Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

정상교합자의 치열궁 형태

권용철,성정옥,권오원,성재현 대한치과교정학회 1989 대한치과교정학회지 Vol.19 No.1

This study was designed to investigate dental arch shapes buccally and lingually at Bracket Level of Koreans. This involved studying 63 inviduals (37 males, 26 females) with normal occlusion ranging in age from 17 to 24 yesrs old. The landmarks were digitized and measurements and statistical analysis were performed by NEC 9801 V-M computer. The Results were as Follows: Bicanine width, Bipremolar width and Bimolar width were larger in males than in females. Buccal and lingual arch form and coordination form were obtained by NEC 9801 V-M computer. The parabolic equations which represents buccal and lingual arch form were obtained.

소형 트럭용 CNG/가솔린 겸용 엔진 개발과 성능 분석

권오운,김재수,박용국,김성준 江原大學校 産業技術硏究所 2006 産業技術硏究 Vol.26 No.B

A diesel truck of 1 ton is re-powered by a gasoline engine and the fuelling system of gasoline engine is modified to gasoline/CNG bi-fuel system. The engine characteristics such as fuel economy and power are evaluated by driving test, sloping test and dynamometer. The driving test prove the driving cost is saved by 55% and the maximum speed is raised by 13%, which is mainly due to the higher calorific value of CNG. The sloping test is done on thc road of which slope is 15%. The truck shows the mean velocity of 88km/h, which means that are-powered truck is working fine. The BHP are measurcd by dynamomcter. The-power and torque produced by a re-powered truck are reduced by 13% and 14% respectively from the power of gasoline engine. The BHP reduction is one of main problems which one has to solve in near future.

신경섬유종증 환자에게서 발생한 특발성 혈소판 감소증 1예

권세훈,김형호,강지인,장재혁,원경준,장재현,김상용,배학연 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Idiopathic thrombocytopenic purpura is a disease characterized by thrombocytopenia in peripheral blood with positive anti-platelet antibody titer, no splenomegaly, the presence of megakarocyte. The causes of idiopathic thrombocytopenic purpura were usually related to autoimmune disease, infection and drugs. A 46-years-old man was admitted for evaluation of abdominal mass. He has many cafe-au-lait spots and nodules in almost skin for 30 years. Several years ago, he palpated mass in Lt. inguinal area. hIe has known the abdominal mass after checking abdomen CT in local clinic and visited our hospital for evaluation of abdominal mass. At admission, laboratory tests showed hemoglobin 12.5 g/dL, hematocrit 38.4 %, WBC 5,460 /㎣ (neutrophil 64.5%, lymphocyte 21.7%, monocyte 4.1%, eosinophil 5.4%), reticulocyte 0.7%, Platelet 52,000 /㎣, total protein 6.51 g/dL, albumin 3.80 g/dL, alkaline pohsphatase 161 IU/L, AST 110.7 IU/L, ALT 64.9 IU/L, total bilirubin 0.44 ㎎/dL, BUN 18.4 ㎎/dL, creatinine 0.79 ㎎/dL. Peripheral blood smear showed normocytic normochromic anemia, thrombocytopenia. Bone marrow aspiration smear showed normoplastic myeloid and erythroid precursor. The bone marrow biopsy section shows normocellular marrow (35%) for his age and mildly increasing myeloid cell lineage. We have experienced a case of idiopathic thrombocytopenic purpura in a patient being in neurofibromatosis and therefore reporting it with documentary records. 저자들은 신경섬유종증 환자에서 특별한 원인을 발견할 수 없었음에도 특발성 혈소판 감소증이 발생한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

정밀 소형 Ball Screw의 Infeed 전조에 의한 청정 생산기술개발에 관한 연구

권용재,예인수,현동훈 한국공작기계학회 2006 한국공작기계학회 추계학술대회논문집 Vol.2006 No.-

This paper summarizes the results of the parameter conducted to analyze the effect of the rolling pressure, the rotational speed and the feedrate on material flow and thread profile for Ball Screw. Initial bank diameter affect a quality of Ball Screw in small size and the precision rolling process. Therefor, it is very important to determine the optimum bank diameter in the rolling process. And we have to development clean technology of Small Ball Screws by Infeed Rolling Machine.

