사람 腦를 使用한 Thromboplastin 製造에 關한 實驗的 硏究

鄭在泓,宋文源 계명대학교 醫科大學 病理學敎室同門會 1987 樂山 鄭在泓 敎授 頌喜 紀念論文集 Vol.S No.-

1. The author has tried to prepare a standard thromboplastin for the determination of prothrombin time utilizing relatively fresh child human brain obtained at the time of autopsy, through acetone treatment. 2. A 13. 5 second thromboplastin extract, slightly slower than. the 12 second commercially available Difco product, was successfully prepared. 3. No influence on prothrombin time is’ noted when the thromboplastin solution is extracted from the powdered thromboplastin at the temperature, between 45 0C and 550 C. However, definite prolongation is observed when the extraction is made at above 600 C. 4. It appears that the optimal concentrations of powdered thromboplastin for the preparation of thromboplastin solution lie between 300 mg and 500 mg. 5. An attempt was made to prepare a slower acting thromboplastin sensitive at the level of therapeutic range, using rabbit brain and lung extract in equal parts, with uncertain success. 6. It is felt that the prospect of preparing a satisfactory fast acting standard thromboplastin is good, judging from the knowledge acquired through this experimentation. At this time, .however, we are unable to draw any specific conc1usion concerning the preparation of a sensitive slower acting thromboplastin from the rabbit.

血中 Ammonia 微量定量에 있어서 pH 및 Alkali 媒劑가 測定値에 미치는 影響에 對한 硏究

鄭在泓 계명대학교 醫科大學 病理學敎室同門會 1987 樂山 鄭在泓 敎授 頌喜 紀念論文集 Vol.S No.-

An attempt was made to determine the origin of artifactual blood ammonia formed in the shed blood; Experimentation, with blood specimens from more than 400 healthy individuals, was carried out over a period of four and a half years, utilizing two popular microdiffusion blood ammonia methods, those of Seligson and Conway. The actions of several alkali [pstassium carbonate, carbonate-bicarbonate mixture and borate-sodium hydroxide (with a pH of 9 to 11.4)] were compared by placing them in the diffusion apparatus with specimens of blood. It was found that the ammonia concentration tended to be higher with increasing pH and vice versa lowering with decreasing pH. While occasional extremely implausible results were obtained in experiments using the potassium carbonate and carbonate-bicarbonate mixture, on the other hand, no such aberrations were observed with borate-sodium hydroxide. Within the pH range, from 9 to 10.1, the yield of ammonia when plotted against the pH of the blood-alkali mixture showed a straight line. Increasing beyond 10, resulted in an asymptomatic character of diffusion curve. For these reasons, borate-sodium hydroxide reagent which results in a pH of 10.1 in the presence of blood, is selected as the choice of weak alkali media for the determination of true blood ammonia. The author has to abandon his earlier thought that aberrations in ammonia analyses can be largely attributed to faulty technique in collecting and handling blood. Careful control of these techniques resulted in some lowering of the ammonia concentration, but failed to prevent the more serious aberrations encountered. In search for clarification of the origin of extra ammonia, studies were carried out by experimenting with glutamine, both in aqueous solutions and following mixture with blood. The results suggest that non-protein glutamine is an unlikely source of extra ammonia. The only other plausible source of the extra ammonia liberated from blood, therefore, seemed to be the blood proteins, Accordingly, the action of various alkaline reagents on plasma albumin, globulin and on whole blood was tested, after prolonged dialysis to remove preformed ammonia. Ammonia was released from each of the protein solutions used. However, the action of borate in this release was less pronounced than that of the carbonate-bicarbonate mixture. This latter mixture, in turn, liberated substantially less ammonia than did potassium carbonate. Therefore, it is concluded that the origin of artifactual ammonia may be traced to the decomposition of protein by the action of alkali. The author has revised the method of measuring blood ammonia in such a way as to avoid spontaneous production of ammonia from blood proteins. The technique involves the use of sodium borate buffer at a pH of 10.8±0.2, which, when mixed with blood, results in a pH of 10.1 The adequacy of this technic is well proven by the satisfactory results obtained in a large number of recovery studies. The technique described, applied to venous specimens that were collected in EDTA tubes and promptly analyzed, was used to study a group of 16 healthy persons, 20 to 25, male, with no history of previous liver involvement. The mean blood ammonia was 0.42 μg./ml. expressed as N. The lowest value was 0.21, the highest, 0.61, with standard deviation of ± 0.124.

