Effects of Gaze Stabilization Exercise and Cognitive Training on Balance and Gait in Subacute Stroke Patients: Randomized Controlled Trial

장혜련,김예지,김명권 대한물리의학회 2024 대한물리의학회지 Vol.19 No.1

PURPOSE: The purpose of this study was to evaluate the effects of simultaneous application of gaze stabilization exercise and cognitive training on the balance and gait ability in subacute stroke patients. METHODS: Thirty-five patients diagnosed with stroke within 3-6 months were randomly assigned, and the experimental group (n = 18) to which both gaze stabilization exercise and cognitive training were applied and the control group (n = 17) to which only gaze stabilization exercise was applied were targeted. It was performed for 30 minutes at a time, three times a week, for a total of 4 weeks. Berg Balance Scale, Timed Up and Go test, 10Meter Walking Test, and Walking symmetry were evaluated. RESULTS: In the comparison of changes between Berg Balance Scale, Time Up and Go test, 10 Meter Walking Test, and Gait symmetry, both experimental and control groups showed significant differences before and after the intervention, and in the evaluation of Gait symmetry, significant differences between groups. CONCLUSION: As a result of this study, when gaze stabilization exercise and cognitive training were allied simultaneously, it was possible to improve the balance and gait ability of subacute stroke patients, and had a more significant effect on gait ability. In considered that training that simultaneously applies gaze stabilization exercise and cognitive training can be presented as a balance and gait rehabilitation for stroke patients on the future.

브로콜리를 첨가하여 제조한 비단죽의 이화학적 품질특성 모니터링

장혜련,김현순,임지순,금준석 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2009 한국식품저장유통학회 학술대회 Vol.2009 No.-

Inkjet-printed Zinc-tin-oxide TFTs with a Solution-processed Hybrid Dielectric Layer

장혜련,곽영진,최운섭 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.9

Sol-gel TiO2 was synthesized and used as a gate dielectric for oxide thin-film transistors (TFTs). A hybrid gate insulator composed of sol-gel TiO2/thermally-grown SiO2 was applied to the inkjetprintedzinc-tin oxide (ZTO) TFTs for the first time. The electrical properties of an inkjet-printedZTO TFT with a hybrid gate insulator show a mobility of 0.17 cm2/Vs, an on-to-off current ratio of 5× 104, a subthreshold slope of 0.8 V/dec, and a threshold voltage of 0.6 V. The hybrid gate insulatorfor the inkjet-printed ZTO TFT shows a much improved operating voltage and subthreshold slopeand a lower mobility compared to the SiO2 gate insulator.

