경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

NSIP와 BOOP의 고해상전산화단층촬영 소견과 비교

백상현,박재성,차장규,홍현숙,김대호,박성진,조준희,이혜경,최진수 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Purpose: BOOP and NSIP also share similar clinical features such as subacute flu-like illness, the finding of bronchoalveolar lavage, the result of pulmonary function test and more favourable outcome than usual interstitial pneumonia(UIP). The author try to compare the HRCT findings of NSIP with BOOP by pattern and distribution of diseases. Materials and Methods: HRCT findings of histopathologically proven NSIP(Group Ⅰ; 6, Group Ⅱ; 7, Group Ⅲ; 2) in 15 patients(5 male, 10 female, age range, 39-69 years; mean age, 53 years), BOOP in 15 patients(6 male, 9 female, age range, 26-76 years; mean age, 52 years) were reviewed retrospectively. Results: The common pattern of the two diseases was admixed consolidation, ground glass attenuation & reticular densities with/without architectural distortion(NSIP; 53.3%, BOOP; 46.7%). The main component of the pattern wan predominantly consolidation(NSIP; 46.7%, BOOP; 73.3%) and ground glass attenuation(NSIP; 40.0%, BOOP;20.0%). Architectural distotion was more provinent finding with NSIP(mild ; 3, moderate ; 4, severe; 2) compared with BOOP(mild; 7, moderate; 2, severe; 0). The predominant overall distribution was lower lung, peribronchovascular & peripheral lung field in both of the two entities(NSIP;73.3%, BOOP; 73.3%). Peribronchovascular involvement was more common with NSIP(100%) than BOOP(80%), whereas peripheral involvement was more common with BOOP(93.3%) than NSIP(80%). Conclusion: The HRCT findings of NSIP and BOOP were similar in pattern and distribution. But NIP manifested more frequently ground-glass attenuation, whereas BOOP showed more frequently consolidation. Architectural distortion was more severe with NSIP than BOOP. NSIP invoved more frequently peribronchovascular space and BOOP were more common in peripheral lung field.

광주광역시 전문계 고등학교 특성화 및 종합발전방안

나승일,정철영,김진모,안강현,한홍진,김기용,민상기,장현진 한국농업교육학회 2008 농업교육과 인적자원개발 Vol.40 No.1

이 연구의 목적은 광주광역시 전문계 고등학교의 특성화 및 종합발전방안을 수립하는데 있다. 이 연구는 ① 전문계 고등학교 관련 선행연구 분석,② 인력육성 및 특성화 방향을 설정하기 위하여 광주광역시,전라남도,우리나라의 산업여건 분석,③ 광주광역시 전문계 고등학교에 대해 Malcolm Baldrige 평가모형에 의한 진단평가와 SWOT 및 활용전략 분석, ④ 광주광역시 전문계 고등학교의 개편 요구 분석,⑤ 광주광역시 전문계 고등학교의 특성화 및 종합발전방안 설정 등의 과정을 통해 수행되었다. 이 연구의 결과는 다음과 같다. 첫째,비전은 광주광역시 전문계고 특성화와 발전 역량 구축을 통한 산업체 요구에 부합하는 우수 인력 양성이며,이를 위한 전략은 특성화 체제구축,학교교육 혁신,인적 자원 혁신,학교경영 혁신,인프라 구축으로 설정하는 것이 필요하다. 둘째, 특성화 체제 구축은 특성화 체제 개편,교육과정 중심 특성화,학과 재배치 통합형 고교 도입,특성화고 신설을 통해 추진할 수 있 는데 특히,교육과정 중심 특성화가 적극 도입되어야 한다. 셋째,학교교육 혁신은 교육과정 개편,교수 학습 개선,진로지도 개선,시설 및 기자재 개선을 통해 추진할 수 있다. 넷째,인적자원 혁신은 학교 관리자 역량 강화,교원 역량 강화,학생 역량 강화를 통해 추진할 수 있다. 다섯째,학교경영 혁신은 경영 리더십 제고,경영 성과관리 강화,학교 재정 혁신을 통해 추진할 수 있다. 여섯째,인프라 구축을 위해 지자체,대학,산업체,지역주민과 연계 강화를 통해 추진할 수 있다. 일곱째,13개 전문계 고둥학교의 여건 및 특성에 적합한 단위학교별 특성화 및 종합발전방안을 수립하였다. The purpose of this study was to suggest strategies to specialize and develop vocational high schools in Gwangju Metropolitan City. The study was orderly performed as follows: (1) reviewing literature about vocational high school, (2) analyzing the condition of industries, (3) diagnosing the vocational high school through Malcolm Baldrige model, (4) analyzing the SWOT and application strategies, (5) analyzing the needs of reform, and (6) establishing the strategies for the specialization and development of Vocational High Schools in Gwangju Metropolitan City. The major findings of this study were as the following: First, the vision was to bring up excellent human resources to corresponds industrial needs through specialization and development of vocational high schools in Gwangju Metropolitan City. Five strategies to achieve it were creating the specialization system, innovating the school education, human resources, and the school management, and building the infrastructure. Second, creating the specialization system can be performed through five tasks which were restructuring the specialization system, creating curriculum-based specialization, trading departments in inter-schools, introducing an integrated high school, and building a new specialized high school. Especially curriculum based specialization needs to be accepted. Third, innovating the school education can be performed through four tasks which were reorganizing the curriculum, improving the teaching and learning, improving the career guidance, and improving the facilities and equipments. Fourth, innovating human resources can be performed through three tasks which were enhancing each competencies of a school manager, a teacher, and a student. Fifth, innovating the school management can be performed through three tasks which were improving the management leadership, developing the performance management, and innovating the school finance. Sixth, building the infrastructure can be performed through four tasks which were enhancing the relationships with a local government, colleges, industries, and local residents. Seventh, individual strategies for the specialization and development of thirteen vocational high schools were also developed by corresponding to their conditions and characteristics.

