Staphylococcus lugdunensis에 의한 감염성 심내막염 1예

최성호,박현구,변승운,구동회,강호석,장항제,김양수,우준희,김영휘,최상호 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

Staphylococcus lugdunensis is a coagulase-negative staphylococcus (CNS) that is commonly found on the human perineal skin. Contrary to other CNS, S. lugdunensis is a rare contaminant in cultures and has the potential to cause clinically significant infections, including infective endocarditis. Infective endocarditis due to S. lugdunensis have been known to resemble endocarditis due to S. aureus because of its aggressive clinical course and high mortality. We report a case of infective endocarditis caused by S. lugdunensis in a 21-year-old woman. She was cured of the infection with surgical and antibiotic therapy. S. lugdunensis에 의한 감염성 심내막염은 국내에서보고가 없었던 매우 드물지만 다양한 합병증과 높은 사망률을 보이는 감염증이다. 저자들은 S. lugdunensis가 수술적 치료와 항생제 치료로 완치된 감염성 심내막염 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

우리나라 지역 직업성질환 감시체계의 현황과 전망

임종한,장성실,김성아,문재동,채창호,홍윤철,김수영,김진석,김영욱,한상환,이혜숙,원종욱,송동빈,하은희,강성규 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

기존의 특수건강진단과 작업환경측정을 통한 직업병 관리가 진폐증, 소음성난청 등의 소수 특정질환에 국한되고 실제 직업병 발생 규모 파악이나 신종 직업병의 발견에 한계를 보인다는 사실은 산업의학전문가들 사이에서도 공감을 이루고 있다. 미국과 영국 등에서의 직업성질환 감시체계에 대한 경험은 우리 나라의 직업성질환 감시체계 구축에도 새로운 자극제가 되면서, 1998년이후 인천, 대전, 여천, 구미, 부울경 지역에서 지역 직업성질환감시체계를 산업보건관리의 중요한 시스템으로 구축하려는 노력이 확산되고 있다. 새로이 구축되어지는 이들 지역 직업성질환 감시체계는 감시하고자 하는 대상질환, 활용 가능한 인적자원 및 자료원, 지역 의료체계의 특수성 등에 따라서 목적과 방법을 달리하면서 독특한 형태로 발전을 하고 있다. 각 지역단위 감시체계들이 그 상황에 맞게 독특한 목적과 전략들을 발전 시키면서도, 향후 발전할 국가적인 차원의 직업성질환 감시체계 구축을 위하여 직업성질환 감시의 기본 전략 등을 공유하는 등의 노력이 필요하다. 환례 정의 및 기본적인 등록 서식의 공유, 직업성질환 감시 자료원의 발굴, 공동의 정보 네트워크 및 직업성질환 감시 데이터베이스 구축 등 직업성질환 감시활동을 지원하기 위한 여러 기초 인프라 구축에 힘을 모아야 할 것이다. 우리 나라에서 직업성질환 감시체계를 성공적으로 구축하기 위해서는 수집된 자료의 질 관리를 위한 직업성질환 감시의 원칙 제정과 감시 전략의 공유 등이 필요하며, 전국적인 직업성질환 감시체계의 하부구조라고 할 수 있는 지역감시체계의 기초 토대 마련과 강화작업이 절실하게 필요하다.

생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구

민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.

생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

Molecular Cloning of a cDNA Encoding Putative Calreticulin from the Silkworm, Bombyx mori

( Seong Ryul Kim ),( Kwang Sik Lee ),( Ik Soo Kim ),( Seok Woo Kang ),( Si Kab Nho ),( Hung Dae Sohn ),( Byung Rae Jin ) 한국잠사학회 2003 International Journal of Industrial Entomology Vol.6 No.1

Identification of DNA markers linked to resistance genes to rice blast ( Pyricularia grisea Sacc. )

Soo Jin Kwon,Sang Nag Ahn,Ha Cheol Hong,Young Chan Cho,Jung Pil Suh,Yeon Kyu Kim,Kyung Ho Kang,Seong Sook Han,Hae Chune Choi,Huhn Pal Moon,Hung Goo Hwang 한국육종학회 2002 한국육종학회지 Vol.34 No.2

Resistance genes to the blast pathogen (Pyricularia grisea Sacc.) were mapped using a recombinant inbred population consisting of 231 lines derived from a cross between the japonica parents, ‘Suwon365’ and Chucheongbyeo. Phenotypic analysis showed that Su

Review on the Methodology for Evaluating the Radioactivity in the High Integrity Container Packages of Dried Spent Resin and Concentrate Radwaste

Hang-Rae Cho,Seong-Jin Maeng,Ji-Soo Yoon,Kyung-Rok Park,Jung-Kwon Son 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2

