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서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)
김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1
Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.
요중 비소농도와 N-acetyl-β-D-glucosaminidase 농도와의 관련성 평가
이용찬,임동혁,엄상용,김용대,김헌 충북대학교 의과대학 충북대학교 의학연구소 2010 忠北醫大學術誌 Vol.20 No.1
Purposes: This study was performed to evaluate the possibility of impairment of renal tubular function by exposure to inorganic arsenic of low concentration. Materials and methods: Study subjects were 867 individuals (365 men and 502 women) who resided around abandoned mine areas in Chungbuk Province, Republic of Korea. Information about the life style, drinking water type, seafood intake, and mine working history was gathered, and urinary arsenic concentration and N-acetyl-β-d-glucosaminidase (NAG) activity were measured. The correlation between arsenic concentration and urinary NAG activity was tested in groups classified according to urinary NAG activity and seafood consumption prior to urine sampling. Results: No statistically significant difference in urinary arsenic concentrations was observed between different gender and age groups. The participants those who ate seafood within three days before the urinary sample showed a higher mean urinary arsenic concentration than those who did not. In a correlation analysis between natural logarithm of urinary arsenic concentrations and that of urinary NAG activities, no statistical significance was found in a total sample as well as within a gender group. In a group with the urinary arsenic concentrations higher than the geometric mean and the urinary NAG activities higher the geometric mean, the correlation coefficient between two variables was 0.182 and significant. (p-value<0.05) Conclusions: It is suggested that renal tubular damage could be induced by non-occupational exposure to low level inorganic arsenic. 연구목적 : 본 연구는 폐금속광산 주변지역 주민들을 대상으로, 저농도 비소노출에 의하여 신세뇨관 기능이상이 유발될 수 있는지를 평가하는 것을 목적으로 시행하였다. 대상 및 방법 : 충청북도에 소재하고 있는 폐금속광산의 주변에 거주하는 주민 867명을 대상으로 직접 면접조사를 실시하였다. 대상자의 소변을 채취하여 요중 비소농도와 요중 N-acetyl-β-D-glucosaminidase (NAG) 활성을 측정하였고, 조사대상자를 역학적 변수에 따라 구분하여 두 변수 사이의 상관관계를 분석하였다. 결과 : 소변시료를 채취하기전 3일 이내에 해산물을 섭취한 사람들의 요중 비소농도는 그 기간동안 해산물을 섭취하지 않은 사람들의 농도에 비하여 유의하게 높았다. 조사 대상자들의 요중 NAG 농도의 평균값은 남녀차이가 없었으나, 65세 미만 대상자와, 표본을 채취하기 전 3일 이내에 해산물을 섭취한 사람들의 요중 NAG 활성도의 평균값은 그렇지 않은 사람들에 비하여 유의하게 낮았다. 요중 비소농도가 기하평균 이상이고, 요중 NAG 활성이 기하평균 이상인 군에서 두 변수의 상관관계가 0.182 로 유의하였다. 결론 : 정상범위의 비소 노출이라도 요중 비소농도가 8.28 μg/g creatinine을 초과하는 경우에는 미세한 신장손상을 유발할 가능성이 있으며, 해산물을 섭취함으로써 체내에 흡수되는 비소는 이러한 신독성이 거의 없다.
후두 편평세포암종에서 Galectin-1 및 -7의 발현 의의
김건형,강차영,윤혁수,도남용,조성일,임성철 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2
Background and Objectives: The role of different Galectins in the pathogenesis of different types of malignancy is being profoundly investigated recently. In this study, the author investigated the level of Galectin-1 and -7 in the layngeal squamous cell carcinoma tissue to define its relationship to the tumor progression. Materials and Methods: Paraffin-embedded tissue specimens from 77 patients, who were diagnosed as laryngeal squamous cell carcinoma from 1993 to 2007, were immunohistochemically stained for Galectin-1 and -7. Results: Galectin-1 expression was positively correlated with tumor stage and nodal involvement. Galectin-7 expression was increased in better differentiated tumors. Conclusion: Expression of Galectin-1 and -7 can be used as a valuable indicator in laryngeal squamous cell carcinoma under certain limitations.