70년대 멜로드라마의 응전과 실패 - 김승옥 <도시로 간 처녀> 각색 연구 -

장혜련 한국현대문예비평학회 2024 한국문예비평연구 Vol.- No.81

이 글은 7, 80년대 김승옥의 시나리오 작업이 애정물의 통속성만 갖추고 있지 않음을 밝히고자 한다. 특히 여성 노동자에 대한 파격적 형상화를 시도했던 <도시로 간 처녀>를 둘러싼 여러 가지 문제점을 짚어 보고, 70년대 그가 견지한 시대적 응전이 어떻게 좌절되는지 살펴보았다. <도시로 간 처녀>는 홍성원의 「흔들리는 땅」을 각색한 시나리오이다. 「흔들리는 땅」은 버스를 돌아다니며 물건을 파는 행상들을 대상으로 그들의 고단한 노동환경을 그리고 있다. 소설은 남성 인물들 중심으로 그려지며 애인인 남숙을 통해 버스 ‘안내양’의 삶을 스케치한다. 이때 남숙의 투신 사건은 남성 화자에 의해 ‘거룩한’ 행동으로 신비화되고 있다. <도시로 간 처녀>는 전면적인 각색을 통해 중심인물을 버스 ‘안내양’으로 바꾸고 그녀들의 열악한 노동환경과 삶을 본격적으로 그린다. 그러나 노동 분규 끝에 문희가 건물에서 투신하는 장면은 문제적이다. “순결한 처녀들의 생활”을 촉구하며 건물에서 뛰어내린 문희의 행동은 노동 투쟁으로 볼 수 없으며 개인의 도덕적 우월성에 바탕을 둔 극단적 행동이다. 노동자성보다는 개인의 윤리성을 강조하는 시나리오의 문제점은 7, 80년대 김승옥의 멜로드라마 각색 작업의 문제점이기도 하다. 사회문제의 원인을 개인에게 돌림으로써 노동문제를 제대로 진단하지 못하는 결점을 드러낸 것이다. <도시로 간 처녀>의 각색 과정에서 드러난 노동자 재현의 의지가 실패하는 내용적 특징을 살펴봄으로써 김승옥 후기 각색 작업의 멜로드라마 양태를 더욱 다채롭게 조명할 수 있으리라 기대한다. This article aims to clarify that Kim Seung-ok's screenplay work in the 7, 80s does not only have the consistency of affection. In particular, he pointed out the various issues surrounding <The Maiden Who Went to the City> who attempted to portray female workers in an unconventional way, and examined how the response of the times that he maintained in the 70s was frustrated. <The Maiden Who Went to the City> is a screenplay adapted from Hong Sung-won's 『The Shaking Land』.『The Shaking Land』 depicts the hard working conditions of the peddlers who travel around the bus and sell goods. The novel is drawn mainly on male characters, and the life of the bus 'guide' is sketched through her lover, Nam Sook. At this time, the incident of Nam-sook's commitment is mystified by the male narrator as a "holy" act. <The Maiden Who Went to the City> is a full-scale adaptation that changes the central character to a bus ‘guide’and depicts their poor working conditions and lives in earnest. However, the scene in which Moon-hee throws herself in the building after a labor dispute is problematic. Moon-hee's act of jumping from a building calling for the “life of chaste virgins”cannot be seen as a labor struggle, but a problematic action based on individual moral superiority. The problem with the scenario, which emphasizes the ethics of the individual rather than the nature of the worker, is also the problem of Kim Seung-ok's melodrama adaptation work in the 7th and 80s. By blaming individuals for social problems, it reveals the flaw of failing to properly diagnose labor problems.

Microwave-Assisted Synthesis of Reduced Graphene Oxide Nanosheets for Highly Reversible and Ultrafast Energy Storage Applications

장혜련,서인규,오성택,이순직,연정미,박원규,신명선,최선용,백승민 한국에너지학회 2020 한국에너지공학회 학술발표회 Vol.2020 No.11

급성 신손상의 동물 모형

장혜련 대한이식학회 2017 Korean Journal of Transplantation Vol.31 No.3

Acute kidney injury (AKI) is classified into three types according to its pathophysiology: prerenal, intrinsic renal, and post-renal AKI. Experimental models of AKI can be divided into two categories: in vivo and in vitro. Models can be further subdivided according to how AKI is simulated. The pathophysiology of intrinsic renal and post-renal AKI has been investigated using animal models. Most studies have been conducted in murine models using male mice or rats, while large mammals like sheep, pigs, and monkeys have been used in a limited number of studies. The intrinsic renal AKI model is divided into septic vs. aseptic AKI. Aseptic AKI is subdivided into ischemic vs. nephrotoxic AKI. Lipopolysaccharides (LPS) injection or cecal ligation and puncture (CLP) have been used to simulate the septic AKI model in rodents. Ischemic AKI is the most extensively investigated field to date because ischemic AKI is the most common and serious cause of AKI in both native kidneys and renal allografts. Ischemia-reperfusion injury (IRI) surgery has been used to induce ischemic AKI. There are two different methods of IRI surgery: laparotomy vs. flank approach. Warm temperature and male sex are critical to induction of sufficient grade of renal injury in this model. Many nephrotoxicants pertinent to human disease have been used to reproduce nephrotoxic AKI in rodent models. Cisplatin, a common chemotherapeutic agent, has many pathophysiologic features that overlap with IRI. Other nephrotoxicants such as gentamicin or glycerol were studied in the past, whereas much more attention has recently been devoted to environmental nephrotoxicants such as cadmium. However, variant susceptibility to different doses of nephrotoxicants is a big hurdle to set up a reproducible and consistent model of nephrotoxic AKI. Post-renal AKI is simulated with ureteral obstruction surgery, whereas the unilateral ureteral obstruction (UUO) model has frequently been used. Although some novel findings have been reported through numerous studies using murine AKI models, AKI still remains a challenging condition that lacks specific diagnostic or therapeutic tools because of species barriers or experimental settings. Animal AKI models using mammals genetically closer to human like monkeys would be valuable to simulate human AKI more appropriately.

