자살에 대한 태도(Ⅰ)

이미형 中央醫學社 1991 中央醫學 Vol.56 No.8

In an attempt to darify some basic factors directly or indirectly related to the problem, this study is primarily designed to investigate general attitude toward various forms of suicide as well as to investigate general opinions regarding the causal factors for the problem of suicide among students, salarymen and housewives group in Seoul and Suwon. The term "Attitude" applied in this study merely means that whether they, as an individual, conditionary approve of the suicidal act or disaprove. The response for the attitude is expected to choose one out of the following for categories; 1) suicide is an absolutely disapprovable act for me, 2) it is dependent on the circumstance they are faced on, (conditional approval), 3) undecided and 4; others. In regard to the opinions concerning causal factors for suicide, Author formulated three basic categories such as 1) factors related to the family situation 2) factors related to the economical matters and 3) factors related to individual problems and each item contained 4-14 subcategories and each on is asked to choose one out of three categories as well as one out of those subcategories in order to see detailed view of their opinions. The subject of this study were 625 persons including undergraduate, salarymen and hous-wives. The collected data were analyzed by frequency, Mean, and Pearson correlation coefficient using SPSS. The results of this study were as follows; 1. In single sucide, men response more "an absoloutely disaprovable act", while women response more "conditional approval act " (P < 0.05). 2. Religious background of entire groups reveal that those non-believers and Buddhists seem rather liberal toward the problems related to sucide where as those Catholics and Protestants are very definitely influenced by the religious doctrines and most of them firmly disapprove of any forms of suicide (P < 0.01). 3. As to the opinions in regard to the causal factors for single sucide and double sucide, it is noted that there some differences in opinions between sex, the women response more "attitude toward individual life", while the men response more "social factor" (P < 0.01) .

DNA chip을 사용한 myeloid cell의 유전자 발현분석

박형선,신길상,이미영 순천향대학교 기초과학연구소 2000 순천향자연과학연구 논문집 Vol.6 No.1

Total RNAs were extracted from promyeloid cell(HL60)and myeloid cell(U937). Reverse-transcriptions of the RNAs were performed by using AMV-reverse transcriptase. The RNAs of promyeloid cell and myeloid cell were labelled with fluorescent dye of Cy5-dUTP and Cy3-dUTP, respectively. The reverse-transcribed and labelled RNA was hybridized to a DNA chip containing 384 human cDNAs. Comparative analyses of the gene expression profiles for promyeloid cell and myeloid cell were monitored by gene pie plot or scatter plot, and the gene expression ratios of promyeloid cell/myeloid cell were determined. The expression ratios for thymosin beta-10 gene, immunophilin homolog ARA9/HBV-X associated protein gene, Bcl-w/KIAA0271 actin beta gene and heat shock protein86 gene were determined to be 31%/69%, 26%/74%, 11%/89%, 51%/49% and 79%/2l%, respectively.

토착형 P. vivax에 의한 Malaria 4례

박형렬,이성원,이경미,김태겸,한진영,손춘희,정원태,김성은,김종성 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.2

