성인에서 발생한 발진성 가성 혈관종증

서상희 ( Sang Hee Seo ),장호선 ( Ho Sun Jang ),목혜수 ( Hye Soo Mok ),김성준 ( Sung Jun Kim ),김병수 ( Byung Soo Kim ),김문범 ( Moon Bum Kim ),오창근 ( Chang Keun Oh ),권경술 ( Kyung Sool Kwon ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.8

Background: Eruptive pseudoangiomatosis (EPA) is a rare, benign, spontaneously regressing childhood exanthem. It is characterized by the sudden onset of several bright red angioma-like papules surrounded by pale halos with a distinct histopathology from true angiomas. Objective: This study was performed to evaluate the clinical and histopathologic characteristics of EPA occuring in adults. Methods: Ten adult patients who visited Pusan National University Hospital and Mok Hye-SooㆍJang Ho-Sun Dermatology Clinic from March 2005 to September 2006 were evaluated. We prospectively evaluated the sex, age, onset season, past medical history including immunosuppressive abnormalities, systemic disorders and other diseases including allergies. We also investigated the relations of mosquito biting, patients` occupations and outdoor activities to occurrence of EPA. In addition, simultaneous occurrence in family members, the clinical, histopathologic, laboratory findings, disease courses and responses to treatment were evaluated. Based on medical records, photographs and pathologic slides, we retrospectively diagnosed another 20 EPA patients suspected as insect bite from October 2003 to March 2005. The same questions were inquired as for the 10 patients who prospectively underwent evaluation. Results: In the study, female predominance (76.7%) was observed and the average age of onset was 54.2 years. Interestingly, there was no child patient during the period of study. Multiple, 2∼5 mm sized, red angiomatous papules surrounded by pale halos occurred on exposed areas such as the arms (86.7%), legs (50%), and face (46.7%), although it could also occur to a non-exposed area. EPA occuring in adults usually appeared in summer (80%). The mean disease duration was 3.4 weeks. Although EPA spontaneously regressed, it had the potential of recurrence (46.7%). Histopathologic findings showed dilated dermal blood vessels without the evidence of increase in numbers, and perivascular lymphocytes infiltration. Inside the lumen of dermal blood vessels, plump endothelial cells were found. Conclusion: EPA occuring in adults usually happened to exposed sites in summer, so it can be misdiagnosed as insect bite. We suggest that dermatologists should be concerned about EPA in adults and conduct further investigation to have a better understanding of the disease. (Korean J Dermatol 2007;45(8):797∼803)

혈청 감마지티(gamma glutamyl transferase)치와 대사증후군의 연관성

장미,유병욱,조용진,오정은,홍성호,조주연 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.1

Background: Serum gamma glutamyl transferase(GGT) level has been widely used as an index of liver dysfunction and a marker of alcohol intake. But, recently it is identified that the elevated GGT level was associated with insulin resistance. This study aimed to examine the association between metabolic syndrome and elevated GGT level in the women who had less alcoholic influence generally. Methods: From 585 women who received their annual health check-up, 577 women were selected for analysis except for 28 women who had hepatitis B surface antigen positive or antibody to hepatitis C virus positive, Categories of serum GGT were classified into four groups by quartile and then evaluated. Results: A abnormal GGT level(≥52U/L) was seen in 29(5.2%) of the 557 women. As GGT level increased, the prevalence rate of factors(body mass index≥25kg/m2, hypertension, hemoglobin≥14g/dL, total cholesterol≥220mg/dL, triglyceride≥150mg/dL, fasting plasma glucose≥110mg/dL, HDL-choles tero1<50mg/dL) except for hyperuhcemia was increased. The GGT level was correlated with age, body mass index, thglyceride and uric acid in women with fatty liver, but not in women without fatty liver. Factors independently contributing to elevated GGT level was diabetes, hyperthglycehdemia and obesity. Conclusion: The elevated, albeit normal, GGT level was strongly associated with the factors of metabolic syndrome in Korean women. Because measurement of serum GGT level is easy, reliable, and not expensive, it might have more important implication as predictive factor of metabolic syndrome.

Effect of Mn and C on Age Hardening of Fe–Mn–Al–C Lightweight Steels

Sung‑Won Park,Jun Young Park,Kyong Mox Cho,Jae Hoon Jang,Seong‑Jun Park,Joonoh Moon,Tae‑Ho Lee,Jong‑Ho Shin 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.3

The effects of Mn and C content on the age hardening of Fe–Mn–Al–C lightweight steels, which have austenitic or duplex(austenite and ferrite) microstructures, were investigated. An increase in Mn content induced a delay of the age hardeningthat is caused by the formation of intra-granular κ-carbides. In order to interpret the effect of Mn content, first-principlescalculations were conducted using the supercells of Fe24Al8C8,Fe24Al8C7,Fe24(Al7Mn)C8, and Fe24(Al7Mn)C7. The calculationsshowed that an increase in Mn content could be the source of the delay of the intra-granular κ-carbide formation bysuppressing C atom’ occupation of the vacancy at the body-centered site of L12. An increase in C content accelerated theformation of intra-granular κ-carbides, which induced the intense age hardening, and coarse inter-granular κ-carbides, whichresulted in significant decrease in impact absorbed energy due to inter-granular fracture.

