WLAN을 위한 5.2GHz/2.4GHz 이중대역 주차수 합성기의 설계

김광일,이상철,윤광섭,김석진,Kim, Kwang-Il,Lee, Sang-Cheol,Yoon, Kwang-Sub,Kim, Seok-Jin 한국통신학회 2007 韓國通信學會論文誌 Vol.32 No.1A

본 논문은 $0.18{\mu}m$ CMOS 공정으로 설계된 5.2GHz와 2.4GHz 이중 대역 무선 송수신기를 위한 주파수합성기를 제안한다. 2.4GHz 주파수는 스위치드 커패시터와 2분주기를 동작시켜서 발생시키고, 5.2GHz는 전압 제어 발진기의 출력 주파수로부터 직접 발생시키도록 설계하였다. 제안된 주파수합성기의 전체 전력소모는 25mW이며, 전압 제어 발진기의 전력소모는 3.6mW이다. 모의 실험된 주파수 합성기의 위상 잡음은 스위치드 커패시터 회로가 동작할 때, 200kHz 옵셋 주파수에서 -101.36dBc/Hz이고, 락킹 시간은 $4{\mu}s$이다. This paper presents a frequency synthesizer(FS) for 5.2GHz/2.4GHz dual band wireless applications which is designed in a standard $0.18{\mu}m$ CMOS1P6M process. The 2.4GHz frequency is obtained from the 5.2GHz output frequency of Voltage Controlled Oscillator (VCO) by using the Switched Capacitor (SC) and the divider-by-2. Power dissipations of the proposed FS and VCO are 25mW and 3.6mW, respectively. The tuning range of VCO is 700MHz and the locking time is $4{\mu}s$. The simulated phase noise of PLL is -101.36dBc/Hz at 200kHz offset frequency from 5.0GHz with SCA circuit on.

RFID 태그 칩용 로직 공정 기반 256bit EEPROM IP 설계 및 측정

김광일,김려연,전황곤,김기종,이재형,김태훈,하판봉,김영희,Kim, Kwang-Il,Jin, Li-Yan,Jeon, Hwang-Gon,Kim, Ki-Jong,Lee, Jae-Hyung,Kim, Tae-Hoon,Ha, Pan-Bong,Kim, Young-Hee 한국정보통신학회 2010 한국정보통신학회논문지 Vol.14 No.8

본 논문에서는 logic 공정 기반의 소자만 사용한 256bit EEPROM IP를 설계하였다. 소자간의 전압을 신뢰성이 보장되는 5.5V 이내로 제한하기위해 EEPROM의 코어 회로인 CG (Control Gate)와 TG (Tunnel Gate) 구동 회로를 제안하였다. 그리고 DC-DC converter인 VPP (=+4.75V), VNN (-4.75V)과 VNNL (=VNN/3) generation 회로를 제안하였고 CG와 TG 구동 회로에 사용되는 switching power인 CG_HV, CG_LV, TG_HV, TG_LV, VNNL_CG와 VNNL_TG 스위칭 회로를 설계하였다. 일반적인 모의실험 조건에서 read, program, erase 모드의 전력 소모는 각각 $12.86{\mu}W$, $22.52{\mu}W$, $22.58{\mu}W$으로 저전력 소모를 갖는다. 그리고 테스트 칩을 측정한 결과 256bit이 정상적으로 동작을 하였으며, VPP, VNN, VNNL은 4.69V, -4.74V, -1.89V로 목표 전압 레벨이 나왔다. In this paper, we design a 256-bit EEPROM IP using only logic process-based devices. We propose EEPROM core circuits, a control gate (CG) and a tunnel gate (TG) driving circuit, to limit the voltages between the devices within 5.5V; and we propose DC-DC converters : VPP (=+4.75V), VNN (-4.75V), and VNNL (=VNN/3) generation circuit. In addition, we propose switching powers, CG_HV, CG_LV, TG_HV, TG_LV, VNNL_CG, VNNL_TG switching circuit, to be supplied for the CG and TG driving circuit. Simulation results under the typical simulation condition show that the power consumptions in the read, erase, and program mode are $12.86{\mu}W$, $22.52{\mu}W$, and $22.58{\mu}W$ respectively. Furthermore, the manufactured test chip operated normally and generated its target voltages of VPP, VNN, and VNNL as 4.69V, -4.74V, and -1.89V.

