EFFECTS OF LIDOCAINE ON SOMATOSENSORY EVOKED POTENTIALS IN RAT VIBRISSA/BARREL CORTEX

남순현,최병주,김현정,이만기,김영진,이혜숙 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.3

본 실험은 삼차신경 자극으로 발생되는 체성 감각 유발 전위에 대한 국소마취제의 효과를 관찰하였다. 나트륨 통로차단을 통하여 약리작용을 나타내는 것으로 알려져 있는 리도카인를 뇌 피질에 국소 투여한 후 삼차신경의 체성 감각유발 전위의 강도및 지연시간을 측정하였다. 케타민으로 마취된 흰쥐의 대측성 구레나룻 자극후 뇌의 체성 감각영역으로부터 기록되는 유발전위를 분석한 결과, 리도카인을 뇌 피질에 국소 투여시 유발전위의 강도 및 지연시간의 감소가 나타났으며, 필드 전위의 형태는 이상성(양극성 및 음극성) 혹은 삼상성(양극성, 음극성 및 양극성)의 파형으로 나타났다. 필드 전위의 발생 부위는 뇌 피질의 중대뇌동맥의 상행지 상방영역이었다. 본 실험에서 나타난 초기 전위변동은 피질판 상층에 존재하는 신경세포의 탈분극 과정에 의하여 생성되고 후기 전위 변동은 피질판 상층에 존재하는 신경세포의 탈분극 과정에 의하여 생성되고 후기의 전위 변동은 동일 영역의 하층 신경세포에서 과분극 혹은 재분극이 발생한 결과라고 유추된다. 따라서 삼차신경계의 체성 감각 영역에서는 피질 상층및 하층의 과립성 피라미드 세포의 순차적인 활성화에 의하여 기본적인 신경 회로망이 형성되어 있으며 생리적 자극으로 유발되는 필드 전위는 이러한 신경망를 통하여 발생될 것으로 사료된다.

성견의 2급 치근 분지부 결손에서 자가골막 이식에 의한 치주조직 재생

남승지,정현주,김영준 전남대학교 치과대학 2000 전남치대논문집 Vol.12 No.1

Autogenous periosteal grafts are the attractive alternative to existing barrier membrane materials since they meet the reqiurements of an ideal material. But no histological data are available on the effectiveness of periosteal membranes in the treatment of periodontal defects. The purpose of this study was to evaluate effect of autogenous periosteal graft on periodontal regeneration histologically. Calss Ⅱ furcation defects were surgically created on the second, third and the fourth premolars bilaterally in the mandibles of six mongrel dogs. The experimental sites were divided into three groups according to the treatment modalities; control group - surgical debridement only : Group Ⅰ- autogenous periosteal membrane placement after surgical debridement; Group Ⅱ- autogenous periosteal membrane placement after surgical debridement and bone grafting. The animals were sacrificed at 2, 4 and 12 weeks after periodontal surgery and the decalcified and undecalcified specimens were prepared for histological and histometrical analysis. Clinically all treated groups healed without significant problems. Under light microscope, at 2 weeks, control group showed significant apical epithelial migration and bone remodelling only below the notch area. But for the groupⅠ, Ⅱ with autogenous periosteal graft, less apical migration of epithelium appeared and large amount of osteoid tissue was showen above the notch area. Grafted periosteal membrane was indiscernable at 4 weeks, so periosteal membrane might be organized to surrounding tissues. Histometrically, at 4 and 12 weeks, all the test and control groups didn't show significant change of epithelial zone but new attachment level tended to be gained in the test groups than control group. These results suggest that autogenous periosteal grafts could be a good alternative for guided tissue regeneration.

항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

Escherichia coli 패혈증 환자에 합병된 대칭적 하지 말단 괴사증 1예

남해성,유진홍,권순석,민준기,조현선,박민경,심병주,남유정,이지인,김진수,길욱현,조근종,신완식 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

We have encountered a rare case of symmetrical peripheral gangrene complicating Escherichia coli sepsis in a 47-years-old male. He was successfully treated with antibiotics, anticoagulants, and vasodilator. To our knowledge, this is the first report on symmetrical peripheral gangrene complicating E. coli sepsis in Korea.

