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임승관,최영화,박인휘,이위교,김현경 연세대학교의과대학 2012 Yonsei medical journal Vol.53 No.1
Purpose: There is a concern on which antimicrobials are appropriate as empirical agents for community-onset acute pyelonephritis (APN) in regions where the fluoroquinolone resistance rate is high, such as in Korea. Materials and Methods: Three hundred and two strains of E. coli in 2001-2002 and 349 strains in 2008-2009 were isolated from the urine cultures of female adult APN patients, and the antimicrobial susceptibility was compared according to each study period. All the patients were classified as uncomplicated or complicated APN, and a subgroup analysis was done thereafter. Results: The E. coli strains isolated in 2008-2009 showed improved susceptibility to trimethoprim-sulfamethoxazole compared to those isolated in 2001-2002. However, the third generation cephalosporin and gentamicin susceptibility was worsened. Of the 232 isolates from the uncomplicated APN patients, there was no difference between the two different time periods. On the other hand, of the 419 isolates from the complicated APN patients, the susceptibility to third generation cephalosporin, gentamicin and ciprofloxacin was significantly worsened. Conclusion: The antimicrobial susceptibility of E. coli changed over the study period, however, this change occurred mainly in the complicated APN patients. In Korea, ciprofloxacin is still useful as an empirical agent for uncomplicated APN patients, but this is not the case for patients with complicated APN because of high resistance rate to ciprofloxacin in these patients. For the complicated APN patients, the rate of resistance to ciprofloxacin is already more than 30%.
임승관,정재욱,송현주,이영목,서유진,남동호,박해심 대한내과학회 2002 대한내과학회지 Vol.63 No.5
Anaphylaxis is the most common systemic allergic reaction caused by bee stings. Delayed-type allergic reactions, including serum sickness, occur much less frequently. We report a 27-year-old man who developed serum sickness reaction nine days after multiple bee-stings. He had complained of erythematous skin rash, fever, arthralgia, myalgia and proteinuria. High specific IgE to bee venoms (honeybee, yellow jacket, yellow hornet) were observed by CAP system and C3, C4 and circulating immune complex levels measured by C1q binding assay showed normal values. We report a case of serum sickness reaction caused by multiple bee stings.
임승관,이상오,최성호,최재필,김성한,정진용,최상호,우준희,김양수 대한의학회 2011 Journal of Korean medical science Vol.26 No.3
Despite the identification of Acinetobacter baumannii isolates that demonstrate susceptibility to only colistin, this antimicrobial agent was not available in Korea until 2006. The present study examined the outcomes of patients with multidrug resistant (MDR)Acinetobacter species bloodstream infection and who were treated with or without colistin as part of their regimen. The colistin group was given colistin as part of therapy once colistin became available in 2006. The non-colistin group was derived from the patients who were treated with other antimicrobial regimens before 2006. Mortality within 30 days of the onset of bacteremia occurred for 11 of 31 patients in the colistin group and for 15 of 39 patients in the non-colistin group (35.5% vs 38.5%, respectively, P = 0.80). Renal dysfunction developed in 50.0% of the 20 evaluable patients in the colistin group, but in 28.6% of the 35 evaluable patients in the non-colistin group (P = 0.11). On multivariate analysis, only an Acute Physiological and Chronic Health Evaluation II score ≥ 21 was associated with mortality at 30 days. This result suggests that administering colistin,although it is the sole microbiologically appropriate agent, does not influence the 30 day mortality of patients with a MDR Acinetobacter spp. bloodstream infection.
국부적으로 집중질량을 가진 횡으로 진동하는 보의 공진 진동계수
김기만,임승관 金烏工科大學校 1997 論文集 Vol.18 No.-
The object of this study is to analyze the additional inertial effect caused by the local irregularity or the lumped mass being attached to the uniform beam. The additional masses are considered as a point mass and a locally distributed mass. The method of variation of parameters is employed to solve the response of the dynamic system. Dynamic response of beam is analyzed by physical features of the masses attached to the beam, Two edges of beam are assumed to be simply supported. The resonant frequency coefficients caused by harmonic force were evaluated as magnitudes and locations of additional masses. The dimensionless deflections of a beam are plotted versus length of beam at near the first resonant frequency.
전정안구반사를 이용한 평형감각 평가용 시뮬레이터의 개발
임승관 ( S. K. Lim ),김규겸 ( H. C. Jeong ),정호춘 ( G. K. Kim ),진달복 ( D. B. Jin ),김민선 ( M. S. Kim ),박병림 ( B. R. Park ) 한국감성과학회 1997 연차 학술대회 논문집 Vol.1997 No.-
The purpose of this study was to develop a sinusoidal rotatory chair systim for evaluating the vestibular function in patients suffered from vertigo with vestibualr disorders. The sinusoidal rotatory chair system is composed of a rotatory chair system and softwares. Maximum velocity of the rotatory chair was upto 60 degree per second and frequency range was 0.01 to 0.64 Hz. To evaluate the vestibular function in vertigo patients, vestibuloocular reflex was measured by sinusoidal rotation of the whole body about vertical axis in the darkness, and optokinetic nystagmus, visual vestibuloocular reflex , and visual supression test were also performed. Eye movement was measured by means of a electronystgmograph amplifier through Ag-AgCI surface electrodes. Gain, phase, and symmetry were obtained from analysis of the eye movement ineuced by vestibular or visual stimulation. In healthy adults, sinusoidal rotation of the shole body produced nystagmus, of which gain was directly proportional to the velocity of stimulation. The gain of visual vestibuloocular reflex was greater than that of vestibuloocular reflex or optokinetic nystagmus, and it was suppressed markedly by visual suppression test. These results suggest that the sinusoieal rotatory chair system which was developed by this study can evaluate the vestibular function quantitatively, also this system is very useful to diagnose the vertigo patients with vestibular disorders and to estimate the vestibualr function during recovery from vertigo.