야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

신생아 제대혈 Leptin의 농도 : 성별, 출생 체중과의 관계 Concentrations Relationship to Gender and Birth Weight

최영륜,조창이,송태복 全南大醫大 2000 전남의대학술지 Vol.36 No.3

신생아에 심한 심부전증을 일으킨 선천성 뇌동정맥 기형: 풍선 색전 요법을 시도한 1례

박인숙,김영휘,홍창의,조영국,서대철,박영일 울산대학교 의과대학 1993 울산의대학술지 Vol.2 No.2

Cerebral arteriovenous malformation is a rare cause of congestive heart failure in neonates and is known to carry a very poor prognosis even wish prompt recognition and aggressive treatment. We recently encountered a 2-day-old male neonate with huge cerebral arteriovenous malformation who presented with intractable heart failure. Despite aggressive medical treatment and partial embolization with detachable balloon, baby died of severe hearts failure. Since there is no report of percutaneous balloon embolization in a neonate with this lesion in Korean literature, we wish to present our experience in one such neonate. Also we believe this is the first report of color Doppler findings in cerebral arteriovenous malformation in Korean literature.

갈색세포종(증례보고)

조원현,이상숙,장은숙,박영관,예석형 啓明大學校 醫科大學 1998 계명의대학술지 Vol.7 No.1

Pheochromocytoma is a tumor which produces catecholamine and its metabolites and are usually benign unilateral neoplasm of adrenal medulla in more than 80%. In rare cases, it may arise in an extraadrenal sites including perirenal fat, paraganglia, urinary bladder, chest and neck. In less than 1% of hypertension population, pheochromocytoma is a cause of hypertension and most of these cases are curative by surgery. The most common clinical finding is hypertension and it has three frequent symptoms of headache, palpitation and perspiration. The tumor can be diagnosed by urinary excretion of catecholamine and their metabolites such as vanillylmandelic acid and metanephrines. Other tumor, compeuterlized tomogram, 1131 MIBG scitigram, selective arteriogram and selective caval sampling for catecholamine are used. Authors experienced an extraadreanl pheochromocytoma in 71 years old male with intermittent hypertension and huge abdominal mass so reported the case and reviewed literature.

극소 저출생 체중아의 빈도와 생존율 및 예후 변화

김영옥,김선희,조창이,최영륜,국진화,황태주,Kim, Young Ok,Kim, Sun Hui,Cho, Chang Yee,Choi, Young Youn,Kook, Jin Hwa,Hwang, Tae Ju 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.8

