한약과 와파린 병용의 상호작용과 안전성에 대한 연구

권동현 ( Dong Hyun Kwon ),김호준 ( Ho Jun Kim ),이명종 ( Myeong Jong Lee ),송미영 ( Mi Young Song ) 한방재활의학과학회 2010 한방재활의학과학회지 Vol.20 No.2

Objectives: The purpose of this study is to investigate interaction and safety in administering herb-medicine with warfarin. Methods :For this study, we selected 19 patients who have been taking warfarin, from the ones that have been transferred from western hospital to oriental hospital. During their stay in the oriental hospital, we gave herb-medicine in addition to warfarin. Then we gathered informations and data on sex, age, main indications, and International Normalized Ratio(INR) values of selected patients through Electronic Medical Records(EMR) of Dong-Guk university hospital. Accordingly, we compiled all of the above data for a period of 10 days prior and 10 days post admission(western hospital period and oriental hospital period, respectively)Results and Conclusions :The statistical analysis of the data have revealed that there was no significant change of INR values after giving herb-medicine with warfarin(p=0.586). The result shows that administration of herb-medicine with warfarin is safe and has little drug interaction. However, this study was carried out on small sample size and the interaction with other drugs and various kinds of herb-medicine was not considered. Although we attained a restrictive result from this study, we are able to suggest the safety about co-administration of herb-medicine and warfarin.

국내 다기관에서 조사한 지역사회획득 메티실린내성 황색포도알균의 빈도와 임상적 특성

송진수,최평균,송경호,조재현,김성한,방지환,이창섭,박경화,박경운,신수,최희정,김의석,김동민,이미숙,박완범,김남중,오명돈,김의종,김홍빈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

목적 : 최근 전세계적으로 지역사회획득 메티실린내성 황색포도알균(community-associated methicillin-resistant Staphylococcus aureus, CA-MRSA)의 보고가 증가하고 있다. 하지만, 우리나라에서는 CA-MRSA 감염증에 대한 증례보고만 있을 뿐 아직까지 체계적인 연구결과가 없는 실정이다. 저자들은 국내에서 CA-MRSA의 빈도, 감염증의 임상적 양상, 분리된 균주의 항균제내성 양상을 조사하였다. 재료 및 방법 : 2005년 1월부터 2005년 6월까지 7개 병원에서 MRSA가 분리된 환자의 명단을 파악한 후 의무기록지와 건강보험심사평가원의 자료를 검토하였다. 외래나 응급실에서 혹은 입원 후 72시간 이내에 균주가 분리되고 MRSA 획득과 관련된 위험인자가 없는 경우 CA-MRSA로 정의하였으며, 분리된 균주의 임상적 의미에 따라 원인병원체(pathogen), 집락화(colonizer), 미결정(undetermined)으로 분류하였다. Penicillin과 oxacillin을 제외하고 3개 이상의 다른 계열 항균제에 내성이면 다제내성으로 정의하였다. 결과 : 연구기간동안 총 3,251주의 황색포도알균이 분리되었으며, 이 중 MRSA는 1,900주(58.4%)였다. MRSA 가운데 CA-MRSA는 114주(6.0%) 였으며, 이들이 분리된 부위는 귀(62주), 비뇨기계(14주), 피부 및 연부조직(11주), 호흡기계(10주), 혈액(3주) 등이었다. CA-MRSA 균주 가운데 집락균은 22주, 원인병원체는 22주였으며, 나머지 균주에 대해서는 그 임상적 의미를 결정할 수 없었다. 항균제 감수성 검사를 시행한 73균주 중 47주(64.4%)는 다제내성이었다. CA-MRSA 감염증 22예 중 피부 및 연부조직 감염(9예)과 중이염/외이도염(9예)이 가장 흔하였다. 침습적 감염증(invasive infection)은 4명(원발성 균혈증 3예, 감염성 관절염 1예)에서 확인되었지만, CA-MRSA 감염증으로 사망한 환자는 없었다. 결론 : 병원내 감염증에서는 MRSA가 심각한 문제이지만, 아직까지 지역사회 감염증에서 CA-MRSA는 흔하지 않았다. Background : Methicillin-resistant Staphylococcus aureus (MRSA) infection has emerged in patients who do not have the established risk factors. In Korea, little is known about the epidemiology and clinical features of community-associated MRSA (CA-MRSA). Material and Methods : Clinical microbiology laboratory databases of 7 hospitals were reviewed to identify the patients from whom MRSA was isolated during the period of January to July 2005. Only one isolate per patient was enrolled. In order to identify the risk factors of MRSA acquisition, the medical records and the Health Insurance Review Agency databases were reviewed. CA-MRSA was defined as MRSA isolated from patient without established risk factors. We analyzed patient demographics, underlying medical conditions, characteristics of infection, and antimicrobial susceptibility profiles. Results : Of total 3,251 S. aureus isolates, 1900 (58.4%) were MRSAs. Of the MRSA isolates, 114 (6.0%) were CA-MRSA. Of 114 CA-MRSA isolates, 22 (19.3%) were colonizers, 22 (19.3%) were pathogens, and the clinical significance of remaining 70 (61.4%) could not be determined. Median age of the 22 patients with CA-MRSA disease was 47 years. Nine patients had skin and soft tissue infections, 9 ear infections, 3 bacteremia, 1 septic arthritis. Seven patients had underlying medical disease. None died of the CA-MRSA infections. Of the 73 isolates of CA-MRSA, 47 (64.4%) were resistant to more than 3 classes of antibiotics besides β-lactams. Conclusion : Although MRSA is highly prevalent among hospital-associated S. aureus infection, CA-MRSA infections are not common.

