정신보건관련시설 입원(소)자의 주요 정신장애 유병률 : 전국 20개 시설의 입원(소)자를 대상으로

조성진,조맹제,서동우,함봉진,홍진표,배재남,이준영,이동우,박종익,전홍진,김성주,김용익 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.6

Objectives : One of the objectives of this study is to estimate the prevalence rates of psychiatric diagnoses in the combined populations of psychiatric hospitals, psychiatric nursing facilities and homeless asylums using the Korean version of the Composite International Diagnostic Interview (K-CIDI), which is a comprehensive and fully standardized interview schedule to assess psychiatric disorders for diagnosis. The Other objective is to compare with previously studied prevalence rates of Psy-chiatric diagnoses using the results of this study. Methods : The study subjects, aged from 181o 64 years, were randomly selected from 64,582 institutionalized population of psychiatric hospitals, Psychiatric nursing facilities and homeless asylums as of 30, June, 2001. Twelve trained interviewers administered the K-CIDI to the selected respondents. A total of 1,875 respondents (male 1,194, female 681) completed the interview. Results : The lifetime and one year prevalences of any diagnosis excluding nicotine dependence · withdrawal, anxiety disorder, eating disorder, somatoform disorder were 88.2% (male 88.1%, female 88.3%), and 65.8% (male 62.7%, female 73.7%), respectively. The lifetime and one year prevalences of schizophrenia and other psychotic disorders were 78.5% (male 75.3%, female 83.7%), and 56.8% (male 51.9%, female 64.8%), respectively. The lifetime and one year prevalences of alcohol use disorder (dependence/abuse) were 26.7% (male 37.9%, female 8.3%), and 8.7% (male 12.8%, female 2.1%), respectively. The lifetime and one year prevalences of mood disorder were 18.1% (male 13.5%, female 25.8%), and 10.4% (male 7.2%,female 16.9%), respectively. The lifetime and one year prevalences of schizophrenia and other psychotic disorders were comparable with the 2001 community survey by 1.19% to 1.32%, and 0.51% to 0.61%, respectively. The lifetime and one year prevalences of schizophrenia were also comparable by 0.16% to 0.28%, and 0.16% to 0.25%, respectively. There were no significant changes of prevalence rates when correction were applied to other psychiatric diagnosis. Conclusion : The results of this study could be used for evaluating the distribution of psychiatric diagnoses in mental health related facilities and for planning mental health policies.

저장 온도 및 상대습도가 비타민 정제 중 지용성 비타민 함량의 변화에 미치는 영향

김동섭,이재황,김세곤,이동언,박석준,이진희,이강표,최성원,백무열 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.26 No.1

工業敎育大學 敎育改善에 관한 硏究(Ⅲ)

宋周鎬,李昌岬,洪元杓,孟琦錫,任洪彬,李廷玟,李載元,李來烈,權五憲,金振淳,李文洙 충남대학교 공업교육연구소 1982 論文集 Vol.5 No.1

This paper aims at providing a concrete plan to improve technical and vocational teacher education in the College of Industrial Education of Chungnam National University. It is intended to propose a practical four-year regular and short-term course. Also, the estimated required facilities is included in this study as well as their management. The main conclusions and recommendations are summarized as follows; 1) The numbers of students enrollment should be reduced to 220 students which is the approximate number of future demand. 2) In order to offer to the students a broader education and to cope with the increase/decrease in demand of technical and vocational teacher within a specific field, the 8 department existing at the present (Department of Architecture Engineering Education, Civil Eng. Educ., Metallurgical Eng. Educ., Mechanical Eng. .Educ., Electrical Eng. Educ., Electronic Eng. Educ., Industrial Chemistry Educ. and Industrial Technology Educ.) would be combined into 5 (Department of Construction Engineering Education, Mechanical Eng. Educ., Electrical Eng. Educ., Industrial Chemistry Educ. and Industrial Technology Educ.). 3) The short-term course program is recommened to provide additional training and education to those candidates who already have experience in technical fields to meet an occasional demand. 4) It is necessary to add the Teaching Profession Section in the administrative organization of the College.

