정상 한국인에서 연령증가에 따른 혈장 Dehydroepiandrosteronesulfate ( DHEA-S ) 농도 및 DHEA - S / cortisol 비의 변화

박성우,유형준,임성희,최문기,유재명,박민숙,이권엽,박철수,김철홍,김현규,김두만,박규용 대한내분비학회 1997 Endocrinology and metabolism Vol.12 No.2

Backgroud: DHEA-S is the most abundant steroid hormone in circulation, and primarily secreted from the adrenal cortex, but its physiological role is little known. One of the characteristic features of DHEA-S is progressive decrement of plasma DHEA-S level with advancing age, in contrast, plasma levels of other adrenal hormones are not chaging or littie decreasing. To grasp the trends of plasma DHEA-S level and DHEA-S/cortisol ratio by age in healthy Korean, we measured the plasma DHEA-S levels and DHEA-S/cortisol ratios in healthy Korean. Methods: Healthy Korean(men: 99, women: 102, age range: 15-97 year old)were studied. Subjects were not taking drugs(such as glucocorticoid or androgenic medication) or cigarettes known to modify the plasma level of DHEA-S and cortisol, and had no evidence of hepatic, renal disease or hyperlipidemia as determined by serum lipid, bilirubin, SGOT, SGPT, BUN, creatinine. Data were analyzed by 10-year age group for men and women: i.e, 10-19, 20-29, 30-39, 40- 49, 50-59, 60-69, 70-79, 80-89 and 90 year or more. Plasma DHEA-S levels were measured by using a commercially available RIA kit with 125I labeled-DHEA-SO4(Coat-A Count DHEA-SO4), and for the measurement of plasma cortisol levels, commercial Gamma Coat TM[125I] Cortisol Radioimmunassay Kit was used. Results:. 1) In both men and women, plasma DHEA-S level showed high interindividual variation within the same age group. 2) There were individual sex differences in plasma levels of DHEA-S, in all age groups, plasma DHEA-S levels were significantly higher values for men than for women. 3) Maximum plasma DHEA-S levels(men; 237+-3.35 ug/dL, women; 108+-17.5 ug/dL) were at third decade in both men and women. 4) Both men and women showed the continuous decline in plasma DHEA-S level with age. These age-related decline was more prominent in men than in women(men; y= -3.152 * +292.6, r2= 0.8459, P$lt;0.05, women; y= -1.417 * +143.3, r2 = 0.7278, P$lt; 0.05). 5) As an index of aging, there was no stastical difference between DHEA-S and DHEA- S/cortisol ratio. Conclusion: In healthy Korean, there were high interindividual variation of plasrna DHEA-S levels. In both men and women plasma DHEA-S level was peak at third decade, and from when it declined progressively with age. These results suggest that although the reliability of single plasma DHEA-S measurement are limited, the decline of DHEA-S with advancing age might be a specific marker of endocrinologic hormonal milieu(aging index). Also, concerning to individual adrenal secreting capacity, we measured DHEA-S/cortisol ratio. But we did not found that plasma DHEA-S/cortisol ratio is superior to the plasma DHEA-S level as an aging index. (J Kor Soc Endocrinol 12:245-254, 1997)

제2형 당뇨병 환자의 치료에서 복약순응도가 혈당 조절에 미치는 영향

김경선,김민정,박소현,박영주,허정순,이은경,김선영,이수형,김상수,강양호,손석만,김인주,김용기 한국병원약사회 2009 병원약사회지 Vol.26 No.2

Abstract: As known in clinical trial like DCCT, UKPDS, tight glycemic control is essential to prevent complications from diabetes mellitus(DM). In type 2 diabetes taking multiple medication, nonadherence to medications is common problem. The aim of our study is to investigate adher-ence rate of patients with type 2 DM and to evaluate association between many factors including adherence rate and HbA_(1C). 441 patients with type 2 DM who visited Busan National University Hospital endocrine internal department from Aug 13 to Sep 2, 2008(3weeks) were enrolled. We conducted a man-to-man questionnaire survey about general knowledge about diabetes mellitus, medicine and adherence, and measured HbA_(1C). Among them, 305 patients taking oral hypo-glycemic agent(OHA) were analyzed to investigate correlation between adherence rate and glycemic control. We studied 305 patients(male 126, female 179, average age 61.2±9.8 years, DM duration 8.6±6.4 years, average adherence 88.8±16.2%, average HbA_(1C) 7.03± 1.18%). HbA_(1C) showed significant relation with DM duration(r=0.137, p=0.017), number of aHA in regimen (r=0.135, p=0.018), dosage frequency(r=0.132, p=0.026), Medication Refill Adherence(MRA)(r=-0.124, p=0.030) and adherence(r=-0.168, p=0.003). Adherence had significant relation with MRA(r=0.148, p=0.010) but didn't have statical corelationship with DM duration, number of aHA and dosage frequency. Patients that their adherence rate exceed 90% took fewer OHA(p=0.011) and went on a better dietary treatment(p=0.007). In patients controlling diabetes mellitus with aHA, when adherence rate and MRA was higher, HbA_(1C) was lower. As a result, to improve adher-ence rate, it is necessary to enhance patient education, do careful consideration about prescrip-tion medicine number and dosage frequency