ATM망에서 축약 분산 기억 장치를 사용한 호 수락 제어(II)

권희용,송승준,최재우,이인행,황희융 안양대학교 자연과학연구소 1998 自然科學硏究 Vol.5 No.1

본 논문에서는 축약 분산 기억 장치(Sparse Distributed Memory, SDM)를 사용한 신경망 호 수락 제어(Call Admission Control, CAC)를 제시한다. 호 수락 제어는 ATM 망 트래픽 제어의 핵심 요소이다. 이것은 ATM 네트워크 환경의 다양한 변화와 빠른 변화에 적응적이어야 한다. 기존의 ATM 호 수락 제어 방식은 가능한 모든 망 분석을 요구한다. 따라서 최적의 설계는 어렵다. 최근 신경망 방식이 이러한 문제를 해결하기 위해서 도입되었다. 그러나 이것 역시 적응적 제어를 제공하지 않았다. 이것은 부가적인 학습 데이터 테이블과 학습 기간을 요구하였기 때문이다. 우리는 CAC 기능 구현에 더 현실적인 SDM을 기반으로 한 신경망 호 수락 제어 방법을 제안하고, 이것을 기존의 신경망 호 수락 제어 방법과 비교했다. 제안된 방식은 급격한 변화에 적응적인 호 수락 제어를 제공한다. 실험 결과 SDM은 별도의 학습 테이블과 싸이클을 필요로 하지 않아, 빠른 적응력과 안정성을 가짐을 확인할 수 있었다. In this paper, we propose a Neural Call Admission Control(CAC) method using a Sparse Distributed Memory(SDM). CAC is a key technology of ATM network traffic control. It should be adaptable to the rapid and various changes of the ATM network environment. Conventional approach to the ATM CAC requires network analysis in detail in all cases. So, the optimal implementation is said to be very difficult. Therefore, neural approach have recently been employed. However, it does not meet the adaptability requirements. Because it requires additional learning data tagles and learning phase during CAC operation. We have proposed a neural network CAC method based on SDM that is more actual than conventional approach to apply it to CAC. We compared it with previous neural network CAC method. It provides CAC with good adaptability to manage changes. Experimental results show that it has rapid adaptbility and stability without additional learning table or learning phase.

치성낭종으로부터 유래된 편평상피세포암종 : Report of a Case & Review of Literatures

권혁진,현재훈,박형국,김용각 大韓顎顔面成形再建外科學會 1997 Maxillofacial Plastic Reconstructive Surgery Vol.19 No.2

Odontogenic cysts are relatively common pathologic lesions found in the oral and perioral structures, but the case of squamous cell carcinoma arising from those cysts are very uncommon. After first reported of that case in 1889 by Herman, Schwimmer collected 56 cases of previously reported squamous cell carcinoma arising in residual odontogenic cyst during about past one century. More than 60% of cases of carcinoma developing in odontogenic cysts arising in inflammatory periapical or residual cyst, and these tumors are usually well-differentiated with relatively good prognosis, and often are diagnosed as benign lesion in radiographic or clinical examination, therefore definitive diagnosis must be made by histologic examintation. We report a case and review the literatures, in our case, 78-year old woman were clinically and radiographically diagnosed as residual odontogenic cyst. But in histologic examination after enucleation of lesion, mass of squamous cell carinoma were observed, but in other area, typical cyst wall and lining epithelium were observed. And in some area, carcinoma in situ and invading squamous cell carcinoma into the lining epithlium were also observed.

말초혈액에서 Tg mRNA에 대한 역전사 중합효소 연쇄 반응법의 갑상선 재발암의 분자생물학적 진단

권성일,박기룡,김현영,신채희,임영찬,최영식,박요한,이강대,장희경,이재화,염하용 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.4

