In vitro Mammalian Chromosomal Aberration Test of Fullerene-C60

Soo Jin Kim(김수진),Kyung Taek Rim(임경택),Hae Won Cho(조해원),Jeong Hee Han(한정희),Hyeon Yeong Kim(김현영),Jeong Sun Yang(양정선) 환경독성보건학회 2009 환경독성보건학회지 Vol.24 No.1

Fullerene의 유전독성을 평가하기 위하여 Chinese hamster유래의 난소유아세포(CHO-K1 cell)를 이용하여 직접법(-S9)과 대사활성화법(+S9 mix)의 염색체이상시험을 실시하였다. 시험물질은 1% CMC 나트륨염의 현탁액(l% CMC 용액)에 희석하여 조제하였다. 대사활성화를 시키지 않은 직접법의 염색체이상시험에서 24시간 투여군은 8단계의 농도(0.078, 0.156, 0.313, 0.625, 1.25, 2.5, 5, 10mM)로 투여하여 실시하였다. 투여 농도 증가에 따른 염색체이상의 빈도가 증가하는 양상이 나타나지 않았다. 48시간의 투여군에서는 8단계의 농도(0.078, 0.156, 0.313, 0.625, 1.25, 2.5, 5, 10mM)로 투여하여 실시하였는데 투여 농도 증가에 따른 염색체이상의 빈도가 증가하는 양상이 나타나지 않았다. 배수체의 염색체이상은 직접법에서 관찰되지 않았다. 대사활성화법을 이용하여 6시간 시험물질을 투여한 시험에 있어서는 8단계의 용량단계 (0.078, 0.156, 0.313, 0.625, 1.25, 2.5, 5, 10mM)를 설정하였는데 투여 농도가 증가함에 따른 염색체이상빈도의 증가양상이 관찰되지 않았다. 이상의 결과를 종합할 때 본 시험물질은 본 시험 조건하에서 CHO-K1세포에서 대사활성화를 시켰을 때 염색체 이상을 유발하지 않는 것으로 판단된다.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

素問·骨空論에 對한 硏究

曺基烈,鄭憲瑩,琴坰樹,朴炅 대한한의진단학회 1998 大韓韓醫診斷學會誌 Vol.2 No.2

The text of the Go1 Gong Ron (骨空論) of the So Moon (素問) was written in the Kap UI Kyung (甲乙經) volume 2 chapter 2 and volume 8 chapter 1. Also it was written in the Tae So (太素) volume 10, 11 and 26. In the Shin Kyo Jung (新校正), they say that it is wriien in the Jeon Won Ki Bon (全元起本) volume 2 and 6. But Wang (王永) interpreted it in volume 16. Also it was introduced in the Ryu Kyung (類經) volume 8, 9, 21 and 22 by Jang Kae Pin (張介賓) in the Myung (明) dynasty. In Go1 Gong (骨空), Gol(骨) means bone and Gong(空) means hole. So Go1 Gong(骨空) means the holes on bone of the human body. A large number of acupuncture points in 12 meridians are located on the holes of bone, and they are playing an important part in the treatment of diseases. In Go1 Gong Ron (骨空論), many points that is choosed when we treat various diseases by acupuncture are mentioned, locations that the holes of bone are distributed in are introduced. So it is called Go1 Gong Ron (骨空論) . This article of the research on the Go1 Gong Ron (骨空論) can be divided into 4 chapters. Summerking the contents of the Go1 Gong Ron (骨空論) in reference to the contents of successive generation note, the contents were as follows. Chapter 1 is about the way to use in treating various diseases what caused by Pung Sa (風??) and deals with the methods of locating acupoints based on a frame. Chapter 2 is written about lines that Conception Vessel (任??), Governer Vessel (????), and Throughfare Vessel (????) pass through, and pathological explanations on the diseases which are belong to those three meridians. The name of each part of the leg and the treatment corresponded to each phase of diseases of the leg are also mentioned in this chapter. Chapter 3 is concretely written about the name and position of the hole on bone of the human body. Chapter 4 deals with moxibustion therapy which we use to treat having an attack of indigestion, being bitten by dog, and feeling cold and heat in turn. Because the ancient men used acupuncture as main treatment of disease, they thought much of acupoint. A large number of acupoints are located on the holes of bone, and are playing an important part in the treatment of diseases. Therefore well understanding of Gol Gong Ron (骨空論) is very important. It is too difficult to understand the Gol Gong Ron (骨空論), because it is written in old Chinese. Consequence of above reason, the writer of this article has researched to find out the exact meaning of that.

