구조화 전화추적 면담을 이용한 품행장애 입원 치료 환자의 예후

방양원,채정호,문석우,이은회,함웅 대한소아청소년정신의학회 2000 소아청소년정신의학 Vol.11 No.2

연구 목적 : 본 연구의 목적은 입원치료후 퇴원한 품행장애 환자들의 예후와 가족들의 정신과 입원치료의 효능에 대한 인식도를 알아보고 예후에 영향을 미칠 수 있는 요인을 알아보기 위한 것이다. 방법 : 품행장애의 진단 하에 7일 이상 입원치료를 받았으며 퇴원 후 6개월이 경과된 300명 중 전화 추적이 가능하였던 96명에서 퇴원 후 문제행동, 가족관계, 가족들의 인식도를 조사하였으며 이와 관련된 요인을 알아보았다. 결과 : 퇴원 후 문제행동의 양상은 입원전보다 호전된 경우가 90%이었으며 더 심해진 경우는 2%이었으며 8%는 변화가 없었다. 퇴원 후 가족관계는 보다 좋아진 경우가 70%, 나빠진 경우가 2%, 별 차이가 없는 경우가 28%이었다. 병원치료의 효율성에 대한 가족들의 인식도는 도움이 되었다는 경우가 57%, 해가 되었다는 경우가 6%, 그저 그렇다가 37%이었다. 퇴원 후 문제행동, 가족관계, 가족들의 입원치료에 대한 인식도 등 세 가지 항목이 모두 양호하다고 답변한 대상을 양호군으로 설정하고 그 외의 대상을 대조군으로 하여 양군의 특성의 차이를 비교하였을 때 양호군의 연령이 유의하게 낮았으며 가족 형태의 문제가 있었고 MMPI하위척도 중 남성성 -여성성 척도 점수가 유의하게 높았다. 결론 : 비록 본 연구는 여러 제한점이 내포되어 있음에도 불구하고, 정신과 입원치료를 받았던 청소년의 행동이 대부분은 호전된다는 것을 시사하여 품행장애에서의 정신과적 치료에 상당히 고무적인 결과를 나타내었으며 추후 대상자와 치료프로그램의 다양성을 통제한 연구를 지속하는 것이 필요할 것으로 생각되었다. 중심 단어 : 품행장애ㆍ청소년ㆍ예후ㆍ입원치료. Objectives : The major goal of this study was to investigate the treatment outcome of psychiatric treatment in inpatients with conduct disorder and to elucidate factors affecting its prognosis. Methods : We reviewed the medical records of 300 inpatients with conduct disorder who had been treated with a specialized adolescent treatment program. Follow-up structured telephone interview had been performed in 96 patients. Results : 1) At the point of follow-up, 90% of the patients were improved in behavioral patterns, 2% of the patients were worse, and 8% of the patients were unchanged. 2) Intrafamilial relationship was improved in 70% of the patients, worse in 2%, and unchanged in 28%, 3) Fiftyseven percent of families thought to be helped by psychiatric inpatient treatment, 6% replied to be harmed, and 37% thought not to be helpful. 4) Comparing the good prognosis group who were all better in behavioral patterns, intrafamilial relationship, and efficacy of treatment with the rest of subjects, the good prognosis group was significantly younger and had more history of problems in familial structure. Conclusion : Although the present study had some meterological limits, the promising positive results in the outcome of inpatients with conduct disorder encourages further more sophisticated investigations in this problematic psychiatric conditions. KEY WORDS : Conduct disorderㆍAdolescentㆍTreatment outcomeㆍInpatient treatment.

Influence of Section Shapes on Axial Collapse Characteristics of Al/CFRP Composite Thin-Walled Member

Yang, In-Young,Yang, Yong-Jun,Cha, Cheon-Seok,Kim, Ji-Hoon,Chae, Ji-Hoon,Jung, Jong-An,Hwang, Woo-Chae American Scientific Publishers 2015 Journal of computational and theoretical nanoscien Vol.12 No.5

Harnessing an RNA-mediated chaperone for the assembly of influenza hemagglutinin in an immunologically relevant conformation

Yang, Seung Won,Jang, Yo Han,Kwon, Soon Bin,Lee, Yoon Jae,Chae, Wonil,Byun, Young Ho,Kim, Paul,Park, Chan,Lee, Young Jae,Kim, Choon Kang,Kim, Young Seok,Choi, Seong Il,Seong, Baik Lin Federation of American Societies for Experimental 2018 The FASEB Journal Vol.32 No.5