수용성 키토산 유도체를 이용한 방사성 스트론튬의 시험관내 흡착능 및 마우스내 체외배출 효과

김희경,송해미,조덕제,조만기,이정석,이응호 동서대학교 부설 연구소 1996 연구소 논문집 Vol.1 No.-

키토산은 천연착화제로서 효용가치가 높은 무독성의 천연고분자로서 키틴으로부터 탈아세틸화시킨 유도체이다. 키토산에 인산기을 도입한 Water-solubel phosphorylated Chitosam(WSPC)의 Sr에 대한 시험관내 흡착률은 pH 3에서는 97.8%이었으나, pH 5와 pH 7에서는 모두 100%이었다. WSPC를 농도별(0.01%, 0.1%, 1%)로 희석하여 11주령의 ICR 수컷 마우스의 위내로 투여한 직후 Sr을 같은 경로로 처리한 다음, WSPC의 Sr에 대한 체외 배출효과와 골내 잔존률을 평가하였다. 또한 Sr와 농도별 WSPC 처리후 6일째에 척추, 두개골, 대퇴골, 경골, 치아 및 꼬리뼈 등에 대해 Sr 잔존율을 측정하였다. 0.01-0.1% 사이의 WSPC를 접종한 마우스 투여군이 Sr만 경구 투요한 대조군에 비하여 골조직에 잔존하는 Sr의 침착률이 낮게 나타났다.(P<0.01). 또한 방사성 스트론튬의 분뇨를 �蔥�배출 효과 역시 WSPC 처리군이 대조군에 비해 유의성이 인정되었고(P<0.05), 대체로 WSPC 농도가 높을수록 그 효과는 비례하였다.(P<0.05). 본 실험에 사용된 WSPC는 체내에 유입된 Sr을 제거하는데 효과가 인정되어 방사성 스트론튬의 방어약제중 하나로 활용할 수 있다고 판단되었다.

농업구조물의 안전진단 및 개·보수 공법 선정 시스템 개발

김종옥,고만기,최진용,김기동,윤광식,김한중 公州大學校 産業開發硏究所 1998 産業開發硏究 Vol.6 No.-

A study was conducted to develope a system for safety appraisal and repair works on agricultural structures. Location, size, type, maintenance record, structural and functional problems of agricultural structures in Yedang irrigation district were surveyed. A grahpic user interface program assisting onsite field investigation of typical agricultural structural problems such as fractures and cracks of members was developed. Typical rehabilitation methods were investigated and coded for database development.

빛의 파장에 따른 광합성 미세조류의 성장

김현주,이정석,조만기 동서대학교부설연구소 1998 연구소 논문집 Vol.3 No.-

The growth of photoautotrophic organism such as microalgae occurs through photosynehesis in which light is the basic limiting factor in terms of photobiology and photobiotechnology. The light harvesting pigments found in microalgae are chlorphyll, phycobiliprotein and carotenoid. The concentration of photosynthetic pigments and growth are effected by the environment-specifically, photonflux density. Therefore, adaptations of microalgae to photon flux density were studied and compared in Chlorella vulgaris and Spriulina platensis. Chlorella vulgaris and Spirulina platensis were cultured under illumination of red, green, blue, and white spectrum light with equivalent photon flux density(77 μ Em??s?? between 400 and 700nm). Cultures of Cholorella vularis grown under red, green, blue and white light expressed similar maximum specific growth rates (1.3842 day??, 1.3250 day??, 1.4226, 1.4609 day??, respectively). However, maximum specific growth rates of spirlina platensis in red(0.8142 day??) and white (0.7493 day??) light-grown culture were higher than those in green (0.4404 day??) and blue light (0.4485 day??). Since phycobiliproteins aborbed and orange light were associated with photosystemⅡ and transfered absorbing light energy predominatly to photosytem Ⅱ, red and white light including light-absorbing spectrum of phycobiliprotein were effective for growth of Spirulina platensis.

