Genome-wide investigation of a Korean synthetic breed, Woori-Heukdon using the Illumina PorcineSNP60K BeadChip

Yong‑Min Kim,Ha‑Seung Seong,Jung‑Jae Lee,Da‑Hye Son,Jin‑Su Kim,Soo‑Jin Sa,Young‑Sin Kim,Tae‑Jeong Choi,Kyu‑Ho Cho,Joon‑Ki Hong,Jung‑Woo Choi,Eun‑Seok Cho 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Woori-Heukdon (KWH) is a Korean synthetic pig breed generated using Chookjin-Duroc (KCD), Chookjin-Chamdon (KCC), and their crossbreds. Currently, there is a severe lack of studies investigating the Korean breed populations including wild boars (KWB) throughout the genome. Objective: This study was performed to investigate the genetic characteristics of Korean pig populations at the genome-wide level. Methods: Using the SNP dataset derived from genotyped and downloaded datasets using the Illumina PorcineSNP60K BeadChip, we compared the genomes of 532 individuals derived from 23 pig breeds to assess the genetic diversity, inbreeding coefficient, genetic differentiation, and population structure. Results: KWB showed the lowest average expected heterozygosity (HE = 0.1904), while KWH showed the highest genetic diversity (HE = 0.02859) among Korean populations. We verified that the genetic composition of KWH, showing USD of 74.8% and KCC of 25.2% in ADMIXTURE analysis. In population structure analyses, KCC was consistently shown to be separated from other pig populations. In addition, we observed gene flow from Western pigs to a part of Chinese populations. Conclusion: This study showed that Korean native pigs, KCC have genetic differences in comparison with Chinese and Western pigs; despite some historical records and recent genetic studies, we could not find any clear evidence that KCC was significantly influenced by Chinese or Western breeds in this study. We also verified the theoretical genomic composition of KWH at the molecular level in structure analyses. To our knowledge, this is the first genomic study to investigate the genomic characteristics of KWH and KCC.

신호교차점 접근로의 지체해석에 관한 연구

우용한,김대웅,최용석 嶺南大學校 工業技術硏究所 1998 工業技術硏究所論文集 Vol.26 No.2

This study was a selection circular road of Taegu city and four intersections approach which is located in the suburbs as the subject of study. And then, observed the relation between volume, traffic, speed and distribution of vehicle speed. It was examined the goodness of fit after making a model through the decelerated delay, accelerated delay and stopped delay which are calculated on the basis of the survey data. And also looked into the relation among the approach delay and the stopped delay and vehicles delay of signalized intersection approach which was caused by the traffic congestion. In the comparison of the average stopped delay for the model, KHCM model have an observation values and an approximate value. It was known the fact that the prediction model (1) and (2) that is provided by this study can applied at present. It could use this result to the shortest route search method and the signal system operation, the calculation of the service level at the signalized intersections.

비정상 질확대경검사 소견을 보이는 환자에서 환상투열요법의 직접적 적용에 관한 연구

우헌탁,이철민,박교훈,조용균,최훈,김복린,이홍균 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

Objective: Large Loop Excision of the Transformation Zone (LLETZ) has been widely used for evaluating cervical dysplasia/cancer. We performed this study to evaluate if colposcopically suspected cervical high-grade dysplasia or cancer could be directly evaluated and treated with LLETZ. Methods: 93 women who were scheduled for colposcopic evaluation because of an abnormal cervical cytology report were included in the study in Sanggye Paik Hospital from Jan to Dec 2001. Mean age of the study population was 38.6±9.0. colposcopy directed punch biopsy was not performed and histologic diagnosis was made by LLETZ. Sensitivity and specificity of colposcopic evaluation was calculated and compared with those of cervical cytology. Results: On histopathological examination by LLETZ, 11(11.8%) patients had invasive cancers including 3(3.2%) adenocarcinomas. The sensitivity and specificity of colposcopy for the detection of cervical dysplasia or cancer was 71.7% and 72.3% respectively, wile those of cytology was 56.5% and 74.5% respectively. Conclusion: LLETZ may be adequately performed for the diagnosis and treatment of cervical dysplasia/cancer based on the results of pap smear and colposcopy without punch biopsy. Cost benefit might be anticipated while cost-effectiveness analysis is necessary in the future.

Pyridostigmine과 Neostigmine의 골격근이완계 길항 효과에 관한 연구

우현제,신용섭,김태관,이정은,최세진 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.2

This present study was undertaken to observe the effects of pyridostigmine and neostigmine of heart rate and it's antagonistic effect on pancuronium in 62 patients during general anesthesia. We obserived the effect of pyridostigmine and neostigmine with atropine and glycopyrrolate of heart rate, appearance of arrhythmia, time required for returning of spontaneous breath an sustained tetanic response and effect on the amount of secretion in oral cavity and trachea. The result are as follows: 1. The incidence of bradycardia was the highest in the group of atropine and neostigmine i. v. administration together, and the lowest in the group of glycopyrrolate and pyridostigmine i. v. administration together. 2. The incidence of tachycardia was the highest in the group of atropine and pyridostigmine i. v. adminstration together, and the least in the group of glycopyrrolate and pyridostigmine i. v. administration together. 3. Among the experimental cases, only one showed arrhythmia which is PVD. 4. The time required for returning of spontaneous respiration was 4.6-6.1 minutes range in all groups. 5. The group of glycopyrrolate administrated showed the greates antisialogue effect.