To safely dispose of highly radioactive spent resin and concentrate waste generated through nuclear power plant operations, it is essential to meet the physicochemical properties requirements of the packages and ensure the accuracy and reliability of radiological characteristics determination. Both spent resin and concentrate are packaged in high-integrity containers (HICs) after drying and are homogeneous waste products generated in the primary system and liquid radioactive waste treatment system. Meeting the physicochemical properties requirements does not appear to be difficult. However, to achieve reliable radiological characterization of high-integrity container packages, it is necessary to take a representative sample and perform accurate radiological analysis. Therefore, this paper discusses the methodology for evaluating the radionuclide inventory of high radioactive resin and concentrate packages, as well as the essential element technology and considerations. For relatively high radioactive resin and concentrate packages, the radionuclide inventory for each package should be evaluated with high reliability through direct radiological analysis of the representative samples collected for each package. This can contribute to the efficient operation of radioactive waste disposal facilities. Radionuclide-specific concentrations directly analyzed for each package will be managed in a database. As analytical data accumulates and direct measurements of high-integrity container package such as the radwaste drum assay system (RAS) become feasible, statistical techniques such as correlation analysis between easy-tomeasure (ETM) nuclides and difficult-to-measure (DTM) nuclides can lead to the development of efficient and reasonable indirect evaluation methods, such as scaling factor and the mean activity concentration method. As for the element technology, a remote representative sampling technique should be developed to safely and effectively take representative samples of highly radioactive materials, including granulated or hardened concentrate waste. Considerations should also be given to determining the sample quantity representing each package, as well as establishing radiation calibration and measurement methods appropriate to the radiation levels of the representative samples.

cDNA Sequence of a Novel Immulectin Homologue from the Silkworm, Bombyx mori

( Seong Ryul Kim ),( Kwang Sik Lee ),( Ik Soo Kim ),( Seok Woo Kang ),( Si Kab Nho ),( Hung Dae Sohn ),( Byung Rae Jin ) 한국잠사학회 2003 International Journal of Industrial Entomology Vol.6 No.1

대장전이로 발견한 원발 폐암 1예

안성은 ( Seong Eun Ahn ),이항락 ( Hang Lak Lee ),이오영 ( Oh Young Lee ),윤병철 ( Byung Chul Yoon ),최호순 ( Ho Soon Choi ),함준수 ( Joon Soo Hahm ),박세우 ( Se Woo Park ),박혜선 ( Hye Sun Park ) 대한소화기학회 2009 대한소화기학회지 Vol.53 No.2

Primary lung cancer is a leading cause of cancer-related deaths in Korea. Approximately 50% of patients have metastatic disease at the time of presentation. The preferential sites of extrapulmonary spread include lymph nodes, liver, brain, adrenal glands, and bones. Gastrointestinal metastasis from primary lung cancer is extremely rare and only a few case reports have been published. Herein, we report a case of metastatic colon cancer from primary lung adenocarcinoma, presenting multiple cecal polypoid masses. (Korean J Gastroenterol 2009;53:121-125)

부산광역시 사상공단지역의 지하수 및 토양 위해성 평가

전항탁 ( Hang Tak Jeon ),함세영 ( Se Yeong Hamm ),정재열 ( Jae Yeol Cheong ),류상민 ( Sang Min Ryu ),장성 ( Seong Jang ),이정환 ( Jeong Hwan Lee ),이수형 ( Soo Hyung Lee ) 대한지질공학회 2009 지질공학 Vol.19 No.3

본 연구는 지하수, 토양, 대기의 노출경로에 따라서 부산광역시 사상공단의 지하수와 토양이 인체와 환경에 미치는 영향을 평가하였다. 토양과 대기의 노출경로에 따른 발암 위해는 나타나지 않았으나, 지하수에서는 TCE와 PCE의 발암 위해성이 각각의 기준 한계값인 1.0E-6과 1.0E-5에 대해서 각각 6.7E-6과 1.0E-5로 나타나 발암 위해가 있는 것으로 판단되었다. 대기에서는 비발암성 위해가 나타나지 않았다. 토양의 위해계수와 위해지수는 각각 3.4E-5와 5E-5로서 기준 한계값(1.0) 보다 낮게 나타났으나, 지하수의 위해계수와 위해지수는 각각 0.7 (위해성이 없음)과 1.4(위해성이 있음)로 나타났다. TCE의 최소성분감소비(CRF)는 2.5로서 TCE의 정화작업이 요구된다. 18개의 노출인자에 대한 민감도 분석 결과, 8개의 노출 인자(비 발암 물질에 대한 평균 수명, 발암 물질에 대한 평균 수명, 체중, 노출기간, 노출빈도, 피부노출빈도, 토양 섭취율, 물 섭취율)의 변화에 따라서 위해도가 변화하는 것으로 나타났다. The risk assessment of groundwater and soil in Sasang industrial complex in Busan Metropolitan City was carried out in order to estimate risks to human health and the environment. The carcinogenic risk (CR) of receptors to soil and air was not identified. However, the CRs for TCE and PCE were 6.7E-6 and 1.0E-5, respectively. Hazard quotient (HQ) and hazard index (HI) did not appear through air exposure pathways. Yet the HQ and HI of soil were 3.4E-5 and 5E-5, respectively, and lower than the critical value (1.0). On the contrary, HQ and HI with respect to groundwater were calculated as 0.7 (not hazardous) and 1.4 (hazardous). The constituent reduction factor (CRF) for TCE in the study area was determined as 2.5, and thus remediation work is demanded. As a result of sensitivity analysis for 18 exposure factors, eight exposure factors (life time of carcinogens, age, body weight, exposure duration, exposure frequency, dermal exposure frequency, water ingestion rate, and soil ingestion rate) varied with the variation of risk.