범불안장애 혹은 공황장애 환자에서 Mindfulness에 기반한 인지치료의 장기치료 효과 : 1년 추적관찰

윤지원,이상혁,김용우,김묘정,육근영,류미,최태규,김근향 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.1

Objectives Mindfulness-base cognitive therapy (MBCT) has been used to treat patients with depression to prevent relapse. The purpose of this study was to examine the effectiveness of Mindfulness-Base Cognitive Therapy for patients who suffer with generalized anxiety disorder or panic disorder for 1 year. Methods 19 patients with generalized anxiety disorder or panic disorder were assigned to receive MBCT for a period of 8 weeks. The Hamiltion Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D), the Beck Anxiety Inventory (BAI) and the Beck Depression inventory (BDI) were used at 0 weeks, 8 weeks and 1 year to assess the results. Results MBCT demonstrated significantly decreases on all the anxiety scale scores (HAM-A, p=0.00 ; BAI, p=0.00) and depressive scale scores (HAM-D, p=0.99 ; BDI, p=0.00). The patients who received 8-week of MBCT showed a higher remission rate (15/19, 78%) during the 1-year follow-up period. Conclusion MBCT may be effective at relieving the anxiety and depressive symptoms of patients who suffer with generalzed anxiety disorder or panic disorder for 1 year. However, further well-designed controlled trials are needed to assess the value of MBCT.

광대역 입력신호를 위한 선형 트랜스컨덕터와 Multiplier의 설계

尹暢焄,吳成根,辛烘圭,金東龍 全北大學校 1993 論文集 Vol.36 No.-

The linear transconductor and analog four-quadrant multiplier are designed. The DDA(differential difference amplifier) of new active component can be improved matching problems of external elements in op-amp application circuits. We have designed transconductor which have excellent linearity and is the most important block in DDA. And analog four-quadrant multiplier is designed using the designed transconductor and MOSIS 2㎛ design rule. We are simulated the linear transconductor and analog multiplier by SPICE program.

공간구성 및 복지지원 서비스 측면에서 살펴본 공공업무시설의 시설적·제도적 개선 방안 : 전국 44개 시청 및 구청의 실태조사를 통하여

윤영삼,이인기,강병근,김상운,성기창,박광재 한국의료복지시설학회 2006 의료·복지 건축 Vol.12 No.2

The purpose of this study is to suggest institutional reformation of public office facilities by analysis the status of services on welfare for the aged and disabled. For this study, we have researched and analyzed on two different aspects. The aspects are space composition of public office facilities, welfare systems and service support within region. And we can get the following important points as conclusion; ① We need to consider on not only access for public office facilities site hut also the connection on business such as block plan on zone and connection between quarters. Architectural plan has to be considered. ② Most of the public office facilities use human service resources as a supporting system for shortage of convenient facilities. Variety of welfare services are required. ③ We need to secure various programs and space for local peculiarities and social demand.

바이폴라 집적소자용 Si Photodioded의 설계 및 시물레이션

장지근,이상열,김윤희 단국대학교 신소재기술연구소 2001 신소재 Vol.10 No.-

Optical Link용 receiver module을 one chip IC로 실현하기 위해 바이폴라 집적소자용 si photodiode를 설계하고 simulation기법(tool: SILVACO/ATLAS)을 이용하여 이의 전기·광학적 특성을 분석하였다. 제안된 그물망(web) 모양의 소자는 바이폴라 IC기술로 제작이 가능하며, simulation 결과 에피층의 두께가 12㎛, 도핑정도가 1.1×10^15/㎤인 Si 웨이퍼를 사용할 경우 우수한 디지털 광신호 분리능력{I(1-state_/I(0-state)>10^2}과 약 700nm의 파장 범위에서 peak spectral response를 나타내었다. A Si photodiode was designed and its electro-optical characteristics were analyzed by simulation(tool: SILVACO/ATLAS) to realize one chip received module for optical link. the proposed device can be fabricated by bipolar IC technology. The simulation results show that the web type device has the good discrimination characteristic{1(1-state)/I(0-state)>10^2} between digital optical signals and peak spectral response in the wavelength of about 700 nm when it is fabricated from Si water with epitaxial thickness of 12um and the doping concentration of 1.1×10^15/㎤.

창원지역에서의 대기오염물질 배출량 산정

김유근,박상철,문윤섭,오인보,황미경 부산대학교 환경문제연구소 2002 環境硏究報 Vol.20 No.-

Emissions of air pollutants (TSP, SO2, NO2, CO, and HC) was estimated in Changwon city that has the industrial complex and basin terrain. We found that the emissions of TSP, SO2, NO2, CO, and HC were 897 tons, 3,287 tons, 5,706 tons, 10,057 tons, and 1,470 tons for a year, respectively and the main source of air pollutants were vehicle. The ratios of vehicle emissions to total emissions ware TSP 63.8%, SO2 26.1%, NO2 65.5%, CO 91.0%, HC 94.4%. The ratios of industry emissions to total emissions were TSP 30.8%, SO2 60.2%, NO2 25.2%, CO 6.4%, HC 3.7%. The ratio of life emissions to total emissions are TSP 5.4%, SO2 13.7%, NO2 9.3%, CO 2.6%, HC 1.9%. The concentration distributions of air pollutants simulated by ISCST3 model were similar to its emission distributions, and relatively high concentrations of air pollutants occurred in the Palyong-dong (industrial area) and Banlim and Chungang (residual area).

돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향

최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8

Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-r, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18, It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PKl5 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.

연쇄상구균을 실험감염시킨 넙치치어의 병리조직학적 관찰

조성환,류시윤,김현수,박배근,김덕환,손화영,윤원기,신창호 충남대학교 수의과대학 동물의과학연구소 1999 動物醫科學硏究誌 Vol.7 No.-

Pathological observations were examined after abdominal inoculation in 7∼8㎝ sized flounder (Paralichthys olivaceus) with 1X10^7 cfu/㎖ of Streptococcus faecalis. The infected flounder were clinically observed and weighed a fish body at 0, 5, 10, 15, 20, 25, 30 days post inoculation. In infected group, mortality were 70% and feed efficiency were 7.2%. In non-infected group, mortality were 10% and feed efficiency were 18.2%. Macroscopically, the significant lesions were characterized by protrusions and opacity of the eyes and ulcer of the caudal pecuncle. Histopathologically, the lesions were observed a degeneration. necrosis and inflammatory cells in muscle of the caudal peduncle and a degeneration and necrosis of the rod cells and detached retina from the black pigmented layer

돈육의 저장중 이화학적 성질에 미치는 토코페롤 급여효과

진상근,김일석,송영민,하경희,이성대,김회윤 한국국제농업개발학회 2003 韓國國際農業開發學會誌 Vol.15 No.1

비육후기 돼지 사료에 첨가되는 우지 함량 중 2%를 들깨유로 대체 급여한 돈육(T1), T1처리구에 비타민 E 250ppm 첨가 급여한 돈육(T2), 우지함량 중 2%를 오징어유로 대체 급여한 돈육(T3), T3에 비타민 E 250ppm 첨가 급여한 돈육(T4)을 1±1℃에서 28일간 저장하면서 육질특성을 조사한 결과는 다음과 같다. 저장기간에 따라 육색 L^*과 b^*값, 지방색 b^*값 및 drip loss는 증가하였다. 총단백질추출성과 보수력은 14일까지 증가 후 감소하였으며, 염용성 단백질추출성 및 지방색 L^*값은 감소하였다. 근절길이에서는 저장기간에 따라 T3구는 감소하였다. 총단백질추출성은 T1보다는 T2가 낮은 반면 T3보다는 T4가 높았다. 염용성단백질추출성은 비타민 E 첨가구들이(T2, T4) 첨가하지 않은 구들(T1, T3)에 비하여 높았으며, drip loss와 육색 a^*값은 비타민 첨가구들이 첨가하지 않은 구들에 비해 낮게 나타났다. 보수력은 T1보다는 T2가 낮은 반면 T3보다는 T4가 높았다. 지방색 L^*값은 저장 1일째는 비타민을 첨가한 처리구들이 첨가하지 않은 처리구들에 비해 높았으나, 저장 28일째에는 낮게 나타났고, b^*값은 비타민을 첨가한 처리구들이 낮게 나타나 비타민 첨가구가 drip loss, 육색과 염용성단백질 추출성에서 좋은 효과를 나타내었다. The quality of pork meat was determined as following treatments. The meat samples were obtained from pigs which had been fed finishing pig diets containing 2% perillar seed oil in beef tallow(T1), 250ppm vitamin E in T1(T2), 2% squid oil substituted of beef tallow(T3), 250ppm vitamin E in T3(T4). During storage period, meat color L^*, b^* value, fat color b^* value and drip loss were increased. The extraction amount of total protein and water holding capacity were increased until 14 days after then were decrease. The extraction amount of salt soluble protein and fat color L^* value were decreased and sarcomere length were decrease in T2 as well. T1 was higher than T2 in the extraction amount of total protein and its of T4 was higher than T3. The extraction amount of salt soluble protein of the T2 and T4 was higher than that of T1 and T3. The drip loss and the a^* value of meat color were lower in vitamin treated one than non treated one. On water holding capacity. T1 was higher than T2 and T3 was lower than T4. The L^* value of fat in vitamin treated ones was shown higher than that of non treated ones on day 1, however, it and the b^* value of the meat were low on day 28.

돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향

최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 생물공학연구소 2004 생물공학연구지 Vol.10 No.1

Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-γ, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18. It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PK15 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.

섬유판에서 음향방출원의 위치표정

박익근,김용권,윤종학,노승남,서성원 한국공작기계학회 2003 한국공작기계학회 추계학술대회논문집 Vol.2003 No.-

음향방출 신호를 이용하여 목재 섬유판(fiberboards)의 위치표정의 유용성 유무를 실험적으로 검증하였다. 위치표정의 정확도를 향상하기 위해 신호처리 방법중의 하나인 웨이블릿 변환 디노이징 기법을 활용하여 저주파수인 대칭모드(굽힘파)를 활용하고, 고주파수인 비대칭 모드(팽창파)룰 제거하여 신호를 재구성함으로써 섬유판의 위치표정시 문턱값 통과방법을 사용할 때 발생하는 도달시간차를 최소화 할 수 있음을 확인하였다. 디노이징 기법을 활용한 섬유판의 위치 표정과 굽힘강도에 대한 사상총수를 기초로 하여 목재 구조물 및 문화재의 건전성을 평가 할 수 있을 것으로 기대된다.