생마늘 페이스트의 저장 과정 중 품질 변화

정재홍 한국식품영양학회 1998 韓國食品營養學會誌 Vol.11 No.3

생마늘의 풍미와 색상을 유지하면서 장기간 저장하기 위하여 정제염, 말토덱스트린과 dl-사과산을 첨가한 뒤 가열 처리하여 생마늘 페이스트를 제조하여 가공 공정을 검토하였고,30℃와 5℃의 온도에서 6개월동안 저장하면서 품질 변화를 측정하였다. 생마늘 페이스트는 엽경을 제거하고 쵸핑하여 87%의 수율을 얻었으며 pH는 5.85로 측정되었다. 생마늘에 10%의 정제염, 10%의 말토덱스트린과 0.1%의 dl-사과산을 첨가한 뒤 85℃에서 5분간 가열 처리하여 제조한 생마늘 페이스트는 5℃의 저온에서 6개월 이상 저장할 때 풍미, 색상, thiosulfinate와 pyruvate의 함량, 관능 평가 및 품질의 변화를 거의 볼 수 없었다. 이와 같은 결과로 볼 때 생마늘에 10%의 정제염, 10%의 말토덱스트린과 0.1%의 dl-사과산을 첨가한 뒤 85℃에서 5분간 가열 처리하여 생마늘 페이스트를 제조한 뒤 5℃의 저온에서 보관하는 것이 품질 변화없이 6개월 이상 장기 저장할 수 있었다. An attempt was made in this study to investigate the possibility of processing fresh garlic into an fresh garlic paste. The characteristics of fresh garlic paste and processing properties were investigated and the effect of salt, maltodextrin, acid and heat on product quality during storage were studied. After the processed fresh garlic paste was stored at 30℃ and 5℃ without light for 6 months. The weight and pH of clove were 93% of total and 5.85, respectively. Addition of 10% salt, 10% maltodextrin, 0.1% dl-malic acid, and heat on fresh garlic paste maintain color of fresh garlic could be preserved for 6 months at 5℃. Judging from thiosulfinate and pyruvate content, and sensory evaluation, quality damage of fresh garlic paste which was made of 10% salt, 10% maltodextrin, 0.1% dl-malic acid, and heat on fresh garlic paste hardly occurred at 5℃ but occurred considerable level at 30℃ during storage for 6 months.

삼계탕의 세계화 - 삼계탕의 세계화를 위한 레시피 개발

정재홍,Jeong, Jae-Hong 한국육계협회 2011 월간 닭고기 Vol.17 No.8

MCNPX 시뮬레이션을 이용한 엑스선관 모델링 비교

정재홍,이준재,이우필,안현준,김상현 (사)한국방사선산업학회 2018 방사선산업학회지 Vol.12 No.3

The MCNPX (Monte Carlo N-Particle Extended) is a program defined as thesimulation using a stochastic system for decision making in an uncertain situation. In this study,general X-ray tube modeling and apply energy-spectrum were compared physical characteristicsincluding the photon fluence, percent depth dose (PDD) and energy-spectrum. For photon fluence,X-ray tube modeling was lower than apply energy-spectrum modeling. For PDD and energyspectrum,X-ray tube modeling was similar to other modeling. However, simulation time at X-raytube modeling was higher than other modeling. Consequently, apply energy-spectrum modelingcould be useful in terms of simulation time with reliability in MCNPX simulation

토모테라피를 이용한 두경부암 방사선치료에서 Aid-pillow 사용에 따른 Pitch와 Yaw의 변화 분석

정재홍,조광환,김용호,문성권,민철기,김은석,이경배,정주영,서태석,최보영,Jung, Jae Hong,Cho, Kwang Hwan,Kim, Yong Ho,Moon, Seong Kwon,Min, Chul Kee,Kim, Eun Seog,Lee, Kyung-Bae,Jung, Joo-Young,Suh, Tae-Suk,Choe, Bo-Young 한국의학물리학회 2013 의학물리 Vol.24 No.1