High Dose Vitamin D3 Attenuates the Hypocalciuric Effect of Thiazide in Hypercalciuric Rats

장혜련,이재욱,김세중,허남주,이정환,김효상,정지용,오윤규,나기영,한진석,주권욱 대한의학회 2010 Journal of Korean medical science Vol.25 No.9

Thiazide is known to decrease urinary calcium excretion. We hypothesized that thiazide shows different hypocalciuric effects depending on the stimuli causing hypercalciuria. The hypocalciuric effect of hydrochlorothiazide (HCTZ) and the expression of transient receptor potential vanilloid 5 (TRPV5), calbindin-D28K, and several sodium transporters were assessed in hypercalciuric rats induced by high calcium diet and vitamin D3. Urine calcium excretion and the expression of transporters were measured from 4 groups of Sprague-Dawley rats;control, HCTZ, high calcium-vitamin D, and high calcium-vitamin D with HCTZ groups. HCTZ decreased urinary calcium excretion by 51.4% in the HCTZ group and only 15% in the high calcium-vitamin D with HCTZ group. TRPV5 protein abundance was not changed by HCTZ in the high calcium-vitamin D with HCTZ group compared to the high calciumvitamin D group. Protein abundance of NHE3, SGLT1, and NKCC2 decreased in the hypercalciuric rats, and only SGLT1 protein abundance was increased by HCTZ in the hypercalciuric rats. The hypocalciuric effect of HCTZ is attenuated in high calcium and vitamin D-induced hypercalciuric rats. This attenuation seems to have resulted from the lack of HCTZ’s effect on protein abundance of TRPV5 in severe hypercalciuric condition induced by high calcium and vitamin D.

Effects of Thiazide on the Expression of TRPV5, Calbindin-D28K, and Sodium Transporters in Hypercalciuric Rats

장혜련,허남주,김효상,Soren Nielsen,오윤규,나기영,주권욱,한진석,김세중,이정환,전은실 대한의학회 2009 Journal of Korean medical science Vol.24 No.-

TRPV5 is believed to play an important role in the regulation of urinary calcium excretion. We assessed the effects of hydrochlorothiazide (HCTZ) on the expression of TRPV5, calbindin-D28K, and several sodium transporters in hypercalciuric rats. Sprague- Dawley rats were divided into 4 groups; control, HCTZ, high salt, and high salt with HCTZ group in experiment 1; control, HCTZ, high calcium (Ca), and high Ca with HCTZ group in experiment 2. To quantitate the expression of TRPV5, calbindin- D28K, and sodium transporters, western blotting was performed. In both experiments, HCTZ significantly decreased urinary calcium excretion. TRPV5 protein abundance decreased in all hypercalciuric rats, and restored by HCTZ in both high salt with HCTZ and high Ca with HCTZ group. Calbindin-D28K protein abundance increased in the high salt and high salt with HCTZ groups, but did not differ among groups in experiment 2. Protein abundance of NHE3 and NKCC2 decreased in all hypercalciuric rats, and were restored by HCTZ in only high Ca-induced hypercalciuric rats. In summary, protein abundance of TRPV5, NHE3, and NKCC2 decreased in all hypercalciuric rats. The hypocalciuric effect of HCTZ is associated with increased protein abundance of TRPV5 in high salt or calcium diet-induced hypercalciuric rats.

포스터 전시 발표 : 신장 ; 찜질방에서 발생한 중증 열사병 1례

장혜련,손민정,허남주,이재욱,주권욱,김연수,안규리,한진석,김성권,이정상 대한내과학회 2003 대한내과학회 추계학술대회 Vol.65 No.10

길림시 조선어 단모음에 대한 실험음성학적 분석

장혜련(?慧?) 길림성민족사무위원회 2020 중국조선어문 Vol.226 No.-

본 론문은 실험음성학적 방법과 통계분석 방법을 리용하여 경상도방언 사용자를 대상으로 길림시 조선어 단모음에 대하여 연구를 진행하였다. 그 결과 길림시 조선어의 단모음은 경상도 방언과 차이를 보이는데 주요하게 /ㅓ/와 /ㅡ/의 변별이 명확하지만 /ㅔ/와 /ㅐ/, /ㅗ/와 /ㅜ/의 변별은 명확하지 않고 /ㅚ/와 /ㅟ/는 스펙트로그람에서 전이구간이 보이므로 이중모음으로 볼 수 있다.