고혈압 환자에 대한 이베사탄의 혈압강하효과 및 안전성을 평가하기 위한 양측 눈가림, 무작위 배정, 에날라프릴과의 비열등성 4상 임상시험

김광일,배장환,강현재,서선예,김상현,오세일,채인호,조주희,김명아,김효수,손대원,오병희,박영배,최윤식,박병주,이명묵,Kim, Kwang-Il,Bae, Jang-Whan,Kang, Hyun-Jae,Suh, Sun-Ye,Kim, Sang-Hyun,Oh, Se-Il,Chae, In-Ho,Zo, Joo-Hee,Kim, Myoung-A,Kim, Hyo-Soo,Sohn 대한임상약리학회 2003 Translational and Clinical Pharmacology Vol.11 No.2

Background: Irbersartan, an orally active antihypertensive agent, effectively reduces blood pressure by blocking angiotensin II receptors without any significant adverse effects. The purpose of this study is to compare the antihypertensive efficacy, safety and tolerability of irbesartan and enalapril in hypertensive patients. Methods: In this two centers, double-blind, randomized, non-inferiority study, the efficacy, safety and tolerability of once-daily irbesartan(150mg) versus once-daily enalapril(10mg) were evaluated over 8 weeks in 67 patients who had diastolic pressure between 95mmHg and 114mmHg on two measurements. If trough sitting diastolic blood pressure was equal to or greater than 90mmHg after a 4-week treatment period, the dosage for both study drugs was doubled until the end of the study. Baseline pressures, antihypertensive effect, side effects, laboratory findings were compared before and after treatment. Results: Data from 57 of 67 patients were eligible for intention to treat analysis. After the 8 weeks treatment with dose titration, mean reductions in peak sitting diastolic blood pressure were 11.9mmHg(95% confidence interval 7.61 -16.13) with irbesartan and 10.9mmHg$(95%\;confidence\;interval\;7.05{\sim}14.70)$ with enalapril. There was no significant difference between the two treatments in the percentage of patients achieving an effective blood pressure reduction or in the degree of change in mean systolic and/or diastolic blood pressure. Safety profiles were also similar between treatments. Conclusions: The antihypertensive efficacy of once-daily administration of irbesartan is non-inferior to that of enalapril in hypertensive patients. Both irbesartan and enalapril are well tolerated with similar safety profiles.

아토피 피부염 모델에 대한 β-1,3/1,6-glucan과 Lactobacillus plantarum LM1004의 면역 조절 효과

김인성(In Sung Kim),김성학(Sung Hak Kim),김정아(Jeong A Kim),유다윤(Da Yoon Yu),김광일(Gwang Il Kim),박동찬(Dong-Chan Park),임종민(Jong Min Lim),이상석(Sang Suk Lee),최인순(In Soon Choi),조광근(Kwang Keun Cho) 한국생명과학회 2018 생명과학회지 Vol.28 No.1

