콜하스와 츄미의 라 빌레뜨 공원 계획안 비교 분석 - 드로잉에 나타난 점, 선, 면의 구성과 작동을 중심으로 -

김인성,Kim, In-Sung 한국건축역사학회 2011 건축역사연구 Vol.20 No.4

International Competition for Parc de la Villette has evoked the old architectural question that is about the conflict between unchanging architecture and ever changing time. Tschumi and Koolhaas suggested well-known solutions for it, both of which had started from the criticism of general urban design approach that ignored changing factors in time. However, this study argues that the approaches of Tschumi and Koolhaas are even opposite to each other in spite of their common aims. Influenced by deconstructivists' theories, Tschumi tries to generate the 'text' on the surface of la Villette so that the different users of the park can read it differently. The text is built by 'superimposing' different systems such as points, lines, and surfaces. This study criticizes such formalistic approach since such 'forms' do not generate any dialogue with the real users but just stay as a backdrop for irrelevant events. Meanwhile, Koolhaas concentrates on the 'ground-ness' of la Villette. What he deals with is the real ground which embraces all the potentials on it already. His 'bands' express nothing but the metamorphosis of the ground, and the ground generates the 'differences' out of itself by repeating itself ceaselessly. This study tries to clarify all those happenings and meanings by intimate investigation of various drawing works for the la Villette project by Tschumi and Koolhaas.

근무력증과 왜소증을 동반한 Bartter syndrome 1례

김인성,강주형,신윤혜,이동국,김순남,배기수,Kim In-Sung,Kang Ju-Hyung,Shin Yun-Hei,Lee Dong-Kuk,Kim Soon-Nam,Pai Ki-Soo 대한소아신장학회 2002 Childhood kidney diseases Vol.6 No.2

Bartter syndrome is a rare disorder characterized by the association of hypokalemic hypochloremic metabolic alkalosis, hyperreninemia, hyperaldosteronemia, short stature and nephrocalcinosis. This disorder presents with hyperplasia of juxtaglomerular apparatus on renal biopsy. We experienced a case of late-onset Bartter syndrome with nephrocalcinosis in a 9-year-old boy, whose chief pictures were muscle weakness, short stature, persistent sterile pyuria and microscopic hematuria. We report this case with a brief review of related literatures.

갈대-상(床)을 이용한 쓰레기 매립지 침출수의 생물학적 연속흐름 처리

김인성,조용주,최홍근,이은주,Kim, In-Sung,Cho, Yong-Joo,Choi, Hong-Keun,Lee, Eun-Ju 한국생태학회 2004 Journal of Ecology and Environment Vol.27 No.6

We investigate the biological treatment of processed-leachate from SUDOKWON landfill site in Korea by the reed (Phragmites australis)-bed with a continuous flow system. The reed individuals showing superior growth in processed-leachate experiment were selected among the reeds of thirteen natural habitats by means of the comparisons between the removal rates of nutrient salts, eco-physiological responses and growth. The reed-beds (combination of the reed individuals showing superior growth with helper microorganisms) were continuously supplied with processed-leachate. We monitored the effluents that passing through the reed-beds during the experiment period. After five weeks, analysis results of effluent from each reed-bed were as follows; chromaticity, total nitrogen, total phosphorus, biological oxygen demand, chemical oxygen demand, total dissolved solid and salinity decreased $29.5{\sim}36.9\%,\;49.4{\sim}67.2\%,\;42.1{\sim}94.6\%,\;74.5{\sim}88.8\%,\;15.6{\sim}20.8\%,\;17.5{\sim}35.4\%\;and\;15.3{\sim}34.7\%$, respectively. These results represented the substantial improvement of water-quality after passing through reed-bed in a continuous flow system.

