18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

물질남용 치료프로그램 후 재범여부에 대한 예비적 추적조사 연구

김현수,조선미,오은영,임기영,정영기,윤웅장,이영미 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: 본 연구는 물질사범에게 시행되는 수강명령 프로그램의 효과를 재범률을 중심으로 살펴보고자 한 것이다. 방 법: 이 연구의 대상집단은 보호관찰소에서 의뢰받은 물질남용자집단이다. 이들은 법원으로부터 보호관찰, 수강명령, 치료명령, 사회봉사 등을 부과받았다. 총 104명의 대상자집단을 치료프로그램을 이수한 수강군과 비수강군으로 나누었으며 이들에 대한 재범률을 조사하였다. 결 과: 프로그램을 이수한 수강군이 비수강군에 비해 재범률이 낮았다(p<.05). 또한 단기 수강군과 장기수강군의 재범률의 차이를 조사하였는데 대상자 집단의 수가 적기 때문에 장기 수강군의 효과가 통계적으로 입증되지는 않았다. 결 론: 우리는 물질남용자에 대한 정책이 보다 교육적으로 변화할 것을 본 논문을 통하여 제시하려 하였으며 정부 및 법무부는 물질남용자에게 교육과 치료를 제공해주어야만 한다. Objectives: Using recidivism rate, we investigated the outcome after our substance abuse treatment program had been implemented. Methods: Our target population was substance abuse criminals referred by probational office. They either received the parole and probation order, treatment order or social service order from the court. We divided 104 substance abuse criminals into treatment group and non-treatment group. We examined their recidivism rate. Results: We reached a conclusion that treatment group had lower recidivism rate than non-treatment group(p<.0.5). We examined the effectiveness of short-term and long-term programs. However, no effectivess of long-term program was found because the sabject number was too small. Conclusion: We suggest that the strategies for substance abuse should be changed to more educative ones. The Government and Ministry of Justice must provide education and treatment to the substance abuse criminals.

일부 운수사업장 근로자의 건강진단 유소견자의 사후관리 실행과 관련요인

윤혜은,박종,이영선,강성득,김철호 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Objective : The purpose of this study was to find the relationship between the follow-up management status for medical problem to be treated and various characteristics of some workers at transportation business. Methods : A questionnaire survey was made toward 183 workers with medical problem(C and D2) among 945 examine in 1997. Results: Sixty four point five percent of surveyee received the examination result report and 40.5% were explained about the result 80.3% of surveyee answered that they knew the result of health examination. Most workers felt the necessity of the health examination, but 54.1% were dissatisfied with present health examination system and 66.7% pointed it out as nominal The rate of follow-up management for the medical problem was 62.8% By the multiple logistic regression the follow-up management rate for those who knew the health examination result were 2.98 times higher than those who didn't know the result (OR=2.98, 95% CI 1.41~6.29) The rate for those who perceived the medical problem already were 2.64 times higher than those who perceived the problem for the first time (OR=2.64, 95% CI 1.13~6.15). The rate for those who had subjective symptoms were 2.83 times higher than those who didn't have subjective symptoms. Conclusion : sixty two point eight percent of workers with medical problem performed the follow-up management and perception of health examination result, perception of the problem in the past and experience of subjective symptoms were related with the follow-up management.

서양복식에 나타난 복색규제에 관한 고찰

은영자,이해연 啓明大學校 生活科學硏究所 2005 科學論集 Vol.31 No.-

The costumes have been changed and developed with the development of the mankind. Also the color of the costume reflect the culture of the times and change. Furthermore the color of the costume has been used as symbol of social status. This study analysed the restrictions of color in the sumptuary of the western costume. The relations between the symbolic meaning of color and the sumptuary of the costume color were analysed through a literature survey. On the western costume sumptuary law, the major restriction colors were red, purple and violet. These were used only for governing class who have the Power and authority. Especially purple was used only for royal family. The symbolic meanings of color are given to costumes of specific social status. The color of the costume was related to the symbolic meanings of a specific color in the times and societies.

톨루엔의 급성흡입이 마우스의 1차 체액성 면역반응에 미치는 영향

표명윤,주은영 숙명여자대학교 약학연구소 1998 약학논문집-숙명여자대학교 Vol.15 No.-

Toluene was inhaled at concentration of 10,000ppm to ICR mice for 10, 20, 30min, and mice were sacrificed on day 2, 4, 6 or 8 following inhalation. Acute toluene inhalation didn't change the body weight gains, thymus and kidney weights. Spleen weight was slightly decreased, but there's no significant difference. Liver weight was significantly decreased on the 6th day after inhalation and recovered on the 8th day after. The number of WBC was significantly decreased on the 4th day and recovery from toluene hazard was appeared on the 8th day. Platelets were markedly and significantly decreased only on the 2nd day in every inhaled group. Red blood cells were increased on the 6th day and recovered on the 8th day after. The number of IgM plaque forming cells in splenocytes and IgM level in antiserum were increased in every inhaled group when toluene( 10,000 ppm, 10, 20, 30 min) was exposed to mice prior to primary immunization. When mice were exposed to toluene after immunization, IgM plaque forming cells and IgM level were increased in 10 min inhaled group and similar to PFC of control in 30 min inhaled group. Therefore the acute toluene inhalation at high dose in mice seems to increase the primary humoral immune response irrespective to the time of SRBC-antigen injection.

