Purge & Trap-GC를 이용한 의약품 필름코팅 정제 중 잔류용제에 관한 연구

장준식,이명자,소유섭,문춘선,이주헌,박희라,김진숙,강경모,이선옥,방성연,유미자,유문균,금오성,이병욱 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약품은 약물을 생체에 적풋하기 위하여 유효성분의 효과가 언제나 일정하게 확보되고 사응에 편리하도록 만들어지는 것이므로 유효썽분 이외에 약효에 영향을 주지 않는 성분이 첨가되는 경운가 많다. 이 때 사용되는 용매들은 제피의 광택 및 건쪼시간의 단축 등을 위하여 휘발점이 낮을 용매들이 주로 사용되어진다. 본 연구는 의약품 필름코팅정제 중 잔류용매 4종(chlorofonr benzen, trichloro ethylen, 1,4-dioxane)에 대한 변형된 pirge & trap-GC 장치를 이용한 동시분석방법을 개발하였으며, 각 표준품의 RSD 값은 chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69% and 1,4-dioxane 3.41%였다. 또한 시중 유통중인 의약품 50종에 대하여 잔류웅매 양을 측정하였으며, 검출되는 잔류용매는 한 건도 없었다. This study nras carried out to develope the analytical method for the mixture of chlorefonn, benzen, trichloroethylen and 1,4-dioxane simultaneously and determine the remainingorgauic solvents in coating tablets by Purge & Trap-GC. The results were as follouFs ; 1. Chloroform, benzen, trio:tloroethylen and 1,4-dioxane separated by tenax #5 trap by HP-624GC column by terrlperature programming. The peaks were separated completely at retentiontime of 6.88min for chloroform, 8.21min for benzen, 10.38miu for trichloroethylen and 11.95minfor 1,4-dioxane. 2. Standard RSD were individually chloroform 3.03%, benzen 3.17%, trichloroethylen 3.69%and 1,4-diorane 3.41%. 3. 60 samples were not detrcted chloroform, benzen, trichloroethylen and 1,4-dioxane.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

개인 신용평가에서의 거절자 추론

이군희,황순임 서강대학교 경영학연구원 2004 서강경영논총 Vol.14 No.2

바젤2 협약 기반 소매여신의 신용위험 측정 방법론에 대한 연구

이군희 서강대학교 경영연구소 2004 서강경영논총 Vol.15 No.2

2004년 6월 26일에 발표한 바젤2 협약에서는 규제자본 산출을 위한 신용위험 측정 방법론을 제시하고 있다. 바젤2 협약에서 제시하고 있는 방법론은 Merton 모형을 기반으로 하는 단일요인모형(one-factor model)으로, 본 논고에서는 이에 대한 이론적 배경을 설명하고, 바젤2 협약에서 제시하는 신용위험 측정모형의 한계점에 대하여 논의하였다. 일반적으로 신용위험 측정모형은 0.1%의 확률로 나타날 수 있는 경기침체기 상황에서 부도확률을 증가시킬 뿐만 아니라 회수율도 감소시키는 것은 널리 알려진 사실이다. 하지만 바젤2 협약에서 제시하고 있는 신용위험 측정모형은 경기침체 시 부도확률의 증가는 인정하지만 회수율의 감소나 담보가치의 하락에 따른 손실을 고려하고 있지 않다. 즉, 부도가 발생되었을 경우, 은행이 담보를 처리하는 과정에서 담보가치의 하락 및 기타 비용 등의 문제에 있어서 경기 변동 요인이 심각하게 영향을 받고 있지만 이를 고려하지 않고 신용위험의 측정이 이루어진다는 것이다. 본 논고에서는 경기침체기 상황에서 담보가치의 하락이나 회수율 감소효과를 어떻게 측정하고 신용위험 측정에 반영할 것인지를 단일요인모형을 기반으로 제시하고자 한다. 이러한 측정이 적절하게 이루어지게 되면 차주의 신용상태는 우량하지 못하여 바젤2 협약에서는 높은 규제자본량을 설정하고 있지만 담보설정이 확실하다면 어느 정도 자본 요구량을 줄일 수 있는지에 대한 측정이 가능하게 된다. 바젤2 협약의 시행에 앞서 우리나라 감독당국은 국내은행과 함께 많은 준비가 필요하며, 특별히 손실에 대한 자료를 통한 LGD추정 문제는 현재 직면하고 있는 주요 문제 중 하나이다. 자료를 축적하고 우리나라 소매금융의 행태를 분석하여, 분석결과를 바탕으로 하는 구체적인 가이드라인이 제시되는 과정은 바젤2 협약의 성공적인 적용을 위하여 반드시 필요한 과정이다. 자료 분석을 기반으로 하지 않은 바젤2의 적용은 의미가 없으며, 결국 추상적으로 접근하는 비현실적인 규제밖에 될 수 없고 선진화된 금융경제의 모습은 기대할 수 없게 될 것이다.

