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어수택,박춘식,백승호,나현,최득린,김기정 대한핵의학회 1985 핵의학 분자영상 Vol.19 No.2
To evaluate the clinical significance of lung ventilation scan using (99m)^Tc-DTPA in patient with bronchiectasis, we cornpared the involovement area of bronchogram and lung ventilation scan according to lobar and segmental distribution. There were no correlation between impairment of pulmonary function test and the number of branchiectatic lobe and segment(p$gt;O. 5). Lung ventilation scan showed 66.7% of sensivity, 100% of specificity, and 91.7g of accuracy according to lobar distribution, and 51.9 of sensivity, 96.9% of specificity, and 88.9% of accuracy according to segmental distribution. These results suggest that lung ventilation scan can be used as diagnostic tool in patient with bronchiectasis in whom broncbogram is not tolerable.
어수택,김양기,이영목 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
A bronchial carcinoid tumor is identified in the patients with cough and normal chest PA or during routine examination of chest PA. Sometimes it is very difficult to diagnose the bronchial carcinoid tumor with normal chest PA, especially if the patient complains the typical symptoms of bronchial asthma. We experienced a 30 year-old female, who had been suffered from coughing and dyspnea in spite of asthma medications for 1 year, with bronchial carcinoid tumor. We describe here a case of bronchial carcinoid tumor mimicking refractory bronchial asthma.
어수택 대한내과학회 2013 대한내과학회지 Vol.84 No.4
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal fibrotic lung disease in many patients. In spite of extensive research for many decades, the exact pathogenesis of IPF is unknown. At recent, the role of alveolar epithelial cells has been focused in the initiation of IPF in terms of epithelial-mesenchymal transition, dysregulated Wnt signaling, and activation of transforming growth factor-β (TGF-β). The resulting excess collagen deposition and destruction of lung architecture by myofibroblasts and fibroblastic foci leads to the development of IPF. IPF can be diagnosed by typical high resolution chest tomogram (HRCT) or by multidisciplinary discussion based on the new guideline published on 2010. 현재까지도 IPF의 발생 원인은 알려져 있지 않지만, 여러연구의 발달로 병인을 밝히는 데 많은 발전이 있었다. 특히후생학 연구의 발달로 IPF의 병인을 DNA부터 전사 후(post-transcription)의 변화까지 알 수 있게 되었다. 하지만 섬유화에 가장 중요한 TGF-β 활성화만으로는 IPF의 병인을 모두 설명할 수 없으며, 섬유화에 이르게 하는 여러 세포와 단백질이 상호 활성화시키면서 섬유화가 계속 진행하는 것으로 보이며, 이에 대한 연구가 진행되어야 할 것이다. 병인과 달리 진단은 많은 발전이 있었다. 특히 최근에 발표된 지침을 통하여 폐 조직 검사 없이도 진단할 수 있는 근거를 마련하였으며, IPF의 진단을 위하여 관계하는 과간의상의를 통하여 진단할 수 있게 되었다.