본 연구의 목적은 두경부암 환자에서 aid-pillow 사용에 따른 pitch와 yaw의 변화를 분석하고자 하였다. 두경부암 환자 총 14명을 선정하여 aid-pillow 미사용 그룹(without, n=7)과 사용 그룹(with, n=7)으로 나누어 비교 분석하였다. 총 333회의 MVCT 영상을 이용하여 미사용 그룹(153 image set)과 사용 그룹(180 image set) 각각 종축 일치도(translational adjustments (lateral, longitudinal, vertical))와 회전축 일치도(rotational adjustments (pitch, roll, yaw))를 구하였다. Pitch의 변화 즉, 편차는 미사용 그룹 $0.12^{\circ}$이고, 사용 그룹 $0.09^{\circ}$였다. 그리고, yaw는 미사용 그룹 $0.47^{\circ}$이고, 사용 그룹 $0.17^{\circ}$였다. 전반적으로 사용 그룹이 미사용 그룹에 비해 편차가 작았다. 따라서, 토모테라피를 이용하여 두경부암 방사선치료 시 aid-pillow를 사용하여 pitch와 yaw의 변화를 줄임으로써, 치료의 재현성을 높일 수 있을 것으로 사료된다. The aim of this study was to analysis of the pitch and yaw deviations with or without using an aid-pillow for the head and neck cancer on the TomoTherapy. A total of 14 head and neck patients were selected to without-group (n=7) and with-group (n=7). A total of 333 MVCT image sets used to evaluate the translational (lateral, longitudinal and vertical) and rotational adjustments (pitch, roll and yaw) with 153 and 180 MVCT image sets at without- and with-group, respectively. Deviations of without- and with-groups were $0.12^{\circ}$ and $0.09^{\circ}$, respectively at pitch. And, deviations without- and with-groups were $0.47^{\circ}$ and $0.17^{\circ}$, respectively at yaw. In generally, with-group had reduced than without-group for the pitch and yaw deviations. Therefore, using an aid-pillow, it will able to increase the reproducibility of treatment for the head and neck cancer patients on the TomoTherapy.

고밀도 DRAM용 CMOS 하부 워드라인 드라이버 ( Simplified CMOS Sub-Word Line Driver for High Density DRAMs )

정재홍,안진홍,김용수,주양성,오준환,이희국 대한전자공학회 1996 대한전자공학회 워크샵 Vol.1996 No.-

융모상피암종성 분화를 보이는 직장의 선암종

정재홍,조용범,박치민,윤해란,이원석,서연림,윤성현,이우용,전호경 대한대장항문학회 2007 Annals of Coloproctolgy Vol.23 No.4

A choriocarcinoma of the rectum is extremely rare and has a very poor prognosis. Its rarity and the obscurity of its histogenesis make the entity of disease hard to define. We report a case of a choriocarcinoma of the rectum which showed synchronous liver and lung metastasis. A 52-year- old male patient presented with tenesmus, hematochezia and pain on defecation for 4 months. The preoperative colonoscopy revealed a mass at the rectum, 3 cm proximal to the anal verge. The biopsy revealed a poorly differentiated adenocarcinoma. An abdominoperineal resection was performed, and the pathologic examination confirmed a choriocarcinoma arising from an adenocarcinoma. Immunostain for β-human chorionic gonadotropin (hCG) was strongly positive for the choriocarcinoma component. Serum hCG checked postoperatively was as high as 4,222 IU/L, but the serum carcinoembryonic antigen (CEA) was normal. Although chemotherapy was begun at the 5th week after the operation, the patient died on the 47th day after the operation. A choriocarcinoma of the colon or the rectum is very rare and is aggressive. Although radical resection and chemotherapy are performed, the clinical outcome is very disappointing. Even though a choriocarcinoma of the colon or the rectum is very rare, it should be included on the list for differential diagnosis of a colorectal carcinoma.

정확한 환자 확인을 위한 의료생체인식기술

정재홍,이경배 대한자기공명기술학회 2022 대한자기공명기술학회지 Vol.32 No.1

This study discusses medical biometrics for accurate patient identification in the medical field. It first provides information concerning the definition, classification, and types of biometrics. It then reviews recent relevant research regarding information technology and types of medical biometric recognition technology that use biological signal and medical imaging. Finally, the current status of the medical environment is examined, along with the types of biometrics applied in medical fields. We believe that medical biometrics for patient identification will be gradually introduced into the medical field. Our study can be used to understand medical biometrics for accurate patient identification and utilized as primary data for research. 본 연구는 의료분야에서 정확한 환자 확인(patient identification)을 위한 의료생체인식기술(medical iometrics)을 소개하고 자 한다. 첫째, 생체인식기술(biometrics)에 대한 정의, 분류 및 종류와 같은 기본 정보다. 둘째, 생체신호(biological signal)와 의료영상(medical imaging)을 활용한 의료생체인식기술의 종류와 최근 연구에 관한 정보를 기술했다. 마지막으로 의료 환경에서 적용되는 생체인식기술의 종류와 사례와 함께 의료 환경의 현주소를 언급했다. 환자확인이라는 궁극적인 목적을 가진 의료생체인식기술은 의료 현장에 점진적으로 도입되리라 생각한다. 본 연구는 본 연구가 정확한 환자확인을 위한 의료생체인식기술을 이해하고 연구방향에 도움이 되는 기초 자료로 활용될 것으로 사료된다.

국가별 삼계탕에 대한 선호도 조사

정재홍,최희숙,장정옥,김형렬,양미옥 한국식품영양학회 2010 한국식품영양학회 학술대회논문집(학술심포지움) Vol.2010 No.12