Cytokine Production by Whole Blood Cells: Relationship to InterleukinGene Polymorphism and Bone Mass

김정구,구승엽,Kyung Sil Lim,지병철,서창석,김석현,최영민,문신용 대한의학회 2005 Journal of Korean medical science Vol.20 No.6

The aims of this study were to investigate the relationships between the production of interleukin-1 (IL-1), and IL-6 system by whole blood cells, and bone mineral den-sity (BMD), and polymorphisms in IL-1 system and IL-6 gene in postmenopausal Korean women. The production of IL-1 , IL-1 , IL-1 receptor antagonist (IL-1ra), IL-6, and soluble IL-6 receptor (sIL-6r) by lipopolysaccharide-stimulated whole blood cells was measured by ELISA in 110 subjects. Serum osteocalcin, C-telopeptide of type I collagen, and BMD at lumbar spine and proximal femur were measured. IL-1 C -889 T polymorphism, IL-1 C -511 T polymorphism, 86-base pair variable num-ber tandem repeat polymorphism in the IL-1ra gene, and IL-6 C -634 G polymorphism were analyzed. The production of IL-1 correlated positively with BMD at femoral neck, whereas the production of other ILs did not correlate with BMD at the skele-tal sites examined. No significant differences in the production of ILs were observed among normal, osteopenic and osteoporotic postmenopausal women, and among the different IL system polymorphisms groups studied. No correlation between bone turnover markers and the production of ILs was noted. In conclusion IL-1 may regulate bone metabolism at femoral neck, and the IL system polymorphism do not affect the production of ILs by whole blood cells.

대학생의 노인복지에 대한 인식도

차병준,김무룡,김기열,차경미,김귀희,김현실,서인선,임상규,이순자,위광복,남철현 慶山大學校 保健福祉硏究所 1999 保健福祉硏究 Vol.2 No.-

The purpose of this study is to grasp the change of consciousness of young people in order to seek new approach of policy for aged era. 1,200 students attending collages and universities in three small or medium sized cities were inquired for 2 months, from October 1 to November 30, 1996. The result is as follows. 1. The characteristic of the respondents of this survey is that they include 72.1% of women, 40.4% of people aged between 20 to 21, and 49.1% of people who do not have any religion. Those who are from big cities and those who are form farming villages or fishing village occupy equally 40.2%, those who reside in that cities for a long period 49.0%, and those who live with their family 60.9%. 2. The family feature of the subject is that 31.5% of them are those whose father is the age of 55 and more than 55, 10% of them are those whose mothers age is so, 33.1% of them have 5 family members, 29.5% of them have the family income of 1,000,000 to 1,490,000 won, 83.9% of them are from middle class, 47.7% of them are the people whose grand parents have passed away, 70.4% of them live apart from their grand parents, and 60.9% of them are second child. 3. 64.0% of males, 70% of respondents who are aged over 24, 58.1% of respondents who are from rural communities, 62.4% of respondents who live in rural area, and 58.3% of respondents who live alone, prefer to live with grand parents, marked higher rate than other groups. The groups whose father and mother are the age of more than 55 marked higher rate of 55.9% and 58% each than any other groups(p<0.05). The groups whose family member is less than three, whose grand parents both have passed away in middle class, who live with their grand parents, and who are second children, give more positive answers than any other groups. 4. Those who are older, who are buddhists, who are from rural area or live in rural area, whose family is small, whose family income is small, who are from lower class and whose grand parents are still alive, shows preference to support their parents after marriage. 5. Females(89.4%), those who are from small or medium sized cities(89%), who live with their family(85.6%), whose father is the age of 55 and more than 55, whose mother is the age of 54 and less than 54, whose family member is 6, who are from middle class, whose grandparents are still alive and who are the eldest child in their family, give more response that they prefer to live apart from their children in their old age than any other groups. 6. What elderly people need most right now is past time(42.3%), and the respondents whose age is 20 to 21, who are buddhists, who are from middle sized cities and live alone, whose parents are the age of more than 55, who have small family income, who live with their grand parents and who are second children show higher level than any other groups. 7. 76.8% of respondents answer that they do not need their parent's fortune, marked still higher rate than the opposite answer. Those who are older, who are buddhists, who are from big cities, who reside in rural area, who live alone and have smaller family, who are in bad family economic conditions and who live with grand parents present higher rate of positive response. 8. 59.3% of respondents reply that they think about death from time to time, and those who are female, who are in the age of 20 to 21, who are christian, who live with their family, whose siblings or other family members offer their education expenses show higher rate than any other groups. 9. 92.3% of respondents answer that the budget for welfare facility for elderly people is very small. The younger the respondents are and the worse economic condition they have among those who live in big cities, the more answered that. 10. 50% of respondents think social security should provide for their old age, and 42.8% of them believe they themselves provide against it. The respondence that social security ought provide for it appeared more among those whose age are over 24, who are female, who reside in rural area, who are christian, who are in bad economic condition, and who ever used medical institutions in recent one month, marked higher level than other groups. 11. The adequate time of retirement is 59.97±5.60 for public officers, the highest and 59.28±6.35 for teachers, the next. 12. 35.2% of respondents reply that the adequate budget for the old age after their retirement at the age of 60 is 220 million won, showed the highest level of respondence. 13. The factors which affect on the old people in the charged welfare facilities are sex(p<0.01), the type of housing(p<0.05) and whole family income(p<0.05). 14. The factors which affect on remarriage are sex(p<0.05) and religion(p<0.05). For varying old population and expanded welfare service for them, government and relevant authority should give more attention to secure the budget, establish effective plans to expand various program and the facilities for elderly people in order that elderly people spend the rest of life time more happily and more fruitfully. To do that, each college and university should open Health courses, and educate and inform about health and welfare.

