열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구

배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.

수증기 개질반응용 니켈촉매에 첨가된 리튬의 효과

최재석,윤정숙,임태훈,홍성안,이호인 한국공업화학회 2005 응용화학 Vol.9 No.1

In the direct internal reforming type molten carbonate fuel cell, alkali carbonates used as electrolyte in the cell are transported to reforming catalyst of which activity drastically decreases. In our previous work, the deactivation of the nickel catalyst was studied with increasing the amount of added lithium. Unexpectedly, the increase of activity was observed with a small amount of lithium less than 1wt%. The results of TPR, XRD and chemisorption showed no significant difference between the fresh catalyst and the Li-added one, implying that lithium did not cause the change of morphological property of the supported nickel. To elucidate the effect of lithium the methanation of CO was applied to the catalysts, which was considered as the reverse reaction of the key elementary step of methane steam reforming. It can be seen by an online mass spectrometer that the small injection of CO/H₂ mixture into the Li-added catalyst reactor at 650 ℃ showed the longer tail of produced methane than into the fresh one. The delay should be originated from the effect of lithium, which determined the overall rate on the Li-added catalyst.

Ficin의 酵素化學的性質에 관한 硏究

崔甲晟,徐在信 順天大學校 1985 論文集 Vol.4 No.1

One of ficin, isolated from Fig latex, was conducted to investigate some chemical properties of enzyme. The results are as follows; 1. The activity of crude ficin was 2.3 unit/mg and milk clotting activity was 8.33x10-²unit/mg 2. The hydrolytic activity to substrate was 6.8%, which is thought to be of low value. 3. While activities of enzyme after adding 10?? Mcysteine and those concentration of 2-mercaptoe thanol were high. 10-³M-Na₂S₄O?? was the strongest inhibitor among others. 4. The value of enzyme activity was the highest when the concentration of casein solution was 3%.

흰쥐의 발치아에 이식된 태아 치아싹의 발육

최병재,장석철,정한성,이제호,김성오 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.1

정상적인 치열의 형성 및 치아의 생성과정을 분석하고 실제로 임상에 적용하기 위해 치아의 발생과정을 연구하는 것은 매우 중요하다. 본 연구는 이식된 태아 치아싹의 석회화가 가능하고 정상적인 구조로 발육할 수 있는지 밝히기 위해, 그리고 악골 자체가 새로운 이식 공여부로 사용가능한지 알기 위해 흰쥐의 발치와에 치아싹을 이식하여 치아의 형성을 살펴보고자 하였다. 이를 위하여 성숙한 흰쥐의 상악 제 1구치를 발거한 발치와에 13.5일된 태아쥐의 치아싹을 이식한 후 4,8주 후에 희생하여 조직학적 및 방사선학적으로 관찰하여 다음과 같은 결과를 얻었다. 1. 이식된 치아싹에서 상아질과 백악질, 치수, 치주인대의 소견을 갖는 석회화된 조직이 형성되었다. 2. 형성된 경조직 및 연조직은 정상적인 치아형성과정에 비해 발육이 늦었으며 유착 및 골양상아질(osteodentin)과 같은 비정상적 조직이 관찰되었다. 3. 석회화된 조직은 8주내에 악궁으로 맹출하는 소견이 관찰되지 않았다. The developmental process of a tooth is being presented as an important study subject to analyze formation of normal dental arch and tooth. The purpose of this study was to see the formation of tooth from a tooth bud transplanted in a white rat regarding that the jawbone could be used as a new donor site of a trasplant. The first molar of a matured white rat was extracted and the tooth bud of a 13.5 day rat embryo was transplanted. The histological and radiographical results after 4 and 8 weeks respectively are as the following. 1. Calcification in dentin, cementum, pulp and periodontal ligament was formed from the tooth bud transplanted in the alveolar socket. 2. The development of hard and soft tissue was delayed compared to the normal tooth formation and abnormal histologic features such as ankylosis and osteodentin were found. 3. The formed hard tissue did not erupt into the jaw within 8 weeks.

