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유쾌한,이수진,조진현,이기형,박건욱,김기환,조은경,최윤희,김혜련,김훈구,안희준,이하연,윤환중,강진형,정재헌,최문영,정신호,선종무,이세훈,안진석,박근칠,안명주 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2
Purpose The optimal cytotoxic regimens have not been established for patients with non-small cell lung cancer (NSCLC) who develop disease progression on first-line epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Materials and Methods We conducted a multi-center randomized phase II trial to compare the clinical outcomes between pemetrexed plus cisplatin combination therapy followed by maintenance pemetrexed (PC) and pemetrexed monotherapy (P) after failure of first-line EGFR-TKI. The primary objective was progression-free survival (PFS), and secondary objectives included overall response rate (ORR), overall survival (OS), health-related quality of life (HRQOL), and safety and toxicity profiles. Results A total of 96 patients were randomized, and 91 patients were treated at 14 centers in Korea. The ORR was 34.8% (16/46) for the PC arm and 17.8% (8/45) for the P arm (p=0.066). With 23.4 months of follow-up, the median PFS was 5.4 months in the PC arm and 6.4 months in the P arm (p=0.114). The median OS was 17.9 months and 15.7 months in PC and P arms, respectively (p=0.787). Adverse events grade 3 were reported in 12 patients (26.1%) in the PC arm and nine patients (20.0%) in the P arm (p=0.491). The overall time trends of HRQOL were not significantly different between the two arms. Conclusion The outcomes of pemetrexed therapy in NSCLC patients with disease progression after firstline EGFR-TKI might not be improved by adding cisplatin.
권희진,유쾌한,김인영,이슬기,장혜련,권기영 대한의학회 2015 Journal of Korean medical science Vol.30 No.1
Megalocytic interstitial nephritis is a rare form of kidney disease caused by chronicinflammation. We report a case of megalocytic interstitial nephritis occurring in a 45-yroldwoman who presented with oliguric acute kidney injury and acute pyelonephritisaccompanied by Escherichia coli bacteremia. Her renal function was not recovered despiteadequate duration of susceptible antibiotic treatment, accompanied by negativeconversion of bacteremia and bacteriuria. Kidney biopsy revealed an infiltration ofnumerous histiocytes without Michaelis-Gutmann bodies. The patient’s renal function wasmarkedly improved after short-term treatment with high-dose steroid.
이슬기 ( Seulkee Lee ),유쾌한 ( Kwai Han Yoo ),이걸 ( Keol Lee ),김인영 ( In Young Kim ),권희진 ( Hee Jin Kwon ),정혜민 ( Hyemin Jeong ),고은미 ( Eun Mi Koh ) 대한내과학회 2015 대한내과학회지 Vol.88 No.3
Overlap syndrome is defined as a disease entity that fulfills the classification criteria of at least two different rheumatologic diseases simultaneously. Overlap of systemic sclerosis (SSc) and rheumatoid arthritis (RA) is less common than the overlap of polymyositis with SSc or systemic lupus erythematosus. Distinguishing RA from SSc can be difficult because arthralgia is a frequent symptom of both. We observed three cases of RA and SSc overlap. In each case, RA occurred in sequence with SSc, with a period of 4-15 years between the onset of each disease. In one case, the patient had diffuse SSc, which is rare among overlap syndrome patients. Previously, only one case of overlap syndrome involving SSc and RA has been reported in Korea; herein, we report our cases with a review of the literature. (Korean J Med 2015;88:350-355)
전원선,이은정,김태형,유쾌한,왕동현,오태연,위지완,윤서영,서미선,조아라,박진성,전민혁,추은주,추은주 순천향대학교 순천향의학연구소 2009 Journal of Soonchunhyang Medical Science Vol.15 No.1
The synergistic infection of syphilis and HIV (Human immunodeficiency virus) infection is a re-emerging problem of global health after AIDS (Acquired immunodeficiency syndrome) era. Neglected treatment of syphilis in HIV-positive patients may lead to increased chance of HIV transmission in community and neglected screening of HIV in syphilis patients may delay diagnosis of HIV which now become a controllable chronic diseases. HIV-positive persons with syphilis co-infection are more likely to have neurologic complications and a higher rate of treatment failure with currently recommended regimens. And the neurologic manifestations of syphilis in HIV patients tend to occur earlier periods of HIV infection. But neuropsyphilis in HIV patients is still poorly understood, despite > 2 decades of clinical experiences.
김희경,함준수,변성규,유쾌한,정기선,송하나,조진현,이지윤,임성희,김혜수,김지연,이정언,김석원,남석진,이세경,배수연,안진석,임영혁,박연희 대한암학회 2016 Cancer Research and Treatment Vol.48 No.4
Purpose The purpose of this study was to assess the tumor characteristics and long-term clinical outcomes of adjuvant treatments after surgery with a curative aim for patients with breast cancer who are 65 years and older. Materials and Methods Patients with breast cancer who underwent curative surgery from 2000 to 2009 were analyzed (n=4,388). Tumor characteristics and survival outcome were compared by dividing the patients into two age groups (< 65 and 65 years old). The Kaplan-Meier method was used for comparison of survival rates by log-rank test, and a Cox regression model was used to examine the effect of variables. Results Among 4,388 patients with invasive breast cancer, 317 patients (7.2%) were 65 years or older and the median age of all patients was 47 years (range, 18 to 91 years). Tumor characteristics were similar between the two age groups, but the older patients were treated less often with adjuvant treatments. During a median follow-up period of 122 months, recurrence-free survival (RFS) was equivalent for patients 65 years and older compared to younger patients, but significantly worse in overall survival (OS) and breast cancer–specific survival (BCSS) (5-year OS, 94.3% vs. 90.5%; p < 0.001 and 5-year BCSS, 94.7% vs. 91.8%; p=0.031). In the multivariate model, age 65 years old was identified as an independent risk factor for OS and RFS. Conclusion Elderly breast cancer appeared to have worse outcomes with very low prevalence in Korea, despite similar tumor characteristics. More active adjuvant therapies would have a role for aggressive subtypes for fit, elderly patients.