Korean Vegetables : The Value and Utilization of Edible Mushrooms as Foods

Lee, Mie-Soon,Kim, Gun-Hee 식물자원연구소 덕성여자대학교 2006 植物資源硏究誌 Vol.5 No.-

채소류의 고품질유지를 위한 MA 저장의 효과

이은경,김건희 덕성여자대학교 자연과학연구소 2001 자연과학 논문집 Vol.7 No.-

The use of modified atmosphere(MA) storage have increased steadily and have contributed significantly to extending the postharvest life and maintaining quality of several vegetables. The beneficial effects of MA on vegetables are reduction of respiration and ethylene production rate, maintenance of quality and weight loss, and content of ascorbic acid and chlorophyll. The use of modified atmospheres should be considered as a supplement to proper temperature and relative humidity. The potential of benefit or hazard from using MA is dependent upon the commodity, variety, physiological age, atmospheric composition, temperature, storage period and so on. For optimal MA storage, it is very important to select proper thickness and type of packaging films to maintain atmospheric composition for keeping quality of vegetables.

골프연습장 소비자의 라이프 스타일과 구매의사 결정과정 연구

이진석,장건희 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

This study analyzes the life style of consumers at golf practice clubs, exercising consistently market segmentation, products positioning and facilitation strategy. The results were used as basic data to set up a marketing strategy commensurate with the enhanced consumers' needs. Ultimately, this study researches the effects of golf consumers' life style on the purchase decision-making process. As an object of this study, the consumers were selected at 15 golf practice clubs in Seoul, Gyeonggi-do Province and Chungnam Province. They were used as a mother group and collected a total of 366 questionnaires by convenient sampling method. Excluding the data showed uniform or repetitive answers, 331 questionnaires were finally used for this study. For data processing Descriptives Analysis, Multiple regression analysis were used. The attention level of the statistics is at p <.05, and the study is summarized as follows. Firstly, the life styles of substance-oriented purchase and brand-oriented purchase shown by golf club consumers have effect on problem recognition. Secondly, the consumer's life styles of substance-oriented purchase and pioneering purchase have effect on information search. Thirdly, the consumer's life styles of rational purchase, substance-oriented and brand-oriented purchase have effect on alternative evaluation. Fourthly, the life style of golf club consumers does not produce any effect on purchase. Fifthly, the consumer's life styles of mail order and pioneering oriented purchase bring effect on after-purchase evaluation.

모시대의 식품이용화 가치 증진을 위한 품질특성

이소라,김수정,김건희 덕성여자대학교 자연과학연구소 2001 자연과학 논문집 Vol.7 No.-

This study was conducted to increase the value as an useful food resources of Adenophora remotiflora. The contents of dietary fiber was 0.25 g/100 g(dry basis) and tannin was 155.2 ppm. The minerals in Adenophora remotiflora identified calcium(31.63 ㎎/㎏), potassium(149.51 ㎎/㎏), magnessium(14.15 ㎎/㎏), iron(1.40 ㎎/㎏), and sodium(1.46 ㎎/㎏). We examined the quality characteristics of Adenophora remotiflora kimchi during fermentation at 20℃ and 4℃. In color, L and a values gradually increassed at both storage temperature, the b values were decreased slightly at both 4℃ and 20℃. The results of pH decreased from 5.43 to 3.60∼4.60 at 20℃ and 4℃. However, tirtaratable acidity increased from 0.96% to 2.29∼3.98%. Also vitamin C and reducing sugar contents decreased during storage at both temperatures. In sensory evaluation, overall acceptability of Adenophora remotiflora kimchi showed lower scores as storage times increased.

Instrumental Variable 법을 이용한 시스템 매개변수의 직접추정

이건명,신봉인,이한희 경상대학교 생산기술연구소 2001 工學硏究院論文集 Vol.1 No.-

The direct parameter estimation method can estimate system parameter matrices from measured time data of excitation force and acceleration. The acceleration data are integrated numerically to obtain the velocities and displacements, and the system parameters are estimated from these data by solving equations of motion. The parameter estimation method has some advantages over other estimation methods. But the method is very sensitive to measurement noise and cannot estimate accurate parameters from noise corrupted measurements. To solve this problem, the instrumental variable method is applied to direct parameter estimation. Simulation results show that the accuracy of the estimated parameters is much improved by the application of the instrumental variable method.