상자성 복합체의 분자량에 따른 T1 및 T2 자기이완시간에 관한 연구

김인성,이영주,김주현,김숙경,김태정,강덕식,장용민,Kim In-Sung,Lee Young-Ju,Kim Ju-Hyun,Sujit Dutta,Kim Suk-Kyung,Kim Tae-Jeong,Kang Duk-Sik,Chang Yong-Min 한국의학물리학회 2006 의학물리 Vol.17 No.2

To evaluate the T1, T2 magnetic relaxation properties of water molecule according to molecular weight of paramagnetic complex. 4-aminomethyicyclohexane carboxylic acid (0.63 g, 4 mmol) was mixed with the suspension solution of DMF (15 ml) and DTPA-bis-anhydride (0.71 g, 2 mmol) to synthesize the ligand. The ligand was then mixed with $Gd_2O_3$ (0.18 g, 0.5 mmol) to synthesize Gd-chelate. For the measurement of magnetic relaxivity of paramagnetic compounds, the compounds were diluted to 1 mM and then the relaxation times were measured at 1.57 (64 MHz). Inversion-recovery pulse sequence was employed for T1 relaxation measurement and CPMG (Carr-Purcell-Meiboon-Gill) pulse sequence was employed for T2 relaxation measurement. In case of inversion recovery sequence, total 35 images with different inversion time(T1)s ranging from 50 msec to 1,750 msec. To estimate the relaxation times, the signal intensity of each sample was measured using region of Interest (ROI) and then fitted by non-linear least square method to yield T1, T2 relaxation times and also R1 and R2. Compared to T1=($205.1{\pm}2.57$) msec and T2=($209.4{\pm}4.28$) msec of Omniscan (Gadodiamide), which is commercially available paramagnetic MR agent, T1 and T2 values of new paramagnetic complexes were reduced along with their molecular weight. That is, T1 value was ranged from $(96.35{\pm}2.04)\;to\;(79.38{\pm}1.55)$ msec and T2 value was ranged from $(91.02{\pm}2.08)\;to\;(76.66{\pm}1.84)$ msec. Among new paramagnetic complexes, there is a tendency that the R1 and R2 increase as the molecular weight is increases. As molecular weight of paramagnetic complex increases, T1 and T2 relaxation times reduce and thus the increase of relaxivity (R1 and R2) Is proportional to molecular weight.

아토피 피부염 모델에 대한 β-1,3/1,6-glucan과 Lactobacillus plantarum LM1004의 면역 조절 효과

김인성(In Sung Kim),김성학(Sung Hak Kim),김정아(Jeong A Kim),유다윤(Da Yoon Yu),김광일(Gwang Il Kim),박동찬(Dong-Chan Park),임종민(Jong Min Lim),이상석(Sang Suk Lee),최인순(In Soon Choi),조광근(Kwang Keun Cho) 한국생명과학회 2018 생명과학회지 Vol.28 No.1