농촌지역 노인들의 우울증상에 관련된 요인들의 특성

송미숙,전기홍,송현종,김정은,박승구,신상건,이동훈,정성현,최연주,최완철,최민규,황재철,홍지만 아주대학교 1997 아주의학 Vol.2 No.2

This study was performed to identify risk factors for depression among the elderly in a rural area. A survey was done for the elderly living in Gosam-myenn, Ansung-kun during the period of July 28, 1997 and July 30, 1997. Demographic and sodoeconornic characteristics, and functional and health Status were assessed using a structured questionnaire, and the level of depression was measured by GDS score. The data obtained were analyzed by frequencies, percentage, t-test, ANOVA, and multiple regression, and the results were as follows: 1. The total sample consisted of 133 elderly. Of them, 47 elderly (35.4%) showed significant depressive Symptoms. 2. The GDS score was the highest for the group over 85 years of age (p < 0.05). Those living alone or widowed showed lower GDS score than those living with someone or married (p < 0.05). 3. The GDS score was the highest in the absolutely dependent group, followed by the partially dependent group, and the independent group (p < 0.01). The elderly who perceived their health Status as excellent showed the lowest GDS score. In contrast, those who had more than five chronic diseases showed the highest GDS score. 4. The elderly receiving financial and emotional support from their family or friends showed lower GDS score compared to those without any support. 5. The economically dependent group showed higher GDS score than that of independent group. 6. The elderly who involved in leisure activities showed lower GDS score than those without any involvement. 7. In terms of risk factors for depression, we found that perceived health Status, subjective economic Status, leisure activities, living arrangement and financial support were inversely associated with GDS score, whereas labor support was positively associated with GDS score. Based upon the above findings, this study suggests that these risk factors for depression in the elderly should be taken into consideration for a comprehensive mental health program for the elderly living in the rural area.

춘천 지역의 담수어류 분포

송호복,백현민,조동현 강원대학교 부속 환경연구소 2004 Journal of the Environment Vol.1 No.-

The environmental characteristics of streams, ichthyofauna and structure of fish community were surveyed in Chuncheon, Gangwon-do from May and October in 2004. Streams were Aa and Aa-Bb types. In stream environment, middle and upper parts of Yulmoon and Palmi sterams were good condition. Twenty four species belonging to 8families were collected. Cyprinidae fish occupied 74,5%, Gobiidae 11.6% and Cobitidae 10.8%. According to relative abundance, Rhynchocypris oxycephalus (25.2%) was dominant species and Zacco platypus (18.3%) was subdominant. Rhinogobius brunneus (11.5%), Zacco temmincki (10.8%) and Pseudolasbora parva (7.5%) were common, and Silurus asotus, Silurus microdorsalis and Chaenogobius urotaenia were rare species. Endemic species of Korea were 6 species (25.0%) and exotic fish was Micropterus salmoides. By analyzing of fish community in the surveyed area, the species richness. evenness, diversity and dominance were calculated as 0.49~2.04, 0.35~0.94,0.38~1.97 and 0.41~1.00 respectively.

임베디드 시스템에서 Mobile IP 프로토콜 구현

宋東勳,裵振勝,鄭燦赫,吳世德,李基源,劉忠烈,河載承,李光培,金玄郁 명지대학교 산업기술연구소 2005 産業技術硏究所論文集 Vol.24 No.-

With rapid growth of the internet, need for the mobile communication networks is increasing. In this paper, we implement and test Mobile IP Protocol in Embedded System. Our Mobile IP-based testbed consisted of two sub-networks and each sub-network was configured to operate independently through use of router. To satisfy integrated wired/wireless network model established on the testbed design and show generality of the testbed, we implemented mobile nodes, home agent, foreign agent and router on the basis of Linux operating system. As the results of the evaluation, we confirmed that mobile nodes operated properly according to Mobile IP Protocol.

원주시 소각시설의 입지와 주변지역의 대기질예측에 관한 연구 : 입지여건의 평가를 중심으로

송동웅,김기현 한국환경과학회 2000 한국환경과학회지 Vol.9 No.1

In this study, we investigated the site feasibility for the construction of the incineration facilities in Won Ju City. To assess the environmental impact of its construction, we examined the current status of air quality in the selected candidate sites and predicted the extent of air quality change upon its operation through modification of stack type. If the stack height is assumed to be 70 m, the concentrations of SO_2 and dioxin in the surrounding area were predicted to increase by 0.05 ppb and 0.09 pg/㎥, respectively. The impact of its operation was assessed and compared among different sites. According to this analysis, more impact was expected from the residential area for the Dan-Gye site than from agricultural areas of the Kwan-Sul and Sa-Je site.