임신 제 일삼분기와 제 이삼분기 초음파의 태아기형 진단의 유용성에 대한 고찰

최승도,최규연,이정재,정성윤,이임순,이권해 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Objective: Ultrasonographic screening between 9 and 13 weeks for fetal structural abnormalities using transvaginal sonography in unselected population. Visualization of detailed fetal anatomy in the first trimester has improved as a result of technological progress in ultrasound machines and the introduction of transvaginal sonography(TVS). Our study aims to evaluate the accuracy of TVS as a screening tool for detecting fetal malformations in a nonselected population of pregnant women. For this purpose we compared the results obtained by using second trimesster TA scanning with those obtained using TVS at 9-14 weeks' gestation. Methods: From March 2001 to February 2003, 620 unselected consecutive pregnant women were recruited at their initial visit at Soonchunhyang university hospital, department of obstetrics and gynecology and offered a TVS scan at the average gestational age of 9-13 weeks in addition to the TA screening usually performed between 22-26 weeks. To fulfill the technical requirements of a screening test, ultrasonographic examinations were performed by skillful operators with different degrees of experienced using adequate instruments Aloka SSD 5500 (Aloka Co. Ltd., Tokyo, Japan) provided with either a 3.5-5MHz TA probe or a 5-7.5MHZ TV probe) in a fixed scanning time of maximum 30 min, generally considered sufficient for a complete fetal anatomic survey. Results: During the study period we found in our unselected population an overall prevalence of target abnormalities of 2.2%(24 malformed fetuses out of 600 screened). In the fetuses examined by TVS, 16 abnormalities were detected whereas 8 were not; of these, 6 were detected at transabdominal rescreening at 22-26 weeks and the remaining 2 were observed after birth. A nuchal region abnormality was the most frequent type of malformation detected in the early scan, including six cases of nuchal edema, two cases of cystic hygroma associated with hygroma associated with hydrops, three cases of hydronephrosis, one case of fetal neck teratoma, one case of cleft lip. Conclusion: This study has demonstrated the potential of screening a low risk population for fetal abnormalities at 9-13 weeks of gestation using transvaginal sonography and rescreened via transabdominal sonography at 22-26 weeks. Larger studies are required to establish the clinical value of the first trimester scan.

Fusobacterium nucleatum의 테트라사이클린 내성여부를 검사하기 위한 세균배양법과 중합효소연쇄반응법의 비교

최재흥,성진효,국중기,김동기 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.4

The purposes of this study were to identify the detection and incidence of tetracycline resistance determinant tet(M) by PCR method and to evaluate the availability of PCR method guided for clinical use of antibiotics in dentistry. Subgingival plaque samples were collected from 172 sites of 29 patients. Both original sample and subculturd sample, PCR amplification was used to detect tet(M) in Fusobacterium nucleatum. The percentage of tet(M)-positive subjects and sites in original samples were 100%, 95.9%, respectively. And the percentage of tet(M)-positive subjects and sites in subcultured samples were 17.2%, 3.5%, respectively. In subcultured samples, probing pocket depth and clinical attachment level in tet(M)-positive sites were higher than in negative sites (p<0.05). The sensitivity and specificity of PCR method compared with broth dilution method as a gold standard were 0.91 and 0.86, respectively. The results suggested that tet(M) assay using PCR method was available to detect the tetracycline-resistant F. nucleatum.