적혈구 유무에 따른 벤젠, 스티렌, 트리클로로에틸렌에 의한 림프구 중 자매염색분체 교환 빈도

성재혁,김형아,신민정,최미정,이세훈 가톨릭대학교 산업의학센터 2001 韓國의 産業醫學 Vol.40 No.4

This study was performed to investigate the possible role of oxyhemoglobin in the metabolic activation of benzene, styrene and TCE by observing the difference of the SCE frequency between isolated lymphocyte and whole blood lymphocyte cultures exposed to these chemicals. Isolated lymphocyte and fresh heparinized peripheral whole blood samples from a healthy donor(male, smoker) were cultured in the phytohaemagglutinin stimulated culture media for 72 hours. The cells were treated with 100, 300, 1000, 3000 μM benzene, 250, 500, 100, 2000 μM styrene or TCE respectively. Slides were stained with Giemsa's solution for SCE. SCE was analyzed for each subject from coded slides by one researcher. The results were as follows : 1.The frequency of SCE increased dose-dependently with concentration of benzene in isolated lymphocyte and whole blood lymphocyte cultures, however there were no significance. There was no significant difference of SCE frequency between isolated lymphocyte and whole blood lymphocyte cultures. 2.The frequency of SCE in whole blood exposed to sytrene significantly increased in dose-dependant relationship, but not in isolated lymphocyte. The difference of SCE frequency between isolated lymphocyte and whole blood lymphocyte of 2000μM styrene exposure was marginally significant(P=0.0540). 3.In TCE, the frequency of SCE did not increase at any concentration used in this study of isolated lymphocyte and whole blood lymphocyte. Above results suggested that oxyhemoglobin in erythrocytes play an important role in the metabolic activation of styrene but not in benzene or TCE. Key Words : Benzene, Styrene, Trichloroethylene, Sister chromatid exchange, Metabolic activation, Oxyhemoglobin

중추성 요붕증이 동반된 랑게르한스 세포 조직구증 1예

김진호,문준성,문선중,이지은,최재원,은미정,천경아,조인호,윤지성,원규장,이경희 신덕섭,이형우 영남대학교 의과대학 2005 Yeungnam University Journal of Medicine Vol.22 No.2

Central diabetes insipidus (DI) is a syndrome characterized by thirst, polydipsia and polyuria. Langerhans cell histiocytosis is one of the etiologies of DI. Recently we experienced a central DI associated with Langerhans cell histiocytosis. The 44 years old female patient complained right hip pain polydipsia and polyuria. We carried out water deprivation test. After vasopressin injection, urine osmotic pressure was increased form 109mOsmol/Kg to 327mOsmol/Kg (300%). Brain MRI showed a thickened pituitary stalk and at hot bone CT.CT guided biopsy revealed abnormal histiocytes proliferation and abundant lymphocytes, The final diagnosis was central DI associated with systemic Langerhans cell histiocytosis invading hip bone, L-spine and pituitary stalk. Desmopressin and etoposide chemotherapy were performed to the patient.

전립선 기질세포의 증식과 COX-2 발현에 대한 프로게스테론의 영향

정수련,김성한,최이화,박지은,전은미,강영진,이광윤,최형철 영남대학교 의과대학 2006 Yeungnam University Journal of Medicine Vol.23 No.1

전립선비대증은 노인 남성에서 흔히 유발되는 질환이며, 노화가 진행될 수록 빈도가 높아지는 특징을 가진다. 이 질환의 원인은 전립선기질세표의 과도한 증식으로 유발된다고 알려져 있지만 그 자세한 기전에 대해서는 잘 알려져 있지 않다. 전립선비대증에서 progesterone 수용체 양성 세포가 다른 전립선 종양에 비해서 많고, progesterone은 testosterone에서 DHT로 전환되는 것을 감소시키는 역할을 가진다고 알려졋다. 또한 남성 전립선 평활근의 과증식에 의한 질환이므로 평활근 세포의 증식과 관련성이 있다고 보고된 COX-2의 전립선비대증에 대한 영향에 대한 연구가 필요하다. 전립선 기질세포에 progesterone을 3일간 투여하여 배양한 경우 기질세포 증식은 차이가 없었다. Progesterone을 단독 또는 DHT와 같이 투여한 기질세포에서 남성호르몬 수용체 mRNA 발현은 비처리군과 비교하여 유의한 차이가 없었다. 또한 progesterone과 DHT 동시 투여에 의한 COX-2 mRNA 발현에도 차이가 없었다. 그러나 progesterone에 의한 남성 호르몬 수용체와 COX-2 단백 발현에서는 대조군과 비교하여 유의하게 감소시켰다. 이상의 결과는 progesterone은 남성호르몬 수용체에 대해 전사 후 반응 (post-transcriptional response)에 효과를 나타내어 남성호르몬 수용체 발현을 감소시키는 작용은 가지며, COX-2 발현 억제효과를 나타내므로 전립선비대증의 치료에 이용될 수 있을 것으로 사료된다. Background: Benign prostatic hyperplasia (BPH) is the most common benign tumor in older men; the etiology of this disease remains poorly understood. Testosterone and dihydrotestosterone (DHT) both act as androgen via a single androgen receptor. Testosterone is converted to DHT by 5α-reductase in prostatic stromal cells. Progesterone has been reported to inhibit DHT conversion; howevwe, its effect on prostatic stromal cells remains to be elucidated. Materials and Methods: In this experiment, we investigated the effect of progesterone on androgen receptor expression induced by DHT. We also tested the effect of progesterone on cyclooxygenase-2 (COX-2) expression, as well as prostate stromal cell proliferation using the cell count kit-8. Results: Progesterone did not cause an increase of prostate stromal cell proliferation. The mRNA expression of the androgen receptor and COX-2 were not changed by progesterone; the expressions of androgen receptor and COX-2 proteins were decreased by progesterone in prostate stromal cells. Conclusion: These results suggest that in prostate stromal cells, progesterone decreases androgen receptor protein expression, which results in decrement of COX-2 protein expression. This effect might be mediated by post-transcriptional regulation.