Serum TSH Level in Healthy Koreans and the Association of TSH with Serum Lipid Concentration and Metabolic Syndrome

( Yeo Kyung Lee ),( Jo Eun Kim ),( Hyun Ju Oh ),( Kyung Sun Park ),( Soo Kyung Kim ),( Seok Won Park ),( Moon Jong Kim ),( Yong Wook Cho1 ) 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.4

Background/Aims: The proper treatment of subclinical hypothyroidism and the normal range of serum thyroid stimulating hormone (TSH) concentration are intensely debated. However, few reports have investigated TSH concentrations in Asian ethnic groups. Therefore, the present study was designed to define the TSH reference range in a Korean population and to investigate the metabolic significance of TSH concentration. Methods: We enrolled patients who underwent medical examination at the CHA Bundang Medical Center. Anthropometric data were evaluated, and serum TSH, free T4, and lipid profiles were assayed. Results: A total of 7,270 subjects were included. Mean TSH concentration of the study population was 1.82 ± 0.95 mU/L, and we observed a sex-related difference in TSH concentration (male, 1.67 ± 0.87 mU/L; female, 2.02 ± 1.01 mU/L; p < 0.01). When the 2.5 and 97.5 percentiles were calculated, 95% TSH reference limits were 0.52-4.29 mU/L. TSH concentration was higher in elderly subjects, during winter, in postmenopausal women, and in obese males. Moreover, TSH showed significantly positive correlations with serum total cholesterol, triglyceride, and low density lipoprotein cholesterol regardless of sex, age, season, obesity, or menopausal status (all p < 0.01). Finally, TSH concentration was positively related to the prevalence of metabolic syndrome. Conclusions: We demonstrated the association between TSH concentration within the normal reference range and serum lipid levels. TSH concentration varies according to sex, age, season, and body mass index (only in males). Moreover, high normal TSH levels were significantly associated with an increased prevalence of metabolic syndrome, which may be of importance when evaluating subjects with high normal TSH concentration.

용접공들의 면역능에 관한 연구

이수일,조봉수,김영욱,고광욱,조원근,김영실,강수용,황인경,조병만,김돈균 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.1

The authors examined human immunity indicators such as CD4, CD8, Natural Killer(NK) cell, IgG, IgA, and IgM, and heavy metals such as Pb, Cr, Cd to evaluate the health hazard of welders. We selected total 126 male subjects, 60 welders who had more than 5 year working history as an exposure group, and 66 office workers and medical college students as a control group. This immunity evaluation approach is the first newly designed study that has never been tried in past studies on welder's heath evaluation. And the results were as follows. 1. Total lymphocyte count of peripheral blood was significantly higher in welder group, 2,615±650 ea/㎕ compared with 2,368±681 ea/㎕ in control group(p>0.05). 2. The proportion of CD4, CD8, NK cell in welder group was 37.5±9.4%, 24.0±8.8%, and 21.0±9.5%, respectively, and 35.5±6.5%, 25.0±6.9%, and 19.6±8.8% in control group. CD4 and NK cell were slightly higher, and CD8 was slightly lower in welder group. but there was no statistical significance between two groups(p≥0.05). 3. IgG, IgA, and IgM in welder group were 15.9㎎/㎗, 2.7㎎/㎗ and 1.5㎎/㎗, respectively, and 15.6㎎/㎗, 2.9㎎/㎗ and 1.7㎎/㎗ in control group. There was no statistical significance between two groups(p≥0.05). 4. Blood lead, cadmium and chromium concentrations were 4.2±1.8㎍/㎗, 0.4±0.38㎍/㎗, 1.2±0.6㎍/㎗ in welder group and 3.2±1.7㎍/㎗, 0.44±0.29㎍/㎗, 1.1±0.6㎍/㎗ in control group, respectively, and these value were within normal ranges.