<P>A novel protein-folding function of RNA has been recognized, which can outperform previously known molecular chaperone proteins. The RNA as a molecular chaperone (chaperna) activity is intrinsic to some ribozymes and is operational during viral infections. Our purpose was to test whether influenza hemagglutinin (HA) can be assembled in a soluble, trimeric, and immunologically activating conformation by means of an RNA molecular chaperone (chaperna) activity. An RNA-interacting domain (RID) from the host being immunized was selected as a docking tag for RNA binding, which served as a transducer for the chaperna function for <I>de novo</I> folding and trimeric assembly of RID-HA1. Mutations that affect tRNA binding greatly increased the soluble aggregation defective in trimer assembly, suggesting that RNA interaction critically controls the kinetic network in the folding/assembly pathway. Immunization of mice resulted in strong hemagglutination inhibition and high titers of a neutralizing antibody, providing sterile protection against a lethal challenge and confirming the immunologically relevant HA conformation. The results may be translated into a rapid response to a new influenza pandemic. The harnessing of the novel chaperna described herein with immunologically tailored antigen-folding functions should serve as a robust prophylactic and diagnostic tool for viral infections.—Yang, S. W., Jang, Y. H., Kwon, S. B., Lee, Y. J., Chae, W., Byun, Y. H., Kim, P., Park, C., Lee, Y. J., Kim, C. K., Kim, Y. S., Choi, S. I., Seong, B. L. Harnessing an RNA-mediated chaperone for the assembly of influenza hemagglutinin in an immunologically relevant conformation.</P>

Cell density-dependent acetylation of ΔNp63α is associated with p53-dependent cell cycle arrest

Chae, Yang-Seok,Kim, Hyunji,Kim, Dongsung,Lee, Hyunsook,Lee, Hae-ock Elsevier 2012 FEBS letters Vol.586 No.8

<P><B>Highlights</B></P><P>► Acetylation regulates the function of p53 family members. ► We identified acetylation sites for p63 and generated acetyl-p63 specific antibodies. ► Acetylation of ΔNp63α is associated with cell cycle arrest in high density cell culture. ► Acetylation of ΔNp63α may be a mechanism for epidermal homeostasis.</P> <P><B>Abstract</B></P><P>ΔNp63α is a p63 isoform that is predominantly expressed in the epidermal stem cells and in cancer. To find the regulatory pathways of ΔNp63α, we assessed whether ΔNp63α is acetylated and determined the functional implications of acetylation. First, the hinge region of p63 was shown to be acetylated by PCAF, similarly to other p53 family members. Second, acetylation synergistically induced cytoplasmic localization of ΔNp63α. Finally, acetyl-ΔNp63α was induced during high-density culture, suggesting that acetylation of ΔNp63α may reinforce cell cycle arrest upon cell contact. Altogether, these findings suggest that acetylation of ΔNp63α contributes to the epidermal homeostasis.</P><P><B>Structured summary of protein interactions</B></P><P><B>PCAF</B> acetylates <B>ΔNp63α</B> by acetylation assay (View Interaction: <U>1</U>, <U>2</U>, <U>3</U>)</P><P><B>ΔNp63α</B> physically interacts with <B>ΔNp63α</B> by anti tag coimmunoprecipitation (<U>View interaction</U>)</P><P><B>ΔNp63α</B> physically interacts with <B>p53</B> by anti bait coimmunoprecipitation (<U>View interaction</U>)</P>

건설사업관리 계약을 위한 발주단계 업무절차 구성 연구

채영석(Chae Yeong Seok),박서영(Park Seo Young),박진정(Park Jin Jung),이양규(Lee Yang Kyoo),강인석(Kang Leen Seok) 대한토목학회 2009 대한토목학회 학술대회 Vol.2009 No.10

Efficacy of Initial Treatment with Clevudine in Naive Patients with Chronic Hepatitis B

( Hyeon Woong Yang ),( Byung Seok Lee ),( Tae Hee Lee ),( Heon Young Lee ),( Kwan Woo Nam ),( Young Woo Kang ),( Hee Bok Chae ),( Seok Hyun Kim ),( Seok Bae Kim ),( Hyang Ie Lee ),( An Na Kim ),( Il H 대한내과학회 2010 The Korean Journal of Internal Medicine Vol.25 No.4

Background/Aims: Clevudine, a pyrimidine nucleoside analogue, has potent antiviral effects in patients with chronic viral hepatitis B (CHB). We report the efficacy of initial treatment with clevudine in naive patients with CHB living in Daejeon and Chungcheong Province, South Korea. Methods: One hundred five adults with CHB were administered 30 mg of clevudine per day for an average of 51 weeks. We evaluated viral markers and liver biochemistry retrospectively every 3 months. Results: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatitis B virus (HBV) DNA before the treatment were 184 ± 188 IU/L, 150 ± 138 IU/L, and 7.1 ± 1.2 log copies/mL, respectively. Undetectable rates (< 60 IU/mL) of DNA were 36.2%, 68.9%, 83.6%, 76.2%, and 75.8% at 12, 24, 36, 48, and 60 weeks, respectively. Seroconversion rates were 9.1%, 13.6%, 24.6%, 26.5%, and 26.1% and ALT normalization rates were 64.5%, 78.1%, 87.9%, 90.0% at 12, 24, 36, and 48 weeks, respectively. Six patients (5.7%) had a viral breakthrough. Conclusions: Clevudine is a useful drug in the initial treatment of patients with CHB, with a potent antiviral effect and low incidence of viral breakthrough. (Korean J Intern Med 2010;25:372-376)

