http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 채양석 (검색결과 122 건)
- 무료
- 기관 내 무료
- 유료
-
타액선 암종세포의 식물응집소 수용체 분포에 관한 면역조직화학적 연구
채양석,염범우,이대일 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1
Malignant tumors of the salivary glands are variable in their histologic pictures, and their histochemical changes in membrane carbohydrate composition have not been fully understood. The author selected formalin fixed, paraffin embedded normal tissue and malignant tumors of salivary gland, and performed immunohistochemical study on the selected tissue materials by avidin biotin peroxidase complex method using lectins such as Concanavalin A (Con A), Soybean agglutinin (SBA), Wheat germ agglutinin (WGA), Dolichos biflorus agglutinin (DBA), Ulex europaeus agglutinin I (UEA I), Peanut agglutinin (PNA), Ricinus communis agglutinin I (RCA I), and Pinellia ternata agglutinin (PTA). The results are summarized as follows: 1. Lectins showing different reaction pattern between normal and malignant tumor cells of the salivary glands were DBA, UEA-1, SBA and PNA. 2. DBA and SBA showed positive reaction with normal duct epithelium, but they did'nt react with malignant turner cells. 3. UEA-1 revealed positive reaction with normal duct epithelium and cancer cells of the mucopeidermoid carcinoma. But it did'nt react with adenoid cystic carcinoma cell and acinic cell carcinoma cell. 4. PNA showed positive reaction with mucoepidermoid carcinoma cell and negative reaction with nor-mal duct epithelium, adenoid cystic carcinoma and acinic cell carcinoma cell. Above findings suggest loss of N-acetyl-galactosaminyl moiety in malignant tumors of salivary gland, loss of L-fucosyl in adeniod cystic cacinoma and acinic cell carcinoma, which are present on normal duct epithelium, and appearance ofβ-D-galactosyl moiety in mucoepidermoid carcinoma which is absent on normal duct epithelium.
-
-
채양석,김인선,백승룡 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.2
The authors reviewed the histopathologic and clinical features of 32 primary prostatic carcinomas seen at Korea University Hospital from 1982 to 1987, and made an attempt to categorize these cases by modified Gleason grading system. Immunohistochemical study for prostate specific antigen (PSA) and prostate specific acid phosphatase(PSAP)by avidin biotin complex method was performed to evaluate the diagnostic usefulness in surgical pathology. The results were as follows. 1. Patient's age at initial diagnosis ranged from 56 to 84 years with a mean of 69. 2. Histologically there were 29 cases of conventional adenocarcinoma, 2 cases of mucinus carcinoma and 1 case of endometrioid carcinoma. By modified Gleason grading system, 6 cases were in below grade 4, 14 cases were in grade 5 to 7, and 12 cases were graded above 8. 3. Immunohistochemically prostatic carcinoma was positive for PSA and PSAP in 30 cases (93.7%), respectively. PSA was diffusely positive in 22 and focally in 8. PSAP was focally positive in 6 and diffusely positive in 24. Four cases in which one of antigens was negative belonged to grade 5 to 10.
-
-
이정규,전지현,김민정,이규재,김한겸,조현득,채양석 大韓法醫學會 1999 대한법의학회지 Vol.23 No.2
Although it is known that hypothyroidism can cause cardiac dysfunction, it is very hard to find a case report on sudden death due to hypothyroidism. There are only two reported cases on mediline; one is about a 15-year-old girl who died suddenly of Hashimoto's thyroiditis and the other is about a 31-year-old man who also died suddenly of hypothyroidism associated with chronic lymphocytic thyroiditis. Recently we found a young woman who unexpectedly died while she was sleeping. She was diagnosed as hypothyroidism when she went to hospital about a month before she died. At autopsy there were roughly four abnormal findings; Hashimoto's thyroiditis, mild chronic active hepatitis, diverticulosis and accessory spleen. Trace of chlorpheniramine was detected in gastric remains and blood alcohol level was 0.37 percent. To our knowledge, this is the first case reporting sudden and unexpected natural death associated with hypothyroidism in Korea.
-
전신성 홍반성 낭창 환자에서 발병된 골 Cryptococcosis 1예
채양석,김우주,김준미,신상원,우흥정,강세용,최윤상,임채승,박승철 대한감염학회 1991 감염 Vol.23 No.3
Cryptococcosis is a systemic fungal infection by Crytococcus neoformans. This mycosis most commonly involves central nervous system, but bone involvement may occur as many as 5-10% of the patients. We experienced a case of bone cryptococcosis in a patient with SLE. The patient was a 28-year old woman, who diagnosed as SLE 3 years ago. She had been treated with immune suppressants such as steroid and cyclophosphamide. She noticed painful erythematous swelling on her left forearm and skin of left breast. X-ray findings showed sclerotic changes on her posterior aspect of left proximal ulnar. Pathologic and microbiologic examination revealed characteristic findings compatible with bone cryptococcosis. The patient was treated with bone curettage and systemic amphotericin B. The clincal symptoms and bone lesion were improved significantly without sequellae.