5HT 2A/T102C 다형성과 정신분열병 및 임상아형과의 관련연구

홍현상,백인호,김정진,이창욱,이 철,도규영 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.4

목 적 : 가계연구, 입양연구, 쌍생아연구들은 정신분열병의 원인으로 유전학적 요소가 매우 중요하다는 것을 지적해 주고 있다. 그러나 정신분열병의 유전적인 복잡성으로 인하여 많은 연구들이 시행되었음에도 유전방식이나 원인 유전자를 밝히지는 못하였다. 최근에는 5HT₂a수용체가 비정형항정신병약물의 주된 작용부위하는 것이 밝혀지면서 5HT₂a 수용체의 유전자가 정신분열병의 원인과 관련이 있을 것이라는 관심이 늘어나게 되었다. 따라서 저자들은 한국인 정신분열병환자들을 대상으로 5HT₂a 수용체 T102C 다형성과의 association study를 시행하였다. 방 법 : 환자군은 강남성모병원에 입원했던 DSM-Ⅲ-R의 진단기준에 의한 정신분열병환자로 250명이었으며 평균연령은 30.1±9.3세 이었다. 정신분열병환자를 위한 양성증상과 음성증상척도의 종합척도를 기준으로 점수가 1이상인 경우를 양성군, -1이하인 경우를 음성군으로 하였다. 대조군은 정신과나 신경과 질환의 과거력이나 가족력이 없는 236명의 지원자로 구성하였으며 평균연령은 23.6±3.7세이었다. 다형성과 정신분열병 및 임상양상과 임상아형 사이의 유전적인 관련성의 분석에는 로지스틱 회귀분석과 일원 변량분석을 시행하였으며 통계 프로그램으로는 SPSS 7.5를 사용하였다. 말초혈액에서 DNA를 분리한후 중합효소 연쇄반응으로 증폭하였으며, 증폭산물을 제한효소인 MspI으로 처리하여 유전자형을 판별하였다. 결 과 : 5HT₂a 수용체 T102C 다형성의 대립유전자 빈도와 유전자형 분포는 환자군과 대조군 사이에 유의한 차이를 보여주지 못하였으며, 임상아형과도 유의한 관련이 없는 것으로 나타났다. 그러나 정신분열병환자를 위한 양성증상과 음성증상척도중 음성증상척도는 유전자형에 따른 유의한 차이를 나타내었다(F=3.828, df=2, p=0.023). 결 론 : 본 연구의 결과는 한국인에서 5HT₂a 수용체의 T102C 다형성이 정신분열병의 발생과 임상아형의 결정에는 관련이 없으나 음성증상의 발현에는 관련이 있음을 시사해 준다고 하겠다. Objectives : Family, twin and adoption studies indicate that genetic factors play a crucial role in the etiology of schizophrenia. However, mode of inheritance of schizophrenia is uncertain, and genes for schizophrenia have not yet been identified despite extensive studies due to the complexity of the genetics of schizophrenia. Currently, 5HT₂a receptor gene has attracted considerable interest as a susceptibility gene of schizophrenia since the 5HT₂a receptor has been known as one of the major target sites of atypical neuroleptics. We conducted an association study of T102C polymorphism in the 5HT₂a receptor gene in Korean schizophrenic patients using PCR-RELP method. Methods : Two hundred and fifty biologically unrelated schizophrenic patients meeting DSM-Ⅲ-R criteria from Kangnam St. Mary's Hospital affiliated with Catholic University of Korea were recruited for our study. The patient group consisted of 123 male and 127 female subjects, aged 30.1±9.3years. The controls were volunteers for DNA library of Kangnam St. Mary's Hospital without family history of psychiatric or neurologic illness. The control group consisted of 124 males and 112 females, aged 23.6±3.7years. Amplified genomic DNA was digested by MspI. The significance of genetic association of the polymorphism was estimated by the logistic regression analysis and ANOVA using SPSS 7.5. Results : The allele frequencies and the genotypic distribution of 5HT₂a receptor gene were not significantly different between the patient and control group. In addition the allele frequencies and the genotypes of 5HT₂a receptor gene were not significantly associated with subtype of schizophrenia. However, negative symptom score according to genotype show significant difference(F=3.828 df=2 p=0.023). Conclusion : It is suggested that even if the development and subtype of schizophrenia may not be associated with T102C polymorphism of 5HT₂a receptor in Korean population, T102C polymorphism may be associated with the severity of negative symptom.

