서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

종설(綜說) : 한의학 학술지에 발표된 탈모에 관한 연구현황 분석

김광중 ( Kwang Joong Kim ),백승엽 ( Seung Yeob Baek ),임채광 ( Chae Kwang Im ) 대구한의대학교 제한동의학술원 2012 東西醫學 Vol.37 No.4

We performed a systemic analysis of the research situations on hair and alopecia published in the journal of oriental medicine to understand the search trend in the area of hair and alopecia, prepare the basis for the interests and basis on hair and alopecia in the oriental medicine area and above that, to support for the applications in the clinics through this and came to the following conclusions. 1. There are total 95 publications in the domestic journals of oriental medicine area from 1986 to 2011. 2. Total 95 articles were published in 23 journals. “Dong-eui journal of physiology and pathology” had the largest number of articles which was 22(23%) followed by “Oriental journal of ophthalmology, otolaryngology, and dermatology” of 19(20%). 3. The authors who published the largest number of articles as the first author were “Cheon-jong Kim”, “Hyeon-taek Shin”, and “Tae-hu Lee” who published 3 each, and the correspondent author who published the largest number of articles was “Chang-hyeon Lee” who published 8 articles. 4. For the contents and methodologies of the study, there were 16 literature reviews, 36 clinical trials, and 43 animal and other experimental studies and 3 literature reviews were published in 2002, 6 animal and other experimental studies were published in 2006, and 6 clinical trials were published in 2004, 2006, 2009, and 2010 each the most. Based on this study, we hope not only scientific treatises but also these for the oriental medicines and alopecia study related to the oriental medicines to be continued.

複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

자궁경부암에서 p53과 human papillomavirus의 분포에 관한 연구

김영식,김대중,김의한,강상균,양승하 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

Uterine cervical carcinoma is the most common malignant tumor of woman in Korea. Cervical lesions are associated with various subtypes of human papillomavirus(HPV), and recently there is many reports for interrelationship between p53 gene and HPV in development of cervical carcinoma. HPV is associated with condyloma acuminatum, flat condyloma, cervical intraepithelial neoplasm(CIN), and invasive carcinoma in uterine cervix. Among the subtypes of HPV, type 6b and 11 are reported as low risk group and type 16 and 18 are high risk group. p53 is an one of oncogene which control the cellular proliferation. The loss of p53 function by mutation and complex binding with HPV E6 could act an important role in developmental mechanism of cervical carcinoma. To observe the relationship between expression of p53 and HPV in CIN and invasive carcinoma, we analysed CIN 26 cases and invasive squamous cell carcinoma(SCC) 62 cases processed for immunohistochemical stain using monoclonal mouse anti-p53 and polyclonal anti-bovine papillomavirus. Then positivity of p53 and HPV was compared. The results are as followings: 1) The p53 in CIN showed positive reaction in twelve cases(46.2%) of twenty-six cases. Positive rates of CIN Ⅰ, CIN Ⅱ, and CIN Ⅲ are 33.3%, 42.9%, and 50% respectively. 2) The p53 in invasive squamous cell carcinoma showed positive reaction forty-four cases(71.0%) of sixty-two cases. Positive rates of microinvasive and invasive SCC are 53.8% and 75.5%, respectively. According to cell type, keratinizing type were eighteen cases(81.2%) of twenty-two cases and nonkeratinizing type were ninteen(70.4%) of twenty-seven cases. 3) Papillomavirus revealed low expression rate in CIN(26.9%) and invasive SCC (16.1%). 4) The p53 showed positive reaction in fourteen(82.4%) of papillomavirus-positive seventeen cases. Above results revealed higher positive rate of p53 according to progression of CIN and SCC, and in keratinizing type than in nonkeratinizing type of SCC. Positive rate of papillomavirus was very low, but high positive rate in p53 positive cases which suggest that p53 and HPV corelate in development of cervical carcinoma.

긴 관동맥병변에서 긴 스텐트삽입에 대한 임상경과 및 재협착율

김영학,박성욱,정상식,박훈기,이상곤,이일수,이철환,김재중,홍명기,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6

U343 교종 세포주에서 GFAP와 Fascin과의 상호작용

김동석,박승우,김태곤,이규성,최중언 The Korean Neurosurgical Society 2004 Journal of Korean neurosurgical society Vol.35 No.5