창녕지역 농촌생활용수 암반지하수의 수질과 분포암석과의 관계연구

박현주,박종남,이재경,박인석 東亞大學校 環境問題硏究所 2005 硏究報告 Vol.27 No.1

As of the end of 2001, even though about 89% of the population throughout the country are blessed with water service, areas of seashore, island and parts of inland are still in difficulties with drinking water. For this reason, the water resources project for stable supply by developing groundwater has been conducted since 1992, under the auspices of Ministry of Agriculture & Froestry. As of 2003, a total of 594 project areas have been completed in the Gyeongsang Province by the KARICO Gyeongnam Branch. Among these, 60 samples in the Changyeong area developed since 1999, were chosen for chemical analysis of groundwater developed in varieties of rock. As a result, there appears excess fluorine in the granite, gneiss and diorite in this area. Correlation analysis between rock type and groundwater chemistry show that the fluorine has high correlation with Fe and aluminum in diorite, and nitrate nitrogen in the andesite rock, while hardness, total solids and SO^(2-)_(4) have high correlations each other not only in sedimentary rocks but also in all other types of rocks. It has been known that the TDS (fluorine, hardness, total solids, and SO^(2-)_(4)) of groundwater increase with depth due to water rock interaction by increasing the amount of pumping rate at the well. However, in this study, the well depth and groundwater chemistry show little correlation in between. This may be partly due to limited number of samples used in the study with a total of 46 points suitable for drinking water. It may be thought that well distributed sampling points with more samples throughout the whole area should be collected for analysis, so as to increase reliability in the result.

초등학교 고학년과 중학년의 주행변인 비교분석

조현영,정남주 호남대학교 2008 학술논문집 Vol.29 No.2

The purpose of this study was to investigate the kinematical analysis on the running motion of elementary students. The subject of this study was 12 healthy elementary students. A scholastic year were divided into 2 group : high group[6 grade], middle group[3 grade]. The following findings are obtained: It's appear that time ratio of the stance and swing in running motion about high group was 56% vs 44%, and this result was effected to wide step and stride length. Also, it's appear that displacement of center of gravity about high group was larger than middle group, and this result was effected to the horizontal velocity of center of gravity. Trunk angle was slanted to the running direction and upper arm rotation in shoulder angle was larger than middle group. And then this result was effected to the lower extremity movement. It's appear that time ratio of the stance and swing in running motion about middle group was 61% vs 39%, and this result was positively effected to narrow step and stride length. Also, it's appear that displacement of center of gravity about middle group was less than high group, and this result was effected to the low horizontal velocity of center of gravity. Trunk angle was slanted to the running direction and upper arm rotation in shoulder angle was less than high group. And then this result was negatively effected to the lower extremity movement.

Propylthiouracil에 의한 중증 급성간염 1예

임종주,심미령,이명수,김태현,오석규,안선호,박무림,김남호,박병현,조성구 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2

PTU에 의한 간염의 발생은 매우 드물게 발생하는 것으로 알려져 있으나 저자들은 Graves씨 병으로 진단 받고 propylthiouracil 투여를 받고있던 환자에서 중증의 급성 간염이 발생한 1예를 경험하였기에 보고하는 바이다. Propylthiouracil is widely used to treat patients with hyperthyroidism. This drug has been associated with severe hepatotoxicity rarely. We presented the case of jaundice and profound liver dysfunction from a 23-year old woman treated with propylthiouracil for hyperthyroidism. Viral, metabolic, and autoimmune liver disease could be excluded and liver biopsy revealed a pattern of acute hepatitis. After discontinuing the drug, there was a progressive resolution of hepatic symptoms and decrease in biochemical data of the liver. Despite propylthiouracil induced hepatitis in rare case, patients receiving propylthiouracil are exposed to develope severe hepatotoxicity. Therefore it might be advisable to monitor level of the transaminase on regular base from patients receiving propylthiouracil.