본 연구에서는 아토피 피부염 동물 모델에 대한 β-1,3/1,6-glucan과 L. plantarum LM1004의 면역조절 효과를 확인하고자 하였다. 가려움증의 횟수와 유출된 evans blue, 그리고 혈청 IgE와 histamine의 농도는 β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취한 그룹에서 아토피 피부염 유발그룹에 비해 유의적으로 감소하는 결과를 나타내었다. 아토피 피부염이 유발되면 전사 수준에서 Th2 및 Th17 세포의 전사인자 및 cytokine은 과발현되며, β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취하였을 때 이를 유의적으로 감소되었다. 또한 β-1,3/1,6-glucan과 L. plantarum LM1004는 Th1 및 Treg 세포의 전사인자(T-bet, GATA-3, RORγT, Foxp3) 및 cytokine (INF-γ, IL-4, IL-17, TGF-β)의 발현을 증가시킴으로써 면역 균형을 조절하는 것으로 나타났다. Galectin-9과 filaggrin은 아토피 피부염 유발 처리군에서 유의적으로 가장 낮았으며, β-1,3/1,6-glucan 처리군에서 유의적으로 가장 높게 나타났다. 이와 반대로 TSLP는 아토피 피부염 유발그룹에서 유의적으로 가장 높았으며 β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취한 그룹은 대조군과 유사한 수준이었다. 이러한 결과를 통해 β-1,3/1,6-glucan과 L. plantarum LM1004는 아토피 피부염 동물 모델에서 면역조절 작용 및 아토피 피부염의 개선 효과를 가짐을 알 수 있었다. 따라서 β-1,3/1,6-glucan과 L. plantarum LM1004는 아토피 피부염에 유용한 천연소재로서 사용될 것으로 기대된다. In this study, we examined the efficacy of the immune regulation of β-1,3/1,6-glucan and Lactobacillus plantarum LM1004 on atopic dermatitis models. The oral administration of β-1,3/1,6-glucan and L. plantarum LM1004 on mice significantly decreased the amount of scratching, leakage to evans blue, and concentrations of serum immunoglobulin E (IgE) and histamine compared with the atopic dermatitis–induced group. When atopic dermatitis was induced, the transcription factors (GATA-3, retinoic acid-related orphan receptor γ T [RORγT]) and cytokines (interleukin-4 [IL-4], IL-17) of Th2 and Th17 cells were overexpressed at the transcriptional level, and they significantly decreased with oral administration of β-1,3/1,6-glucan and L. plantarum LM1004. In addition, β-1,3/1,6-glucan and L. plantarum LM1004 were shown to modulate the immune balance by increasing the expression of Th1 and Treg transcription (T-bet, forkhead box p3 [Foxp3]) and cytokines (interferon-γ [IFN-γ], transforming growth factor-β [TGF-β]). Galectin-9 and filaggrin were significantly lower in the atopic dermatitis–induced group and significantly higher in the β-1,3/1,6-glucan-treated group. In contrast, thymic stromal lymphopoietin (TSLP) was highest in the atopic dermatitis–induced group, while mice that were orally administered β-1,3/1,6-glucan and L. plantarum LM1004 showed similar TSLP levels to the control group. These results indicate that β-1,3/1,6-glucan and L. plantarum LM1004 have immunomodulatory effects and atopic dermatitis improvement effects in an animal model of atopic dermatitis. Therefore, it is expected that β-1,3/1,6-glucan and L. plantarum LM1004 can be used as natural materials in the treatment of atopic dermatitis.

다발성의 분화도가 좋은 태아형 폐선암종 - 1예 보고 -

김광일,이주한,문정석,김한겸,Kim, Kwang-Il,Lee, Joo-Han,Mun, Jeong-Seok,Kim, Han-Kyeom 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.1

Well differentiated fetal adenocarcinoma of the lung Is a subtype of pulmonary blastoma. In this report, CT-guided fine needle aspiration smears were performed at the right upper lobe of the lung in a 45 year-old male patient who had the smoking history of one pack per day for 25 years. The smears disclosed round, papillary, and tubular patterns of cell clusters. The individual cells had relatively uniform, small to medium sized nuclei without nucleoli, and showed vesicular or eosinophilic cytoplasm with Indistinct cell border. The morules were seen in the central area of papillary clusters. They were composed of two cell types, outer single layered cuboidal cellular lining and central three-dimensional cluster of cells simulating fetal lung. These cytologic features need to be differentiated from usual pulmonary adenocarcinoma, carcinoid, and pulmonary blastoma. On histologic findings, the tumor arised in the bronchial epithelium. And the tumor cells had abundant intracytoplasmic glycogen with neuroendocrine feature on histochemical study. In addition, the multiplicity of this tumor is the unique point comparable to the previous reports.

위암에서 E-cadherin과 $\beta-catenin$ 발현과 유전자 돌연변이에 관한 연구

김광일,박성혜,한선애,채양석,김인선,Kim Kwang Il,Park Sung-Hye,Han Sun-Ae,Chae Yang-Seok,Kim Insun 대한위암학회 2001 대한위암학회지 Vol.1 No.4