본 연구에서는 아토피 피부염 동물 모델에 대한 β-1,3/1,6-glucan과 L. plantarum LM1004의 면역조절 효과를 확인하고자 하였다. 가려움증의 횟수와 유출된 evans blue, 그리고 혈청 IgE와 histamine의 농도는 β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취한 그룹에서 아토피 피부염 유발그룹에 비해 유의적으로 감소하는 결과를 나타내었다. 아토피 피부염이 유발되면 전사 수준에서 Th2 및 Th17 세포의 전사인자 및 cytokine은 과발현되며, β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취하였을 때 이를 유의적으로 감소되었다. 또한 β-1,3/1,6-glucan과 L. plantarum LM1004는 Th1 및 Treg 세포의 전사인자(T-bet, GATA-3, RORγT, Foxp3) 및 cytokine (INF-γ, IL-4, IL-17, TGF-β)의 발현을 증가시킴으로써 면역 균형을 조절하는 것으로 나타났다. Galectin-9과 filaggrin은 아토피 피부염 유발 처리군에서 유의적으로 가장 낮았으며, β-1,3/1,6-glucan 처리군에서 유의적으로 가장 높게 나타났다. 이와 반대로 TSLP는 아토피 피부염 유발그룹에서 유의적으로 가장 높았으며 β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취한 그룹은 대조군과 유사한 수준이었다. 이러한 결과를 통해 β-1,3/1,6-glucan과 L. plantarum LM1004는 아토피 피부염 동물 모델에서 면역조절 작용 및 아토피 피부염의 개선 효과를 가짐을 알 수 있었다. 따라서 β-1,3/1,6-glucan과 L. plantarum LM1004는 아토피 피부염에 유용한 천연소재로서 사용될 것으로 기대된다. In this study, we examined the efficacy of the immune regulation of β-1,3/1,6-glucan and Lactobacillus plantarum LM1004 on atopic dermatitis models. The oral administration of β-1,3/1,6-glucan and L. plantarum LM1004 on mice significantly decreased the amount of scratching, leakage to evans blue, and concentrations of serum immunoglobulin E (IgE) and histamine compared with the atopic dermatitis–induced group. When atopic dermatitis was induced, the transcription factors (GATA-3, retinoic acid-related orphan receptor γ T [RORγT]) and cytokines (interleukin-4 [IL-4], IL-17) of Th2 and Th17 cells were overexpressed at the transcriptional level, and they significantly decreased with oral administration of β-1,3/1,6-glucan and L. plantarum LM1004. In addition, β-1,3/1,6-glucan and L. plantarum LM1004 were shown to modulate the immune balance by increasing the expression of Th1 and Treg transcription (T-bet, forkhead box p3 [Foxp3]) and cytokines (interferon-γ [IFN-γ], transforming growth factor-β [TGF-β]). Galectin-9 and filaggrin were significantly lower in the atopic dermatitis–induced group and significantly higher in the β-1,3/1,6-glucan-treated group. In contrast, thymic stromal lymphopoietin (TSLP) was highest in the atopic dermatitis–induced group, while mice that were orally administered β-1,3/1,6-glucan and L. plantarum LM1004 showed similar TSLP levels to the control group. These results indicate that β-1,3/1,6-glucan and L. plantarum LM1004 have immunomodulatory effects and atopic dermatitis improvement effects in an animal model of atopic dermatitis. Therefore, it is expected that β-1,3/1,6-glucan and L. plantarum LM1004 can be used as natural materials in the treatment of atopic dermatitis.

경기도 대부도 모래해변에 잔류하는 미세플라스틱의 계절별 분포특성

김인성 ( In Sung Kim ),김승규 ( Seung Kyu Kim ) 한국환경분석학회 2015 환경분석과 독성보건 Vol.18 No.4

Seasonal variation in the abundance and distribution of microplastics (MPs) in beach sediments was investigated for the Daebu island, Gyeonggi-do, South Korea. Beach surface sediments were sampled at five stations along the high strandline of the island beach in July and November 2013 and March 2014 to represent the summer, winter, and spring seasons, respectively. Six sizes ranging from 0.3 to 5 mm were classified and seven types of polymers were determined using FT-IR. The abundances of microplastics were 8,776-891,844 particles/ m2 in summer, 4,628-17,724 particles/m2 in winter, and 13,784-100,196 particles/m2 in spring with a predominant contribution of expanded polystyrene (EPS) of >95% in all seasons. Distinct seasonal differences were exhibited in the MPs abundance (i.e., 6-26 times higher in summer) and spatial distribution pattern (i.e., higher at northern stations in summer with southerly winds but southern stations in winter with northerly winds). On the other hand, similarities in size distribution as well as polymer composition were observed among seasons and stations. Particularly, there were good correlations between EPS of fishery-activity origin and non-EPS of inland origin. In conclusion, well-mixed currents seem to cause spatial and temporal homogeneity in size and polymer distribution, while different wind directions with seasons were likely to generate differences in the MPs abundance with time and space in the beach. However, whether the distribution characteristics of MPs on the beach sediments were determined by the direct reflection of those in flooding seawaters or by the redistribution of deposited MPs is unclear. Further study is required to identify the major mechanism.

