봉독약침이 류마티스 관절염 환자의 기능회복 및 삶의 질에 미치는 영향

이상훈,이현종,박상민,김수영,박재경,홍승재,양형인,이재동,최도영,김건식,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective: To evaluate the effects of bee venom acupuncture(BVA) on the rehabilitation and quality of life in rheumatoid arthritis(RA) patients Methods: Patients with RA were treated with the BVA therapy twice a week for 3 months. Tender joint counts, swollen joint counts, morning stiffness, Erythrocyte Sedimentation Rate(ESR), C-reactive protein(CRP), patient global assessment, physician global assessment, Korean health assessment questionnaire(KHAQ) were estimated and analyzed before and after BVA therapy. Results: Tender joint counts, swollen joint counts, morning stiffness showed significant decrease after BVA therapy. But, as acute inflammatory reactants, ESR showed no significant difference and CRP showed significant increase after BVA therapy. Patient global assessment physician global assessment, and KHAQ index showed significant improvement after BVA therapy. Conclusions: BVA therapy can improve rehabilitation and health-related quality of life RA patients as well as clinical symptom and signs. Further study is required in more population with large scale including acute inflammatory reaction of BVA therapy.

봉독약침이 류마티스 관절염 환자의 관절 통증, 종창 및 급성 염증 반응에 미치는 영향

이상훈,이현종,백용현,김수영,박재경,홍승재,양형인,김건식,이재동,최도영,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective In order to study the effects of bee venom(BV) on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis(RA) patients. Methods Patients with RA who met the ACR(American College of Rheumatology) 1987 revised criteria for the diagnosis of RA were treated with the BV therapy twice a week for 3 months. Tender Joint counts, swollen joint counts, Visual analog scale(VAS), morning stiffness, ESR. C-reactive protein(CRP) were analyzed before and after BV therapy. Results The results as follows. 1. Tender joint counts in patients after BV therapy were significantly lower than those before BV therapy(9.0±7.9 vs 15± 11.4, p=0.002). 2. Swollen joint counts of the patients after BV therapy were significantly lower than those before BV therapy(50±61 vs 15±23, p=0.001). 3. VAS in patients after BV therapy was significantly lower than those before BV therapy(608± 17.6 vs 380± 159, p=0.000). 4. Duration of morning stiffness in patients after BV therapy was significantly reduced compared with that before BV therapy(119.1± 112.6 min vs 59.0±89.7 min, p=0.009). 5. ESR and CRP were not significantly changed before and after BV therapy, suggesting BV itself could make inflammatory reaction as well as therapeutic effect. Conclusions BV therapy improved tender joint counts, swollen joint counts and duration of morning stiffness in this study, and further study is needed on long-term effect of BV therapy.

뇌졸중 후 중추성 통증 환자에 대한 동서협진이 진통과 재활에 미치는 영향

이현종,김수영,이상훈,서동민,이두익,김건식,이재동,이윤호,양형인,박재경,최도영 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Purpose : In order to study the effectiveness of East-West pain treatment on central poststroke pain(CPSP), we evaluated its effect on alleviation of pain and rehabilitation of CPSP Patients who were treated with electroacupuncture and west pain treatment for four weeks. Methods : Twenty four patients diagnosed by their pain characteristics of central pain from stroke were treated with sympathetic nerve block, gabapentin, amitriptyline, and electroacupuncture for four weeks. Pain intensity through the visual analogue scale(VAS), and improvements of mobility and rehabilitation through the modified Barthel index(MBI) and Rankin scale(RS), respectively, before and after pain treatment were also assessed. Results : VAS pain scores were significantly improved from 7.7±1.7 to 4.4±2.0 with pain treatment(p<0.05). In accordance with improvement of pain scores, RS and MBI scores were also improved from 2.88±0.95 to 2.13± 1.01 and from 83.0± 16.9 to 94.7±9.5(p<0.05), respectively, with pain treatment(p<0.05). Conclusions : It was suggested that the active pain treatment was contributed to the rehabilitation of CPSP patients, resulting in improvement of quality of life of CPSP patients. Futhermore, East pain treatment in combination with West pain treatment may be useful modality to alleviate CPSP.