Effects of maternal cigarette smoke exposure on the progression of nonalcoholic steatohepatitis in offspring mice

Yang Daram,Kim Jong Won,Jeong Hyuneui,Kim Min Seok,Lim Chae Woong,Lee Kyuhong,Kim Bumseok 한국독성학회 2023 Toxicological Research Vol.39 No.1

Cigarette smoke (CS) is a dominant carcinogenic agent in a variety of human cancers. CS exposure during pregnancy can adversely affect the fetus. Non-alcoholic fatty liver disease (NAFLD) is considered as a hepatic manifestation of a metabolic disorder, and ranges from simple steatosis to cirrhosis leading to hepatocellular carcinoma. Non-alcoholic steatohepatitis (NASH) is a more severe phase of NAFLD. Recently, there is increasing apprehension about the CS-related chronic liver diseases. Therefore, we examined whether maternal CS exposure could affect the pathogenesis of NASH in offspring. Mainstream CS (MSCS) was exposed to pregnant C57BL/6 mice via nose-only inhalation for 2 h/day, 5 days/week for 2 weeks from day 6 to 17 of gestation at 0, 300, or 600 μg/L. Three-week-old male offspring mice were fed methionine and cholinesupplemented (MCS) diet or methionine and choline-deficient including high-fat (MCDHF) diet for 6 weeks to induce NASH. Maternal MSCS exposure increased the severity of NASH by increasing serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, hepatic total cholesterol (TC) and triglyceride (TG) levels, pro-inflammation, fibrosis, and steatosis in offspring mice. Especially, maternal MSCS exposure significantly downregulated the phosphorylation of AMPactivated protein kinase (AMPK) in MCDHF diet-fed offspring mice. Subsequently, the protein levels of sterol regulatory element-binding protein (SREBP)-1c and stearoyl-CoA desaturase-1 (SCD1) were upregulated by maternal MSCS exposure. In conclusion, maternal MSCS exposure exacerbates the progression of NASH by modulating lipogenesis on offspring mice.

타액선 암종세포의 식물응집소 수용체 분포에 관한 면역조직화학적 연구

채양석,염범우,이대일 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1

Malignant tumors of the salivary glands are variable in their histologic pictures, and their histochemical changes in membrane carbohydrate composition have not been fully understood. The author selected formalin fixed, paraffin embedded normal tissue and malignant tumors of salivary gland, and performed immunohistochemical study on the selected tissue materials by avidin biotin peroxidase complex method using lectins such as Concanavalin A (Con A), Soybean agglutinin (SBA), Wheat germ agglutinin (WGA), Dolichos biflorus agglutinin (DBA), Ulex europaeus agglutinin I (UEA I), Peanut agglutinin (PNA), Ricinus communis agglutinin I (RCA I), and Pinellia ternata agglutinin (PTA). The results are summarized as follows: 1. Lectins showing different reaction pattern between normal and malignant tumor cells of the salivary glands were DBA, UEA-1, SBA and PNA. 2. DBA and SBA showed positive reaction with normal duct epithelium, but they did'nt react with malignant turner cells. 3. UEA-1 revealed positive reaction with normal duct epithelium and cancer cells of the mucopeidermoid carcinoma. But it did'nt react with adenoid cystic carcinoma cell and acinic cell carcinoma cell. 4. PNA showed positive reaction with mucoepidermoid carcinoma cell and negative reaction with nor-mal duct epithelium, adenoid cystic carcinoma and acinic cell carcinoma cell. Above findings suggest loss of N-acetyl-galactosaminyl moiety in malignant tumors of salivary gland, loss of L-fucosyl in adeniod cystic cacinoma and acinic cell carcinoma, which are present on normal duct epithelium, and appearance ofβ-D-galactosyl moiety in mucoepidermoid carcinoma which is absent on normal duct epithelium.

Moisture Content of Poly(Sorbitan Methacrylate) Hydrogel

Seok-Hwan Park,Gwi-Taek Jeong,Hee-Seung Yang,Jae-Hee Park,Suk-Won Chae,Hae-Sung Kim,Changshin Sunwoo,Hwa-Won Ryu,Don-Hee Park 한국생물공학회 2007 한국생물공학회 학술대회 Vol.2007 No.4

Natural substances that have the effect of reducing scuticociliatosis in flounder, Paralichthys olivaceus

Seok Jin Bang,Jae Won Seol,Chae Won Lee,Chan Yeong Yang,Su Yeong Yun,Chang Yeal Jung,Chan Huen Lee,Yong Ju Heo,Sang Hoon Choi 한국수산해양기술학회(구 한국어업기술학회) 2017 한국수산해양기술학회 학술발표대회 Vol.2017 No.11