고마리 내에서 Cu 의 흡수량과 Phytochelatin 의 관계

강경홍,김인성 ( Kyung Hong Kang,In Sung Kim ) 한국환경생물학회 1997 환경생물 : 환경생물학회지 Vol.15 No.2

When Persicaria thunbergii was treated with Cu(NO_3)_2 of 5mM and 10 mM for 48hr in laboratory, the biolmagnification of copper in the leaf and root of plants and the rate of increase of phytochelatin were examined. The concentration of Cu in the root was greater than in the leaf and the Cu concentration in Cu(NO_3)_2 treated plants was higher than in Cu(NO_3)_2 5mM treated plants as follows; in the case of Cu 5mM treated plants, the leaf was 5.04㎍/g and the root was 11.25㎍/g and in 10 mM treated plants, the leaf was 6.96㎍/g and the root was 13.91㎍/g. But, in the extract of the soluble protein of the leaf and root tissue of plants with extraction buffer (20mM Tris-HCl, pH 8.0 and 10mM β-mercaptoethanol), the contcentration of Cu in the leaf was higher than in the root of plants. The phytochelatin (Cu-binding protein) was isolated from the tissue of leaf and root and chromatographed on the gel filtration resin Sephadex G100. The rate of increase of Cu-binding protein increased with increasing heavy-metal addition in nutrient solution as follows: Compared with that of the control, in the case of leaf, Cu 5mM treated extract was 202% and 10 mM treated extract was 222% and in root, Cu 5mM treated extract was 120% and 10 mM treated extract was 182%. And, it had a high UV absorption at 254 ㎚ and a low absorption at 280㎚.

하천유역의 관속식물에 의한 중금속의 생물학적농축 및 중금속 오염도 평가에 관한 연구 3. 고마리 ( Persicaria thunbergii ) 에 의한 서식처 토양의 Pb , Cu 및 Zn 의 제거

박기남,강경홍,김인성 ( Ki Nam Park,Kyung Hong Kang,In Sung Kim ) 한국환경생물학회 1995 환경생물 : 환경생물학회지 Vol.13 No.2

The biological magnification and the uptake patterns of lead, copper and zinc in Persicaria thunbergii naturally grown at the areas of the rivers were investigated. The biological magnification values of lead, copper and zinc in the plant were 82.4∼254.6㎍g^1, 284.6∼688.4㎍g^1 and 635.5∼1979.4㎍g^1 individually. The tendency of the biological magnification in the each organ of the plant was as follows : Pb an Zn were increased of stem<leaf<root but Cu was leaf<stem<root. The amount of heavy metals in the plant were in the order of Pb<Cu<Zn. The magnification force of heavy metals in the plant were 13.2 times in Pb, 73.2 times in Cu and 58.7 times in Zn to compare with the content of heavy metals in the habitat soil and have a tendency to follow the content of those in the habitat soil but not proportional. In the mixture medium applied heavy metals, Cu induced the Zn depiciency in the plant. Concludly, the P. thunbergii was the excellent plant which removed the heavy metals from the soil and water of the habitat.

Lipoxygenase 결핍된 Non-GM콩의 특성

이수정(Soo-Jung Lee),김인성(In-Sung Kim),이혜진(Hye-Jin Lee),정종일(Jong-Il Chung),성낙주(Nak-Ju Sung) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.10