수박 덩굴마름병 저항성 판별을 위한 SNP 표지인자 탐색

이혜은,홍종필,서혜영,허윤찬,안율균,김진희,김도선 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

:Watermelon (Citrullus lanatus) is an important vegetable crop in the world and contains various health promoting compounds including many antioxidants such as lycopene and beta-carotene. Genetic diversity of cultivated watermelon is very narrow, which is one of major factors limiting the improvement of watermelon breeding program. Gummy stem blight (Didymella bryoniae (Auersw.)) is one of the most destructive diseases and causes crown blight, defoliation and fruit rot, resulting in severe production loss in watermelon. Single nucleotide polymorphisms (SNPs), important molecular markers for genetic studies are frequent sequence variation in the plant genome. This study was performed to develop SNP markers related to gummy stem blight resistance from three watermelon lines, one susceptible and two resistant to gummy stem blight. Of them, 22 SNP primers which were sequence information on SNPs derived from comparing a resistant and susceptible line was used for high resolution melt analysis. A total of 14 candidate SNP primers were detected melt temperature difference. These SNP primers can be useful for developing disease resistance-related markers and, therefore, beneficial to watermelon breeding program.

병원급식 체계에 관한 조사 연구

이정윤,서정숙,방병호,정은자,강남이,이진영 서울보건대학 1995 서울보건대학 부설 병원경영연구소 논문집 Vol.1 No.1

This study was conducted to evaluate the hospital foodservice management practices in Seoul and to suggest the guideline for the effective foodservice management. Questionnaire survey method were used in this study. Questionnaire were administered to dietitians in twenty hospitals. Data were analyzed for frequency, percentage, χ^(2)-test, and one-way ANOVA using SAS PC Package program. The results were summerized as follows : The number of dietition were less than the required number for efficient foodservice. Centralized foodservice method was adopted in most hospitals and conventional foodservice system was taken in all the hospitals. The space of a kitchen and a dining room were confined and sanitary facilities and working condition revealed problems. Equipped facilities in surveyed foodservice operations were assessed as the insufficient condition, especially, efficient facilities such as a cutting machine were scarecely make up.

FET형 CO₂센서의 제조 및 감응특성

이은숙,이영철,정지영,윤종훈,김창수,손병기,이흥락 경북대학교 센서기술연구소 1995 센서技術學術大會論文集 Vol.6 No.1

A FET type micro CO_(2) sensor based on a Severinghaus type arrangement has been prepared and its response characteristics were examined. The sensor was fabricated by formation of hydrogel layer containing bicarbonate/chloride ions on the PH-ISFET and the Ag/AgCl reference electrode prepared by the thermal evaporation and chemical chloridation methods. And then gas-permeable membrane was dip-coated on the hydrogel layer of the sensor. Gas-permeable membranes were fabricated with silicon rubber and polyurethane dissolved in toluene and THF, respectively. The CO_(2) sensor with the silicon rubber membrane showed better sensitivity and lower detection limit than the CO_(2) sensor with the polyurethane membrane for dissolved CO_(2). The sensor with silicon rubber membrane at optimal conditions showed a good response: linear range of 1.60X10^(-4) ~ 4.40X10^(-2) M CO_(2), sensitivity of 57.30 mV/decade, and detection limit of 7.50x10^(-4) M.

백반증 병변에 국한되어 발생한 건선 1예

김윤전,강희영,이은소,김유찬 대한피부과학회 2006 대한피부과학회지 Vol.44 No.4

肢발생중 세포 증식성에 미치는 Etretinate의 영향에 관한 연구

황정연,김은영,박선화,전용혁 고려대학교 의과대학 1994 고려대 의대 잡지 Vol.31 No.1

Cell proliferation in the developmental sequence of fore-limb in the DDY mouse with the adverse effect of single dose of etretinate (Tigason®) on it correlated to the drug-induced dysmorphogenesis was studied by measns of argyrophil technique for nucleolar organizer regions(AgNORs) and expression of proliferating cell nuclear antigen(PCNA). The number of AgNORs per nucleus displayed regional differences in the limb bud on day 11 of gestation, as higher values in apical ectodermal ridge(AER) and growing tip but decreased rapidly thereafter compared with those in the other parts of epithelia and subepithelial mesenchyme, while in core mesenchyme where the higest in its value on day 11, the numbers decreased depend not on the age but on the chondrified stage specific. Antibody reaction to PCNA expressed in almost all of the cells, stronger in mesenchyme than in epithelia on day 11 and then decreased gradually with the development proceed. Siver reactions to NORs as well as PCNA expression were decreased sharply by etretinate but recovered gradually from 24 hours after treatment except the value of AgNORs in the chondrified mesenchyme. The results Indicate that growth conducted by AER with subridge mesenchyme and chondrification in the core mesenchyme are two of major processes in the early development of limb, and the adverse effects of etretinate on proliferation and differentiation persist longer in the chondrified area but decreased expression of proliferative activities by the drug do not appear to be the result subsequent to the drug-induced cell death. The results suggest that temporal inhibition or interruption of the proliferation could deprive the programmed sequence of development of its appropriate timing with subsequent disturbance of the pace in growth which might be a role of limb dysmorphogensis but the drug's affinity to the chondrified cells remains a question.