한국판 임상가용 아동 및 청소년을 위한 외상후 스트레스장애 척도의 신뢰도 및 타당도 연구

구정일,김태형,은헌정,최말례,이선미,조수진,송옥선,김형욱 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6

Objectives : This present study was conducted to explore the reliability and the validity of Clinician Administered PTSD Scale for Children and Adolescents Korean version (CAPS-CA) Mcthods : The Subjects were children and adolescents (8-13yrs) from different places: a certain elementary school, three orphanages, a general hospital, and two neuropsychiathc local clinics. Only subjects who experienced a catastrophic traumatic event were tested by CAPS-CA, CDI, RCMAS, and TSC. Rcsults : The range of correlations between item-criterion were .67-.84. The coefficients of internal consistency were .87. and test-retest reliability was .90, were all the coefficients in the proper range. Inter-correlations of CAPS-CA, CDI, RCMAS, and TSC scale showed significant correlation. TSC showed the highest correlation coefficient. CAPS-CA can be a useful clinician-administered diagnostic instrument for children and adolescents PTSD symptoms. Conclusion : The reliability and the validity of CAPS-CA were confirmed. CAPS-CA could be applied for diagnostic purposes of PTSD in children and adolescents.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

The incidence of tuberculosis after a measles outbreak.

Lee, Chang-Hoon,Lee, Eun Gyu,Lee, Ju-Young,Park, KeeHo,Lee, Beom Hee,Han, Hwasoon,Oh, Eunjung,Kim, Hee-Jin,Kang, Mi-Kyoung,Oh, Soo Yon,Bai, Jeong Ym,Bai, Gill-Han,Lee, Duk-Hyoung,Oh, Dae-Kyu,Lee, Jong The University of Chicago Press 2008 Clinical infectious diseases Vol.46 No.6

<P>Among 53,974 cases of measles that occurred during the 2000-2001 outbreak in Korea, the incidence of tuberculosis following measles was 47 cases per 214,949.6 person-years, which was significantly lower than that in the general population (standardized incidence ratio, 0.73; 95% confidence interval, 0.54-0.96). In conclusion, we did not find a positive relationship between measles and tuberculosis.</P>

Synthesis and characterizations of carbazole–isoindigo–carbazole oligomers for photovoltaic application

Lee, Ji-Young,Lee, Song-Mi,Lee, Soo-Hyoung,Kim, Dong-Hee,Lee, Sang Hee,Lee, Youn-Sik Elsevier 2016 Chemical physics letters Vol.658 No.-

<P>6,6'-Dibromo-N,N'-(2-octyldodecanyl)isoindigo was coupled to either 4-(N-carbazolyl)phenyl boronic acid or 9-phenyl-9H-carbazole-3-boronic acid to give two different conjugated molecules of P-II-P and C-II-C, respectively. The optical band gap/HOMO levels of P-II-P and C-II-C were 1.90/-5.60 eV and 1.85/-5.39 eV, respectively. Based on the experimental and calculation data, C-II-C is more highly conjugated than P-II-P. The performances of C-II-C-based photovoltaic devices were better than those of P-II-P-based devices, with the best power conversion efficiency of 0.44%. (C) 2016 Elsevier B.V. All rights reserved.</P>