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아토피 피부염 모델에 대한 β-1,3/1,6-glucan과 Lactobacillus plantarum LM1004의 면역 조절 효과
김인성(In Sung Kim),김성학(Sung Hak Kim),김정아(Jeong A Kim),유다윤(Da Yoon Yu),김광일(Gwang Il Kim),박동찬(Dong-Chan Park),임종민(Jong Min Lim),이상석(Sang Suk Lee),최인순(In Soon Choi),조광근(Kwang Keun Cho) 한국생명과학회 2018 생명과학회지 Vol.28 No.1
본 연구에서는 아토피 피부염 동물 모델에 대한 β-1,3/1,6-glucan과 L. plantarum LM1004의 면역조절 효과를 확인하고자 하였다. 가려움증의 횟수와 유출된 evans blue, 그리고 혈청 IgE와 histamine의 농도는 β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취한 그룹에서 아토피 피부염 유발그룹에 비해 유의적으로 감소하는 결과를 나타내었다. 아토피 피부염이 유발되면 전사 수준에서 Th2 및 Th17 세포의 전사인자 및 cytokine은 과발현되며, β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취하였을 때 이를 유의적으로 감소되었다. 또한 β-1,3/1,6-glucan과 L. plantarum LM1004는 Th1 및 Treg 세포의 전사인자(T-bet, GATA-3, RORγT, Foxp3) 및 cytokine (INF-γ, IL-4, IL-17, TGF-β)의 발현을 증가시킴으로써 면역 균형을 조절하는 것으로 나타났다. Galectin-9과 filaggrin은 아토피 피부염 유발 처리군에서 유의적으로 가장 낮았으며, β-1,3/1,6-glucan 처리군에서 유의적으로 가장 높게 나타났다. 이와 반대로 TSLP는 아토피 피부염 유발그룹에서 유의적으로 가장 높았으며 β-1,3/1,6-glucan과 L. plantarum LM1004를 섭취한 그룹은 대조군과 유사한 수준이었다. 이러한 결과를 통해 β-1,3/1,6-glucan과 L. plantarum LM1004는 아토피 피부염 동물 모델에서 면역조절 작용 및 아토피 피부염의 개선 효과를 가짐을 알 수 있었다. 따라서 β-1,3/1,6-glucan과 L. plantarum LM1004는 아토피 피부염에 유용한 천연소재로서 사용될 것으로 기대된다. In this study, we examined the efficacy of the immune regulation of β-1,3/1,6-glucan and Lactobacillus plantarum LM1004 on atopic dermatitis models. The oral administration of β-1,3/1,6-glucan and L. plantarum LM1004 on mice significantly decreased the amount of scratching, leakage to evans blue, and concentrations of serum immunoglobulin E (IgE) and histamine compared with the atopic dermatitis–induced group. When atopic dermatitis was induced, the transcription factors (GATA-3, retinoic acid-related orphan receptor γ T [RORγT]) and cytokines (interleukin-4 [IL-4], IL-17) of Th2 and Th17 cells were overexpressed at the transcriptional level, and they significantly decreased with oral administration of β-1,3/1,6-glucan and L. plantarum LM1004. In addition, β-1,3/1,6-glucan and L. plantarum LM1004 were shown to modulate the immune balance by increasing the expression of Th1 and Treg transcription (T-bet, forkhead box p3 [Foxp3]) and cytokines (interferon-γ [IFN-γ], transforming growth factor-β [TGF-β]). Galectin-9 and filaggrin were significantly lower in the atopic dermatitis–induced group and significantly higher in the β-1,3/1,6-glucan-treated group. In contrast, thymic stromal lymphopoietin (TSLP) was highest in the atopic dermatitis–induced group, while mice that were orally administered β-1,3/1,6-glucan and L. plantarum LM1004 showed similar TSLP levels to the control group. These results indicate that β-1,3/1,6-glucan and L. plantarum LM1004 have immunomodulatory effects and atopic dermatitis improvement effects in an animal model of atopic dermatitis. Therefore, it is expected that β-1,3/1,6-glucan and L. plantarum LM1004 can be used as natural materials in the treatment of atopic dermatitis.