과실이 크고 품질이 우수한 조생종 배 ‘금촌조생’ 육성

조광식(Kwang-Sik Cho1),손동수(Dong-Soo Son),강삼석(Sam-Seok Kang),김명수(Myung-Su Kim),홍경희(Kyung-Hui Hong),윤석규(Seok-Kyu Yun),조강희(Gang-Hui Cho),조현모(Hyeon-Mo Cho) 한국원예학회 2004 원예과학기술지 Vol.22 No.1

‘금촌조생’ 품종은 농촌진흥청 원예연구소 나주배연구소에서 1971년 ‘금촌추’의 품질을 개선하기 위해 당도가 높고 육질이 유연한 ‘단배’를 교배하여 1982년 1차 선발되었고, 1997년부터 5년 간 지역적응시험을 거쳐 2001년 최종 선발 및 품종보호출원 되었다. 수세는 비교적 강하고, 수자는 반개장성이다. 꽃가루가 풍부하며, 주요 재배품종과 교배친화성을 보인다. 또한 흑반병에 대하여 강한 포장저항성을 나타내었다. 숙기는 재배중인 ‘원황’ 품종보다 약 5일 정도 늦은 9월 3일로 추석에 출하하기 알맞은 품종이다. 과형은 ‘금촌추’와 같은 도원추형이고, 과피색은 황갈색이다. 과중은 593g이고, 당도는 13.2Bx이다. 육질은 유연하며 과즙이 풍부하고, 석세포가 없어 식미가 매우 우수하다. 그러나 과육선숙형 품종으로 원예적 수확기에도 과피에 녹색이 남지만, 완숙과가 되면 황갈색으로 착색된다. 상온저장 기간은 20일 정도로 다른 조생종에 비해 저장력은 좋은 편이다. ‘Geumchonjosaeng’ pear cultivar (Pyrus pyrifolia var. culta Nakai) originated from the cross between ‘Imamuraaki’ and ‘Danbae’ to improve the fruit quality of ‘Imamuraaki’ cultivar in 1971 at Naju Pear Research Institute of National Horticultural Research Institute (NHRI), Rural Development Administration (RDA). It was preliminarily selected in 1982 and named in 2001. The tree habit shows vigorous growth and upright spreading. It carries abundant pollen grains and shows cross compatibility with leading cultivars. Also it shows high resistance to black leaf spot (Alternaria kikuchiana) in the field condition. Optimum harvest time is around Sep. 3, which is 5 days later than that of ‘Wonwhang’, and it could satisfy consumer’s demand for high quality pear fruit in “Chuseok”. The obovate fruit shape resembles maternal parent, ‘Imamuraaki’ and skin color is green yellowish brown at normal harvesting time and gradually turned to yellowish brown at full ripennig state. Fruit weighs about 593 g, and the soluble solid content is 13.5 ˚Bx. The flesh is very soft and juicy and, rendering good eating quality. Shelf life is about 20 days under the ambient temperature, and it is a relatively long period as compare with other early season cultivars.

작문매체와 학습자의 메타인지가 작문의 질과 길이 및 작문태도에 미치는 영향

조경은,김회수,염시창 한국교육정보미디어학회 1999 교육정보미디어연구 Vol.5 No.2

본 연구의 목적은 작문에서의 컴퓨터(워드프로세서) 사용이 최근 작문에서 중요하게 논의되고 있는 학습자의 메타인지와 함께 작문의 결과에 미치는 영향을 알아보는 것이었다. 이를 위해 광주에 있는 U중학교 3학년 남학생 80명을 대상으로 메타인지 수준별(상·하)과 워드집단과 지필집단으로 무선 배정한 후 수업시간에 작문을 하도록 하고 작문 결과와 작문 태도 검사를 통해 작문의 길이와 질, 그리고 작문에 대한 태도 및 그 상호작용 효과를 실험하였다. 실험 결과 워드를 사용한 집단과 메타인지 상위 집단의 작문의 길이와 질은 더 좋았으나, 작문의 태도나 작문 매체와 메타인지 수준에 따른 작문의 길이와 질, 태도의 상호작용 효과는 의의 있는 차이가 없었다. 이에 작문 매체와 메타인지 수준은 작문의 길이와 질에 영향을 준다는 것과, 작문의 태도 및 매체와 메타인지 수준의 상호작용 효과는 다양한 실험 설계와 충분한 시간, 워드프로세서를 이용한 작문 기회의 확대 등과 더불어 다시 논의되어져야 할 것임을 알 수 있었다. The purpose of this study was to examine the effects of media and metacognition and their interactive effects on writing quantity, quality, and students' attitudes toward writing. The subjects of this experiment were selected 80 male students from third grades at U middle school in Kwangju city. The research design was 2x2 factorial design with four groups by levels of metacognition and writing medm. On the basis of metacognition test scores, the subjects were divided into two groupshgh vs. low), and these groups were randomly assigned to ane of word-processor writing group and hand-writing group, forming four groups in total. After pretest of writing attitudes, each group were given 45 minutes writing time and took the posttest of writing attitudes after a week. ANOVA and ANCOVA were employed to analyze the data and the significance level, alpha was set at a .05 level. The results were as follows: First, the word-processing group was superior to the hand writing group in writing quantity and quality. second, the high-metacognition group was superior to the low metacognition group in writing quantity and quality. But, writing media and metacognition didn't have a significant effects on student' s attitudes. third, there was no interaction effects between the writing media and the levels of prior metacognition on writing quantity, quality and students' attitudes. Last, in the word-processing group, high metacognition subjects received higher scores than low metacognition subjects. The findmgs from this study indicated that writing media and metacognition had significant effects on writing quantity and quality, and that we must rethink