무작위 대조 이중맹검 시험을 통한 봉독 약침의 류마티스 관절염 치료 효과 연구

이상훈,홍승재,김수영,양형인,이재동,최도영,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective : This study was performed in order to evaluate the effect of bee venom therapy on rheumatoid arthritis by randomized controlled double blind method. Method : RA patients were recruited and divided into an experiment group and a control group by random selection. As a double blind test, the experiment group was treated with bee venom injection on acupoints, and the control group was treated with normal saline injection on acupoints twice a week for 8 weeks. Tender joint count, swollen joint count, morning stiffness, pain, health assessment questionnaire, ESR. and CRP were estimated and analyzed at baseline, and at 1 month and 2 months after bee venom therapy Results : Compared to the control group, the experiment group showed significant decrease in tender joint count swollen joint count, morning stiffness, and health assessment questionnaire after 2 months. Pain, ESR and CRP showed significant decrease in the experiment group after 1 & 2 months. Conclusions : These results suggests that bee venom therapy could be an effective method in the treatment of patients with rheumatoid arthritis.

플라즈마 소결 PZT 세라믹스의 유전특성

이형직,송두규,권혁병,정해경,윤상옥,이형복,이홍림 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-

소결첨가제나 바인더를 넣지않고 만든 무첨가 PZT 분말 성형체를 플라즈마 소결-로 열처리 후의 미세조직의 변화, PbO의 거동 그리고 이에 따른 유전특성을 로소결한 경우와 비교하여 다음과 같은 결과를 얻었다. 플라즈마 소결-로 열처리로 만든 PZT 시편이 로 소결 시편과 비교하여 입성장이 크게 일어나지 않은 미세조직을 나타내었으며, 또한 균일한 Pb, Zr, Ti 성분분포를 보였다. 유전특성에 있어서는 1kHz에서 20%정도의 유전율의 향상을 얻을 수 있었으며 유전소실 또한 40%정도 낮출 수 있었다. 상기의 결과는 DC 플라즈마 소결법의 특징인 소결초기의 급속가열 효과와 PbO의 증발 억제 효과에 의한 것으로 고려된다. PZT powder compacts without additives and binder were processed by plasma sintering-furnace annealing. Microstructures, PbO behaviour and dielectric properties were investigated, and compared to the specimen obtained by furnace sintering. The specimen prepared by plasma sintering-furnace annealing showed more not only fine microstructures but also homogeneous pb, Zr, Ti composition distribution, and revealed 20% higher dielectric constant as well as 40% lower dielectric loss (measured at 1kHz). Above results might be considered to be caused by rapid heating effects, high temperature sintering effects and preventing effects of PbO evaporation characterized by dc plasma sintering.

침 치료가 오십견(五十肩) 환자의 적외선 체열촬영에 미치는 영향

김건형,이로민,남동우,김종인,임사비나,이두익,최도영,이윤호,이재동 경희대학교 동서의학연구소 2006 東西醫學硏究所 論文集 Vol.2006 No.-

Objectives : To observe the effect of acupuncture treatment on Digital Infrared Thermographic Imaging(DITI) in frozen shoulder patients. Methods : 17 voluntary patients received acupuncture treatment on LI15, TE14, GB21 and Master Dong's acupuncture points, Shin-gwanand Gyun-joong, twice a week for 4 weeks. The patients were instructed to practice self exercise during their daily lives. Evaluations were made before treatment, after 1 week of treatment, after 2 weeks, 3 weeks and after 4 weeks of treatment. Constant Shoulder Assessment(CSA), Shoulder Pain and Disability Index(SPADI), Range of Motion(ROM) and the patient's satisfaction concerning the treatment was measured by Visual Analogue Scale(VAS). DITI was measured before treatment and after 4weeks of treatment. The obtained data was analyzed. Results : CSA, SPADI, VAS, adduction and extension showed significant(p<0.05) improvement. Abduction and flexion both improved after 4 weeks of treatment, but the improvement was statistically insignificant(p>0.05). DITI showed improvement but the improvement was insignificant(p>0.05). Conclusion : 4 weeks of acupuncture treatment significantly improved CSA, SPADI, VAS, adduction and extension in frozen shoulder patients(p<0.05). The improvement of abduction and flexion after 4 weeks of acupuncture treatment was insignificant(p>0.05). DITI results improved after 4 weeks of acupuncture treatment. But the change of thermal difference was insignificant(p>0.05).