구리 지역에서 조사한 고혈압의 인지도, 치료률 및 관리률

홍철호,김순길,홍택원,이제,신진호,이재웅,김경수,김정현,임헌길,이방헌 대한간질학회 2003 대한간질학회지 Vol.9 No.1

Effects of Pilger Rolling and Heat Treatment on Microstructure and Corrosion Resistance of Ag-electroplated 304 Stainless Steel Tubes

Hyun Park,Woo‑Jin Lee,Jae‑Han Son,Han‑Kyun Shin,Sung‑Kyu Hong,Hyo‑Jong Lee 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.8

We introduce a cost-effective method that combines electroplating with metal cold working processes to manufacture compositetubes with robust corrosion resistance. First, a 3-step electroplating process was developed to form an adhesive anduniform Ag coating on the outer wall of a 304 stainless steel tube. The process consisted of a Ni-strike step for removing thepassivation layer of the initial 304 tube, Cu deposition for smoothing the surface by adding a buffer layer, and Ag deposition. To reinforce the interfacial adhesion between the electroplated layers and the 304 tube and increase the area of the Ag coating,a pilger rolling or pilger rolling + heat-treatment process was performed after the Ag electroplating process. Scanningelectron microscopy of the composite tubes after each process indicated that the as-deposited Ag coating changed fromhaving a rough to smooth surface after only pilger rolling and with additional heat treatment. Electron backscatter diffractionanalysis of the microstructures and textures of the tubes revealed that dynamic recrystallization occurred extensively duringpilger rolling, resulting in the formation of a relatively defect-free grain structure without heat treatment. Furthermore,electrochemical polarization curves determined that the Ag-coated composite tubes are superior to the uncoated 304 tubein terms of corrosion resistance under Cl−atmosphere, owing to the formation of a AgCl passivation layer during testing. Surface analysis of the composite tubes suggests that the properties of the AgCl passivation layer are related to the grainsize of the Ag coating and the density of plastic-deformation-induced defects.

ADPCM 통신을 위한 ISDN 기본율 접속구조

홍진표,허재헌,권원현 안양대학교 자연과학연구소 1995 自然科學硏究 Vol.2 No.-

비저지 시스템을 강력하게 추진하려는 전송설비와 통신망에 저속 코딩 기술이 출현하고 있다. 본 논문에서는 하나의 국제 표준 ISDN 기본율 접속을 통한 ADPCM 음성전송을 위하여 스위치 액세스 구조를 제안하였다. 제안한 구조에서는 2개, 3개 또는 4개의 음성 터미날과 데이타 터미날이 접속을 통하여 동시에 동작될 수 있다. 다양한 기술적 내용을 논의하였으며 제안한 기본율 접속구조, 기본율 S와 T 접속 비트 프레밍 요구와 Q.931 호 제어와 새로운 구조에 필요한 회선할당 절차를 논의하였다. 연구결과 기존 ISDN 스위치에서 제안한 구조로 갱신하는데 비교적 간단한 하드웨어 추가로 될 수 있고 표준 ISDN S와 T접속은 그대로 유지된다. This paper proposes a switch access architecture for Adaptive Differential Pulse Code Modulation voice transimssion over a single international standard Inetegrated Services Digital Network, Basic Rate Interface. In this proposed architecture, data terminals with two voice terminals, three voice terminals, or four voice terminals can be operated simultaneously through the interface. Various technical topics are dicussed : the proposed Basic Rate Interface architecture. BRI S and T interface bit framing requirements and the Q.931 call control and channel assignment procedures required for the new architecture. The study results show that relatively simple additional hardware could be used to upgrade an existing ISDN switch to this proposed architecture and the standard ISDN S and T interfaces remain intact.

