전시-P-91 : Costs and Productivities of Forest Biomass Harvesting Operations in the US

( Han Sup Han1 ),( Sang Kyun Han ),( Du Song Cha ),( Nam Hun Kim ) 韓國木材工學會 2013 한국목재공학회 학술발표논문집 Vol.2013 No.-

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

전자제품 조립업체 근로자에게 직무 요구, 직무 조직, 경력 개발, 역할 압력, 경제력 압력등의 직무 스트레스가 업무관련 상지 근골격계 질환에 미치는 영향

한상환,조수현,김지영,성낙정 大韓産業醫學會 2003 대한직업환경의학회지 Vol.15 No.3

목적: 직무스트레스를 직무 요구, 직무 조직, 경력개발, 역할 압력, 경제적 압력 등 요인별로 구분한 후 업무관련 상지 근골격제 질환과의연관성이 높은 직무 스트레스 요인을 도출하기 위한 목적으로 본 연구를 시도하였다. 방법: 이동전화기 부품 조립 업체 여성 근로자 112명, 전수, 냉장고 조립 업체 3개 부서 남성 근로자 237명 전수, 그리고 사무직 근로자 87명 전수 등 총 436명을 대상으로 업무관련 상지 근골격계 증상과 직무 스트레스에 관한 설문 조사를 실시하였다, 물리적 작업 요인은 작업 과정을 인간공학적 평가서로 평가하였다. 근골격계 증상과 직무 스트레스 평가서에 제대로 응답하지 않은 53명을 제외한 총 382명을 최종 분석대상으로 하여, 직무스트레스 요인에 대한 요인분석을 실시하고 적합성이 높은 요인별로 직무스트레스 요인을 구분한 후 로짓 희귀 분석으로 상지 근골격계 질환과의 연관성을 분석하였다. 결과: 각 연구 대상군에서 목과 어깨 부위의 증상 호소율이 가장 높았으며, 손목과 손가락 부위, 팔꿈치 부위 순이었다. 목과 어깨 부위와 손목과 손가락 ㅂ위에서 부적절한 작업 자세와 힘 요인의 연관성이 관찰되었으며, 직무의 단순성, 직무 구분의 모호성, 직무의 자율성 부재, 경제적 압력, 승진 장애, 퇴직 압력 등의 직무 스트레스 요인이 유의한 것으로 나타났다. 여서 조립 작업자에서 증상 호소율이 더 높았으며, 근골격계 질환과 직무 스트레스의 연관성의 강도는 남성 조립 작업자보다 여성 조립작업자와 사무직 근로자에서 더 높은 것으로 나타났다. 결론: 본 연구 결과 물리적 작업 요인에 의한 영향을 보정한 후에도 사무직 근오자와 생산직 근로자 모두에서 직무 스트레스가 업무관련 상지 근골격계 질환에 영향을 미치는 것으로 해석할 수 있었으며, 특히 경제적 요인과 경력 개발 요인 들의 중요성이 부각되었다. 따라서 향후 직무 스트레스와 업무관련 상지 근골격계 질환에 대한 다양한 직종에서의 경험적 연구결과가 축적외어 우리 나라의 조직문화적 특성을 고려한 직무 스트레스 위험 요인 파악이 필요하다고 하겠다. Objects: To evaluate the association od upper extremity musculoskeletal disorders with job demand-control and effort-reward related job stress. Methods: Questionnaires concerning symptoms, psychosocial factors and work conditions were completed by 436 workers from a refrigerator assembly line, mobile phone assembly line, and an office, musculoskeletal conditions of the upper extremities were defined by the frequency, duration, and intensity of symptoms. A walk-through survey was performed to evaluate various physical work factors. Data were analyzed with the use of logistic regression. Results: A total of 32 workers completed the survey, for whom neck and shoulder symptoms were the most frequently reported, followed by finger and wrist, and then elbow symptoms. Both awkward working posture and forceful exertion were associated with an imcrease in shoulder/neck and finger/wrist symptoms. In addition, job stress factors such as monotony, low job clarity, low job control, low promotion prospect, economic issues, and retirement pressures were associated with increased neck/shoulder, elbow, and finger/wrist conditions. Women were more likely to report symptoms, and the association between musculoskeletal conditions and job stress factors was stronger in female assembly line workers and office workers than in male assembly line workers. Conclusions: The results suggest that musculoskeletal conditions of the upper extremities are associated with not only physical work factors but also job stress factors. In particular, economin issues and career development factors are important influences on workers in Korea.

