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      • 경화성 담관염을 동반한 랑게르한스 세포 조직구증 1예

        황재철,김도현,이은희,정재학,심진영,정재연,이기명,유병무,김진홍 대한소화기내시경학회 2003 Clinical Endoscopy Vol.26 No.1

        Langerhans cell histiocytosis is a rare disorder with abnormal proliferation of histiocytes. Besides the infiltration of a variety of organs, patients with Langerhans cell histiocytosis can develop sclerosing cholangitis, with bile duct involvement, progressive fibrosis, and cirrhosis. We report a case of Langerhans cell histiocytosis with sclerosing cholangitis. Endoscopic retrograde cholangiopancreatography revealed multiple strictures and dilatations of left intrahepatic and extrahepatic bile duct. Endoscopic biopsy of common bile duct showed diffuse infiltration of histiocytes and eosinophiles in lamina propria. Immunohistochemical stain showed positive reactions for S-100 and CD1a and a negative reaction for cytokeratin in infiltrating histiocytes. (Korean J Gastrointest Endosc 2003;26:56-60) 랑게르한스 세포 조직구증이 담관을 침범하는 경우 경화성 담관염의 발생 및 담도폐쇄에 의한 담즙성 간경변으로 나타날 수 있다. 60세의 여자 환자가 2개월 동안 5 kg의 체중감소와 심와부통증을 주소로 내원하였다. 내원 당시 활력징후 및 신체 검사에서 이상소견은 없었고 검사실 소견에서 총 단백 7.1 g/dL, 알부민 3.6 g/dL, 총 빌리루빈 0.5 mg/dL, AST 68 U/L, ALT 77 U/L, ALP 618 U/L, γ-GT 1,202 U/L이었다. 간염 바이러스 검사에서는 HBsAg, HCVAb는 음성이었으며, HBsAb 양성이었다. 복부 전산화 단층촬영술에서 좌측간내담관 및 총담관의 확장과 간외담관벽의 비후를 보였다. 내시경적 역행성 담췌관 조영술에서 좌측간내담관과 간외담관에 다발성 협착 및 확장을 보여 경화성 담관염으로 진단하였으며, 관강 내 초음파검사에서 총담관 벽의 미만성 비후를 보여 총담관에서 겸자조직생검을 시행하였다. 조직병리학적 소견은 점막고유층에 조직구 및 호산구의 침윤이 있었고, 면역조직학적 염색 소견에서는 S-100 및 CD1a은 양성이었고 cytokeratin은 음성을 보여 담관에 발생한 랑게르한스 세포 조직구증으로 진단되었으며, 진단 후 증상의 악화 없이 경과 관찰 중이다.

      • KCI등재

        Medical treatment of hepatolithiasis

        황재철 대한췌담도학회 2012 대한췌담도학회지 Vol.17 No.1 (Suppl)

        Hepatolithiasis can cause recurrent attacks of cholangitis or biliary cirrhosis. Definitive treatment should aim for complete elimination of bile stasis and removal of the entire stones. Endoscopic retrograde cholangiopancreatography is not well established for hepatolithiasis because of frequent failures due to associated biliary strictures, angulated ducts or peripherally impacted stones. Percutaneous transhepatic cholangioscopic lithotomy(PTCSL) for the treatment of hepatolithiasis is partic- ularly suited for those patients who poor surgical risks or who refuse surgery and those with previous biliary surgery or stones distributed in multiple segments. PTCSL is a relatively safe and effective for treating hepatolithiasis, and that complete stone clearance is mandatory to diminish the sequelae of hepatolithiasis. Intrahepatic duct stricture was the main factor contributing to incomplete clearance and stone recurrence. Long-term follow-up is required because the overall recurr- ence rate of hepatolithiasis is high and hepatolithiasis is also associated with cholangiocarcinoma. Oral dissolution therapy may be effective for the prevention of recurrence after removal of cholesterol hepatolithiasis by PTCSL.

      • KCI등재

        식품제조업 고령 여성 근로자의 재해 특성과 예방대책

        황재철,정명진,오소윤,최동아,최민재 국제문화기술진흥원 2020 The Journal of the Convergence on Culture Technolo Vol.6 No.4

        Compared to other manufacturing industries, the food manufacturing industry has a relatively large number of women casualties compared to men, and the number is steadily increasing. The age of casualties is also increasing as the society enters into an aging society. This is also evident in the food manufacturing sector. Therefore, this study conducted a survey on the safety and health awareness of workers by age and gender at small workplaces in the food manufacturing industry. Among them, we would like to focus on elderly women workers and analyze their accident characteristics to suggest ways to reduce the accident rate. 식품제조업은 다른 제조업종에 비해 상대적으로 남성 대비 여성 재해자의 수가 많은 편이며 그 수는 꾸준히 증가하고 있다. 고령화 사회로 접어듦에 따라 재해연령 또한 높아지고 있다. 이는 식품제조업종에서도 뚜렷이 나타나고 있다. 따라서 본 연구는 식품제조업의 소규모 사업장에서 연령 및 성별에 따른 근로자들의 안전·보건 인식에 대하여 설문조사를 실시하였으며. 그중 고령 여성 근로자들에 초점을 맞추어 재해 특성을 분석해 재해율이 감소할 방안을 제시하고자 한다.