목 적 : 한 나라의 건강 지표로 중요한 의의를 갖는 영아 사망의 2/3는 신생아기에 일어나며 주로 저출생 체중아에 의한 것이다. 최근 신생아 집중치료의 발달로 1,500 gm 미만의 극소 저출생 체중아의 생존율이 향상되는 추이여서, 본 연구는 1996년 부터 2001년까지 6년간 전남대학교병원에서 극소 저출생 체중아의 발생 빈도와 생존율 및 이환율 변화를 알아보고자 하였다. 방 법 : 본 연구는 1996년 1월부터 2001년 12월까지 전남대학교병원 신생아 집중 치료실에 입원했던 1,500 gm 미만의 극소 저출생 체중아 565명을 대상으로 하였다. 1996년부터 1998년까지를 전반기, 1999년부터 2001년까지를 후반기로 나누어 기간별 VLBWI의 생존율, 이환율 및 입원 기간의 차이를 비교하였고, 이를 또한 출생 체중과 재태 연령별로도 비교하였다. 생존 환아에서의 이환율은 '단기 질환'과 '장기 질환'으로 질환을 구분하여 비교하였고, 원내 출생아에서의 VLBWI 발생 빈도 및 기간별 변화, 기간별 주산기 인자와 생존율과의 상관관계, 사망 원인에 대해서도 조사하였다. 결 과 : 원내 출생 VLBWI의 발생 빈도는 총 8.3%이었으며 전반기 6.0%, 후반기 11.0%로 후반기에 그 빈도가 증가하였다. VLBWI 총 생존율은 76.8%이었으며, 전반기(71.8%)에 비해 후반기(80.1%)에 향상되었고, 특히 출생 체중 1,000-1,249 gm과 재태 연령 28-30주에서 개선되었다. 주산기 인자 중 후반기에 제왕 절개 분만이 증가하였고, 다태아에 비해 단태아일 경우, 질식 분만에 비해 제왕 절개 분만일 경우에 생존율이 증가하였다. 사망의 빈도는 생후 7일 이전 사망이 전체 사망의 58.8%로 가장 빈번하였다. 사망 원인으로는 신생아 호흡 곤란 증후군이 주요한 원인이었고, 패혈증, 폐출혈 빈도순이었다. 이환율은 전반기(82.5%)에 비해 후반기(92.3%)에 유의하게 증가하였다. 생존한 환아에서 전반기에 비해 후반기에 총 이환율과 단기 이환율은 증가하였으나 장기 이환율은 통계학적으로 유의한 차이가 없었으며, 출생 체중 1,000-1,499 gm과 제태 연령 28-33주에서는 단기 이환율이 유의하게 후반기에 증가한 반면 오히려 장기 이환율은 감소하였다. 생존 환아에서 평균 입원 기간은 전반기에 비해 후반기에 유의하게 연장되지는 않았다. 결 론 : VLBWI의 빈도가 증가하고 생존율이 향상된 반면 이환율은 증가되었다. 그러나, 출생 체중 1,000-1,249 gm과 재태 연령 28-30주에서 현격한 생존율 증가와 함께 '단기 이환율'은 증가되었으나 오히려 '장기 이환율'은 감소하였다. Purpose : The survival rate of very low birth weight infants(VLBWI) has improved by virtue of specialized neonatal care. This study was performed to analyze the changes in incidence, survival rate and morbidity of VLBWI who admitted to Chonnam National University Hospital from 1996 to 2001. Methods : We enrolled 565 VLBWI, and compared the incidence and the survival rate according to the birth weight or gestational weeks between period I(1996 to 1998) and period II(1999 to 2001). The mortality rate according to the postnatal age, cause of death, morbidity and days of hospital stay were also compared. Morbidity is categorized into 'short term' which is curable until discharge, and 'long term' causing any types of sequelae after discharge. Results : Incidence of VLBWI significantly increased in period II over period I(6.0% vs. 11.0%, P< 0.001). The survival rate also increased in period II(71.8% vs. 80.1%, P<0.05), especially in 1,000 to 1,249 gm of birth weight(P<0.001) and in 28 to 30 weeks of gestation(P<0.001). The most common cause of death was respiratory distress syndrome in period I; however it was sepsis in period II. Although overall and short term morbidity rate increased, long term morbidity and days of hospital stay didn't increase in period II. Conclusion : Although the incidence of VLBWI significantly increased and the survival improved in period II compared to period I, especially in 1,000 to 1,249 gm of birth weight and 28 to 30 weeks of gestation, 'long term' morbidity rate and hospital days didn't increase.

3-deoxysilybin exerts anti-inflammatory effects by suppressing NF-κB activation in lipopolysaccharide-stimulated RAW264.7 macrophages

Cho, Byoung Ok,So, Yangkang,Jin, Chang Hyun,Nam, Bo Mi,Yee, Sung-Tae,Jeong, Il Yun Japan Society for Bioscience, Biotechnology and Ag 2014 Bioscience, Biotechnology, and Biochemistry Vol.78 No.12

Clinical and Microbiological Characteristics of Chryseobacterium indologenes Bacteremia: A 20-Year Experience in a Single University Hospital

Chang Jeonghyun,Kim Sollip,Kwak Yee Gyung,Um Tae Hyun,Cho Chong Rae,Song Je Eun 대한감염학회 2023 Infection and Chemotherapy Vol.55 No.3

