Case Report : Six-week Diet Correction for Body Weight Reduction and Its Subsequent Changes of Gut Microbiota: A Case Report

( Bumjo Oh ),( Jong Seung Kim ),( Meera Kweon ),( Bong Soo Kim ),( In Sil Huh ) 한국임상영양학회 2016 Clinical Nutrition Research Vol.5 No.2

Impact of intestinal microbes on obesity and health is a new topic recently started to get attention. Comparing to the global concern and research trends, there are few research on the association between intestinal bacteria and life style disease in Korean. One voluntary case (female) was reported to show the change in gut microbiota and weight by diet intervention. She was overweight (BMI 23.2 kg/㎡) and has abnormal liver function, and the causes of overweight were frequent drinking and meat consumption at the late evening hours. For 47 days, she was administered an improved diet on breakfast and dinner with reduction of meat consumption frequency by 50%. Alcohol consumption was reduced to once a week. As a result, she lost 3 kilograms of body weight. Her fecal sample was collected before and after the intervention, and gut microbiota change was compared using a high-throughput sequencing technique. After diet correction, the shift of gut microbiota was clearly observed with decreased proportion of Firmicutes (from 75.7% to 47.3% in total microbiota) but increased proportion of Bacteroidetes upto 47.7%. After incorporating the diet intervention, it is meaningful to confirm the changes in dominant gut microbiota and weight loss.

Prediction of Suicidal Ideation among Korean Adults Using Machine Learning: A Cross-Sectional Study

Bumjo Oh,Je-Yeon Yun,Eun Chong Yeo,Dong-Hoi Kim,Jin Kim,Bum-Joo Cho 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.4

Objective Suicidal ideation (SI) precedes actual suicidal event. Thus, it is important for the prevention of suicide to screen the individuals with SI. This study aimed to identify the factors associated with SI and to build prediction models in Korean adults using machine learning methods. Methods The 2010–2013 dataset of the Korea National Health and Nutritional Examination Survey was used as the training dataset (n=16,437), and the subset collected in 2015 was used as the testing dataset (n=3,788). Various machine learning algorithms were applied and compared to the conventional logistic regression (LR)-based model. Results Common risk factors for SI included stress awareness, experience of continuous depressive mood, EQ-5D score, depressive disorder, household income, educational status, alcohol abuse, and unmet medical service needs. The prediction performances of the machine learning models, as measured by the area under receiver-operating curve, ranged from 0.794 to 0.877, some of which were better than that of the conventional LR model (0.867). The Bayesian network, LogitBoost with LR, and ANN models outperformed the conventional LR model. Conclusion A machine learning-based approach could provide better SI prediction performance compared to a conventional LRbased model. These may help primary care physicians to identify patients at risk of SI and will facilitate the early prevention of suicide.

The Relationship between Electronic Cigarette Use with or without Cigarette Smoking and Alcohol Use among Adolescents: Finding from the 11th Korea Youth Risk Behavior Web-based Survey

Kwang Ho Oh,Cheol Min Lee,Bumjo Oh,Seung-Won Oh,Hee-Kyung Joh,Ho Chun Choi,Seung Jae Kim,Sho Rry Lea 대한가정의학회 2019 Korean Journal of Family Medicine Vol.40 No.4

Background: Electronic cigarette (EC) consumption (‘vaping’) is rapidly increasing, not only in adults but also in adolescents. Little is known about the association between vaping and problem behaviors such as drinking.Methods: We used data from the 11th Korea Youth Risk Behavior Web-based Survey, which was conducted in 2015 and included 68,043 participants who were Korean middle and high school students. The survey assessed EC, ciga-rette, and alcohol use. Multiple regression analysis was used to examine risk of current drinking and problem drinking across the following categories of users: never user (never used either product), former user (use of EC or cigarettes in the past, but not currently), vaping only, smoking only, and dual user (current use of both products).Results: EC only users were 1.2% in males, and 0.3% in females. Dual user of both conventional cigarettes and ECs were 5.1% in males, and 1.2% in females. Drinking frequency, drinking quantity per once, and problem drinking were higher among vapers than non-vapers and former-vapers, moreover, were higher among daily vapers than intermit-tent vapers. Compared to never users, EC only users were higher on risk of current drink and problem drink. The dual users were highest on risk of current drink.Conclusion: Vaping is independently associated with alcohol use problems in Korean students, even those not cur-rently smoking. Moreover, dual use of cigarettes and ECs is strongly associated with alcohol use problems. There-fore, vaping students should be concerned about their hidden alcohol use problems.