김치용 간절임 배추의 저장에 관한 연구 : Ⅱ. 젖산, Calcium Chloride, 저장온도가 저장중 간절임 배추의 품질에 미치는 영향

김윤숙,김중만,백승화,문정옥,황호선,김인숙 圓光大學校 1987 論文集 Vol.21 No.2

배추를 다듬기 하는데 발생한 폐기량은 7.5∼14% (w/w)이었고 10±2℃에서 30일간 방치한 경우 약 17∼25% 발생하였다. 간절임 배추의 pH값은 저장온도가 낮을수록, 염도가 높을수록 높았으나 calcium chloride 첨가가 절임배추의 pH값의 변화에는 영향을 주지 않았다. 유리당의 함량변화는 최소 약 4% 수준에서 산의 함량과는 반비례적으로 변화하여 저장 90일에는 소금농도가 낮고 저장온도가 높은 경우 적게 감소되었다. 균수변화에서 세균과 효모는 전 기간을 통해 증가한 반면, 곰팡이는 감소하였다. 한편 산의 첨가와 CaCl? 첨가시 소금으로만 절인 경우보다 세균과 효모는 낮은 속도로 증가했다. 저장중 경도는 온도가 낮고 염도가 높으며 젖산을 첨가한 경우 다소 높게 유지됐고, CaCl? 첨가의 경우 잎과 줄기에서 월등히 높았다. 휘발산과 불휘발산의 함량변화에서 온도가 낮고 염도가 높은경우 불휘발산의 함량이 낮았는데 특히 젖산 첨가시 불휘발산의 증가를 억제하는 것으로 나타났다. flavor score 는 저온과 고염도 젖산첨가시 유리하였다. This study was to investigate the effects of storage temperature, lactic acid and calcium chloride addition about the pH values, sugar content, firmness, volatile and nonvolatile acidity, microbial counts and flavor of the salted chinese cabbages during storage (90 days), and trim loss of chinese cabbages during the trimming of raw and storaged (30 days) chinese cabbages. The waste rate was in the course of trimming of raw chinese, cabbages was 7.5-14(w/w). The proportion of trim loss was highly correlated to sunshine duration, temperature, humidity and handling for the storage. Free sugar was decreased fast and much in the case of high temperature and low level sodium chloride in comp rison of low temperature and high sodium chloride, but ?? and lactic acid did not affect its changes. Time to reach the lowest pH values were fast in the case of high temperature and low salt content. Lactic acid affected inital pH value (4.38-4.57) and constant pH value in each case was increased at low salt content, at high temperature, and then the pH values were slowly increased when volatile acidity was increased. Firmness was high in the case of addition of lactic acid and calcium chloride, low temperature, high sodium chloride concentration. Especially, calcium chloride addition remarkably showed high firmness. Flavor score was high in the case of low storage temperature, high yeast counts were slowly increased in spite of low temperature and high salt content, but mold counts were slightly increased during all period Lactic acid, low temperature and high sodium chloride were effective to inhibit the growth of microorganisms. Volatile and nonvolatile acidity was increased during all storage period ; however, lactic acid and low temperature storage inhibited their increase. To conclude, quality of salted chinese cabbages was effective at low temperature storage, lactic acid and calcium chloride addition, and high salt concentration.

찻물에서의 Cd과 Pb 이온 제거에 관한 차입자의 효과

김중만,백승화,박성수 한국식품영양학회 1998 韓國食品營養學會誌 Vol.11 No.5

차재료를 찻물에 담근 후 차건데기를 건저내고 마시는 차류의 중금속 제거력을 조사하기 위하여 Cd과 Pb 용액에서 보리차, 옥수수차, 쟈스민차, 현미녹차, 홍차, 결명자차, 감껍질차, 귤껍질차, 누룽지의 입자별, 농도별, 온도별 제거 정도를 조사한 결과는 다음과 같다. 입자의 크기가 작아질수록 모든 차에 있어서 중금속 제거력은 증가되었고, 금속별 제거량은 Cd는 결명자차(3.253∼6.136㎎/g)가, Pb은 쟈스민차(6.784∼7.557㎎/g)가 높았다. 농도별 중금속 제거량은 중금속의 농도가 증가할수록 증가하였는데 Cd와 Pb는 쟈스민차(1.209∼4.815㎎/g, 0.642∼7.004㎎/g)가 제거력이 높았다. 농도별 중금속의 제거작용은 모든 차류에서 증가되었으나 옥수수차는 Pb에서 0.497∼0.647㎎/g로 제일 낮았다. 온도별 중금속 제거량은 온도가 높아질수록 증가하여 Cd은 결명자차가 4.080∼7.799㎎/g, Pb는 쟈스민차가 7.003∼7.763㎎/g으로 증가하는 경향을 보였다. Removabilities of heavy metals(Cd and Pb) by the tea materials (barley-tea, corn-tea, jasmin-tea, brown rice-green tea, cassia tora-tea, persimmon peel-tea, orange peel-tea and rice-tea) in the tea-water were studied in the various conditions ; particle size of tea(20, 40, 70 mesh), concentration of heavy metal(25, 50, 100 ppm) and extraction temperature(20, 30, 50, 100℃). The removabilities by the tea solids were increased as the particle size decreased, concentration of heavy metal increased, and extracting temperature increased. Of the nine kinds of tea, Cd and Pb removability by jasmin-tea was highest. In addition, heavy metal removability by cassia tora tea was better than that of other tea as extraction temperature was increased.

Ba-Ferrite를 이용한 자기 연마재 개발

김희남,송승기,정윤중,윤여권,김희원,조상원,심재환 한국안전학회 2003 한국안전학회지 Vol.18 No.2

The magnetic polishing is the useful method to finish some machinery fabrications by using magnetic power. This method is one of the precision techniques and has an aim for clean technology in the transportation of the pure gas in the clean pipes. The magnetic abrasive polishing method is not so common in the field of machine that it is not known to widely. There are rarely researcher in this field because of non-effectiveness of magnetic abrasive. Therefore, in this paper we deals with the development of the magnetic abrasive with the use of Ba-Ferrite. In this development, abrasive grain WA has been made by using the resin bond fabricated at low temperature. And magnetic abrasive powder was fabricated from the Ba-Ferrite which was crushed into 200 mesh. The XRD analysis result shows that only WA abrasive and Ba-Ferrite crystal peaks were detected, explaining that resin bond was not any more to contribute chemical reaction. From SEM analysis, we found that WA abrasive and Ba-Ferrite were strongly bonding with each other.

성공적인 경피적 승모판 교련절개술 후 임상 경과와 재협착율

김영학,강덕현,송재관,최기준,이철환,홍명기,김재중,박성욱,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.2