만성적 스트레스 및 불규칙적인 운동이 심혈관 질환의 위험인자에 미치는 영향

송영주,권대근,장창현,정영미,황정윤,성동진 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

This study was conducted to invastigate the effect of everyday life stress level and temporary physical activity by the stress on stress-related hematologic indices. The subjects were 83 male older aged men and they were received a questionaire about everyday life stress level and temporary physical activity by the stress and collected whole blood after overnight fasting state. Obtained results were as follows: 1. CRP level CRP level of MS group was significantly increased compared to SS group(p<.05). However, CRP level between PA and NP was not significant difference. 2. Cholesterol, triglyceride, phospholipid level Cholesterol, triglyceride, phospholipid level of MS group was significantly increased compared to SS group(p<.05). However, Cholesterol, triglyceride, phospholipid level between PA and NP was not significant difference. 3. WBC counts WBC counts of MS group was significantly increased compared to SS group(p<.05). However, WBC counts between OP and PA was not significant difference. From these results, increased stress in everyday life aggravate blood components related cardiovascular risk factors and immune system. In addition, acute exercise for stress attenuation does not improve blood components related cardiovascular risk factors and immune system. In summary, regular exercise and optimal nutrition and rest will be attenuate cardiovascular risk factors and immune system.

AgClBr Microcrystal의 결정성장과 Morphology에 관한 연구

송현,권동주,이의수,이명천,임종주 동국대학교 산업기술연구원 2001 산업기술논문집 Vol.12 No.2

감광성 유제(AgClBr)의 제조에 있어 가장 중요한 변수인 할로겐화은염 결정의 크기 및 결정형태 변화를 물리숙성 온도, 반응물의 투입속도, 젤라틴 농도, 할로겐 이온(Cl^-, Br^-)의 농도비등을 변수로 하여 관찰하였다. 실험결과 물리숙성 온도가 증가함에 따라 형성된 AgClBr 결정의 크기는 증가하지만, 반면에 질산은과 할로겐화염의 주입속도의 증가는 AgClBr 결정의 크기가 감소하는 경향을 나타냈다. 또한 젤라틴의 농도 증가는 이온상태로 존재하는 반응물의 이동을 억제하여 결정을 성장하는데 요구되는 회합속도를 저하시켜 결과적으로 생성되는 결정의 크기가 감소하였다. AgClBr의 결정형태는 Cl^-과 Br^- 이온의 농도비에 따라 가장 민감한 변화를 나타냈으며, Br의 농도비가 증가함에 따라 AgClBr 결정은 cubic형에서 round 형태로 변화하는 경향이 관찰되었다. The preparation and the morphology of silver chlorobromide crystals were studied by double-jet method. The crystal size and morphology of silver chlorobromide have been estimated by SEM photos. The influence of physical ripening temperature, rate of addition of reactants, concentration of gelatin and molar ratio of two hailde ions on the crystal growth and change of crystal morphology of obtained silver chlorobromide microparticles were investigated. The crystal size of silver chlorobromide were grown in propotion to increasing of ripening temperature, however the increasing of rate of addition of reactants induced decreasing of crystal size. The crystal morphology of photosensitive silver chlorobromide varied from cubic to round type by the increasing of concentration of bromide ion.

작은 치아종으로 인한 맹출 장애

송지현,이광희,라지영,이동진 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.3

스케일이 있는 급수관내의 유도초음파의 전파 특성에 관한 연구

송성진,김영환,이동훈,이현동,배철호,박정훈 한국비파괴검사학회 2003 한국비파괴검사학회지 Vol.23 No.1

배관 내의 스케일은 통수비를 감소시키므로 배관을 적절히 관리하기 위해서는 스케일량에 대한 정량적인 평가가 필수적이다. 상수도 급수관내의 스케일량을 평가하기 위해서 유도초음파를 사용하였다. 가변각 웻지를 사용하여 유도 초음파의 여러 모드를 발생시키고, 노후 배관을 따라서 전파하는 특성을 분석하였다. 실험적으로 관내의 스케일이 증가함에 따라서 f×d=1.5㎒·㎜인 경우에 F(M,2) 모드들의 진폭이 크게 감소하는 것을 알 수 있었다. 본 연구의 결과로 상수도 급수관의 스케일량 평가에 적합한 유도 초음파는 F(M,2) 모드들임을 알 수 있었다. Since the scale in pipes reduces the flow rate, a quantitative evaluation of the scale is essential for the proper maintenance of pipes. Guided waves were employed to estimate the amount of scale in water supplying pipes. Using variable angle wedge, several modes of guided waves were generated and their propagation charcteristics along the pipes with scale were analyzed. It was experimentally observed that the amplitude of F(M,2) modes at f×d=1.5㎒·㎜ decreased significantly with increasing amount of scale. The present study showed that F(M,2) modes were optimal to evaluate the scale in water supplying pipes.