Statistical Parametric Mapping 분석을 이용한 알쯔하이머병과 혈관성 치매의 Tc-99m HMPAO SPECT 영상 소견

박경원,강도영,김응규,김상호,김재우 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.1

Background:Functional neuroimaging of single photon emission computed tomography (SPECT) has been used to diagnose or to define the pathophysiological mechanisms of dementias. The purpose of this study was to assess the specific patterns and the differences of regional cerebral blood flow (rCBF) in the patients with Alzhermer's disease (AD) and vascular dementia (VD) using Tc-99m HMPAO SPECT. Methods:Fifty five AD, 34 VD, and 30 normal control subjects participated in this study. Patients with VD and AD were matched for age and clinical dementia rating scores. Three groups were evaluated with Tc-99m HMPAO SPECT for measuring rCBF. Statistical parametric mapping (SPM) software was used for analysis of SPECT image data. The SPECT data in the patients with AD and VD were compared with the normal control subjects and then compared with each other. Results:SPM analysis of the SPECT image showed significant perfusion deficits in the bilateral frontotemporal regions in the patients with AD and in the bilateral frontotemporoparietal regions in the patients with VD compared with normal control subjects (uncorrected p<0.001). AD patients, compared to VD patients, revealed significant hypoperfusion in the bilateral frontal areas, left middle temporal gyrus, right fusiform gyrus, right precuneus and right postcentral gyrus (uncorrected p<0.01). VD patients, compared to AD patients, revealed significant hypoperfusion in the bilateral thalami, left insula, bilateral postcentral gyri, right cuneus, right cingulate gyrus and bilateral frontal subcortical regions (uncorrected p<0.01). Conclusions:Our study shows the characterisitcs and patterns of perfusion deficits in AD and VD patients, and defines the specific areas of hypoperfusion in these two dementias.

생체신호 측정 및 데이트 수집 장치의 개발

우응제,박승훈 건국대학교 의과학연구소 1994 건국의과학학술지 Vol.4 No.-

We have developed biological signal measurement modules and PC-based data acquisition system. Biological signals included in this system are ECG, EEG, EMG, invasive blood pressure, respiration, and temperature. Parameters of each module can be controlled by PC through a data acquisition and control card. The data acquisition and control card can collect up to 16 channels of biological signals with sampling rate of 50~10,000Hz and 12-bit resolution. All measurement modules and data acquisition functions are controlled by microcontroller which receives commands from PC. All data transfers among PC, microcontroller, and ADC are done through a shared RAM access by polling method for real time operation. This system is being used in KKU BME Medical Instrumentation Laboratory in research areas such as ECG interpretation, high-resolution ECG, polysomnography, long-term monitoring of biological signals, design of intelligent alarm system, etc.