증폭원리를 이용한 초정밀 나노스테이지 개발

최수창,김용우,김진근,박정우,이득우 한국공작기계학회 2008 한국공작기계학회 추계학술대회논문집 Vol.2008 No.-

The laser-interferometer and capacitive displacement sensors were used to increase the resolution of the feedback system for stage used for measuring and processing the system. However, it was difficult to obtain high-resolution measurements, considering the measuring method and structural characteristics. This study developed a inverse magnification type stage to evaluate characteristics. Therefore, we introduced a nano-stage with a magnification mechanism for the position feedback system.

원자력 사고후 쌀알과 배추내 ^90Sr 및 ^137Cs 농도 예측

최용호,임광묵,황원태,이한수,이창우 대한방사선 방어학회 2002 방사선방어학회지 Vol.27 No.3

원자력 사고후 시간경과에 따른 작물체내 핵종 농도를 보다 현실적으로 예측할 수 있는 방법을 수립하고 단위 건침적에 대하여 백미와 배추내 ^90Sr 및 ^137Cs의 50 년간 농도를 예측하였다. 비생육기 사고의 경우 농도는 두 핵종 모두 시간경과에 따라 서서히 감소하였고 50년 내내 ^90Sr이 ^137Cs보다 높았다. 생육기 사고의 경우 처음 1년간 농도는 비생육기 사고에 비해 대체로 ^90Sr은 최고 30 배, ^137Cs은 최고 1,000 배 정도까지 높았다. 50 년간의 누적농도는 백미에서는 비 생육기 사고의 경우 ^90Sr이, 생육기 사고의 경우 ^137Cs이 더 높았으나 배추에서는 어느 경우에나 ^90Sr이 더 높았다. 생육기 사고시 50년간의 누적농도에 대한 지배적 경로는 대체로 ^90Sr의 경우 뿌리흡수, ^137Cs의 경우 작물체 직접오염이었다. 재부유의 영향은 무시할 수 있을 정도였다. 예측 결과에 입각하여 사고 조건별로 대책의 방향을 제시하였다. A method of more realistically predicting radionuclide concentrations in crop plants varying with time after a nuclear accident was established to estimate 50 years' concentrations of ^90Sr and ^137Cs in polished rice seeds and Chinese cabbage for unit dry deposition. After non-growing season accidents, concentrations of both nuclides decreased gradually with time and ^90Sr concentrations were higher than those of ^137Cs throughout the whole period. Radionuclide concentrations in the 1st year after growing season accidents were on the whole higher than those after non-growing season accidents by factors of up to 30 for ^90Sr and up to 1,000 for ^137Cs. In polished rice seeds, the 50 years-integrated concentration was higher for ^90Sr than for ^137Cs after non-growing season accidents, whereas the opposite was true after growing season accidents. In Chinese cabbage, however, it was higher for ^90Sr than for ^137Cs after both types of the accident. Generally speaking, the dominant pathway for the integrated concentration after the growing season accident was root uptake for ^90Sr and direct plant contamination for ^137Cs. The effect of resuspension was negligible. Based on the predicted results, the direction of planning countermeasures was suggested for various accident conditions.

당뇨병 환자의 사례관리 실시 전후 혈당 및 자가관리 이행수준 변화

최용우,이용환,전만중,유병철 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Background : Diabetes mellitus is one of the common chronic disease in Korea. As most chronic diseases need continuous cares and behavioral controls, one of the effective managements for diabetes is maintenance healthy life style which is based on correct medical knowledge. So, we conducted this study to assess change of blood sugar levels and self-management behavior of diabetic patients following the case-management program enforced by National Health Insurance Corporation (NHIC). Methods : We conducted this study during the period from January 2006 to December 2006, 29 case managers performed the case management program for 672 diabetic patients in the districts of Busan, Woolsan, and Gyeongnam. We evaluated the effectiveness of the case management program based on the changes of blood sugar level, knowledge for diabetes and self-management behavior of diabetic patients. Data analysis was performed with t-test, paired t-test, McNemar X2-test and correlation analysis using SPSS program(ver 12.0). Results : After the case management program, smoking rate was reduced from 22.3% to 21.4% and exercise rate was increased from 65.0% to 80.2%(p<0.05). The knowledge standard of diabetics on 10-point scale revealed considerable increase from 6.05 before the management to 8.69 after the case management(p<0.05). All of diabetic self-management behaviors including nutrition management, self-test on blood sugar level, foot care, oral care and diabetic medication showed considerable improvement; the overall behavioral change, on a 5-point scale, improved from 3.25 to 3.75(p<0.05). The FBS level was improved from 138.4mg/dl to 131.5mg/dl and the blood sugar level 2 hours after a meal was improved from 203.7mg/dl to 183.5mg/dl(p<0.05). Conclusion : From the above results, we concluded that the case management program enforced by the NHIC showed positive behavioral changes on smoking and exercise, increased knowledge about diabetes as well as the level of nutrition management and also demonstrated decline of blood sugar levels. So, we need research of customized information for every patients rather than generally summarized information on diabetes and a self-dependent group formations for sustaining improved self-management after case management as well as development of education and training programs for case managers.

