성인원외폐렴의 원인미생물에대한 전향적 다기관 연구 : 성인원외폐렴의 원인으로 세균의 역할을 중심으로

우준희,강재명,김양수,신완식,류진홍,최정현,김양리,정희진,어수택,박춘식,정문현,정기석,이찬주,류지소 대한감염학회 2001 감염 Vol.33 No.1

Background : Communite-acquired peumonia (CAP) is one of the leading causes of mortality and morbidity. Despite progress in diagnostic techniques and treatments, management of pneumonia remains challenging, because the precise etiology remains uncertain in as many as 49% of cases. The limitaions of identifying etiologic agents make it necessary to use empiric antibiotics in almost all patients, and furthermore emergence of antibiotic-resistant organisms pose difficulties to the selection of an empiric antibiotic regimen. For the optimal choice of empirical antibiotics, we should know the frequency of etiologic agents and antimicrobial resistance rates in the community. Methods : A prospective multicenter study of community-acquired pneumonia in Korea was carried out between May 1997 and April 2000. The microbiologic diagnosis was based on the results of sputum culture, blood culture and pleural culture. Results : Five hundred eighty eight cases of community-acquired peumonia in 562 patients admitted to the hospitals. The mean age was 59.9 with male predominance (58.3%), and 370 (63%) had underlyin gillness. The etiologic agents were identified in 38.3%, and the list of individual agents, in decreasing order, was Streprococcus pneumoniae (21.7%), Klebsiella pneumoniae (14.8%) Pseudomonas aeruginosa (9.8%), Staphylococcus aureus (9.5%), viridans group streptococci (5.7%), Enterobacter cloacae (4.2%), Hemophillus Influenza (3.8%), The rates of admission to the intensive care unit was 10.4%. The motality was 7.1%. Susceptible rates of S. pneumoniae to penicillin was 36.6% and showed multidrug resistant. Forty percents of S. aureus were methicillin-resistant S. aureus. K. penumoniae were susceptible to cephalosporin and quinolone. Conclusion : In Korea, S.pneumoniae is the most important agent causing community-acquired pneumonia. Susceptible rates of S. pneumoniae to penicillin was 36.6% and showed multidrug resistant. Gram negative bacteria such as K. pneumoniae, P. aeruginosa showed high incidence when compared with that of other countries. Most of them had underlying diseases including bronchiectasis and chronic obstructive pulmonary diseases. (Korean J Infect Dis 33:1∼7, 2001)

항공기 날개 스파의 단면적과 위치를 설계변수로 하는 중량 최적화 연구

朴燦宇,盧政武 경상대학교 생산기술연구소 2001 工學硏究院論文集 Vol.1 No.-

In this paper, the optimization is performed to find a more efficient aircraft wing box structure. A less weight aircraft wing box while satisfying required constraints is found by adjusting the wing spar cross-section area and location. Every optimization problem is constituted by an object function, design variables and constraints. In this thesis, stress conditions at each spar are used as constraints. In the case of the spar cross-section area optimization, two cases are handled. First, the spar cross-section area is assumed same at all span and there is one design variable for a spar. Secondly, the spar cross-section area is different by span direction and there are several design variables for a spar. In the case of spar location optimization, end positions of the each spar are selected as design variables. The reasonableness and accuracy of the optimization result is verified by comparing stress distributions and deformations before and after optimization. MSC/NASTRAN is used for the finite element analysis and the optimization.

ISO 9000의 추진동기 및 품질요건 이행이 기업성과에 미치는 영향에 관한 연구 : 국내 전기ㆍ전자 제조업을 중심으로 In Electronic and Electric Manufacturing Industry

이병찬,김승호,김정우 한국의사결정학회 1998 경영과학연구 Vol.7 No.-

The objective of this study is to examine the influence factors for successive performance of ISO 9000. Especially we focus to propelling motives and quality requirements in certifying ISO 9000. The data for empirical test was gathered from the obtaining firms of ISO 9000 quality certification among electronic and electric manufacturing industry. The results of empirical study suggested that there is significant positive impact competitive advantage motive to quality requirement enforcement. And we found that quality management system establishment, employee's perception and behavior change about quality were impacted very strong to competitive advantage motive and quality improvement requirement enforcement. But competition improvement was impacted to customer claim motive very strong. Also we investigated the problems in certification obtaining progress, post-operational management, and the ISO regulation & system. The result appeared very important factors to overloading of worker in certification obtaining progress, less participation of company-wide employee in post-operational management, and much maintaining cost in the ISO regulation & system.