Purpose: When cancer cels invade the stroma, they should be dissociated from the adjacent cells at first. E-cadherin and $\beta-catenin$ constitute an important protein complex associated with cellular adhesion, development, and differentiation, especially in epithelial cells. The role of E-cadherin and $\beta-catenin$ in gastric carcinogenesis were studied. Materials and Methods: The expression of E-cadherin and $\beta-catenin$ in gastric adenocarcinomas by using immunohistochemical staining and the mutation by using polymerase chain reaction- single stranded conformation polymorphism (PCR-SSCP) and sequencing were performed in 40 adenocarcinomas and 5 dysplasia of stomach. Thirteen cases, which had lymph node metastasis, were also included for immunohistochemical staining. Results: Inappropriate cytoplasmic and/or nuclear expression of a E-cadherin-$\beta-catenin$ complex was more frequent in poorly differentiated, diffuse type signet ring cell carcinomas than in well-differentiated, intestinal type adenocarcinomas (P<0.05). However, the expression was not related with clinical stage or lymph node metastasis. Mutation of E-cadherin was detected in 4 cases by using PCR-SSCP, whereas mutation of $\beta-catenin$ was detected in 2 cases. Conclusion: E-cadherin and $\beta-catenin$ seem to be important in gastric carcinogenesis, especially in poorly differentiated diffuse type.

프레임 분할과 3D 웨이블릿 변환을 이용한 비디오 워터마킹

김광일(Kwang-il Kim),최기철(Cui Jizhe),김종원(Jong-Weon Kim),최종욱(Jong-Uk Choi) 한국정보보호학회 2008 정보보호학회논문지 Vol.18 No.3

본 논문에서는 동영상 콘텐츠의 저작권 보호를 위해 3D 웨이블릿 변환과 대역확산방법(direct spread spectrum)을 이용한 비디오 워터마킹 알고리즘을 제안하였다. 제안한 방법은 동기 워터마크를 삽입한 다음 사용자 정보를 갖는 워터마크를 삽입하게 된다. 입력된 프레임을 분할하고, 다시 홀수행과 짝수행으로 정렬하여 각각 3D 웨이블릿 변환을 수행한 다음 대역확산 방법으로 워터마크를 삽입한다. 기존의 3D 웨이블릿을 이용한 비디오 워터마킹 알고리즘과는 달리 제안한 방법은 blind 방식으로써 원본 영상 없이 워터마크 검출이 가능하다. 실험결과 PSNR은 평균 40 dB 이상으로써 높은 비가시성을 만족하는 동시에 프레임 절삭, 잡음 첨가, 압축 등의 공격에서도 10% 이하의 BER을 기록하여 공격에 강인한 것으로 확인되었다. In this paper we proposed a video watermarking algorithm based on a three dimension discrete wavelet transform (3D DWT) and direct spread spectrum (DSS). In the proposed method, the information watermark is embedded into followed frames, after sync watermark is embedded into the first frame. Input frames are divided into sub frames which are located odd row and even row. The sub frames are arranged as 3D frames, and transformed into 3D wavelet domain. In this domain the watermark is embedded using DSS. Existing video watermarking using 3D DWT is non-blind method but, proposed algorithm uses blind method. The experimental results show that the proposed algorithm is robust against frame cropping, noise addition, compression, etc. acquiring BER of 10% or below and sustains level of 40dB or above on the average.

환관과 지식인

김광일(Kim, Kwang Il) 한국중어중문학회 2015 中語中文學 Vol.60 No.-

Extended Meaning of the Great Learning(Daxue Yanyi) is a reference book for imperial instruction compiled by Zhen Dexiu(1178-1235) in 1229. According to “eight pricilples” of the Great Learning(Daxue), Zhen Dexiu’s Extented Meaning covers extensive historical ground and offers practical wisdom for the guidance of rulers. This book deals only to the sixth discipline “the Core of Regulating the family(Qijia).” Many scholars in later centuries criticized the structural incompleteness of the book, but it could be Zhen Dexiu’s intentional design for emphasizing “self-cultivation for governance of men” or “self-discipline for the ordering of the state” to rulers and intellectuals. In this paper, I discuss some issues in “the Core of Regulating Family”, by analysing the structure and meaning of the chapter for “Strict distinction of Household(Yan Neizhi)” which deal mainly with historical conflicts between eunuchs and intellectuals.