Methylation Status and Expression of E-cadherin in Oral Squamous Cell Carcinomas Compared to Benign Oral Epithelial Lesions

Son, Hyun-Jin,Chu, Jung-Youb,Cho, Eui-Sic,Lee, Dong-Geun,Min, Myung-Gee,Lee, Suk-Keun,Cho, Nam-Pyo The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Expression of invasion/metastasis suppressor, E-cadherin, is reduced in many types of human carcinomas. Although somatic and germline utations in the CDH1, which encodes the human E-cadherin, have frequently been reported in cases with diffuse gastric and lobular breast ancers, irreversible genetic inactivations are rare in other human carcinomas. Recently, it has been well documented that some genes in human cancers may be inactivated by altered CpG methylation. Herein, we determined the expression and methylation status of E-cadherin in oral squamous cell carcinoma (SCC) by immunohistochemistry and methylation-specific PCR. The expression of E-cadherin was significantly higher in the well-differentiated oral SCCs than the moderately or poorly differentiated ones. None of eight tested benign pithelial hyperplasias showed aberrant methylation, whereas five of 12 oral squamous cell carcinomas showed aberrant methylation. When we compared E-cadherin expression with methylation status, oral SCCs with normal methylation showed a higher expression of E-cadherin than those with methylation. These findings suggest that aberrant CpG methylation of CDH1 promoter region is closely associated with transcriptional inactivation and might be involved in tumor progression of the oral mucosa.

[환경] 음용 원수의 염소소독에 의한 소독부산물 생성패턴에 관한 연구 Ⅱ

이강진(Kang Jin Lee1),홍지은(Jee Eun Hong),표희수(Heesoo Pyo),박송자(Song-Ja Park),유제강(Je Kang Yoo),이대운(Dae Woon Lee) 한국분석과학회 2004 분석과학 Vol.17 No.1

한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

스포츠센터 종사자들의 직무스트레스가 조직몰입에 미치는 영향

이병익,--,노동연,장영광 龍仁大學校 體育科學硏究所 2002 體育科學硏究論叢 Vol.12 No.1

The purpose of this study is to find out the influence to organization-absorption caused by duty stresses of employees in sports centers. To achieve this purpose, I analyzed the difference of job stresses under social and demographic characteristics, first and then the difference of organization-absorption under the same condition and finally the relationship between job stresses and organization absorption. I used a random cluster sampling to collect data from 250 respondents who worked for 12 sports centers, and actually used data were from 214 respondents excluding 36 persons who were considered to respond insincerely or omit some parts. I consisted of totally 55 questions --- six related to social and demographic characteristics, 25 related to job stress-causing factors, and the others related to organization-absorption from the measuring tools used as research tools. The statistic analysis methods used in the study are frequency, t-test, one-way analysis of variance (Oneway-ANOVA) and Scheffe's multiple range test. I finally got the following results in this study through the data analysis from the above-stated methods and procedure. First, among the job characteristics, role related factor, human relation, rewarding, and organization characteristics showed a statistically significant difference at the level of 5 percent in gender, in position, and monthly payment, in age, in service period, and position and in monthly payment, respectively. Second, among the organization absorption, defined absorption, long-service absorption, and regulatory absorption also showed the significant difference at the level of five percent in age and educational background, in age, service period, educational background, position and monthly payment and in gender, age, service period, educational background, position and monthly payment.

인슐린 비의존성 당뇨병에 동반된 심상성 천포창 1 례

이상준,박진용,임태형,윤영호,권순대,남창욱,허규찬,박근용,구본식,김상표,장종억 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.3

저자들은 인슐린 비의존형 당뇨병 환자에서 통증성 구강내 미란 및 전신성 수포성 미란을 동반한 심상성 천포창 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Various skin conditions such as diabetic dermopathy, necrobiosis lipoidica diabeticorum, bullosis diabeticorum, granuloma annulare occur frequently in diabetes, although common lesions may be associated by chance. Pemphigus vulgaris(PV) is a blistering skin disease seen predominantly in elderly patients. This disorder is characterized by the loss of cohesion between epidermal cells with the resultant formation of intraepidermal blisters. These blisters rupture easily, leaving denuded areases that may crust and enlarge peripherally. In half or more of patients, lesions begin in the mouth: approximately 90% of patients have oromucosal involvement at some time during the course of their disease. But the relationship of this disorder with diabetes is not clear. We experienced a case of pemphigus vulgaris associated with NIDDM in 67 years old woman who was admitted due to painful oral ulcer and control of blood glucose, so we present this case with a review of literatures.