연구배경: 갑상선암은 다른 조직에 발생한 암에 비해 비교적 천천히 자라므로 대부분 예후가 양호하지만, 일부에서는 주위 조직으로 침윤하거나 혹은 원격 전이로 인하여 치명적인 결과를 초래할 수 있다. 갑상선전절제술 및 131^I 제거술 후 경과 관찰시 갑상선암의 재발과 전이의 진단에 있어 131^I 스캔과 혈청 Tg의 측정이 현재 임상에서 가장 많이 이용되고 있으나 이 방법에는 여러 가지의 결점이 있다. 최근 Tg mRNA에 대한 RT-PCR법을 이용한 여러 연구결과는 131^I 스캔과 혈청 Tg 측정의 결점을 보완할 수 있는 좋은 보조적인 진단법으로 이용할 수 있을 가능성을 제시하였다. 이에 말초혈액에서 측정한 Tg mRNA에 대한 RT-PCR법이 갑상선 절제술 및 방사성요드 치료 후 갑상선암의 재발 및 전이 유무의 진단에 유용한가를 알아보고자 이 연구 시행하였다. 방법: 분화된 갑상선암으로 진단된 후 갑상선전절제술을 시행받고 방사성요드 치료를 받은 환자 중 현재까지 한차례에 이상 추적 방사성요드 전신 스캔을 시행하고 추적관찰이 가능했던 유두선암 35예, 여포선암 5예를 대상으로 연구를 시행하였다. 대상군은 131^I 스캔 소견상 음성인 군(Group Ⅰ), 잔여조직이 있는 군(Group Ⅱ), 국소전이가 있는 군(Group Ⅲ), 및 원격전이 군(Group Ⅳ)으로 구분하였다. 정상 대조군은 갑상선질환이 없는 10예의 건강인으로 하였다. 대상환자의 말초혈액을 이용한 Tg mRNA에 대해 특이적인 primer를 이용하여 RT-PCR 및 nested RT-PCR을 시행하였다. 결과: 본 연구 결과는 다음과 같다. 1) 131^I 스캔 소견상 음성인 군 21예 중 1예에서 Tg가 양성소견을 보였다. Anti Tg Ab가 양성인 4예 모두 Tg가 음성을 보였다. 잔여조직이 있거나 국소전이 및 원격전이를 보인 군 19예 중 Tg가 양성인 경우는 4예였으나, Tg mRNA는 전예에서 양성이었다. 2) 131^I 스캔에서 국소 및 원격전이 소견을 보인 8예 중 4예에서 Tg가 음성으로 131^I 스캔과 혈청 Tg 사이에 불일치 소견을 보였다. 3) 말초혈액에서 특이적인 primer를 이용하여 RT-PCR 및 nested RT-PCR을 시행한 결과 대상군 40예 및 정상 대조군 10예 모두에서 Tg mRNA가 양성을 보였다. 결론: 본 연구에서 갑상선 절제술 및 방사성요드 치료 후 갑상선암의 재발 및 전이 유무를 평가함에 있어 역전사 중합효소 연쇄 반응법을 이용한 Tg mRNA 측정의 의의는 재평가되어야 한다고 생각된다. Background: Differentiated thyroid cancer is the most common endocrine malignancy. Despite advances in the treatment of thyroid cancer, disease recurrence and metastasis may occur in as many as 20% of patients, and so continues to pose major problems in its clinical management. Serum thyroglobulin (Tg) measurements, by immunoassay, are used to detect residual or recurrent thyroid cancer following thyriod ablation. However, the usefulness of immunoassay is limited by both the requirement for thyroid hormone withdrawal, to attain optimal test sensitivity, and interference by the antithyroglobulin antibody (Anti-Tg Ab). Recent studies have reported the clinical usefulness of reverse transcription-polymerase chain reaction (RT-PCR) detection of Tg mRNA in the peripheral blood of patients with differentiated thyroid carcinomas. We performed this study to evaluated the usefulness RT-PCR of Tg mRNA in peripheral blood of patients with thyroid carcinoma following a total thyroidectomy and radioiodine ablation therapy. Methods: Forty cases that underwent a total thyroidectomy and radioiodine ablation therapy were included in this study. Of the 40 patients, 35 were papillary carcinomas and 5 were follicular carcinomas. Ten normal control subjects were also studied. Tg mRNA was extracted. Then RT-PCR and nested RT-PCR, were run with specific Tg primers. Concurrently, DNA sequencing of the isolates was carried out to prove the isolates were identical to the nucleotide sequence of the Tg. Results: The Tg was detected in 4 of 19 patients, with either a residual thyroid bed, or metastasis, on a 131^I whole body scan and in 1 of 21 patients with a negative radioiodine scan. Surprisingly, the Tg mRNA was detected in all the patients and normal controls. Conclusion: From our results we can not recommend Tg mRNA, detected by RT-PCR in peripheral blood, as a tumor marker superior to that of the Tg serum level. We consider an intensive re-evaluation of the method is required before considering its clinical applications (J Kor Soc Endocrinol 17:501∼513, 2002).

