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A Case of Metastatic Eccrine Porocarcinoma with a Review of the Literatures
이정환,임주한,김루시아,김철수,이현규,나소연,김성현,정지중,이명동,예재호,이문희,Lee, Jung-Hwan,Lim, Joo-Han,Kim, Lucia,Kim, Chu-Soo,Yi, Hyeon-Gyu,Nah, So-Yun,Kim, Seong-Hyun,Jeong, Ji-Joong,Lee, Myung-Dong,Ye, Jea-Ho,Lee, Moon-Hee The Korean Society for Head and Neck Oncology 2011 대한두경부 종양학회지 Vol.27 No.2
에크린 한공암종은 흔하지 않으며, 전이성 에크린 한공암종은 매우 드문 암이다. 에크린 한공암종은 표피내 한관에서 기원하는 피부 부속기 악성 종양으로, 대부분 에크린 한공암종은 항암치료와 방사선치료에 효과가 없으며, 따라서 유일한 치료방법은 전이되기 전에 국소 및 광범위 절제술을 시행하여야 한다. 본 환자는 두피에 발생한 에크린 한공암종이 점점 진행하여 피부, 림프절, 폐 등으로 전이하였고, 다수의 광범위 절제술에 이어 항암치료와 방사선치료를 받았지만, 결국 폐전이가 악화되어 사망하였다. 본 저자들은 항암치료와 방사선치료에 불응한 에크린 한공암종 1예를 치료에 대한 문헌고찰과 더불어 보고하는 바이다.
Al 7050 단조품 표면의 입도성장층 방지에 관한 연구
이정환,이상용,이영선,Lee, Jeong-Hwan,Lee, Sang-Yong,Lee, Yeong-Seon 한국기계연구원 1996 硏究論文集 Vol.26 No.-
Age hardenable aluminium alloys show high specific strength, good thermal and electrical conductivity as well as lightness, and are typical aircraft materials. High fatigue strength and good resistancy against stress corrosion cracking are also important for aircraft aluminium alloys. Al alloy 7050 has been developed to meet the above mentioned requirements and the use of this alloy as forged aircraft part becomes more important. However, forged 7050 parts showed undersiable structures such as severe local grain coarsening in surface area and unproper metal flow that is degrading mechanical properties. In this paper, microstructural aspects of die forging in the Al alloy 7050 are investigated. Also suggested are the optimal forging conditions for microstructural control of Al alloy 7050.
재발하였거나 수술적 제거가 불가능한 뇌수막종에 대한 Hydroxyurea 치료 - Preliminary Report -
이정환,김오룡,김성호,배장호,최병연,조수호,Lee, Jeong-Hwan,Kim, Oh-Lyong,Kim, Seong-Ho,Bae, Jang-Ho,Choi, Byung-Yon,Cho, Soo-Ho 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1
1988년 1월부터 1997년 12월까지 본 교실에 내원하여 뇌수막종으로 진단받고 수술요법을 실시한 87례 중, 완전제거 후 재발한 경우와 부분적 절제후 방사선 치료를 받은 4례를 대상으로 hydroxyurea를 이용해 치료한 결과를 분석하였다. 남자가 1례, 여자가 3례이었으며 연령 분포는 23세에서 55세였다. 조직학적으로 3례가 meningothelial type이었으며 1례는 angiomatous type이었다. 3례에서 소뇌교각부에 발생하였으며 1례에서 해면정맥동에 발생하였다. 모든 환자들은 수술적 치료를 시행받았으며 3례의 환자에서 방사선 치료를 시행하였다. Hydroxyurea를 20mg/kg/day용량으로 투여하였으며 평균 추적관찰기간은 34개월이었다. 치료기간중 4례에서 종양이 줄어든 예는 없었으나 종양이 성장하지는 않았다. 삼차신경통 증상이 있던 1례는 증상 호전 되었으며 수술적 치료를 3차례 받았던 1례에서 두개골절제부위에 팽창되어 있던 뇌는 축소되어 두개강내로 복귀되었다. 혈액학적 부작용으로 백혈구 수치가 1례에서 감소되었으나 2주정도 복용을 중단한 후 다시 수치는 회복되었고 다른 심각한 부작용은 나타나지 않았다. 저자들은 뇌수막종 환자중, 수술후 재발한 경우와 불완전 제거를 시행한 경우 보조적 치료방법으로 hydroxyurea의 사용하여 종양크기의 감소는 없었으나 성장을 억제할 수 있었으며 앞으로 오랜 기간 추적관찰과 많은 증례에 대한 분석을 함으로써 뇌수막종 치료의 보조 방법으로 hydroxyurea를 이용할 수 있을 것으로 생각된다. Objectives : The present study was performed to analyze results of hydroxyurea treatment for unresectable and recurrent meningiomas as adjuvant chemotherapeutic agent. Material and Methods : Among 87 cases of meningioma patients who treated surgically between Jauary 1988 and December 1997 in our department, unresectable and recurrent cases were 4 cases. Histologically, 3 cases were meningothelial type, 1 case was angiomatous type. Tumor orgin was cerebellopontine angle(CPA) in 3 cases, cavernous sinus in 1 case. Three of 4 cases received radiation treatment. All patients received a daily dosage of 20mg/kg/day of hydroxyurea. Hematological monitorning was performed monthly and tumor