소아의 Adenovirus 호흡기 감염증

표진원,이환종 대한감염학회 1996 감염 Vol.28 No.6

목적 : Adenovirus는 항원성에 따라 42가지 이상의 혈청형이 알려져 있으며, 소아 호흡기 감염의 중요한 병원체의 하나이나, 국내에서는 이에 대한 보고가 아직 없다. 이에 저자들은 비 흡인물(nasal aspirate)에서 임상 양상 및 adenovirus가 분리된 호흡기 감염증 환아들의 임상 양상 및 adenovirus의 혈청형을 분석하여 향후 이 질환의 진단과 치료 및 예방에 도움이 되고자 하였다. 방법 : 1990년 12월부터 1995년 3월까지 호흡기 감염 증상을 주소로 서울대학교 소아병원 소아과에 내원한 환아들의 비 흡인물을 채취하여 단클론 항체를 이용한 면역 형광염색법 및 HEp-2세포를 이용한 바이러스는 적혈구 응집억제 시험으로 혈청형을 결정하였다. Adenovirus가 분리된 59례 중 다른 바이러스와 중복 감염이었던 8례를 제외한 나머지 중 의무기록을 확인할 수 있었던 34명의 환아들의 병록을 고찰하여 그 임상 양상을 분석하였다. 결과 : 34례의 검체 중 23례에서 adenovirus의 혈청형이 확인되었던 바, 2형(8례), 3형(6례), 4형(3례), 5형(3례), 6형(2례) 및 1형(1례) 등이 확인되었다. 연구 기간 중 특별한 유행없이 산발적으로 발생하였고, 환아들의 연령은 6개월에서 5세사이가 23례(67.6%)로 가장 많았다. 임상양상은 폐렴이 23례(67.6%)로 가장 많았고, 모세기관지염이 6례(17.6%), 급성 기관지염이 3례(8.8%), croup과 인두결막열이 각각 1례(2.9%)씩 이었다. 선행 각 질환이 없었던 30명의 환아 중 25명에서 간 기능검사를 시행한 바, 17례(68.0%)에서 간 기능이상을 보였으나 선천성 심질환 등의 선행 질환이 없었던 경우 후유증 없이 정상으로 회복되었다. 폐렴의 흉부 X선 소견은 폐나 폐문주위의 침윤, 과환기, 기관지 공기조영, 흉막 삼출 등의 다양한 형태로 나타났다. 총 34명의 환아 중 3명(8.8%)이 사망하였으며, 2명은 복합성 심장기형이 있었고, 1례는 선천성 갑상선 기능 저하증 환아로 만성 설사를 하고 있었다. 결론 : 이상의 결과에서 adenovirus는 소아 호흡기 감염의 중요한 원인의 하나로서, 주로 6개월에서 5세 사이의 소아에서 시만 호흡기 감염을 일으킬 수 있으며, 특히 선천성 심질환이나 면역 기능이 저하된 환아의 경우는 사망과도 연관되어 있었다. 향후 이에 대한 진단과 치료뿐만 아니라 예방에 대한 연구를 더욱 진행시켜야 할 것으로 사료된다. Background : Adenovirus is an important cause of respiratory tract infections in children and more than 42 serotypes have been recovered from humans. The reports on adenoviral respiratory tract infections of Korean children has not been reported previously. This study was performed to characterize the clinical feature of adenoviral respiratory infection and establish the serotypes of adenovirus isolated from Korean children. Methods : Thirty-four cases of respiratory tract infections associated with isolation of adenovirus from nasal aspirates were reviewed retrospectively. The patients were seen at the Seoul National University Children's Hospital during the period from Dec., 1990 to Mar., 1995. Adenoviruses were isolated in HEp-2 cell culture, and serotyped by hemagglutination-inhibition test. Results : During the study period, adenoviruses were isolated from 59 out of 1,032 episodes of respiratory tract infections. Thirty four cases were reviewed, excluding 8 with mixed infection with other viruses and 17 whose medical records were not available. Of 23 cases serotyped, type 2(8 cases), 3(6 cases), 4(3 cases), 5(3 cases), 6(2 cases) and 1(1 case) were identified. Adenoviruses were isolated sporadically throughout the year without any specific epidemic pattern. Sixty-eight percent of patients were between 6 months and 5 years of age. The spectrum of clinical diagnosis was broad such as pneumonia(67.6%), acute bronchiolitis(13.6%), acute tracheobronchitis(8.8%), croup(2.9%) and pharyngoconjunctival fever(2.9%). Associated symptoms included cough(97.1%), fever(91.2%), sputum(73.5%), rhinorrhea(55.9%), tachypnea(52.9%) and dyspnea(44.1%). Gastrointestinal symptoms such as vomiting and diarrhea in conjunction with respiratory infection also occurred frequently. Conjunctival injection was found in 23.5% of 34 cases. Seventeen (68.0%) of 25 cases without underlying liver disease had elevated liver enzymes such as AST and ALT. Nine cases required oxygen therapy for 1-11 days(mean 6.4 days). Three cases(8.8%) expired, 2 of whom had underlying complex heart disease and one had congenital hypothyroidism with chronic diarrhea. Conclusion : These data confirm that adenovirus is an important cause of respiratory tract infection in pediatric age, and suggest that adenovirus may cause rather severe disease with occasional fatal outcome in the immunocompromised children. Further studies on adenoviral respiratory tract infection are needed to diagnose, treat and prevent this illness.