신비체험과 해리성향과의 관계

최낙경,이상혁,우용일,이만홍,현용호 대한신경정신의학회 2000 신경정신의학 Vol.39 No.4

신비체험은 종교의 핵심경험이라고 일컬어질 만큼 종교계에서 가치 있게 평가되고 있으며 여러 사회집단에서도 관심의 대상이 되어왔다. 오래 전부터 심리학자들과 정신의학자들이 신비체험에 대해 관심을 가져 왔지만 그것의 개인적이고 주관적인 특성 때문에 과학적인 접근이 어려웠으며 단지 신비체험의 특성을 나열하고 묘사하는데 그쳤다. 최근 일부 정신병리학자들은 신비체험을 해리현상의 하나로 보는 주장도 있다. 한편 해리는 어린 시절의 외상경험과 연관이 있고 정신병리가 많을수록 해리경향성이 높아진다는 보고가 있어 왔다. 본 연구는 종교인중 신비체험을 경험하지 않은 사람(비신비체험군) 35명을 대조군으로 하여 종교인중에서 신비체험을 경험한 사람(신비체험군) 42명과 해리경향성, 정신병리, 외상경험을 비교하였다. 연구도구로는 한국어판 해리경험 척도, 간이정신진단검사, 외상유무를 묻는 질문지를 이용하였다. 그 결과, 해리경향성은 신비체험군이 비시비체험군보다 유의미하게 높았으며 외상경험도 유의미하게 높게 보고하였다. 그러나 정신병리상의 두드러진 차이는 발견되지 않았다. Mystic experience is highly evaluated so as to be called as core of experience in the religious world and also becomes the subject of concern among various social groups. Psychologists and psychiatrists are concerned about it, but because of its individuality and subjectivity, the scien-tific approach was difficult so that only the description of mystic experience has been researched fo far. There is a current report saying that mystic experience is the one of the dissociative pheno-menon. And there are a lot of reports saying that dissociation is related to childhood trauma experience and rises as much as psychopathological tendencies exist. Consequently, based on the reference that mystic experience is connected with dissociation, the study has been progressed to find out the level of dissociation, psychopathology and trau-ma experience for religious people who experienced mystic experience but excluding patients. Among them, it has been compared between group of non-mystic experience(n=35) and group of mystic experience(n=42). We used Dissociative Experience scale-Korean version(DES-K), Symptom Checklist-90-Revised(SCL-90-R), questionnaire about trauma. The result is that the group of mystic experience had a significantly higher tendency to have dissociation and trauma experience than group of non-mystic experience. However, the differ-ence of psychopathology has not been found.

솔잎(갈비)·솔방울의 수처리에 관한 연구

최순규,엄기수,성현순,김윤영,이시우,정대일,이용균 동아대학교 환경문제연구소 1994 硏究報告 Vol.17 No.2

The absorption ability of low density heavy metal of pine needles and cones is better than one of existing absorption materials in treatment ability and experimental condition. The elimination ability of chlorine of pine needles and cones is better than one of active carbon. In elimination of trihalomethane, the effect of treatment of pine needles is lower than one of pine cones. And surface of pine needles and cones after absorption of heavy metal ion was observed by Scanning Electron Microscope(SEM). Application and availability of pine needles and cones as absorption material need lots of experiments. The experiment on Gal-Bi(fallen leaves) is proceeding.

다수의 동일한 입력원을 갖는 ATM Multiplexer의 정확한 셀 손실 확률 분석

최우용,전치혁 한국경영과학회 1995 한국경영과학회 학술대회논문집 Vol.- No.1(2)

We propose a new approach to the calculation of the exact cell loss probability in a shared buffer ATM multiplexer, which is loaded with homogeneous discrete-time ON-OFF sources. Renewal cycles are identified in regard to the state of input sources and the buffer state on each renewal cycle is modelled as a K(shared buffer size)-state Markov chain. We also analyze the behavior of queue build-up at the shared buffer whose distribution together with the steady-state probabilities of the Markov chain leads to the exact cell loss probability. Our approach to obtaining the exact cell loss probability seems to be more efficient than most of other existing ones since our underlying Markov chain has less number of states.