교육방송 프로그램이 고등학생들의 학력신장에 미치는 효과

최재완,임성규,이효녕 慶北大學校 師範大學 科學敎育硏究所 2007 科學敎育硏究誌 Vol.31 No.-

이 연구는 고등학교 1학년 학생들이 교육방송에 의한 학습을 장기간 지속적으로 시청했을 때 학력에 미치는 효과를 검정하고 현행교육방송의 실태와 개선점을 알아보고자 한다. 대구광역시 내 동일학군에 소재한 일반계 고등학교 중에서 교육방송에 의한 학습을 한 실험집단(A고교)과 교육방송을 하지 않고 자율학습을 한 비교집단(B고교)간의 성취도를 비교하였다. 4월부터 교육방송 수업을 시작한 후 5월 과 11월에 시행된 두 차례의 전국연합학력 평가에서 「수리탐구 I 영역」의 성적을 비교하였다. 그 결과 두 집단간 평균점수 차이가 유의미하다고 나타났다. 그리고 두 집단의 최하위 성적 급간(하위 10% 이내)을 제외한 모든 급간에서 실험집단이 비교집단 보다 성적이 많이 향상되었다고 나타났다. 실험집단을 대상으로 현행 교육방송 프로그램에 대한 의견 조사 결과,개선할 점으로 프로그램 내용의 수준별 편성,보다 다양한 자료의 활용,강의 진행 속도의 조절,그리고 지도방법의 개선 등을 들고 있다. The purpose of this study was to investigate the effect of EBS programs on the Scholasstic Achievement of high school students and make suggestions for facilitating EBS programs in high school. The academic performance of two group of different school students in Daegu was compared; One is experimental group(A school) and the other is comparative group(B school). The experimental group(A) studied through EBS programs for average 21 hours a week, while the comparative group(B) were not given any chance to take advantage of the EBS programs at all. The comparison between the two results of May and November trial exams indicated that in the case of the upper level students belonging to top 10%, the mean scores of the experimental group has increased more remarkably than that of the comparative group.

HPLC를 사용한 쌀 중 잔류농약 동시분석법

최재천,이영자,김소희,최수영,최희주,정성욱,박흥재,김우성 한국환경과학회 2005 한국환경과학회지 Vol.14 No.4

A simple and sensitive analytical method based on RP-HPLC with UV detector(225 nm) and mobile phases using 0.1% phosphoric acid and acetonitrile was developed for simultaneous determination of quinclorac, bentazone, 2,4-D, bensulfuron-methyl, dymuron, capropamide, pencycuron, ethofenprox. This method was resulted in recovery of 78~ 96% with RSD 3.3~7.5%. LODs 0.12~0.84 and LOQs 0.34~1.20 ㎎/L. Calibration curves were linear with r of 0.9995~ 0.9999.

原料의 種類와 形態에 따른 Aspergillus oryzae 麴의 生理活性 및 酵素力

최성현,정재홍,이상덕,손화영,성창근,오만진,김성렬 충남대학교 농업과학연구소 1997 농업과학연구 Vol.24 No.2

CNU O4-5 isolated from conventional Meju, which is used as raw material for making a soybean fermentation food, identified as an Aspergillus oryzae. To make koji, Aspergillus oryzae CNU O4-5 was cultured for 3-4 days at 30℃ with various grain materials such as flour, soybean powder, flour+soybean powder(1:1), soaked soybean and rice. The koji was evaluated for analyze the angiotesin converting enzyne(ACE) inhibition, antioxidative activity, superoxide dismutase(SOD) activity, amylase and protease activity, α-amylase and glucoamylase activities of flour koji wee higher than those of the koji soybean powder. However neutral and alkaline protease activities of flour koji were lower than those of flour+soybean powder and soybean koji. Amylase and protease activities of kojies of soaked soybean and rice showed very low level. The range of the ACE inhibition rate by hot water fraction of the kojies, which are cultured with various gain materials, were from 45% to 54%. The antioxidative activity of ethanol-fraction of koji, which is made by using the soybean powder or soaked soybean, prolonged for 6 days in lard at 60℃. The SOD activity of grinded fraction of koji, which is made by using the flour or soybean powder, was same as 2,000 units per g of each koji.

양수검사에서 small supernumerary marker chromosomes(sSMCs) 발견과 산전상담

문성택,김윤숙,전섭,최승도,선우재근,배동한 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.1

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