measurement was assessed by MR imaging before treatment and every 6 months. Mean follow-up period was 34 months. Rerults : All cases showed no enlargement of tumor mass without any shrinkage. Trigeminal neuralgia in 1 case was improved and external herniation of brain on craniectomy site in 1 case was shrunken. None of the patients had any serious side effects. White blood cell count fell below $3000/{\mu}l$ in 1 case, but recovered 2 weeks later with cessation of medication. Conclusion : Hydroxyurea stopped cell growth by triggering the apoptotic cascade. Our preliminary data indicate that hydroxyurea provides adjuvant medical treatment in patients of unresectable and recurrent meningiomas
이정환,김오룡,김성호,배장호,최병연,조수호,Lee, Jeong-Hwan,Kim, Oh-Lyong,Kim, Seong-Ho,Bae, Jang-Ho,Choi, Byung-Yon,Cho, Soo-Ho 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.2
Objective : The present study was performed to analyze treatment results for 22 cases of arachnoid cyst and to have appropriate surgical method in our department. Material and Methods : We performed a retrospective study in 22 cases in 11 years between 1989 to 2000 that could be followed up. The analysis was based on the results of patients age, sex distribution, developed area, clinical symptom, treatment method, and complication. Results : The age range of cyst development was between 7 months to 60 years with the average age of 21 years. As for sex distribution, 20 were male and 2 were female, with significantly more cyst development in males than females. Thirteen cases were developed in the sylvian fissure, 3 cases in the posterior fossa, 4 cases in the cerebral convexity of the supratentorial area, 1 case in the suprasella and 1 case in interhemiphere. Those cases with the sylvian fissure involvement included 6 cases of Type I, 4 cases of Type II, and 3 cases of Type III. As for the distribution according to hemisphere, more arachnoidal cysts were seen in the right hemisphere. The most common clinical symptom was headache, followed by seizure and speech disturbance. As for the treatment method in 22 cases, surgery was performed in 17 cases and conservative treatment in 5 cases. Fenestration was performed in 14 cases. 13 cases of them showed good outcome, and 1 case with delayed development showed no improvement. Cyst-peritoneal shunt was done in 2 cases. Both fenestration and cyst-peritoneal shunt were done in 1 case. Conclusion : Patients who perforemed fenestration were showed good outcome with few complication. We concluded that fenestration is the most appropriate surgical method for arachnoid cyst.
이정환,조현진,정재열,정해룡,윤정현,Lee, Jeong-Hwan,Cho, Hyun-Jin,Cheong, Jae-Yeol,Jung, Haeryong,Yoon, Jeong Hyoun 한국지하수토양환경학회 2016 지하수토양환경 Vol.21 No.1
Capillary barriers, consisting of relatively fine-over-coarse materials, have been suggested as an alternative to traditional compacted soil covers. So, We were analysed to capillary barrier effect according to five cases of multi-layer cover systems. Water balance simulation was conducted with unsaturated flow model HELP to assess unsaturated hydraulic parameters such as hydraulic conductivity, climate affecting the performance of capillary barriers. Simulation were conducted for 5 Cases in the Ulsan area. Result of simulation indicated that three cases was formed unsaturated condition and capillary barrier effect.