무우자갈버섯 (Hebeloma crustuliniforme) 배양 균사체로부터 분리한 단백다당체 분획 HCA의 항암 및 백혈구감소증 억제효과

조경주,정경수 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

A protein-polysaccharide fraction was isolated from the mycelial culture of a Korean basidiomycetous fungus, Hebeloma crustuliniforme, and was named HCA(Hebeloma crustuliniforme fraction A). When intraperitoneally injected at 200mg/kg/day once daily for 10 days, HCA inhibited the growth of sarcoma 180 solid tumor in ICR mice by 65.1%(p<0.05). HCA also exerted protective effect against leukopenia induced by cyclophosphamide with the protection ratio of 39.7%(p<0.01).

한글과 한자를 이용한 스트룹 과제에서의 간섭 효과

조증열,유경순,김길님,이수란 慶南大學校 人文科學硏究所 1998 人文論叢 Vol.11 No.-

발달지체 영아 조기개입의 시행 현황과 어려움 및 지원요구 : 5개 기관 유형 특수교사 면담을 중심으로

조윤경,김수진,송영희 이화여자대학교 특수교육연구소 2017 특수교육 Vol.16 No.1

Purpose: The purpose of this study was to investigate the present implementation status, difficulties and support needs of early intervention for developmental delayed infants and toddlers by special educators' individual interviewing. Method: A total of five special educators who were working at five different types of early intervention institutions were interviewed. The results of the interviews were recorded for transcription and analysed using a consensual qualitative analysis method. Results: The results of the analysis revealed 12 themes and 55 sub-themes under three categories. Special educators replied that the diagnosis period was getting earlier, the number of developmental delayed infants and toddlers were increasing, and the contents and strategies of early intervention varied by types of facilities. The difficulties of functional assessment, IFSP implementation practices, family-centered approach, parents’ emotional problem and lack of parenting-role recognition, education opportunities of interventionist, multidisciplinary collaboration etc. were reported. Conclusion: This study suggested five desirable directions in establishing the implication frame of early intervention for special educators. 연구목적 : 본 연구는 발달지체 영아 조기개입 주요 제공자인 특수교사와의 면담을 통해 발달지체 영아 조기개입 시행 관련 현황과 어려움 및 지원요구를 찾아내고 이에 대한 해결방안을 모색하고자 하였다. 연구방법 : 발달지체 영아 조기개입 제공기관을 5개 유형으로 분류하고, 각 기관마다 특수교사 1명을 연구참여자로 선정하여 총 5명의 특수교사와 개별면담을 실시하였고, 면담 내용은 질적 분석을 통해 3개의 범주 하에 총 12개의 주제와 55개 하위주제가 도출되었다. 연구결과 : 면담 내용 분석 결과, 첫째, 특수교사는 조기개입 대상 영아의 진단시기가 빨라지고, 그 수가 증가하고 있으며 조기개입의 내용과 방법은 각 기관유형별로 조금씩 다르게 진행되고 있다고 응답하였다. 특수교사는 가족기능 진단의 어려움, IFSP 실행지침의 부재, 가족중심 접근의 부족, 팀협력 체계 부족, 부모의 심리적 불안, 부모역할인식의 부족, IFSP 실행을 위한 전문지식과 사전교육의 부족, 제공인력의 부족, 다영역 전문가와의 협력의 부족 등을 조기개입에서의 주요 어려움으로 보고하였다. 셋째, 조기개입을 위해 부모심리정서지원, 가정 내 양육기술지원, 제공기관 확대, 제공자의 부모 지원 역량 강화, 현직연수, 조기개입 실행지침 제공, 다영역 전문가 배치, 가족중심 강화 등을 요구하였다. 결론 : 이러한 결과를 토대로 특수교사가 발달지체 영아 조기개입의 효과적 수행하기 위해 시급히 실현되어야 하는 주요 다섯 가지 주제를 중심으로 논의하였다.