유분(劉?) <대책(對策)>의 문화사적 의미(1) - ≪신당서(新唐書)≫ <유분전(劉?傳)>의 해제와 역주

김광일 ( Kim Kwang-il ) 중국어문연구회 2016 中國語文論叢 Vol.0 No.75

Emperor Wenzong of Tang Dynasty held a temporary imperial examination at 826 in order to pick out talented officials with whom he wanted to overcome a lot of serious confusion in state affairs. At this examination, Liu Fen handed in a scathing Answer, which created quite a stir in the Royal Court and society. “A Biography of Liu Fen” in New History of Tang Dynasty contains Liu Fen’s Answer for the Emperor’s Question and introduces the details surrounding Liu Fen’s failure in this examination. The Biography is composed of four sections: 1) Liu Fen’s career and its time period, 2) Emperor’s Question at the Examination in 826, 3) Liu Fen’s Answer for the Qustion, 4) the reverberation caused by Liu Fen’s failure. The aim of this paper is to translate and annotate “A Biography of Liu Fen” in New History of Tang Dynasty in order to inquire the cultural meaning of Liu Fen’s failure, for it is very convoluted to understand and appreciate Liu Fen’s Answer because of a lot of precedential expression.

다양한 전처리 방법에 따른 당근의 이화학 및 영양학적 특성 분석

김광일(Kwang-Il Kim),황인국(In-Guk Hwang),유선미(Seon-Mi Yoo),민상기(Sang-Gi Min),최미정(Mi-Jung Choi) 한국식품영양과학회 2014 한국식품영양과학회지 Vol.43 No.12

본 연구는 당근을 열처리법 중에서 열수침지, 과열증기 및 볶음 처리에 따른 이화학적 및 영양학적 특성을 분석한 논문으로 열처리가 당근에 미치는 영향을 비교하고자 하였다. 상품을 구매할 때 1차적인 구매요소인 색도 및 경도 측정과 추가적으로 pH와 조직 관찰 결과로 최적 조건 선정 후 영양학적 및 관능검사를 실시하였다. 열처리를 하지 않은 대조구에 비해 짧은 시간의 열처리에서는 더 진하고 선명한 색을 띠었으나, 장시간 동안 처리한 열처리 시료는 색의 침착을 보였다. 원물과의 색은 열처리 후 차이를 나타냈지만 열수 및 과열증기 2분 처리까지가 원물과 가장 유사한 색을 나타냈으며, 경도는 열처리 시간에 따라 감소 경향을 나타냈고 볶음 처리는 짧은 시간으로도 물성이 연화됐으며, 열수침지 및 과열증기 처리는 2분까지 원물에 가까운 경도를 유지했으나 처리 시간이 길어질수록 경도가 확실히 감소하였다. 비타민, 유리당 및 유기산의 경우 열수침지 처리에서 가장 큰 손실을 보였고, 과열증기, 볶음 처리 순으로 손실된 결과를 보였다. 특히 유기산에서 succinic acid는 열수침지 처리시 큰 손실률을 보이며 감소된 결과를 나타냈다. Peroxidase activity 변화는 열수침지 및 과열증기 처리에서 볶음처리보다 높은 불활성화를 보였다. 당근의 열처리 조건은 과열증기 처리법으로 2분 동안 처리하는 것이 다른 처리법에서 처리한 시간들에 비해 최적으로 나타났다. 식품마다 열처리 방법 별 각각의 최적 처리 시간을 가지고 있어, 높은 효율성이나 산업적으로 이용하려면 최적의 전처리 방법과 처리 시간을 산정하는 것이 중요하다. Pre-thermal treatment is important to minimize quality changes during main cooking or storage. In this study, to optimize pre-thermal treatment of carrots, three types of pre-thermal treatments were applied to carrots and quality changes such as physicochemical, nutritional, or sensory properties were observed. Washed and sliced carrots were thermally treated by hot-water immersion (100℃, 1~10 min), steaming (100℃, 1~10 min), and stir-frying with oil (10~80 sec). Carrot tissue was maintained until 2 min hot-water immersion or steaming, and they were damaged by just 30 sec of stir-frying. Color and hardness were significantly affected by treatment time and temperature. Color was completely changed after 5 min and 7 min by hot-water and steam treatments, respectively. Hardness decreased to 44% compared with fresh carrot (4,500 g) after 1 min, 3 min, and 20 sec of hot-water, steam, and stir-frying, respectively. For nutritional changes, ascorbic acid, organic acid, and peroxide activity were reduced by all treatments compared with fresh carrot. Especially, succinic acid was dramatically reduced by hot-water treatment. Otherwise, free sugar contents were increased with greater treatment time in all samples. In this study, pre-thermal treatment of carrot was optimal at 2 min steaming treatment.