소아 수부 화상의 임상적 고찰

이두형,류인성,장충현 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.3

During 10 years from June 1982 to June 1992, 266 patients were visited to the Department of Plastic and Reconstructive Surgery in Kyung Hee University Hospital, for treatment of pediatric hand burn. The most common etiology of pediatric hand burns was scalding burn(41.7%), followed by flame(25.2%), steam(18.8%), contact(10.5%), and electrical burn(3.8%) but, at recent after 1984, the most common etiology was changed to steam burn(51.1%), followed by scalding(21.5%), flame(10.2%) contact burn (10.2%)and electrical burn(6.8%). The age distribution of the patients was as follows ; early infantile period(8.3%), late infantile period(19.9%), toddler period(39.8%), preschool age(23.7%), and school age(8.3%) but all of steam burn was developed before 3 years old, especially, in late infantile period(7 month~1 year). Males were affected more often than females. Male to female ratio was 1.2 : 1, especially in steam burn and electrical burn, male more predominated. The most frequent affected region was middle finger(61.7%), followed by index finger(54.5%), little finger(44.0%), thumb(30.5%), palm(30.0%), dorsum of hand(7.3%) and wrist(17.3%). The most frequently affected web space in postburn syndactyly was second web space, followed by third(30.9%), fourth(24.1%) and first(13.6%), especially in steam burn, the most frequently affected web space was second web space(52.8%), The highest incidence of pediatric hand burn was in winter(45.2%), followed by spring(25.0%), autumn(16.9%) and summer(12.9%) but, steam burn was developed all around monthly. The most common type of surgical procedure was release and FTSG(59.2%), followed by release and STSG(21.9%), Z-plasty(16.8%), distant flap(1.5%), and free flap(0.6%).

법랑라세포종의 면역조직화학적 및 전자현미경적 연구

이두형,조성덕,양문호,장충현,박재훈 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.3

Clinicopathologic analysis of ameloblastoma in 24 cases and their ultrastructural and immunohistochemical studies, especially to cytokeratin expressions according to morphologic classification were performed to clarify the tumor cell differentiation and origin. Reaction with broad spectrum and high molecular weight cytokeratin were generally positive in the stellate cell of the follicular and acanthomatous ameloblastoma, suggesting more squamous differentiation than peripheral basal cell type. Although ultrastructually common origin from oral epithelium was evidenced by presence of tonofilaments and desmosome, variations were prominent among the different histopathologic types of tumor. In granular cell ameloblastoma there were pleomorphic osmiophilic lysosome-like granules.

부신피질 호산성 과립세포종 1예

이성진,이호권,박철영,정인경,홍은경,오기원,김현규,김두만,유재명,임성희,최문기,유형준,박성우 대한내분비학회 2004 Endocrinology and metabolism Vol.19 No.1