올림픽 이념의 교육적 의의 : Coubertin 을 중심으로

박현우,정웅근 師範大學 體育硏究所 1992 서울大學校 體育硏究所論集 Vol.13 No.2

Am Ende des 19. Jahrhunderts standen Materialismus, Animalismus und Nationalismus im Zentrum der europaischen Gesellschaft. Diese fuhrten das Geistesleben aller Menschen zum Chaos der Lebenswelt. Coubertin(1863∼1937) wollte diese Problem nicht Kurzsichtig, sondern langfristig uberwinden, indem eine revolutionare Padagogik durch sportliche Tatigkeit und Spiele angeboten werden sollte. Padagogische Probleme fuhrten endgultig zur Aufgabe der Aufgabe der Erziehung und Bildung besonders im Hinblick auf die Menschenwerdung zuruck. Neuhumanisten des 18./19. Jahrhunderts bestimmten den Menschen als Wesen der Krafte bilden kann, und zugleich als ein aktives,ein bildsames Wesen(Meinberg, 1984:55). Fur Humboldt ist es der hochste Zweck des Menschen, sich zu bilden(Humboldt, 1964:8). Hier ist es sehr klar, daß die Menschen aus sich selbst heraus und durch andere Krafte bilden Konnen. Erziehung erscheint in diesem Kontext als ein weg der Menschenbildung, weil das Kernproblem der Erziehung die Bildung verschiedener Kraften im Hinblick auf die Menschwerdung ist. Wenn die Menschwerdung von der proportionallen und harmonischen Entwicklung aller Kraften abhangig ist, kann eine wichtige Aufgabe in der Erziehung das sein, wodurch fur diese Entwicklung hochste Effektivtat erreicht werden kann. Coubertin wollte durch seine Padagogik, d.h durch die Olympische Idee und sportliche Tatigkeit, einheitliche Bildung aller Krafte gestalten. Fur ihn dient die sportliche Erziehung folgenden Aspekten: 1. durch die Gesunderhaltung und Fordenung des Geistigen dem Bilden des Leib-Seele-Einheit des Menschen. 2. durch den Konkurrenzgeist der Selbstbeherrschung, der Egalitat, der Gerechtigkeit ung dem besten Konnen. 3. durch das moralische Prinzip der Befolgung der Regeln,der Regeln, der Rechten, und der Praxis der Menschenliebe. 4. durch den asthetischen Kunstsinn der Selbstbestimmung der individuellen Moralitat, der Verschonerung,der Umgebung und hingblicklich auf den asthetischen Schutz des Naturschutzes. Der einheitlichen Bildung aller Krafte, die durch sportliche Erziehung gebildet werden konnen,d.h korperliche, geitige, moralische, asthetische Kraft, entspricht genau die olympische Idee und die Grundlage der Padagogik Coubertins. Wir mussen noch einmal ernst an den Sinn der sportlichen Erziehung denken, die notwendige Faktoren fur Men-schenbildung und-erziehung enthalt.

다발성 대장암 간전이 환자의 간절제를 위한 새로운 시도

주종우,김형철,임철완,신응진,조규석,유기원,송옥평,홍대식,박성진,조준희,이혜경,김희경,권계원,고은석 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Multiple bilobar liver matastases (MBLM) are the main cause of low resectability in the colon cancer liver metastases. The authors experienced one case of initially non-resectable colon cancer liver metastases. He was curatively and safely treated with a two-stage hepatectomy using the new method of future remnant liver volume growing. A 54-year-old man was referred to our department with the sigmoid colon cancer combined with MBLM, which were checked in two small metastatic lesions in the left lobe and five large sized lesions in the right lobe in the computed tomogram (CT). A laparoscopic assisted anterior resection was primarily performed. We performed the 1^(st) stage hepatectomy 3 weeks after the colon resection. Intra-operative Ultrasonogram (US) found 9 small superficial metastatic lesions in the left lobe. All that lesions were completely removed by non-anatomical wedge resection. An occlusion ballon catheter was placed in the right portal vein through a small branch of the inferior mesenteric vein at that time. The future remnant liver volume was sufficiently increased 3 weeks after the 1^(st) hepatectomy. A right hepatectomy was safely performed 22 days after the 1^(st) hepatectomy. The patient received a regional chemotherapy (interleukin2 based immuno-chemotherapy through hepatic artery) for 4 months, then received 9 cycles of systemic chemotherapy (biweekly Oxaliplation, leucovorin, plus 5-fluorouracil) without any recurrence evidence.

공무원 다문화역량 교육프로그램 개발연구를 위한 요구 분석

이병준,박응희,한현우 한국문화교육학회 2010 문화예술교육연구 Vol.5 No.1

노동의 세계화와 국제결혼, 다양한 종교의 유입 등 변화하고 글로벌화하는 사회환경에 따른 여러 문제들은 이제 지역차원에서의 적극적인 대응을 행정서비스에 요구하고 있다. 본 연구의 목적은 다문화사회의 진입에 따른 직접적인 행정서비스를 수행하고 있는 공무원들을 대상으로 그들의 다문화역량개발에 도움을 줄 수 있는 교육프로그램을 개발하기 위한 요구를 파악하기 위함이다. 다문화역량은 다문화학습의 과정을 거쳐 생겨난다고 알려져 있다. 특히 다문화역량의 구성요소에 관해서는 국가와 연구자별로 차이를 보이고 있는데, 미국의 경우 다문화역량은 문화적 의식, 등을 거쳐 습득되는 문화적 역량의 개념으로 이해되어지며, 독일의 경우 다문화역량은 의사소통능력, 갈등관리능력 등의 기초역량에서부터 문화 간의 차이 인정 능력에 이르기까지의 문화적 역량이 포괄된 역량으로 이해되어지고 있다. 본 연구의 결과로 나타는 현재의 공무원들의 다문화역량에 대한 의식수준은 전반적으로 평균수준이며 결핍된 역량에 대한 교육요구는 상당히 높다고 볼 수 있다. 특히 적지 않는 공무원들이 자기 자신의 변화가 우선적으로 중요하다고 답변한 것은 프로그램의 기획에 있어 시사하는 바가 적지 않다고 볼 것이다. The purpose of this study is to make basic materials of education programs helping competency development for public officials who are conducting public service directly, as the multi-cultural society has come. The variety of issues came after the changeable and globalized social environment such as globalization in labor industry, international marriage and introduction of diverse religion. Those are in need of active responses to public service. We recognize the need of education programs that fit in the multi-cultural paradigm, then it can possibly be used for building curriculum and education system of multi-cultural competency development as basic materials. We have to promote a learning culture for the proper response to the multi-cultural society. It can be helpful to enter a mature civil society when we recognize and embrace identities of minority groups through an education for public officials who directly provide the multi-cultural public service.