-
Cahe, Yang Seok,Hedley-Whyte, E. Tessa 고려대학교 의과대학 1996 고려대 의대 잡지 Vol.33 No.2
Flow cytometric analysis was applied to embedded tissue to measure the proliferative activity and the DNA ploidy of sixteen recurrent and seventeen nonrecurrent pituitary adenomas. The results were compared with data from a previous study which demonstrated that proliferationg cell nuclear antigen (PCNA) labelling index was higher in recurrent adenomas than in nonrecurrent adenomas. Flow cytometric analysis as a tool for predicting aggressive behavior has been useful in a variety of human tumors, however its prognostic value in pituitary adenoma is controversial. Therefore we decided to explore the relationship of the results of flow cytometry and proliferating cell nuclear antigen labelling indices with the prognosis of pituitary adenomas. Three out of 16 recurrent adenomas and five out of 17 nonrecurrent adenomas demonstrated a DNAaneuploid pattern. All the nonfunctional recurrent adenomas had a diploid pattern, while only 40% of the functional recurrent adenomas had a diploid pattern. The G0/Gl phase fraction was higher in the recurrent adenomas than in the non- recurrent ones. (p=0.0005) In contrast, the S phase fraction and the coefficient of variation were 1 higher in the nonrecurrent adenomas (5.9 1.0%, 7.0 0.75, respectively) than in the recurrent ones(2.5 0.6%, 4.0 0.2%, respectively) (P=0. 003 and p=0. 001, respectively). The proliferating cell nuclear antigen lavelling indices were higher in the recurrent adenomas (18.9 4.5%) than in the nonrecurrent adenomas (2.6 1.6%) (P=0.003). The S phase of flow cytometry correlated weakly with the proliferating cell nuclear antigen labelling indices when the recurrent and the nonrecurrent adenomas were considered as one group. (r=-0. 356, p=0.033) But no significant correlations were observed when the groups of recurrent (r=0.311, p=0.195) and nonrecurrent tumors (r=-0.019, P=0. 942) were compared separately. The results of flow cytometric analysis suggests that recurrent adenomas may have a higher proportion of cells in the presynthetic phase than the nonrecurrent adenomas. This study suggests that flow cytometric analysis is of limited value in predict- ing recurrence of pituitary adenomas.
-
정지윤,채양석,강영진,이유진,김어진,안보경,이은정,김주영,이정현,이영석,김철환 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.2
Background: Colorectal cancer (CRC) is one of the most common malignancies worldwide. Approximately 10%–15% of the CRC cases have defective DNA mismatch repair (MMR) genes. Although the high level of microsatellite instability status is a predictor of favorable outcome in primary CRC, little is known about its frequency and importance in secondary CRC. Immunohistochemical staining (IHC) for MMR proteins (e.g., MLH1, MSH2, MSH6, and PMS2) has emerged as a useful technique to complement polymerase chain reaction (PCR) analyses. Methods: In this study, comparison between the MMR system of primary CRCs and paired liver and lung metastatic lesions was done using IHC and the correlation with clinical outcomes was also examined. Results: Based on IHC, 7/61 primary tumors (11.4%) showed deficient MMR systems, while 13/61 secondary tumors (21.3%) showed deficiencies. In total, 44 cases showed proficient expression in both the primary and metastatic lesions. Three cases showed deficiencies in both the primary and paired metastatic lesions. In 10 cases, proficient expression was found only in the primary lesions, and not in the corresponding metastatic lesions. In four cases, proficient expression was detected in the secondary tumor, but not in the primary tumor. Conclusions: Although each IHC result and the likely defective genes were not exactly matched between the primary and the metastatic tumors, identical results for primary and metastatic lesions were obtained in 77% of the cases (47/61). These data are in agreement with the previous microsatellite detection studies that used PCR and IHC.
-
방광의 이행세포암종에서 변이된 p53종양억제유전자와 hsc70단백 및 nm23단백 발현에 관한 비교 연구
김종우,채양석 고려대학교 의과대학 1996 고려대 의대 잡지 Vol.33 No.2
The author investigated the structural change of the p53 gene to elucidate the molecular difference between superficial and invasive transitional cell carcinomas of urinary bladder by polymerase chain reaction single-strand conformation polymorphism analysis. Also this result was compared with the immumohisto-chemical expression of hsc70 and nm23 proteins. In thirty four bladder carcinomas p53 gene mutations were investigated in exon 5 to 8. Only one of 11 superficial carcinomas was found to have p53 gene mutation in comparison to 7 carcinomas (30.4%) of twenty three invasive carcinomas. Among them six cases were mutated in exon 8 of p53 gene, one case in exon 5 and 8. But no mutation in exon 7 existed. The expression rate of hsc70 was higher in the poorly differentiated tumors (p<0.05) and in the deeply invasive tumors. (p<0.05) Also the expression rate of the hsc70 was higher than p53 mutation or nm23. In the cases of mutated p53 gene, hsc70 protein was highly expressed but not with nm23 protein. The expression of hsc70 protein was the best prognostic indicator in invasive carcinomas among three candidates.
-
RISS연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