Background: Chryseobacterium indologenes is ubiquitous in nature and rarely causes infections. However, the clinical impact of C. indologenes has increased in recent years, especially in immunocompromised patients, and has resulted in high mortality rates. We aimed to investigate the clinical and microbiological characteristics of C. indologenes bacteremia. Materials and Methods: We retrospectively reviewed medical records of a 642-bed university-affiliated hospital in Korea, dating from January 2001 to December 2020, to investigate C. indologenes bacteremia. Results: A total of 22 C. indologenes isolates were identified from blood culture records. All patients were hospitalized at the time of bacteremia, and the most common manifestation was primary bacteremia. A sizable majority of the patients (83.3%) had underlying diseases, and all patients received intensive care unit care during their admission. The 14-day and 28-day mortality rates were 8.3% and 16.7%, respectively. Importantly, all C. indologenes isolates were 100% susceptible to trimethoprim-sulfamethoxazole. Conclusion: In our study, most of the infections were hospital-acquired, and the susceptibility pattern of the C. indologenes isolates showed multidrug resistance. However, trimethoprim-sulfamethoxazole is a potentially useful antibiotic for C. indologenes bacteremia treatment. More attention is required to identify C. indologenes as one of the most important nosocomial bacteria with detrimental effects in immunocompromised patients.

Accomplishment of the Safety Innovation Master Plan for Republic of Korea

Jeong Yee Bae,Seong-Il Cho,Chang Hyo Bae,Dong Su Han,Tae-Hyen Lee 위기관리 이론과 실천 2016 위기관리 이론과 실천 학술대회 Vol.2016 No.08

Wagner 재치환 대퇴스템을 이용한 인공 고관절 재치환술

김이석 ( Yee Suk Kim ),조창민 ( Chang Min Cho ),황규태 ( Kyu Tae Hwang ),김영호 ( Young Ho Kim ),최일용 ( Il Yong Choi ) 대한고관절학회 2010 Hip and Pelvis Vol.22 No.2

Purpose: We evaluated the results of revision total hip arthroplasty using a Wagner revision femoral stem. Materials and Methods: We enrolled 54 patients who underwent hip arthroplasty using a Wagner revision stem between 1996 and 2004. The mean age at revision surgery was 65.4 years and the mean follow up period was 7.2 years. There were 42 aseptic loosenings and 12 periprosthetic fractures. The pre-operative femoral defects were classified according to the Paprosky classification system. Clinical and radiological results were evaluated. Results: The mean Harris hip score improved from 43 preoperatively to 89 at the latest follow up. There were 2 cases with inguinal pain and 1 with thigh pain; in each case pain was reduced by medications. All cases showed endosteal bone formation around the stem. Five cases showed radiolucency in Gruen zones 1 and 7. Six cases had hips that showed subsidence (average=3.1 mm). There was 1 dislocation (1.8%) and 1 intraoperative periprosthetic fracture (1.8%). There were no re-revisions. Conclusion: Use of a Wagner revision femoral stem for revision total hip arthroplasty elicits satisfactory results including stable fixation of the stem, a low rate of subsidence, and a low rate of dislocation.

A DNA-sensing–independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-κB–mediated innate immunity against DNA virus infection

Ng, Yee ,Ching,Chung, Woo-Chang,Kang, Hye-Ri,Cho, Hye-Jeong,Park, Eun-Byeol,Kang, Suk-Jo,Song, Moon ,Jung Oxford University Press 2018 Nucleic acids research Vol.46 No.17

<P><B>Abstract</B></P><P>DExD/H-box helicase 9 (DHX9), or RNA helicase A (RHA), is an abundant multifunctional nuclear protein. Although it was previously reported to act as a cytosolic DNA sensor in plasmacytoid dendritic cells (pDCs), the role and molecular mechanisms of action of DHX9 in cells that are not pDCs during DNA virus infection are not clear. Here, a macrophage-specific knockout and a fibroblast-specific knockdown of DHX9 impaired antiviral innate immunity against DNA viruses, leading to increased virus replication. DHX9 enhanced NF-κB–mediated transactivation in the nucleus, which required its ATPase-dependent helicase (ATPase/helicase) domain, but not the cytosolic DNA-sensing domain. In addition, DNA virus infection did not induce cytoplasmic translocation of nuclear DHX9 in macrophages and fibroblasts. Nuclear DHX9 was associated with a multiprotein complex including both NF-κB p65 and RNA polymerase II (RNAPII) in chromatin containing NF-κB–binding sites. DHX9 was essential for the recruitment of RNAPII rather than NF-κB p65, to the corresponding promoters; this function also required its ATPase/helicase activity. Taken together, our results show a critical role of nuclear DHX9 (as a transcription coactivator) in the stimulation of NF-κB–mediated innate immunity against DNA virus infection, independently of DHX9’s DNA-sensing function.</P>