도서관조직의 기술혁신 및 행정혁신에 관한 조직상황론적 연구

홍현진 한국문헌정보학회 1993 한국문헌정보학회지 Vol.25 No.-

치간 삭제 후 불소 또는 수산화인회석 도포 시 재광화 및 탈회억제에 관한 연구

홍현실,김호영,성지영,조진형,김상철 대한치과교정학회 2010 대한치과교정학회지 Vol.40 No.4

치간 삭제 후 재광화 및 치아우식 예방법을 찾기 위한 노력의 일환으로 1.23% 인산화불소 젤 또는 5%, 10% 수산화인회석함유 페이스트를 치간 삭제된 법랑질 표면에 도포하였고, 그 후 젖산탈회용액으로 처리하였다. 법랑질 표면의 재광화 및 탈회 후 결정구조 변화를 주사전자현미경으로 관찰하고 칼숨, 인, 불소 함량 등의 변화를 energy dispersive X-ray spectroscopy 로 분석해서 비교하였다. 치간 삭제 후 5%, 10% 수산화인회석함유 페이스트를 도포한 군에서 칼숨과 인 합량이 증가하였고, 1.23% 인산화불소 젤 도포 군에서는 불소 함량이 증가하였다. 또한 모든 재광화 제제에서 법랑질 표면이 매끄럽고 부드러워졌으며 결정구조가 작고 치밀해짐을 관찰할 수 있었다. 10% 수산화인회석합유 페이스트로 재광화한 군은 탈회 후에도 칼슐과 인 함량이 증가된 채로 유지되었고, 5% 수산화인회석합유 페이스트로 재광화한 군은 탈회 후 인 함량이 증가된 채로 유지되었다. 치간 삭제 후 탈회 처리 시 대조군의 법랑질은 파괴양상이 심해 거친 굴곡으로 이루어진 불규칙한 표면 상태를 나타내었으나 불소 및 수산화인회석으로 재광화한 군에서는 법랑질의 파괴양상이 적어 작은 결정입자들과 미세공극이 유지되었다. Objective: The aim of this study was to evaluate the effect of remineralization and inhibition to demineralization after fluoride gel (acidulated phosphate fluoride, APF) or hydroxyapatite (HAp) paste application on interdentally stripped teeth. Methods: After interdental stripping, 1.23% APF or 5%, 10% HAp paste were applied for 7 days for remineralization. Afterwards, teeth were exposed to lactate carbopol buffer solution for demineralization. Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) were used to compare change in surface contents and crystal structures after remineralization, and then after demineralization. Results: EDS analysis indicated that calcium (p < 0.001) and phosphate (p < 0.01) contents were increased after 10% HAp paste application on stripped enamel, calcium (p < 0.05) and phosphate (p < 0.01) contents were increased after 5% HAp paste application, and fluoride (p < 0.01) contents were increased after 1.23% APF application. SEM image showed that enamel surfaces became smoother and crystal structures became small and compact after APF or HAp application. After demineralization, calcium (p < 0.05) and phosphate (p < 0.05) contents remained increased on the enamel remineralized with 10% HAp paste, and phosphate (p < 0.05) contents remained increased on the enamel remineralized with 5% HAp paste. After demineralization, surfaces looked less destroyed in the enamel remineralized beforehand than those of the control, and small pores between crystal structures, formed by remineralization were remained. Conclusions: Hydroxyapatite paste and fluoride gel were helpful to remineralize and inhibit deminerlization on stripped enamel.

정신병적 증상이 동반된 기면병 1예

홍승철,송정민,정종현,권용실,한진희,이성필 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.5

Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hypnagogic hallucinations and disrupted nocturnal sleep. We report a patient with a diagnosis of schizophrenia who was subsequently diagnosed as narcolepsy. A case of a 22-year-old woman with concomitant narcolepsy and psychotic symptoms was discussed from a perspective of the diagnosis and therapeutic challenges, particularly on pharmcological treatment dealing with issues raised by their coexistence.