무도전공자들의 입시준비 실태에 관한 연구

이병익,김진표,최은환 龍仁大學校 武道硏究所 2004 武道硏究所誌 Vol.14 No.2

This study of intended to survey the actual condition of the students who want to be admitted to the Department of Martial Arts of University, the realities and the influence of home, school, and private institution as the influencing factors and their relations to the preparation for the physical examination. This study is also designed to plant the right perception of the Physical training in the minds of the students preparing for the physical examination for the Department of Martial Arts, help them make the most of special abilities and be prepared for the future as professionals. For teachers who guide them, the goals of this study are to make them understand the importance of students choosing major, let them know the things to be improved, and provide the right direction and fundamental data on Martial Arts education. In order to achieve these goals, those 300 student who are taking lecturess from private institutes to apply for the department of Martial Arts in Suwon city, pyungtak city and Osan city were sampled, except those insincere answers of 4 students, The rest reliable answers of 296 students were used for statistical use with the statistic software SPSS 10.0 for Windows package. The results of the research on the Actual condition of the Applicants Preparing for the Phyical Examination for the Department of Martial Arts are as follows: Firstly, the major factor of choosing the Department of Martial Arts is ones own will and majority of the students are going to major it in order to be teachers or coaches. It was indicated that only a few students are going to choose the major because of their grades. Secondly, the money spent on the preparation for the physical examination per month varied from 10 thousand won to 40 thousand won and it seemed that the differences among tuition fees came from the characteristic of the institutes. Overall the parents of those student showed positive response to the preparation for the physical examination for the Department of Martial Arts. Thirdly, the sources of the information on physical examination were mostly gained from internet and seniors. The time spent on the institute was more than 4 hours per day and the length of course taken by students were mainly lass then a year and over 3 years. The majors to be applied in Department of Martial arts were Judo, Taekwondo, Yonpmdo, Kando, Taekyun, and etc. in order. Lastly, it seemed that many students thought the money spent on the preparation for the physical examination was excessive but most of them would not change their choice. Although some students answered that they might change their major according to their grades, but majority of the students were very sure of what they are going to do and also told that they would do their best to achieve their goal.