답손(Dapsone)중독환자의 예후와 특성 분석

장석준,정성필,김승환,구홍두,심호식 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

We reviewed 26 dapsone intoxication patients who had visited Severance Hospital Emergency Care Center from January 1991 to January 1995 : 13 of them ingested intentionally, but the other ingested accidentally. Among the admitted patients the highest and lowtheest initial value of methemoglobin level is 59.6% & 10.1%. The frequency of symptoms at presentation was following 16 patients complained cyanosis of lip area, 10 patients complained dyspnea, 4 patients complained mental change, 4 patients complained vomiting, 2 patients complained nausea. The inital level of methemoglobin was less than 50% except in one patient. In the view points of total doses of methylene blue used, less than 100mg was used in 9 patients(34.6%) but in one case, amount of 6400mg was loaded. There were 5 patients(19.2%) in September & 4 patients (15.4%) in January. In respect of result, there were 13 discharged cases (50%) for symptom improvement, and 5 mortality cases(19.2%). The transferred cases from Gangwondo account 19 patients(73.1%). All of them is not directly emergency care center visiting patients but transferred patients from remotely located hospitals. Dapsone intoxication results in severe tissue hypoxic symptoms from malfunction of normal hemoglobin thus only with appropriate available doses of methylene blue & activated charcoal, good outcomes will be expected. If aggressive therapy such as hemodialysis is introduced in treatment of severe dapsone intoxication, the outcomes may be slightly improved better than in other supportive care cases.

스포츠센터 관계마케팅 실행요인이 관계품질, 구매행동에 미치는 영향

장호성,석용근 龍仁大學校 體育科學硏究所 2008 體育科學硏究論叢 Vol.17 No.1

The meaning of this research work lies in providing useful basic resources which can be utilized in the strategic respect of internal marketing by investigating how sports center customer in relation to relationship marketing implement factors on relationship quality and purchasing behavior, and by identifying how their service orientation affect business performance taking service quality as parameter. Customer of sports centers in Chungnam region were selected as the subjects of this survey and 248 participants were sampled by Convenience Sampling Method. Resulting data were processed by Frequency Analysis, Exploratory Analysis, Correlation Analysis, Regression Analysis using SPSS 11.0 program. The results from these research methods and analyses revealed the followings: First, results from regression analysis of performance factors of relationship marketing and relations quality revealed that customer-relations orientation, responsiveness and incentive had significant influences on reliability, and that customer-relations orientation and responsiveness, on involvement. Second, results from regression analysis of performance factors of relationship marketing and purchase behavior exhibited that incentive had a significant influence on repurchase intention, and that responsiveness and incentive, on positive word of mouth. Third, results from regression analysis of relationship quality and purchase behavior revealed that there were significant influences of all variables including reliability and involvement on repurchase intention and positive word of mouth.

설악산 국립공원의 어류분포

장민호,조가익,하진용,정광석,박성배,주기재 한국어류학회 2002 韓國魚類學會誌 Vol.14 No.4

설악산 국립공원지역 산간계류의 17개 지점에서 2000년 6월부터 2001년 6월까지 어류상 및 이화학적 요인을 계절별로 총 4회에 걸쳐 분석하였다. 모든 조사지점은 1~3차의 하천으로 비교적 물리·화학적 교란이 적었으며 하천폭은 5~30 m 정도였다. 채집된 어류는 총 18과 42종 2,557개체였고, Cyprinidae는 16종으로 84.7%의 상대풍부도를 나타냈으며, Gobiidae 4종, 5.0?의 상대풍부도를 보였다. Cyprinidae는 전체 채입종의 37.2%를 나타냈다. 우점종은 Zacco temminck로 10개 지점에서 738개체가 채집되어 28.9%의 상대풍부도를 나타냈으며, 아우점종은 Rhynchocypris kumkangensis와 Z. platypus로 각각 4개 지점 648개체(25.3%)와 7개 지점 344개체(13.5%)로 나타났다. 한국고유종(Korean endemic species)은 모두 4과 11종 781개체로 30.5%의 상대풍부도를 나타냈으며, 고유화 빈도는 25.6%로 한국의 평균 고유화 빈도와 유사하게 나타났다. 본 조사에서 외래어는 채집되지 않았다. 국립공원 내에 서식하는 어류의 다양성 유지와 회복을 위해서는 공원 내는 물론 경계지역 하천의 체계적인 관리가 요구된다. The fish fauna of mountain streams in the Seorak National Park area was investigated from June 2000 to June 2001 (4 times). All 17 sites were relatively undisturbed 1st to 3rd order streams. A total of 2,557 individuals were collected and classified into 17 families and 43 species. Cyprinidae accounted for 37.2% (16 species) of the total fish species and 84.7% (2,165 ind.) of the total abundance. Subdominant families were Gobiidae (4 species, 5.0%) and Balitoridae (3 species, 3.4%). Zacco temmincki (RA 28.9%, 10 sites) dominated. Subdominant species were Rhynchocypris kumkangensis (25.3%, 4 sites) and Zacco platypus (13.5%, 7 sites). Eleven of the species are endemic to Korea (4 families, 30.5%). Exotic species were not collected in this survey. Fish diversity was higher in streams around the boundary area than in the national park. Therefore, management of streams in the boundary area to protect the fish biodiversity can be efficiently conducted. Habitat degradation should be reduced for the conservation and restoration of fish diversity.