Lipoxygenase(LOX)가 결핍된 non-GM콩인 개척#1(검정콩, LOX2,3-free), 개척#2(황색콩, LOX2,3-free) 및 진양콩(황색콩, LOX1,2,3-free)의 이화학적 특성과 두부 수율을 LOX가 존재하는 태광콩(황색콩, LOX1,2,3-present)과 비교하였다. 콩의 길이 및 백립중은 태광콩에 비해 개척#1이 유의적인 차이로 컸으며, 황색콩에서는 LOX가 결핍된 품종이 태광콩보다 크기 및 중량이 다소 작았다. 콩을 12시간 동안 수침한 후 콩의 중량 증가율은 217.07~226.55%로 개척#2가 유의적으로 높았다. 전체적인 색차(ΔE)는 개척#1이 유의적으로 높았으며, 3종의 황색콩은 시료 간에 비슷한 경향이었다. 조지방 함량은 태광콩이 17.30%로 유의적으로 높았으며, LOX가 결핍된 콩은 13.71~14.66%로 시료 간에 유의차가 없었다. 조단백질 함량은 개척#1(34.79%)이 타 시료(32.93~33.47%)에 비해 유의적으로 높았다. 구성아미노산 함량은 모든 시료에서 glutamic acid의 함량이 가장 높았으며, 총량은 개척#1이 32.42 g/100 g으로 가장 많았고 개척#2와 태광콩은 비슷한 함량이었다. 이소플라본 함량은 LOX가 결핍된 콩이 태광콩에 비해 더 많았으며, 특히 개척#1(1672.54 μg/g)에서 가장 높았다. 콩의 총 페놀 함량은 개척#1이 276.91 mg/100 g으로 가장 높았으며, 플라보노이드 함량은 개척#1(26.93 mg/100 g)이 타 시료에 비해 2.6~2.8배 정도 높았다. DPPH, ABTS 라디칼 소거활성 및 환원력은 개척#1이 타 시료에 비해 높았다. Non-GM콩으로 제조한 두부의 수율은 개척#2에서 가장 높았다. 황색콩인 개척#2는 이화학적 특성 및 항산화 활성 측면에서 태광콩과 유사하였고 두부 수율이 높아 두부 제조에 적합한 품종인 것으로 사료된다. The properties of non-GM soybeans with lipoxygenase (LOX) free genotypes, such as Gaechuck#1 (black, LOX2,3-free), Gaechuck#2 (yellow, LOX2,3-free) and Jinyangkong (yellow, LOX1,2,3-free), were compared to Taekwangkong (yellow, LOX1,2,3-present) as control. Length and weight of soybeans were significantly longer in Gaechuck#1, but LOX free genotypes of yellow beans was smaller than Taekwangkong, in terms the size and weight. After soaking for 12 hr, increased ratios of soybean weight were 217.07~226.55%, and they were significantly higher in Gaechuck#2. The total color difference (ΔE) to Taekwangkong was the highest in Gaechuck#1, but another yellow soybean were similar. Crude lipids content was significantly higher in Taekwangkong (17.30%), and these LOX free genotypes (13.71~14.66%) did not show significant difference. Crude protein contents were significantly higher in Gaechuck#1 (34.79%) compared to the other soybeans (32.93~33.47%). Contents of glutamic acid among the detected composition amino acid were highest, and its total contents were highest in Gaechuck#1 (32.42 g/100g), and the total content of Gaechuck#2 was similar to Taekwangkong. Contents of total isoflavone were higher in LOX free genotypes than Taekwangkong, especially significantly higher in Gaechuck#1 (1672.54 μg/g). Contents of total phenol were highest in Gaechuck#1 (276.91 mg/100 g), and flavonoids content of Gaechuck#1 (26.93 mg/100g) was 2.6~2.8 times higher than the other samples. DPPH, ABTS radical scavenging activities and reducing power were significantly higher in Gaechuck#1. The yield of soybean curd from tested samples was the highest in Gaechuck#2. Gaechuck#2 as LOX free genotypes was similar to Taekwangkong with regard to physicochemical properties and antioxidant activities. Therefore, we propose that Gaechuck#2 is a more suitable genotype for soybean curd products.