동국대학병원 재활의학과 근전도실의 전기진단학적 검사 분석

권용욱,안재홍 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

1995년 12월부터 1996년 8월까지 신경근육계질환이 의심되어 동국대학교 경주병원 재활의학과 근전도실에서 근전도검사를 시행한 482례를 대상으로, 환자 분포 및 검사전 의뢰 진단과 전기진단학적 결과를 비교 분석하였다. 환자의 연령은 1개월에서 80세까지로, 평균 43세였고, 남자는 60%로 여자환자에 비해 약간 많은 것으로 나타났다. 의뢰 건수에서는 정형외과가 근전도를 가장 많이 의뢰한 것으로 나타났고 재활의학과, 신경외과 순이었다. 의뢰 진단은 radiculopathy가 가장 많았고, 의뢰 당시 의심하는 진단을 밝히지 않은 경우가 7례였다. 검사전 의뢰 진단과 검사 시행후 전기진단학적 진단의 일치율은 46.5%로 나타났고, 가장 일치율이 낮은 것은 radiculopathy였다. 근전도 검사에 대한 깊은 이해와 관심이 검사의 활용도를 높일 수 있으리라 사료된다. The electrodiagnostic findings and pre-test diagnosis of 482 patients with neuromuscular disorder, who were referred to our EMG laboratory from Dec. 1995 to Aug. 1996, were analyzed. Of 482 cases, 290(60%) were male, and the mean age was 43years old. Frequent referring departments orthopedic surgery, rehabillitation medicine, and neurosurgery in order. The most common referring diagnosis was radiculopathy. The case without climical information were 7 cases. The concordance rate of pre-test diagnosis and electrodiagnostic findings was 46.5%. Radiculopathy had the lowest concordance rate. The understanding of electrodiagnosis was needed for increasing utility of electrodiagnosis.

흉막삼출의 유무에 따른 쯔쯔가무시증 환자간의 비교

권세훈,김형호,강지인,하재하,한경택,이재록,김동민,권용은,윤성호,이승일 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Scrub typhus is a potentially fatal infectious disease caused by the organism Orientia tsutsugamushi. Clinical manifestations are fever, skin rash, eschar and varying degree of respiratory distress. The pleural effusion in scrub typhus is rare and secondary to the destruction of vascular endothelium. Because the respiratory symptoms are generally mild and the pleural effusion in scmb typhus is rare than in interstitial pneumonia, there are few comments about the characteristics of scmb typhus with pleural effusion. So we made the comparative study of scmb typhus patients between with pleural effusion and without pleural effusion. 연구배경 치명적일 수 있는 감염질환 중 하나인 쯔쯔가무시중(Scrub typhus)에서 드문 흉막삼출을 동반한 환자에 대한 고찰은 다른 문헌에서도 자주 언급되지 않았다. 따라서 본 저자들은 흉막삼출이 있는 경우와 없는 경우에 따른 쯔쯔가무시중 환자들을 비교하고자 하였다. 방법 2003년에서 2006년까지 조선대학교 병원 내과에 입원중인 환자 중 쯔쯔가무시중 진단을 받은 총 109명의 환자를 대상으로 하여 흉부 X선 검사 및 혈청학적 검사(CPK, LDH, ESR, CRP, AST, ALT, ADA), 혈액학적 검사(WBC, PLT) 및 백분율 검사등을 실시하였다. 결과 흉막삼출이 있는 환자들의 경우 흉막 삼출이 없는 환자들에 비해 ESR 수치가 통계학적으로 의의있게 높았다(p-vaule < 0.05). 결론 흉막삼출 유무에 따른 쯔쯔가무시중 환자간의 비교에 있어 ESR 수치가 통계학적인 의의를 가졌다.