In vitro maturation: Clinical applications

Lim, Kyung Sil,Chae, Soo Jin,Choo, Chang Woo,Ku, Yeon Hee,Lee, Hye Jun,Hur, Chang Young,Lim, Jin Ho,Lee, Won Don The Korean Society for Reproductive Medicine 2013 Clinical and Experimental Reproductive Medicine Vol.40 No.4

Oocyte in vitro maturation (IVM) is an assisted reproductive technology in which oocytes are retrieved from the antral follicles of unstimulated or minimally stimulated ovaries. IVM of human oocytes has emerged as a promising procedure. This new technology has advantages over controlled ovarian stimulation such as reduction of costs, simplicity, and elimination of ovarian hyperstimulation syndrome. By elimination or reduction of gonadotropin stimulation, IVM offers eligible infertile couples a safe and convenient form of treatment, and IVM outcomes are currently comparable in safety and efficacy to those of conventional in vitro fertilization. IVM has been applied mainly in patients with polycystic ovary syndrome or ultrasound-only polycystic ovaries, but with time, the indications for IVM have expanded to other uncommon situations such as fertility preservation, as well as to normal responders. In this review, the current clinical experiences with IVM will be described.

Risk Assessment of Volatile Organic Compounds Benzene, Toluene, Ethylbenzene, and Xylene (BTEX) in Consumer Products

Lim, Seong Kwang,Shin, Han Seung,Yoon, Kyung Sil,Kwack, Seung Jun,Um, Yoon Mi,Hyeon, Ji Hyeon,Kwak, Hyo Min,Kim, Ji Yun,Kim, Tae Young,Kim, Yeon Joo,Roh, Tae Hyun,Lim, Duck Soo,Shin, Min Kyung,Choi, S Taylor Francis 2014 Journal of toxicology and environmental health. Pa Vol.77 No.22

자궁근종조직 및 정상자궁근조직에서 에스트로겐 수용체 알파 , 베타 및 인슐린 유사 성장인자 결합단백질 관계 펩티드 - 1 전령리보핵산의 발현 양상

임경실(Kyung Sil Lim),김정구(Jung Gu Kim) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.3

N/A Objective: To evaluate a possible involvement of estrogen receptor (ER)α ,E R β and insulin-like growth factor binding protein related peptide-1 (IGFBPrp-1)in the growth of leiomyoma. Met hods :The relative expressions of ERα, Rβ and IGFBrp-1 mRNA were analyzed by reverse transcription-polymerase chain reaction in total RNA extracted from the paired specimens of leiomyoma and adjacent myometrium from untreated patients (n=25)and from leiomyoma specimens from patients (n=10) pretreated with gonadotropin releasing hormone agonist (GnRHa)-pretreated for 3 months. Results: There were no significant differences in ER α ,E R β mRNA expression and ERα/ERβ mRNA ratio between adjacent myometrium and leiomyoma, ut IGFBPrp-1 mRNA expression was significantly lower in leiomyoma than in adjacent myometrium from untreated patients. No differences in ERα, ERβ mRNA expressions and its ratio between leiomyoma from GnRHa-pretreated patients and leiomyoma from untreated patients. Leiomyoma from GnRHa-pretreated patients had IGFBPrp-1 mRNA expresion similar to adjacent myometrium from untreated patients and higher than large myoma (more than 150㎤ in volume) from untreated patients. No correlations among ERα, ERβ mRNA expression, its ratio and IGFBPrp-1 Conclusions: IGFBPrp-1 may be involved in the growth of uterine leiomyoma but ER may not.

한국인 인슐린 의존형 당뇨병환자에서 HLA DQA1 및 DQB1 유전자형의 분석

임승길,이대실,김현만,허갑범,이현철,이은직,김경래,김미림,정윤석,김덕희,김용성,박석원 대한당뇨병학회 1994 Diabetes and Metabolism Journal Vol.18 No.2