국내 조혈모세포이식 환자에서 Human Cytomegalovirus gB 유전형의 분포와 질환과의 연관성 : 예비 보고

최수미,김진희,이동건,박선희,최정현,유진홍,박철민,이종욱,민우성,황응수,신완식,김춘추 대한감염학회 2007 감염과 화학요법 Vol.39 No.2

목적 : 사람 거대세포바이러스(Human cytomegalovirus, 이하 HCMV) glycoprotein B (gB)는 UL55 유전자에 의해 부호화되는 당단백으로, UL55 유전자의 염기서열변화에 따라 4가지 유전형으로 나뉜다. 본 연구에서는 국내 조혈모세포이식 환자들에서 HCMV gB 유전형의 분포와 그 특성을 알아보고, gB 유전형에 따라 특정 HCMV 질환 발생과 연관이 있는지 그 임상적 의미를 분석해 보고자 하였다. 재료 및 방법 : 동종 조혈모세포이식 환자 52명의 혈액검체 94개에 대해, Chou 등이 제시한 방법에 따라, 먼저 UL55 유전자 부위를 nested PCR로 증폭한 후, RsaI과HinfI으로 Restriction fragment length polymorphism(RFLP) 분석을 시행하였다. 결과 : gB type 1은 73.1% (38/52), gB type 2는 13.5%(7/52), gB type 3는 1.9% (1/52), gB type 1과 type 2에 의한 혼합감염은 9.6% (5/52)로 나타났다. gB type 4는 관찰되지 않았다. 1명(1.9%)에서 gB 유전형을 결정할 수 없었는데, RFLP 패턴으로 보아 Trincado 등이 제시한 gB type 7에 해당하는 것으로 생각되었고, 이 새로운 아형에 대해서는 현재 염기서열 분석 중이다. 52명 중 5명(9.6%)에서 HCMV 질환이 발생하였고, 3명에서 HCMV 폐렴, 1명에서 망막염과 위장관염, 나머지 1명에서 망막염이 발생하였다. 5명 중 HCMV 질환과 관련하여 사망한 예는 없었고, 감염된 HCMV는 모두 gB type 1이었다. HCMV gB유전형과 HCMV 질환 발생 사이에 유의한 연관성은 없었고, 단일 주에 의한 감염과 혼합감염에 따른 HCMV 질환발생 사이에도 유의한 연관성은 관찰되지 않았다. 자료 분석 중 gB type 2에 감염되어 있던 환자에서 gB type 1에 재감염 되면서 발열, 간효소 수치 상승 및 pp65 HCMV 항원혈증이 나타난 예가 있었다. 결론 : 연구결과 gB type 1이 아주 우세하고, gB type 4는 검출되지 않았으며, 혼합감염의 빈도가 비교적 낮은 분포를 보였다. 이는 외국의 보고와는 다른 국내 조혈모세포이식 환자에서의 독톡한 감염 양상으로 추정된다. 본 연구에서 HCMV gB 유전형과 질환 발생과의 연관성을 밝힐 수는 없었으나, HCMV 유전형에 대한 연구는 바이러스 감염의 발병기전이나 전파 경로 및 양식과 같은 역학적 연구에 중요한 자료가 될 것이다. 현재 더 많은 수의 조혈모세포이식 환자를 대상으로 연구가 진행 중에 있으며, 앞으로 다른 질환군의 환자나 건강한 잠복 감염자에서의 추가 연구가 필요할 것으로 생각된다. Background : Human cytomegalovirus (HCMV) glycoprotein B (gB) is the major envelope glycoprotein, encoded by the UL55 gene. Based on sequence variation in the UL55 gene, HCMV can be classified into four gB genotypes. Previous studies have suggested an association between HCMV gB genotypes and clinical outcome in the immunocompromised hosts. The goal of this study was to determine the distribution of HCMV gB genotypes and the effect of gB genotype in the developement of HCMV diseases in hematopoietic stem cell transplant (HSCT) recipients in Korea. Materials and Methods : DNA was extracted from 94 blood specimen of 52 allogeneic HSCT recipients with HCMV infection. HCMV gB genotype was determined using polymerase chain reaction to amplify a region of UL55, followed by restriction fragment length polymorphism (RFLP) analysis based on RsaI and HinfI digestion. Results : The distribution of gB types were as follows: gB1, 73.1% (38/52) of patients; gB2, 13.5% (7/52); gB3, 1.9% (1/52) and mixed infection (gB1 and gB2), 9.6% (5/52). While gB4 was not detected, a new genotype (described as gB7 by Trincado et al, 2000) was identified on the basis of their RFLP pattern. During average 708 days’ follow up period, HCMV diseases developed in 5 patients. All of them had gB1 genotype. There was no statistically significant association between the incidence of HCMV diseases and the gB genotypes. Re-infection with gB1 strain was detected in one patient who had been previously infected with gB2. This episode was associated with fever, elevated liver enzyme and positive antigenemia. Conclusion : HCMV gB1 was the dominant genotype and no gB4 was detected in allogeneic HSCT recipients in Korea, which is an unique pattern compared with the previous reports. Although we can not find significant association between the HCMV diseases and the gB genotypes, genotyping of HCMV will serve in the study of pathogenesis and transmission of this virus in transplant patients. Further study is underway with large study population.