HY-SPLIT 모형을 이용한 오염물질의 장거리 이동 추적

전의찬,우정헌 東新大學校 1996 論文集 Vol.8 No.-

Due to the rapid economic development for the last 20 years, Asian countries' fuel consumption has doubled twice every twelve years. Also, serious environmental problems, especially air pollution, have followed rapid urbanization and development in Northeast Asia, where Korea is located. The pattern of long range transport of air pollutants was investigated in the Northeast Asia region. The focus of this study was the impact of air pollutants from China on the air quality of Korea. From the meteorological data from the 1st to the 5th of January 1995, the backward and forward trajectories were calculated using the Hybrid model 'HY-SPLIT', and the contributions of air pollutants from cities of China to the air quality in Korea were analyzed. It was concluded that the air pollutants from China could have a great influence on the air quality in Korea. The trajectories showed that the air pollutants from Beijing and Jinan, Shandong Province, the most heavily industrialized areas in China, could be influenced strongly to the air quality in Korea.

류마티스 관절염 환자에서 발생한 Mycobacterium intracellulare에 의한 관절염 1예

박근우,권현희,정승혜,김경찬,최정윤,이영환 대한감염학회 2007 감염과 화학요법 Vol.39 No.1

비정형 항산균에 의한 근골격계 감염은 매우 드물며, 진단이 지연되는 경우가 많다. 저자들은 류마티스 관절염환자에서 수차례 스테로이드 주사 후에 생긴 M. intracellulare에 의한 관절염을 진단하고 수술적 치료없이 약물 치료만으로 좋은 결과를 보인 예를 경험하였기에 보고하는 바이다. Nontuberculous mycobacteria are ubiquitous organisms that are frequently present in the water, soil and animal reservoirs. Nontuberculous mycobacterial infections of the musculoskeletal system are rare and usually associated with predisposing factors, such as prior joint disease, trauma, use of intraarticular or oral corticosteroids, or an immunocompromised state. A sixty five-year-old patient with rheumatoid arthritis was hospitalized due to swelling on the left wrist. M. intracellulare was cultured from the aspirated joint fluid. The patient was successfully treated with clarithromycin, ethambutol, and rifampin. We report this case with review, emphasizing high suspicion for nontuberculous mycobacterial infection in patients with predisposing risk factors.

김치유래 젖산균의 균체지방산 분석을 이용한 분류학적 연구

이정숙,정민철,김우식,이근철,김홍중,박찬선,이헌주,주윤정,이근종,안종석,박완,박용하,민태익 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

표준균주를 포함한 230여개의 김치유래 젖산균에 대한 균체지방산(FAMEs)을 분석하였다. FAMEs profiles는 Euclidian Distance 17.5에 의해 7개의 Major Cluster와 1개의 Single Cluster로 나뉘어졌다. 이중 A, B, C 및 Cluster는 Leuconostoc속으로 분석되어졌고, F는 Lactobacillus속으로 분석되어졌다. 그리고 E와 G cluster는 두개의 Genus가 혼재되어 나타났으며 보충적인 연구가 필요하다. 앞으로 김치유래 젖산균의 균체지방산 분석결과를 기반으로 한 데이타베이스에 95가지 탄소원을 이용하는 수치분류학적 접근방법 및 Pyrolysis Mass Spectrometry 등의 화학적 분석 방법과 분자친화적 연구를 통한 종합적 분류정보 체계가 갖추어지면 젖산균의 신속, 정확한 동정 및 연구에 활발히 이용되어질 것이다. Two hundreds and thirty lactic acid bacteria, mostly isolated from Kimchi, including type strains were sued for analysis of cellular fatty acids. The 230 test strains were recoverd in 7 major and 1 single clusters defined a Euclidian distance of 17.5. These aggregate taxa were equivalent to the genus Leuconostoc (aggregate group A, B, C and D), and the genera Leuconostoc and Lactobacillus (aggregate group G). It is concluded as evident that FAMEs (Fatty Acid Methyl Esters) profile of cell can be used as a criterion in classification of lactic acid bacterial from kimchi. Additional comparative taxonomic studies need to be carried out on well chosen representative strains to determine the most appropriate methods of value.

自動車保險서비스 滿足의 要因에 관한 硏究

閔晶湜,禹勝瓚 東新大學校 1997 論文集 Vol.9 No.-

Among the marketing strategies of the Korean insurances this study will be based on customer satisfaction at the non-life insurance. For the hypotheses of automobile insurance service 1) H_l : The dimension of additive service is positive factor of the customer satisfaction. The result of the test that H_l is rejected at α=0.05. 2) H_2 : The dimension of salesman(life-planner & agent) service is positive factor of the customer satisfaction. The result of the test that H_2 is accepted at α=0.05. 3) H_3 : The dimension of insurance product service is positive factor of the customer satisfaction. The result of the test that H_3 is accepted at α=0.05.