韓國人 內耳의 側頭骨錐體內에 있어서의 形態 및 位置關係에 關한 立體透視模型制作의 試圖

경순표,김애경,김영순,이영재,이은주,임선미,장경이,조정실,최용애,최재화,홍성운 이화여자대학교 의과대학 1969 梨花醫學誌 Vol.- No.2

The reconstruction of the stereoscopic visualization model of the inner ear labyrinth from three temporal pyramids of the Korean newborns has been done using stratified transparent sheath films. 1. The transparent sheath film is highly profitable for a stereoscopic visualization material as a histological reconstruction. 2. The plane surrounded by each of the semicircular canals is on a degree of twisted surface. 3. The plane surrounded by the superior semicircular canals rest on a slope instead of a vertical plane toward the cerebral surface of the pyramid. 4. The plan surrounded by the posterior semicircular canal is not parallel with the cerebellar surface of the pyramid. The distance between the anterior portion of the plane is broader than that for the posterior portion of it. 5. The plane surrounded by the lateral semicircular canal projects as nearly a vertical manner to the planes surrounded by the rest of the semicircular canals. The plane face to posteriorly, superiorly, and medially. 6. The plane surrounded by the basal turn of the cochlea bisects the angle formed by the plane of the posterior and lateral semicircular canals. 7. The largest diameter is obserbable on the plane surrounded by the superior semicircular canal, and is followed by the posterior and lateral, successively. 8. The variability of the posteriorly opened angle between both the right and left pyramidal crests, and that of the degree of slopes formed on the cerebral and cerebellar surfaces of the pyramids depends strictly upon the shape of the head.

Rapid identification and preparative isolation of antioxidant components in licorice

Sil Lee, Yeon,Ha Kim, Seon,Kyu Kim, Jin,Shin, Hyun-Kyung,Kang, Young-Hee,Yoon Park, Jung Han,Lim, Soon Sung WILEY-VCH Verlag 2010 Journal of Separation Science Vol.33 No.4

<P>This study employed the online HPLC-2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonate radical cation (ABTS<SUP>+</SUP><SUP>·</SUP>) bioassay to rapidly determine antioxidant compounds occurring in the licorice extract of Glycyrrhiza uralensis. The negative peaks of the ABTS<SUP>+·</SUP> radical scavenging detection system, which indicated the presence of antioxidant activity, were monitored by measuring the decrease in absorbance at 734 nm. The ABTS<SUP>+</SUP>-based antioxidant activity profile showed that three peaks exhibited antioxidant activity, and then the high-speed counter-current chromatography technique of preparative scale was successfully applied to separate the three peaks I-III in one step from the licorice extract. The high-speed counter-current chromatography was performed using a two-phase solvent system composed of n-hexane–ethyl acetate–methanol–water (6.5:5.5:6:4, v/v). Yields of the three peaks, dehydroglyasperin C (I, 95.1% purity), dehydroglyasperin D (II, 96.2% purity), and isoangustone A (III, 99.5% purity), obtained were 10.33, 10.43, and 6.7% respectively. Chemical structures of the purified dehydroglyasperin C (I), dehydroglyasperin D (II), and isoangustone A (III) were identified by ESI-MS and <SUP>1</SUP>H- and <SUP>13</SUP>C-NMR analysis.</P>

Instant noodle consumption is associated with cardiometabolic risk factors among college students in Seoul

In Sil Huh,Hyesook Kim,Hee Kyung Jo,Chun Soo Lim,Jong Seung Kim,Soo Jin Kim,Oran Kwon,Bumjo Oh,Namsoo Chang 대한지역사회영양학회 2017 Nutrition Research and Practice Vol.11 No.3

BACKGROUND/OBJECTIVES: Increased consumption of instant noodles has recently been reported to be positively associated with obesity and cardiometabolic syndrome in South Korea, which has the highest per capita instant noodle consumption worldwide. This study aimed to investigate the association between instant noodle consumption and cardiometabolic risk factors among college students in Seoul. SUBJECTS/METHODS: The study subjects consisted of 3,397 college students (1,782 male; 1,615 female) aged 18-29 years who participated in a health checkup. Information on instant noodle consumption was obtained from the participants’ answers to a question about their average frequency of instant noodle intake over the 1 year period prior to the survey. RESULTS: Statistical analysis using a general linear model that adjusted for age, body mass index, gender, family income, health-related behaviors, and other dietary factors important for cardiometabolic risk, showed a positive association between the frequency of instant noodle consumption and plasma triglyceride levels, diastolic blood pressure, and fasting blood glucose levels in all subjects. Compared to the group with the lowest frequency of instant noodle intake (≤ 1/month), the odds ratio for hypertriglyceridemia in the group with an intake of ≥ 3/week was 2.639 [95% confidence interval (CI), 1.393-5.000] for all subjects, while it was 2.149 (95% CI, 1.045-4.419) and 5.992 (95% CI, 1.859-21.824) for male and female students, respectively. In female students, diastolic blood pressure was also higher among more frequent consumers of instant noodles. CONCLUSIONS: Our results suggest that frequent consumption of instant noodles may be associated with increased cardiometabolic risk factors among apparently healthy college students aged 18-29 years.

[Erratum] Instant noodle consumption is associated with cardiometabolic risk factors among college students in Seoul

In Sil Huh,Hyesook Kim,Hee-Kyung Joh,Chun Soo Lim,Jong Seung Kim,Soo Jin Kim,Oran Kwon,Bumjo Oh,Namsoo Chang 한국영양학회 2018 Nutrition Research and Practice Vol.12 No.2