연성 방호구조물의 입력변수에 대한 동적 퍼포먼스 민감도 분석

김기동,고만기 공주대학교 방재연구센터 1997 공주대학교 방재연구센터 논문집 Vol.1 No.-

To evaluate the performance of safety appurtenances computer simulation is inevitable in the domestic situation that full scale crash test is not implemented. But, to improve the accuracy of computer simulation, it is important to reasonably determine the input parameters in which the interaction of vehicle-guardrail-soil should be accounted for. This study is focused on how to enhance the reliance of the dynamic performance of guardrail obtained by computer simulation. Analyses were done on the sensitivity of output variables to the change of input parameters by using BARRIER VII of which the usefulness was proved on the barrier-vehicle impact analysis. Through the analyses important input parameters, which give sensitive effects to output of computer simulation, are found out, and methods to determine such parameters are suggested to improve the accuracy of simulation.

평판형 열교환기에 사용되는 얇은 사각 튜브의 동적 특성

김기만 國立金烏工科大學校附設生産技術硏究所 1994 産業技術開發硏究 Vol.10 No.-

The principal problem in the design of the plate-type heat exchanger is the potentiality of structural instabilities due the fluid loading effect during operations. Excessive plate deflections would eventually result in permanent deformation or collapse which would cause an obstruction of the fluid flow in the narrow channels. In this study, a Fluid-structural interaction model was developed to investigate analytically the dynamic characteristics of thin rectangular tube used in the plate-type heat exchanger. The model consists of two flat plates separated by water. The effects of the internal fluid in the channel was studied. As results, the natural frequency coefficients were investigated for the plate aspect ratios, channel heights, and boundary conditions.

국부적으로 집중질량을 가진 횡으로 진동하는 보의 공진 진동계수

김기만,임승관 金烏工科大學校 1997 論文集 Vol.18 No.-

The object of this study is to analyze the additional inertial effect caused by the local irregularity or the lumped mass being attached to the uniform beam. The additional masses are considered as a point mass and a locally distributed mass. The method of variation of parameters is employed to solve the response of the dynamic system. Dynamic response of beam is analyzed by physical features of the masses attached to the beam, Two edges of beam are assumed to be simply supported. The resonant frequency coefficients caused by harmonic force were evaluated as magnitudes and locations of additional masses. The dimensionless deflections of a beam are plotted versus length of beam at near the first resonant frequency.

불확실한 질량점을 지닌 현의 진동 특성

김기만 國立金烏工科大學校附設生産技術硏究所 1995 産業技術開發硏究 Vol.11 No.-

본 논문에서는 연속체인 현에 불확실한 질량점이 부과 되었을 시 나타나는 진동 특성을 이론적으로 해석하였다. 균일한 질량분포를 지닌 현과 비교하여 불확실한 질량점이 주어진 현의 동적거동의 특성을 기본적인 통계를 응용하여 분석하였다. 전체 계의 질량은 일정하다고 가정하여 주어진 질량점의 크기 (전체 질량의 30%이내로 한정)와 위치를 임의로 선택한 100개의 견본을 사용하여 계의 공진주파수와 동적응답에 대한 평균값과 표준편차를 구하여 각각의 분표를 검산하였다. 결론적으로 공진주파수는 질량점의 부가로 인한 변화가 균일한 질량 분포의 현과 비교하여 5% 이내의 편차로 나타났고 외력에 의한 계의 동적응답은 외력의 위치가 그 계의 절점이나 근처에 주어질 때는 질량점의 불확실성에 따라 편차가 심해 지는 것으로 나타났다.

후천성 이중 유문 1예

정규성,조기섭,정재용,조영호,민영돈,박찬국,김만우 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.1

Double pyrolus, one of the relatively rare anomalies of the gastrointestinal tract, is a fistulous communication between the gastric antrum and the duodenal bulb. The first case of a double Pylorus was reported in 1969 by Smith, since then several cases have been reported. Recently, as the frequency of examining upper gastrointestinal series and endoscopy increases, it occurs more frequently and a few cases have been described in our country. According to the reports previously published, it resulted only from cysts, diverticla, atresia, band, membrane malformation of the pylorus, however, it might be also caused by penetration, complication of peptic ulcer. We report a case of double pylorus in a 67-year old man with prolonged administration of corticostetoids due to lumbago who has complained epigastric pain which was confirmed by endoscopy and biopsy.