-40) for schizophrenia, 0.03% (the range of age of susceptibility 21-50) for manic-depressive illness, and 0.13%(the range of age of susceptibility 5-30) for peilepsy. The morbid duration of the mental disorders was more than 5 years in 78.7% of all cases. The family history of the mental disorders was revealed in 27.7% of all cases. Premorbid personality deviation was noticed in 38.3% of all cases. Among all cases, 72.3% did not receive any treatment, and only one epileptic was treated at a general practitioners' clinic. Among all cases, 10.6% depended on drugs without doctor's prescription, and 14.9% on premodern methods such as superstitious, shamanistic and religious methods, and folk therapy or on the oriental medicine like acupuncture and herb drugs.

용인정신병원에 내원한 행려정신질환자들의 특성에 관한 조사

강희찬,오석배,이정균 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.1

This retrospective survey was designed to investigate the socio-demographic and psychiatric characteristics, and to clarify the tentative course of homeless mentally ill patients. One hundred and twelve homeless mentally ill patients who had been admitted to Yong-In Mental Hospital were selected during the period of March 1983 to Feb.1984. The results were as follows: 1)Sex ratio of the 112 subjects was 1: 1.5. Of these subjects, three-fourths were under 40 and 9 percent were above 50 years old. 2)Fifty-three percent had never married and 24percent already had divorced or seperated. Among above 30 of age, 41 percent had never marred ad 45 percent already had divorced or seperated. Seventy-three percent of men were unmarried. The proportion of divorced of women was higher than that of men. 3)Sixty-seven percent of the subjects were schizophrenia, 7 percent affective disorder, 8 percent alcohol dependency or alcoholic psychosis, 6 percent organic brain syndrome, and 9 percent epilepsy and mental retardation respectively. 4)Eighty five percent had more than two year of morbid duration and most of them took chronic course. 5)Fifty percent had history of previous psychiatric hospitalization, and 46 percent had history of asylum institutionalization. Only 23 percent had no history of psychiatric hospitalization or asylum institutionalization. 6)sixty three percent were hospitalized at Yong-In Mental Hospital over six-months. 7)referral sources at admission of Yong-In Mental Hospital were police, asylum and general hospital which 50 percent by police, 44percent asylum and 6 percent from general hospital. Thirty three percent of the 72 discharged patients were discharged by relatives(including family), and 51 percent have been referred to asylum. 8)The authors compared the characteristics, that of age, sex, marital status, clinical diagnosis, morbid duration admission duration and route of discharge between fresh cases who had no history of psychiatric hospitalization or asylum institutionalization. Also the authors compared the characteristics including history of previous psychiatric hospitalization or asylum institutionalization and source of referral between subgroup with relatives and subgroup without relatives.

급성 출혈성 대장염으로 오인된 궤양성 대장염 1예

문희정,장병익,김승범,이호찬,박재현,은종렬,김태년 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2

Ulcerative colitis (UC) is a chronic inflammatory disorder of the gastrointestinal tract that affects the large bowel, Its etiology remains controversial. However, an infectious or immunologic origin is considered the primary cause. The onset of UC is typically slow and insidious, but some patients may present acutely with symptoms mimicking infectious colitis. We report a case of ulcerative colitis mimicking acute hemorrhagic colitis at initial presentation. A 60-year-old man was referred to Yeungnam University Hospital for bloody diarrhea and abdominal pain. Sigmoidoscopy revealed mildly edematous mucosa in the rectum and hyperemic mucosa with petechiae in the sigmoid colon. The patient was treated with antibiotics for several days, and his symptoms improved. However, after one month, his bloody diarrhea relapsed. Follow-up sigmoidoscopy revealed mucosal friability in the rectum and sigmoid colon. He was diagnosed with ulcerative colitis, and his symptoms were improved with mesalazine and a steroid enema.

도시 특성을 강화한 그린 블루 네트워크 재구축 계획 : 수원시를 사례로

김동찬,김도경,박희경 경희대학교 부설 디자인연구원 2007 예술· 디자인학연구 Vol.10 No.1

For the result of excessive development during such a short time suwon became an overpopulated big city. Sporadically formed greens made problems in creating the network which looks as if it is built under obduracy. In this study, I tried to take advantage of the potential of environment friendly city by using water friendly space and characterized networks. Each river will have its own character which will make a unity and establish its own identity. The purpose is to develop suwon to continue as a circulating network.