여성 요실금에서 Kontinence™와 Compact Elite™의 치료효과 비교

양상국,정상원,오미희,노용수,김홍섭,우응제,박승훈,이수열 건국대학교 의과학연구소 1999 건국의과학학술지 Vol.9 No.-

Biofeedback and pelvic floor electrical stimulation are new modalities that have been advocated for the treatment of female urinary incontinence. The aim of this study was to compare prospectively the therapeutic effect of Kontinence™(HMT Co., Korea) with Compact Elite™(ECL Co., France) in female urinary incontinence. All patients were evaluated with a complete history, physical examination, urinalysis, urine culture and urodynamic study. Eighteen patients were treated with Compact Elite™, and thirteen patients with Kontinence™. Enrolled patients had completed 8 office sessions consisting of biofeedback and intravaginal electrical stimulation according to the program of each machines. Overall treatment response was graded by patients on a scale of complete cure to aggravation. At two weeks after last session, overall improvement rate was 78% in Compact Elite™group and 92% in Kontinence™group(p>0.05). Overall patients' acceptability during treatment course was greater than 80% in both machines(p>0.05). There were no unexpected clinical findings during Kontinence™ treatment. After Kontinence™treatment, there were no laboratory changes including electrocardiography, complete blood count, liver function profile, and chest PA. These results showed that the biofeedback and electrical stimulation with Kontinence™was safe and moderately effective for female urinary incontinence comparable to Compact Elite™. However, long-term results of a larger patients are needed to ensure the therapeutic effect of Kontinence™.

열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

Characterization of Porcine Endogenous Retrovirus(PERV) Positive Clones And Contig Construction From A Korean Native Pig BAC Library

Jung, Woo-Young,Kim, Ji-Eon,Kwon, Young-Sook,Jung, Kie-Chul,Yu, Seong-Lan,Moran, Chris,Park, Chang-Sik,Jin, Dong-Il,Park, Eung-Woo,Lee, Jun-Heon 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

건설기준 디지털화를 위한 교량의 설계 및 시공 절차도와 기준맵 구성

박응우(Park, Eung Woo),성원규(Sung, Won Kyu),강대종(Kang, Dae Jong) 대한토목학회 2022 대한토목학회 학술대회 Vol.2022 No.10