저자들은 건강검진에서 시행한 복부 초음파검사상 우연히 좌측 부신 종괴가 발견되어 복부 전산화 단층 촬영검사와 호르몬검사를 시행한 후 부신피질 악성종양과의 감별 진단을 위해 부신절제술과 전자현미경검사를 포함한 병리조직학적 검사를 시행하여 부신피질호산성 과립세포종으로 진단한 증례를 경험하였기에 문헌고찰과 함께 이를 보고하는 바이다. Oncocytomas are neoplasms, histologically are composed of epithelial cells, with abundant, acidophilic and granular cytoplasm. Electron microscopic studies of oncocytomas have shown that the cytoplasm of oncocytes is packed with mitochondria. The adrenal gland is a very rare anatomical site for oncocytomas, and to the best of our knowledge, only thirty-six cases of adrenal oncocytomas have been described. Herein, a case of a large adrenal mass in a forty-year-old man, which was incidentally detected by abdominal ultrasonography, is presented. This patient demonstrated no clinical manifestation associated with adrenal hyperfunction. Hormonal studies showed no abnormal findings, except for a mild elevation of the 24-hour urinary VMA level. Abdominal computed tomography with enhancement revealed a large, well-defined left adrenal mass, measuring 5.0×4.2 ×3.0 cm. The patient underwent a left adrenalectomy, and a light microscopic examination confirmed an adrenocortical oncocytoma, with characteristic oncocytes and polygonal, abundant, eosinophilic and granular cytoplasm. The tumor cells were positive for cytokeratin and vimentin as well as S-100, but negative for chromogranin on immunohistochemical staining. An electron microscopic examination demonstrated closely packed mitochondria, containing intramitochondrial inclusions. After surgery, there was no evidence of a recurrent or distant metastatic disease at the 5 month follow-up. In summary, an extremely rare case of a man with an adrenocortical oncocytoma is reported, which was confirmed by histological examinations, including electron microscopy (J Kor Soc Endocrinol 19:82∼89, 2004).

예후가 불량한 상악 중절치의 유지

이두영,김승혜,최형준,최병재,이제호 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.3

상악 중절치는 저작시 음식물을 찢거나 자르는 기능 외에도 심미적으로 중요한 기능을 하며 상악 악궁의 형태 및 얼굴의 형태와도 관계가 있다고 알려져 있다. 그리고 발음을 하는데 있어서도 전치부는 매우 중요한 역할을 한다. 예후가 불량한 치아의 일반적인 치료는 발거 후 공간 유지장치를 하는 것이다. 그러나 혼합치열기에 있어 상악 영구 중절치의 발거는 치조골의 흡수, 불량한 심미성, 발음과 저작의 문제 등 여러 가지 합병증을 일으킬 수 있다. 이러한 이유로 상악 전치부의 치료는 보존적으로 행해져야 한다. 예후가 불량한 상악 전치부의 치료시 고려해야 할 사항으로는 환아의 나이, 성장 잠재력, 교합 관계, 구강 위생상태, 경제력 그리고 환아의 치료에 대한 협조도 등이 있다. 본 증례는 짧은 치근으로 인해 치아의 동요도가 있어 상악 좌측 중절치의 예후가 불안정함에도 불구하고 치아를 발거하지 않고 치료를 통해 상악 좌측 중절치를 정상 위치로 배열하고 보존하였다. 짧은 치근과 치아 회전으로 인한 추가적인 치근 흡수와 치아 동요도 증가 등 예후가 불안정하였지만 환아의 심리적 안정성, 나이, 심미성 등을 고려하여 보존적인 치료 후 양호 한 결과를 얻었기에 이를 보고하는 바이다. The incisors function as instruments for biting and cutting food during mastication. They also support the lips and face and maintain vertical dimension. In addition, they contribute to overall normal arch appearance. They play important role during the articulation of speech and assist in guiding jaw closure. Extraction and space maintenance are the most common treatment for a tooth with poor prognosis. However, in the mixed dentition, extraction of the upper permanent incisors results in many complications, such as resorption of alveolar bone, poor esthetics, pronunciation, and mastication. Considering these various roles of incisors in oral cavity, approach for traumatized incisors, even the ones with poor prognosis, should be considered first prior to simple extraction. The dentist must take into account the age of the patient, growth potential, occlusion, oral hygiene status, economic status and motivation towards dental health in addition to patient compliance. In this case, although the prognosis was predicted to be unfavorable due to short root and mobility, we could save the central incisor using conservative treatment, reposition by orthodontic appliance instead of extraction.