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난대 상록활엽수림과 곰솔림 임분 특성 및 NVOCs 발산 특성
김광일,김상미,박인택,이계한,오득실,Kim, Gwang-Il,Kim, Sang-Mi,Park, In-Teak,Lee, Kye-Han,Oh, Deuk-Sil 한국환경생태학회 2022 한국환경생태학회지 Vol.36 No.4
This study investigated each forest's stand characteristics and the NVOCs emission characteristics for Quercus acuta, Castanopsis sieboldii, Dendropanax trifidus, Camellia Japonica which are major warm temperate evergreen broad-leaved species, and Pinus thunbergii. Data were collected from May 2019 to January 2020. The seasonal temperature and humidity of each research site indicated the typical climatic characteristics of Korea, which are hot and humid in summer and cold and dry in winter. Also, the atmospheric pressure was generally high in winter and higher in autumn and winter than in spring and summer. Overall, the total volume of NVOCs (Natural Volatile Organic Compounds) from the five research sites was the highest in the summer. The concentration of TNVOCs was relatively high in the Dendropanax trifidus forest in spring and winter, the Castanopsis sieboldii forest in the autumn, and the Quercus acuta forest in the summer. According to the results of this study, it was confirmed that the concentrations of NVOCs emission of warm temperate evergreen broad-leaved species such as Quercus acuta, Castanopsis sieboldii, Dendropanax trifidus and Camellia Japonica were not lower but rather higher than Pinus thunbergii. The correlation was positive (+) between NVOCs emission and temperature (r=0.590, P=0.000) or humidity (r=0.655, P=0.000), whereas it was negative (-) between NVOCs emission and atmospheric pressure (r=-0.384, P=0.000) or wind speed (r=-0.263, P=0.018). Among the micrometeological factors, humidity (β=0.507, P=0.000) was found to have the greatest effect on NVOC emission, followed by temperature, atmospheric pressure, and wind speed.
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간경변증 환자에서 발생한 근경련의 임상적 특성과 염산 에페리손의 효과
김광일 ( Gwang Il Kim ),강선형 ( Sun Hyung Kang ),김정일 ( Jung Il Kim ),채경훈 ( Gyeong Hun Chae ),허원석 ( Won Seog Heo ),정재훈 ( Jae Hun Jeong ),강윤세 ( Yun Se Kang ),김연수 ( Yeon Soo Kim ),박기오 ( Ki Oh Park ),성재규 ( Jae 대한내과학회 2006 대한내과학회지 Vol.70 No.6
Background: Muscle cramps in cirrhotic patients are not serious symptoms but have frequently bad effect on their quality of life. We have evaluated the effectiveness of treatment with eperisone hydrochloride, an antispastic agent, on muscle cramps in cirrhotic patients. Methods: Sixty five cirrhotic patients (cramps 35, no cramps 30) were included in our study. Thirty five patients with muscle cramps were questioned about the frequency and localization of muscle cramps. All patients were evaluated a physical findings and blood chemistry at the beginning of the study and after one month. Eperisone hydrochloride 50 mg per day were given orally to the patients with muscle cramps. Results: There were significant differences for the number of diuretics use (p=0.019), hemoglobin (p=0.005), platelet (p=0.007), total bilirubin (p=0.003), albumin (p=0.000), total calcium (p=0.0001) and Na+ (p=0.001) between with and without muscle cramps. Muscle cramps were found to occur in calf muscles (60%) and hands (54%), to occur several times a week (76%), mainly during sleep (73%) and to last for several minutes (53%). After a month, muscle cramps completely disappeared in 7 patients (20%), decreased in frequency in 18 patients (51%) and were unaltered in 10 patients (29%). Side effects were observed in 7 patients (epigastric discomfort in five, fatigue in two) but any patients were not stopped. Conclusions: Eperisone hydrochloride was significantly effective in treatment for the muscle cramps of the patients with liver cirrhosis. In addition, this agents was well tolerated without any serious adverse effects in the majority of the patients.(Korean J Med 70:643-649, 2006)
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