한민족 화합을 위한 남북체육교류 활성화 방안에 관한 연구

이정흔,우찬명,김홍설 忠南大學校體育科學硏究所 1995 體育科學硏究誌 Vol.13 No.1

The purpose of this research is to propose an approach to creating an atmosphere in which peace and reunification on the Korean peninsula can be achieved through north-south sport exchanges and cooperation. This proposal is intended to show how cooperative north-south sports exchanges will foster an atmosphere conductive to peaceful unification by recovering the homogeneity of the Korean people. The main characteristics of this study are as follows: First, future north-south sports exchanges should not be managed by government agencies, but will require the formation of specialized civilian organization which can carry out the necessary operations. Second, advancement of the north-south sport exchanges will require the establishment of a "North-South Sport Information Reference Center". Third, a north-south cultural facility which would include a unified sport center(including an athlete's village)must be established. Fourth, north-south sports exchanges and cooperation will require the establishment of systematic provisions for the financial support required to advance this endeavor. Fifth, in order to activate the commercial support needed for these exchanges, recognition of the importance of the endeavor will be called for from all sports minded people.

폐결핵 환자 혈청에서 수용성 Interleukin 2 수용체 및 Adenosine Deaminase 활성도에 관한 연구

고정희,박성규,백상현,박찬권,박병수,안진영,최우석,박정규 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

Interleukin-2 (IL-2) induces T cell proliferation in an autocrine manner and provides a means by which antigen triggered T cells can be clonally expanded in vitro. During the following activation, the activity of IL-2 is mediated by specific high affinity IL-2 binding membrane receptors which are expressed shortly after activation. In this process, a 42 KD-fragment (soluble IL-2R) is continuously cleaved off and circulates as a soluble marker of T lymphocyte activation. Elevated level of soluble IL-2R has been identified in the serum of patients with malignant autoimmune and allergic disorders, systemic parasitic infection, undergoing graft versus host disease, acute or chronic lymphocytic leukemia and HIV-infection. ADA (adenosine deaminase) completes the process of differentiation of T cell and is essential for progression of T cell maturation. Therefore level of ADA is to correlated with magnitude of T cell immune response. The fact that expression of sIL-2R and ADA activity increases in peripheral blood T-lymphocytes of patients with active pulmonary tuberculosis suggests that T cell activation might have a major role in the pathogenesis of pulmonary tuberculosis. In order to evaluate the T cell immune response in pulmonary tuberculosis, we measured the serum concentration of sIL-2R and ADA activity in 17 patients with current pulmonary tuberculosis, 10 chronic inactive pulmonary tuberculosis, 10 as normal controls. (1) Current pulmonary tuberculosis had significantly higher levels of sIL-2R (237.24±95.47)when compared with those of inactive tuberculosis (78.6±11.06). and the control (68.17±15.4) group. (2) ADA activity in current pulmonary tuberculosis was significantly increased (34.41±20.63) when compared with those of inactive tuberculosis (24.7±14.36) and control (17.65± 5.94) group. (3) There was good correlation between sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group. (4) sIL-2R concentration and ADA activity was decreased significantly 6 months after anti-tuberculosis drug medication. In conclusion, sIL-2R concentration and ADA activity in serum in current pulmonary tuberculosis group was increased when compared with those of inactive pulmonary tuberculosis and the control group. By the way, T cell mediated immune response was enhanced in current pulmonary tuberculosis, but in inactive chronic pulmonary tuberculosis who had treated by antituberculosis drug medication, the concentration of sIL-2R and ADA activity was nearly normal.

파일럿 플랜트에 의한 음식물 찌꺼기 처리

최성우,류정숙,박정호,임찬섭,박승조 동아대학교 환경문제연구소 1998 硏究報告 Vol.21 No.1

In this study, using the extinctive composting apparatus, it took a day for the degradation of waste food with high temperature and aerobic condition. It was confirmed by the change of organic ratio, condensed water, and weight. Final production included rare organic ratio so that it was easy to degrade microorganism but it was not enough pH and salt for using compost. During reaction, condensed water was produced about 20 ℓ/day, the eighty percent of waste food was degraded by compositing reaction on the basis of weight, therefore, this means that it is go effective on the volume reduction.