한국 성인에서 악력과 건강 관련 삶의 질과의 연관성

오윤환 ( Yun Hwan Oh ),문지현 ( Ji Hyun Moon ),공미희 ( Mi Hee Kong ),오범조 ( Bumjo Oh ),김현주 ( Hyeon Ju Kim ) 대한스포츠의학회 2017 대한스포츠의학회지 Vol.35 No.2

We investigated the association between hand grip strength (HGS) and health-related quality of life (HRQOL). A total number of 9,211 participants from the sixth Korean National Health and Nutrition Examination Survey (2014- 2015) were included. HRQOL was measured by EuroQol-5 dimension (EQ-5D) and EQ-5D index score. Participants were classified as normal HRQOL group or impaired HRQOL group according to the EQ-5D responses and the EQ-5D index scores. HGS was measured using Takei dynamometer. Impaired HRQOL group represented lower mean HGS than that of normal HRQOL group. According to the quintile groups of HGS, group with the lowest HGS showed the lowest mean EQ-5D index score in both sexes. And the more HGS increases, the more EQ-5D index score increases also (p-value for trend <0.001). Men and women with lower grip strength were more likely to report `some` or `extreme problem` in EQ-5D domains (except anxiety/depression and pain/discomfort domain in men), and also more likely to belong to the lowest 20% level group in EQ-5D index score according to logistic analyses. Our findings suggest that HGS is associated HRQOL. Low HGS is associated with impaired status of HRQOL by EQ-5D and EQ-5D index score in Korean men and women. More research is needed to evaluate the specific plausibility between HGS and HRQOL.

Microbiota of Breast Tissue and Its Potential Association with Regional Recurrence of Breast Cancer in Korean Women

( Hyo-eun Kim ),( Jongjin Kim ),( Sejung Maeng ),( Bumjo Oh ),( Ki-tae Hwang ),( Bong-soo Kim ) 한국미생물 · 생명공학회 2021 Journal of microbiology and biotechnology Vol.31 No.12

Recent studies have reported dysbiosis of the microbiome in breast tissue collected from patients with breast cancer and the association between the microbiota and disease progression. However, the role of the microbiota in breast tissue remains unclear, possibly due to the complexity of breast cancer and various factors, including racial and geographical differences, influencing microbiota in breast tissue. Here, to determine the potential role of microbiota in breast tumor tissue, we analyzed 141 tissue samples based on three different tissue types (tumor, adjacent normal, and lymph node tissues) from the same patients with breast cancer in Korea. The microbiota was not simply distinguishable based on tissue types. However, the microbiota could be divided into two cluster types, even within the same tissue type, and the clinicopathologic factors were differently correlated in the two cluster types. Risk of regional recurrence was also significantly different between the microbiota cluster types (p = 0.014). In predicted function analysis, the pentose and glucuronate interconversions were significantly different between the cluster types (q < 0.001), and Enterococcus was the main genus contributing to these differences (q < 0.01). Results showed that the microbiota of breast tissue could interact with the host and influence the risk of regional recurrence. Although further studies would be recommended to validate our results, this study could expand our understanding on the breast tissue microbiota, and the results might be applied to develop novel prediction methods and treatments for patients with breast cancer.

체중조절을 위한 3주간 계단 오르기의 효과

최주헌 ( Juheon Choi ),강경모 ( Kyungmo Kang ),김종성 ( Jong Seung Kim ),오범조 ( Bumjo Oh ) 대한스포츠의학회 2016 대한스포츠의학회지 Vol.34 No.2

This study is designed to check whether everyday-life stair climbing, which is a low-cost and readily accessible form of exercise, is effective for reducing overweight of sedentary people in various health indicators. We selected four overweight people and measured body weight, body fat percentage, muscle quantity, pulmonary function, lower-extremity strength and volume of thigh muscle and fat. After 3-week exercise of climbing stairs in more than 5 minutes twice a day, same procedures were taken. Body weight was reduced by 3.35 kg on average (standard deviation [SD], 0.79), and body fat mass by 2.53 kg (SD, 1.36). Lower extremity strength improved about 5%, and slight loss of thigh fat (right 3.2%; left 13.4%) was observed. However, pulmonary function and muscle quantity did not grow significantly. Although only four people may not be representative as targets, but it is suggested that stair climbing has sufficient utility as an easily accessible exercise.

Association of Salivary Microbiota with Dental Caries Incidence with Dentine Involvement after 4 Years

( Bong-soo Kim ),( Dong-hun Han ),( Ho Lee ),( Bumjo Oh ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.3

Salivary microbiota alterations can correlate with dental caries development in children, and mechanisms mediating this association need to be studied in further detail. Our study explored salivary microbiota shifts in children and their association with the incidence of dental caries with dentine involvement. Salivary samples were collected from children with caries and their subsequently matched caries-free controls before and after caries development. The microbiota was analyzed by 16S rRNA gene-based high-throughput sequencing. The salivary microbiota was more diverse in caries-free subjects than in those with dental caries with dentine involvement (DC). Although both groups exhibited similar shifts in microbiota composition, an association with caries was found by function prediction. Analysis of potential microbiome functions revealed that Granulicatella, Streptococcus, Bulleidia, and Staphylococcus in the DC group could be associated with the bacterial invasion of epithelial cells, phosphotransferase system, and D-alanine metabolism, whereas Neisseria, Lautropia, and Leptotrichia in caries-free subjects could be associated with bacterial motility protein genes, linoleic acid metabolism, and flavonoid biosynthesis, suggesting that functional differences in the salivary microbiota may be associated with caries formation. These results expand the current understanding of the functional significance of the salivary microbiome in caries development, and may facilitate the identification of novel biomarkers and treatment targets.