사회복지 현장의 수퍼비젼 방식 연구

양정남,최은정,정현주 동신대학교 2006 論文集 Vol.16 No.-

The purpose of supervision is to provide clients with the best service. In essence, supervision is a systematic exercise which is realized on the basis of communication and decision-making between a supervisor and a supervisee. The process of supervision is accomplished through good communication. Thus, in order for the supervision to function well in a social welfare agency, not only the contents of the supervision but the way of forming the supervision is seriously taken into account. Even though the supervision content is of good quality and the speciality of the supervisor ensured, the primary purpose and object of the supervision can hardly be achieved unless the communication between the supervisor and the supervisee is effective. For this reason, this study looks into the issue of the process of supervision deliverance and communication, and suggests an application of Shared Decision making, an educational theory, to the supervision for a better outcome. In the 1980s, a startling vision of education's future began appearing in reform proposals: school run by committees of teacher, without an administrator in sight. Since then, SDM has become a significant part of school-reform. SDM is the process of making educational decisions in a collaborative manner at the school level. The purpose of SDM is to improve school effectiveness and student learning by increasing staff commitment and ensuring that schools are more responsive to the needs of their students and community. SDM as a social work supervision model involves six main safeguards and benefits, which are as follows. ① Peer review of professional decisions ② It ensures that no client's liberty is affected(eg coming into care) without scrutiny of that decision. ③ It ensures clients are not left in unacceptable risk situations on the basis of a single individual's assessment or action. ④ It ensures that professionals are not put into a position where situations may exceed their knowledge, skills or experience or where they are having to manage very stressful and emotional situations. ⑤ Protection of the Agency: SDM has the responsibility to safeguard and ensures the importance of both supervisor and agencies role. ⑥ It encourages openness and collective responsibility.

사회복지 수퍼비젼의 장애 요인 분석 : 기관·운영주체의 관점을 중심으로

양정남,최은정,정현주 동신대학교 2006 論文集 Vol.16 No.-

This study analyzes obstacles to supervision which is un being carried out in social welfare agencies in Korea. The study discusses solutions to resolve the issues identified. The present practices of supervision in the agencies is not systematic or practical. Rather, it seems that it is just a nominal supervision named for convenience of the administrative instruction of service. Many researchers suggest various reasons for this process; however, this research notes that a significant difference exists between the supervision of the agencies and that carried out by social workers. In many research papers, it is stated that social workers as a supervisee prefer educational supervision, whereas the administrative supervision is favored by the agencies and the supervisors. Almost all the supervisors are committed to follow the agencies policy on supervision. For this reason, it may be essential to remove the structural obstacles and give the supervisor more flexibility and choice. Agencies view social work supervision from two main perspectives. Firstly supervision is viewed as a purchase rather than an expenses This perspective considers supervision as a production cost rather than a revenue producer. As a production cost the agency needs to manage supervision so that it does not: a. increase the cost of producing outcomes. b. reduce the volume of outcomes produced, therin reducing the amount of revenue available to the agency. The second perspective that agencies' view social work supervision as a risk management system which protects the agency from being blamed for unethical and unprofessional practice by its social workers and social work supervisors. I, therefore, suggest four solutions to help resolve the issues. a. ensure professionalism of social workers. b. ensure that the agencies are fair and democratic. - Social worker and client group should be independent from management. c. improve the assessment methods of social welfare agencies. d. introduce a certificate for the supervisor and an independent professional outside supervisor.

조혈모세포이식환자에서 조혈기능의 회복과 관련된 인자들에 관한 연구

정기주,강명수,권기두,김경하,이상철,김현정,배상병,김찬규,이남수,이규택,원종호,홍대식,박희숙 순천향대학교 의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

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