뇌손상 후 운동신경기능 회복 기전 : 기능적 뇌 자기공명영상의 유용성 The Usefulness of fMRI Study

장성호,한봉수,장용민,변우목,김성호,조윤우 한국뇌학회 2001 한국뇌학회지 Vol.1 No.1

목적: 본 연구는 뇌손상환자에서 기능적 뇌 자기공명영상(functional magnetic resonance imaging, fMRI)을 이용한 대뇌운동피질 뇌지도화를 시행하여, 운동신경기능 회복 기전에 대한 기능적 뇌 자기공명영상의 유용성에 대하여 연구하였다. 방법: 신경학적 증상과 병력이 없는 성인 8명과 뇌손상환자 5인을 대상으로 하였다. 뇌손상환자 중 2명은 뇌종양환자이었으며 1명은 뇌출혈, 1명은 뇌경색, 1명은 뇌낭미충증환자이었다. 기능적 자기공명영상은 1.5T MR scanner로 Blood Oxygen Level-Dependent(BOLD) 기법을 적용하였다. 운동과제는 손가락을 1-2Hz의 주기로 쥐었다 펴기를 반복하도록 하였다. 결과: fMRI를 촬영한 결과 정상인 8인, 즉 총 16개의 손중 15개의 손과 환자 5인의 이환되지 않은 손운동시 반대측 일차 운동피질 꼭지(knob)를 중심으로 일차 감각운동피질(SM1)이 활성화되었다. 정상인 중 1인의 한 손에서 반대측 SM1과 동측 일차 운동피질(primary motor cortex, M1) 및 보조운동영역이 동시에 활성화되었다. 뇌손상환자의 이환측 손운동시 환자 1에서는 일차감각피질(primary sensory cortex, S1), 환자 2와 환자 3에서는 양측 SM1, 환자 4와 환자 5에서는 반대측 SM1이 활성화되었다. 환자 1에서는 손상된 M1의 운동신경기능이 S1으로 이전된 것으로 추정되며, 환자 4와 5에서는 손의 운동신경기능이 피질척수로에 의하여 유지되고 있는 것으로 추정되었다. 그러나 환자 2와 환자 3에서 발견된 동측 운동피질 활성화는 본래 정상적으로 존재하던 운동신경 경로인지 뇌손상 후에 발생한 운동신경기능 회복 경로인지 구분할 수는 없었다. 결론: fMRI을 통한 대뇌 운동피질 지도화는 뇌손상 후 병변 주위로의 재조직되는 회복 기전과 피질척수로에 의해 운동신경기능이 유지되고 있음을 입증하는데에 유용할 것으로 생각된다. Objective: This study investigated the usefulness of functional magnetic resonance imaging (fMRI) in the research of motor recovery mechanisms in brain injured patients. Method: Eight control subjects and five brain injured patients were investigated. Out of five patients, two were with brain tumor, one cerebral hemorrhage, one cerebral infarction, and one neurocysticercosis. fMRI was performed using the blood oxygen level-dependent (BOLD) technique at 1.5 TMR scanner with a standard head coil. The motor activation task consisted of finger flexion-extension exercises in 1-2 Hz cycles. Results: fMRI showed activation of the contralateral primary sensori-motor cortex(SM1) by the hand movements of all control subjects and by the unaffected hand movements of all brain-injured patients. Activation of the supplementary motor area(SMA) by one hand movement was also seen in one control subject. Hand movements of the affected hand of the brain injured patients resulted in activation of the contralateral primary sensory cortex(S1) in patient 1, both SM1 in patients 2 and 3, and the contralateral SM1 in patients 4 and 5. Conclusions: It is concluded that fMRI is useful for the research of perilesional reorganization and sparing of the corticospinal tract during the motor recovery mechanisms after brain injury.