      • KCI등재

        만성 요통환자중 비만그룹과 정상그룹과의 혈중지질 및 체력분석

        황재철,한상완,김용남,Hwang, Jae-Chul,Han, Sang-Wan,Kim, Yong-Nam 대한물리치료과학회 2000 대한물리치료과학회지 Vol.7 No.2

        To examine the blood lipids, muscle strength and flexibility at low back, and muscle strength in the knee joint, 44 women, who were diagnosed as chronic low back pain patients and aged between 40 to 50 years old, were recruited as the subjects. The women were divided into two groups: 1) body fat content less than 25% and 2) body fat content more than 30%. The results were: 1) No differences were found between two groups in blood lipids status. 2) The total cholesterol were less 3.78% in the normal group than the obese group. 3) The HDL-cholesterol were higher 4.85% in the normal group than the obese group. 4) The TG were less 13.1% in the normal group than the obese group. 5) No differences were found between two groups in muscle strength and flexibility 6) No differences were found between two groups in the peak torque of knee joint 7) The total work of the knee joints were higher in the normal group than the obese(P<.05). 8) The abdominal strength were higher 34.04% in the normal group than the obese group. 9) The flexibility of low back were higher 44.54% in the normal group than the obese group.

      • ATM 망에서 비디오 서비스를 위한 동적 VBR 트래픽 특성화

        황재철,조미령,이상원,이상훈 한국컴퓨터산업학회 2001 컴퓨터産業敎育學會論文誌 Vol.2 No.4

        This paper is focused on the traffic characterization for the efficient transmission of the VBR video source in the ATM network. For the traffic characterization, low traffic monitoring technique is applied and the dynamic VBR characterization method is suggested to satisfy the delay requirement. The dynamic VBR method uses the token bucket algorithm buffering though Cumulative Constraint Function. According to the Cumulative Constraint Function, the packet initially started transferring at the peak rate and the token bucket provided proper amount of buffer for traffic after a certain period of monitoring. It also reduced the network resource bandwidth through renewal of the cumulative frame and changed the rate from the previous frame information. It requires only small amount of monitoring and causes little overhead. In addition, it lowered the complexity of Deterministic Constraint Function to 0(n) and mapped the token rate and token depth to the token bucket. This study shows less network resource consumed than the previous method, comparing and analyzing the result of simulations. 본 논문에서는 ATM상에서의 효율적인 VBR 비디오 소스 전송을 위한 트래픽 특성화를 다루었다. 트래픽 특성화를 위하여 전송 중 트래픽이 적은 모니터링 기법을 사용하였고 지연 요구사항을 만족시키는 동적 VBR 특성화 방식을 제안하였다. 동적 VBR 방식은 누적 제한 함수 (Cumulative Constraint Function)를 이용한 토큰 버킷 알고리즘 버퍼링을 사용하였다. 누적 제한 함수는 초기에는 peak rate로 전송을 시작하여 일정시간 동안 모니터링 한 후, 다음 트랙픽을 예측하여 적절한 버퍼를 제공하였다. 누적 프레임의 갱신을 통하여 네트워크 자원 예약량을 감소시켰고 이전 프레임 정보를 가지고 rate를 변경시켰다. 이는 적은 모니터링을 하며 오버헤드도 적다. 그리고 이전의 결정적 제한 함수 (Deterministic Constraint Function)의 복잡도를 0(n) 까지 낮추었고, 토큰 버킷의 토큰 rate와 토큰 depth를 구하여 매핑 하였다. 본 논문은 시뮬레이션을 통한 결과치를 비교 분석하여 이전의 방식보다 적은 네트워크 자원이 소모되는 것을 보여준다.

      • KCI등재후보
      • KCI등재

        Suppressive Effect of Curcuma zedoaria ROSCOE on Pulmonary Metastasis of B16Melanoma Cells

        황재철,김미랑,정용재,이영자,정운석,서운교 대한한의학회 2005 대한한의학회지 Vol.26 No.1

        Purpoes: We examined the antimetastatic effect of Curcuma zedoaria ROSCOE(CZ) on pulmonary metastasis of B16 cells. Materials and Methods: For 6weeks, Zedoariae Rhizoma , made from the dried CZ were dissolved in distilled water and taken to mice 2weeks before they were injected with B16 melanoma cells. Mice were given CZ at doses of 250 and 500mg/kg, and we compared them in lung weight, survival days, NO production. Result: The intake of CZ throughout the experiment extended the average survival time. The intake after B16 cell injection slightly prolonged survival time, but The intake before B16 cell injection did not influence the life span. And we examined the effect of CZ on macrophage function by measuring NO production. After the macrophage being given CZ for 6weeks, the amount of NO generated by the macrophage stimulated with LPS in culture medium was increased. NO generated by the macrophages also served as a cytotoxic factor against B16 melanoma cells. B16 melanoma-conditioned medium reduced NO production by marcrophages. However, CZ treatment reversed the reduction in NO production by the conditioned medium significantly. Conclusion: These findings may suggest that macrophage function-modulating activity by CZ apperars to underlie its antimetastatic activity, which leads to a decrease in the number of lung metastatic surface nodules and the extension of life span.

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