『구입유물공개전』 전시유물 보존처리 : 금속유물을 중심으로
권혁남,이용희,김종오 국립중앙박물관 2000 박물관보존과학 Vol.2 No.-
국립중앙박물관에서는 국내외에서 구입한 유물들을 전시하기 위하여 보존처리를 실시하였다. 처리유물은 금속제 유물을 비롯하여 목제, 회화, 목·칠기 등 다양한데, 이중 금속유물 42점의 보존처리 내용을 재질별로 소개하였다. 유물의 현재 상태를 파악하기 위해 현미경 조사 및 X-선 촬영을 실시하였으며 재질에 따라 이물질 제거 방법, 안정화 처리 방법 등의 처리 방향을 설정하였다. 또한 역사적 자료를 보존하고 일반인들에게 전시할 수 있는 조치를 취하였다. For exhibition, conducted conservation treatment for a variety of collections acquired at home and abroad such as metallic objects, wooden-ware, paintings and lacquer-ware. Conservation treatment methods for 42 metallic objects were introduced for material types. X-ray and microscopic method were used to identify the current state of the collections and in some case if necessary, various foreign particle removing and stabilization method were used depending on material type. Historical data were stored and exhibited to public.
기포유동층 반응기 내에서 천연제올라이트를 사용한 아연계 탈황제의 반응특성연구
김동현,정용길,박노국,이종대,전진혁,류시옥,이태진 한국공업화학회 2003 응용화학 Vol.7 No.2
To improve attrition resistance, calcium oxide was added to durable ZZF sorbent. It was named ZZFCa sorbent. The reactivity of ZZFCa sorbent was investigated in the fluidized-bed reactor. The influencesof the sulfur capacity and the regeneration time for various fluidization velocities from 0.07㎧ to 0.20㎧ were investigated for 5-cycles. As a result, ZZFCa sorbent appeared the high sulfur capacity abouve 10gS/100g sorbent. The sulfur capacity of ZZFCa was maintained, although fluidization velocities increased.
Sarcoma 180 이식마우스에서 Interleukin-2, 4 10의 변화
김광혁,박건영,정영기,이원기 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1
Experiments were undertaken to investigate the effect of cancer cell, sarcoma 180 (S180) on production of interleukin(IL)-2, 4, and 10 in BALB/c mice. Splenocytes of normal mice were incubated with S 180 cells. The culture supernatants were collected at 2, 4, 6, 24, and 72 hr and assessed for IL-2, 4, and IL-10 production by enzyme-linked immunosorbent assay. The production of IL-2 in the culture supernatant of adherent cells exposed with S 180 was not detected, but it increased at 24 and 72 hr in culture with non-adherent or whole splenocyte. The production of IL-4 in the culture supernatant of S 180, adherent, non-adherent or whole splenocyte was detected, but by co-culture with S 180 it showed significant increase at 72 hr. Also, the production of IL-10 in the culture supernatant of S 180, adherent, non-adherent, or whole splenocytes was detected. By exposure with S 180 it increased to 10-80 times in comparison with the control. Normal mice were transplanted with S 180 into peritoneum. Sera and peritoneal fluids(PF) were collected at 2, 4, 6, and 24 hr. The production of IL-2 in sera was not detected, but in PF it was a little. The production of IL-4 in sera or PF was detected, but it showed the significant decrease in comparison with the control. The production of IL-10 in sera was detected in transplantation or control group, and it increased in transplantation group. The production of IL-10 in PF showed the increase at 24 hr. By exposure of S 180 tumor cells in immuno-competent cells or transplantation with S 180 into mouse, IL-4 decreased in sera and PF, but IL-10 showed the remarkable increase in the culture supernatant of splenocytes and in sea. These data suggest that the unbalanced conditions such as suppression of IL-4 production and overproduction of IL-10 in vivo may be responsible for dysfunction of immune system.