Association between sleep duration and musculoskeletal pain : The Korea National Health and Nutrition Examination Survey 2010–2015

Chun, Min Young,Cho, Bum-Joo,Yoo, Sang Ho,Oh, Bumjo,Kang, Ju-Seop,Yeon, Cholog Williams & Wilkins Co 2018 Medicine Vol.97 No.50

<P><B>Abstract</B></P><P>Both extremely long and short sleep durations have been associated with increased risk of numerous health problems. This study examined the association between self-reported sleep duration and reporting of musculoskeletal pain in the adult Korean population.</P><P>This study included data from 17,108 adults aged ≥50 years, obtained from the Korea National Health and Nutrition Examination Survey 2010–2012 and 2013–2015. Self-reported daily hours slept and the presence of musculoskeletal pain in knee joint, hip joint, or low back were examined. Patients were stratified into 5 groups by their sleep duration: ≤5, 6, 7, 8, or ≥9 h. Multivariate logistic regression analysis was performed, adjusting for covariates including age, sex, marital status, smoking, alcohol use, family income level, education, physical exercise, body mass index (BMI), and stress level.</P><P>A U-shaped relationship was observed between the length of sleep duration and the presence of musculoskeletal pain. After adjusting for covariates, sleep duration of ≤5 h or ≥9 h was significantly associated with musculoskeletal pain experienced for more than 30 days over a 3-month period. We also found that the presence of multi-site musculoskeletal pain was significantly higher among those who slept for ≤5 h or ≥9 h than in those who slept for 7 h.</P><P>These findings suggest that either short or long sleep duration is associated with musculoskeletal pain among Korean adults.</P>

Influences of the Liver to Spleen Ratio by The Preoperative Low-dose Computed Tomography on The Prognosis of Breast Cancer

Ki-Tae Hwang,Siwon Jang,Jin Ah Kwon,Myoung Seok Lee,Bumjo Oh,In Sil Choi,Sohee Oh,Jongjin Kim,Jeong Hwan Park,Won Kim 대한외과학회 2021 대한외과학회 학술대회 초록집 Vol.2021 No.11

A randomized, double-blind, placebo-controlled trial investigating cholesterol-lowering effects and safety of yellow yeast rice in adults with mild to moderate hypercholesterolemia : A study protocol

Jeong, Sewon,Lee, Jaekyung,Kwon, Oran,Kim, Ji Won,Oh, Bumjo Wolters Kluwer Health 2018 Medicine Vol.97 No.30

<P><B>Abstract</B></P><P><B>Background:</B></P><P>Elevated levels of blood lipids are well-documented risk factors for cardiovascular disease. For cardiovascular risk reduction, preventive strategies to lower blood cholesterol levels are essential, and these strategies include lifestyle modification and cholesterol-lowering agents. We aim to investigate the cholesterol-lowering effects and safety of yellow yeast rice in a randomized, controlled, double-blind, and parallel group study.</P><P><B>Methods:</B></P><P>Participants for this study will be selected based on the following inclusion criteria:1.<P>Voluntary agreement to participate and sign the written informed consent forms</P>2.<P>Men and women (aged 20–45 years, premenopause)</P>3.<P>Body mass index: 18 to 30 kg/m<SUP>2</SUP></P>4.<P>Fasting low-density lipoprotein cholesterol (LDL-C) levels: ≥130 mg/dL</P>5.<P>Fasting triglyceride levels: <300 mg/dL</P></P><P>Participants are randomly allocated to the placebo or yellow-yeast-rice-treated group. Participants with mild to moderately elevated LDL-C levels will consume 1 pouch of yellow yeast rice powder (containing monacolin K) or placebo twice daily for 8 weeks. Next, the lipid profiles will be evaluated.</P><P><B>Results:</B></P><P>The number of participants required for this study is 68, and is currently recruiting participants. Participants are randomly assigned to control group and intervention group.</P><P><B>Conclusion:</B></P><P>This is the first human intervention study to investigate the cholesterol-lowering effects and safety of yellow yeast rice in adults with mild to moderate hypercholesterolemia. Also, this is a randomized, double-blind, placebo-controlled trial that considers confounders, such as dietary habits, lifestyle factors, and genetic factors.</P>