Lipoxygenase 결핍콩으로 제조한 된장의 품질 특성 및 항산화 활성

이수정(Soo-Jung Lee),김인성(In-Sung Kim),호문사(Wen-Si Hu),하은선(Eun-Seon Ha),정종일(Jong-Il Chung),성낙주(Nak-Ju Sung) 한국식품영양과학회 2016 한국식품영양과학회지 Vol.45 No.1

LOX 결핍콩(진양, 05C4 및 LS)의 가공적성을 평가하기 위하여 재래 된장을 제조하여 일반 콩(태광) 된장과 품질 특성 및 항산화 활성을 비교하였다. 된장에서 수분과 조단백질 함량은 LS 된장이 유의적으로 높았으며, 조지방 함량은 7.92~8.22%로 콩 품종에 따른 유의차가 없었다. 탄수화물함량은 LS 된장이 가장 낮았다. 된장의 환원당은 태광 된장에 비해 진양 된장이 유의적으로 높았다. 아미노태 질소 함량은 태광 된장에 비해 3종의 LOX 결핍콩 된장에서 유의적으로 높았다. 된장의 색깔은 태광 된장에 비해 05C4 및 LS된장은 차이가 없었으며, 진양 된장은 두드러진 색차를 보였다. 된장의 구수한 맛은 태광 된장이 다소 높았으며, 짠맛은 LOX 결핍콩 된장이 다소 높게 평가되었다. 향미는 LS 된장이 가장 강한 것으로 인지되었다. 전반적인 기호도는 시료간에 차이가 미미하였다. 총 아미노산 함량은 태광 된장에 비해 진양 및 05C4 된장에서 다소 높았으며, 필수 아미노산은 태광 된장에 비해 3종의 LOX 결핍콩 된장이 높게 정량되었다. 이소플라본의 총량은 태광 된장(374.79 μg/g)에 비해 3종의 LOX 결핍콩 된장(522.16~684.46 μg/g)에서 유의적으로 높았다. 총 페놀 함량은 태광 된장에 비해 05C4 및 LS 된장이 유의적으로 높았으며, 플라보노이드 함량은 LS 된장만 태광 된장에 비해 유의적으로 높았다. DPPH 라디칼소거 활성과 FRAP법에 의한 환원력은 진양 된장이 우수하였으나 ABTS 라디칼 소거 활성은 LOX 결핍콩 된장이 태광된장에 비해 유의적으로 높았다. LOX 결핍콩으로 제조한 된장은 아미노산과 이소플라본의 함량 및 항산화 활성 측면에서 된장 가공적성에 적합한 것으로 판단된다. To evaluate processing suitability of lipoxygenase (LOX)-free genotype soybeans (Jinyang, 05C4 and LS), quality characteristics and antioxidant activities of their Doenjang products were compared to those of Doenjang made from Taekwang soybean (LOX-present) as the control. Moisture and crude protein contents of Doenjang were significantly higher in LS than the control. Crude lipid content was not significantly different and was in the range of 7.92∼8.22% in all samples. Carbohydrate content was significantly lower in LS than Taekwang. Content of reducing sugar in Doenjang was significantly higher in Jinyang than Taekwang. Contents of amino-type nitrogen were significantly higher in LOX-free cultivars than Taekwang. Colors of 05C4 and LS Doenjang were not different compared to that of Taekwang, whereas Jinyang Doenjang showed a noticeable color difference. Taekwang Doenjang had a slightly stronger savory taste than another sample. LOX-free cultivars had a strong salty taste. Flavor was the strongest in LS, whereas overall acceptability showed little difference among all samples. The total amino acid content was slightly higher in Jinyang and 05C4 than Taekwang, and content of essential amino acids was higher in Doenjang from LOX-free cultivars than Taekwang. Isoflavon content was significantly higher in Doenjang (522.16∼684.46 μg/g) made from LOX-free cultivars than in Taekwang (374.79 μg/g). Total phenol content was significantly higher in 05C4 and LS, and flavonoid content was significantly higher in LS than Taekwang. Antioxidant activities were highest in Jinyang based on DPPH radical scavenging and reducing power. ABTS radical scavenging activity was significantly higher in Doenjang made from LOX-free cultivars than Taekwang. These results suggest that Doenjang from LOX-free cultivars could have a suitable genotype for Doenjang processing since it is more effective in terms of amino acids, isoflavone contents, and antioxidant activity.