제주지역 관광수입 통계에 관한 조사연구 : 여행경비기준산출을 중심으로 The Cheju Island Case

장성수,송재호 한국관광정책학회 2000 觀光政策學硏究 Vol.6 No.1

To make the efficient tourism policy and manage the tourism business is it necessary that the tourism statistics should precisely be drawn up, and the tourist and tourism receipts, the fundamental items of tourism statistics, be estimated precisely and periodically. This survey, which is based on the above recognition calculates the criteria of the per capita tourism expenditures for the purpose of precisely measuring the tourism receipts in cheju island. In addition, the criteria of tourism expenditure and tourism receipts officially published by the Cheju Provincial Government and Cheju Travel Association is compared and analysed. According to the integration of the survey analysis executed four times, per capita tourism expenditure except the round air fare is surveyed 261,175won for the group tourist, 137,544won for the school excursion, 580,204won for the honeymoon, 293,418won for the family tourist, 235,007won for the individual tourist, 2,165,561won for Japanese, 473,007won for Chinese, and 440,683won for the English-Speaking tourist. This results indicates that all travel patterns except the school excursion is higher than the official criteria of Cheju Province Office. Estimating the tourism receipts of Cheju island in 1999 based on the criteria of tourism expenditures suggested by this survey is estimated 1,745,200,000,000 won including the one-way air fare, which is more than 700,000,000,000 won compared to 1,295,000,000,000 won which is the criteria of Cheju Provincial Government. The contents of this study are as follows : I. Purpose of this study, Ⅱ. Conceptual system of the tourism receipts and expenditures, Ⅲ. Analysis of the tourism statistics in Cheju Island, Ⅳ. Survey Design : modelling and sampling, Ⅴ. Results and Implications, Ⅵ. Concluding remarks.

지식 기반 교육컨테츠 저작시스템

장재경,김호성 한국컴퓨터교육학회 2004 컴퓨터교육학회 논문지 Vol.7 No.2

e-Learning에서 교수-학습자들 간에 형성되는 지식들을 체계적으로 관리하여 효과적인 교수-학습을 수행할 목적으로 교수자들이 교수 설계 이론에 따른 다양한 강의들에 교육 컨텐츠를 보다 쉽게 저작할 수 있는 시스템을 개발하였다. SCORM 표준에 따라 학습객체 간 관계를 설정하여 저작된 컨텐츠는 학습자가 학습내용을 개념화하는데 도움을 줄 것이다. 시맨틱 웹의 RDF를 적용하여 학습객체 간의 관계를 설정함으로써 지식맵을 구성하였고, 교수자가 해당 분야에서 사용되는 단어를 등록하여 일종의 어휘사전을 만들 수 있는 온톨로지를 도입하였다. 학습자의 이해도와 성취도를 고려한 개별학습을 제공하기 위하여 도입된 상호작용점을 따라 학습자마다 개별적인 학습맵이 구성되어 학생 개인의 학습활동과 이해도를 평가할 수 있다. For the purpose of an effective instruction-learning process by systematic management of knowledge between instructor and learner in e-Learning, we have developed the authoring system in which the instructor is able to author easily on various lecture frames according to the instructional design theory. The authored contents with the relations among the learning objects based on SCORM standard would help learner to conceptualize the contents. A knowledge map is constructed on the relations among the learning objects using RDF of the semantic web. We introduce the ontology in which the instructor can make a dictionary of terminology by registering the words of the teaching area. The learning activity and comprehension of students can be assessed using each student's learning map along the interaction points which are introduced to present the individual learning by considering each student's capacity of understanding and achievement.

Flavobacterium meningosepticum에 의한 균혈증 1예

장성원,유진홍,진승원,김선우,김연식,박순민,이대훈,최민호,최주연,신완식,강문원,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1

1996년 6월 카톨릭대학교 부천성가병원에 뇌경색으로 입원했던 61세 남자 환자의 혈액에서 Flavobacterium meningosepticum을 분리하였다. 환자는 폐렴을 동반한 패혈증의 예로 ceftriaxone과 metronidazole을 투여하였으나 입원 48시간만에 사망하였다. Flabovacterium meningosepticum is a rae cause of nosocomial infection which shows multi-drug resistance. It mainly invades patients with impaired immunity. Recently, we experienced a case of F. meningosepticum bacteremia in a patient with chronic debilitated state owing to stroke. The clinical progress was so rapid that he died within 48 hours. Blood culture revealed F. meningosepticum which showed characteristic yellow colony in blood agar plate.