설갑상선 : 1 예 보고 A Case Report

한기석,배일헌,차상훈,김성진,박길선 충북대학교 의과대학 충북대학교 의학연구소 2003 忠北醫大學術誌 Vol.13 No.2

갑상선 조직 전체가 설기저부에 발생한 이소성 설갑상선 증례를 경험하였기에 그 방사선학적 소견을 문헌고찰과 함께 보고하고자 한다. 증례는 59세 여자 환자로 40 일전부터 발생한 음성 변화를 주소로 내원하였다. 이학적 검사에서 설 기지부 중앙에 회백색의 격막에 둘러 쌓인 3 cm 가량의 종괴가 있었으며, 종괴는 내장으로 돌출하여 구인두를 막고 있었다. 경부 전산화 단층촬영 측면 정찰 촬영에서, 설 기저부에 후방으로 돌출하여 구인두를 막고 있는 경계가 분명한 연부조직 종괴가 보였으며, 전산화 단층촬영 동맥기와 정맥기에 주변의 혈관과 비슷한 강하고 균일한 조영증강을 보이는 장경 2.5 cm의 원형 종괴가 있었다. 또한 갑상선이 있어야 할 경부 전방 공간에서 정상 갑상선 조직은 전혀 보이지 않았다. 설 기저부의 종괴에서 생검을 시행하였으며 병리 검사에서 갑상선 조직으로 진단되어 설갑상선으로 확진되었다. The authors report a case of ectopic thyroid that whole thyroid tissue was replaced by lingual thyroid. A 59-year-old female presented with dysphonia duration of 40 days. On physical examination, there was a 3 cm sized well encapsulated whitish mass protruding to oral cavity in milline of tongue to base. Computerized tomography of neck revealed homogeneously enhancing well marginated 2.5 cm sized round mass in the cecum of tongue base on arterial and venous phase. And there was no normal thyroid gland in lower anterior neck.

중등학교에서 프랑스어 교수ㆍ학습의 개선 방향 : 교육과정을 중심으로

한상헌 한국프랑스어문교육학회 2001 프랑스어문교육 Vol.11 No.-

Nous pensons que l'onseignement/apprentissage du FLE est dans one conjoncture de crise. Apre`s avoir adopte' les 7me Instructions Offielles, la crise est devenue plus se'rieuse on Core'e. Nous trouvons une cause do cette crise dans la planification e'ducative mal de'finie pour l'onseignement/apprentissage du FLE dans les Instructions Offcielles, Nous ayons compare' ies Instructions Officielles do quelques pays(France, Allemagne, Grande-Bretagne, Etats-Unis) avec les no^tres. Nous avons abouti aux conclusions suivantes pour l'orientation do la nouvelle re'daction des Instrucions Officielles du FLE : 1) Le ministe`re do l'Education nationale devrait adopter une politique e'ducative rendant compte du plurilinguisme et la reprisenter do fac¸fon concre`te dans la nouvelle re`daction. 2) A l'e'tude do la deuxie`me langue e'trange`re, devrait ftre consacre' un volume horaire qui pout e^tre compare' au niveau international : la 2me langue e'trange`re doit e^tre enseigrle`e comme one matie`re obligatoire a` raison do deux ou trois heures par semaine dans l'enseignement secondaire, et on me^me temps elle devrait e^tre une mate`re obligatoire pour l'examen d'entre`e a' l'universite'. 3) Pour on orienter la nouvelle re'daction, l'analyse comparative des Instructions Officielles devrait atre fonde'e sur des crite`res objectifs et l'e'tude systimatique, et les deuxie'mes langues e'trange`res devrait e^tre traie'ies comme matie`re scolaire inde'pendante. 4) Les Bme Instructions Officielles devraient e^tre e'labore'es apre`s avoir effectivement adopte' les 7me Instructions dans la pratique do classe. 5) Les nouvelles Instructions Offircielles devraient of offrir aux e'tudiants les crite`re sotjectifs pour choisir une langue parmi celles propose'es comme deuxie'mes langues itrangires.

하악골 후방이동시 중안면부 연조직의 변화양상에 대한 임상통계학적 연구

한대희,김수남,민승기,김태성,성헌모 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.3

Prediction of the soft tissue changes following hard tissue movement is very important from the esthetic view point for patients who have orthognathic surgery. There are many cephalometric analysis of facial bone and soft tissue on the lower lip and chin region but few soft tissue analysis on the midface after mandibular setback surgery. This study was performed to obtain whether the mandibular posterior movement has influence on the midface and the predictable ratio of post-operative measurement values of the soft tissue changes following mandibular setback surgery. Fifteen patients (8 males and 7 females) who had undergone mandibular setback surgery were selected and analyzed the soft tissue movement on the upper lip and the cheek region. Post-operative changes of the soft tissue measurements after mandibular surgery were examined on pre- and post-operative cephalo-metrics and the ratio of changes were analyzed after drawing the reference line on the face with the barium sulfate solution. The reference lines were perpendicular to the intercanthal line from infraorbital foramen and lateral canthus. The results obtained were as follows : 1.There were tendancy of anterior movement of soft tissue adjacent the nose after mandibular surgery 2.There were incerased tendancy of the amount of anterior movement from the nasal crease to the cheek region. 3.The amount of anterior movement of the soft tissue was larger below the palatal plane compared with above the palatal plane in the cheek region. 4.The upper lip length was increased and moved posterior direction after mandibular setback surgery 5.The lower lip was moved posterior direction by posterior movement of the mandibular structure 6.Soft tissue of the midface around the nose moved anterior direction after mandibular setback surgery but there was no correlation between the amount of mandibular setback and the amount of the soft tissue changes

7차 교육과정에 따른 제 2외국어 교과서 개벌 방향

한상헌 한국 프랑스어문교육학회 1999 프랑스어문교육 Vol.7 No.-

Les nouvelles Instructions officielles (du septieme plan) s'appliqueront en 2002 au lycee. Les methodologistes doivent elaborer les manuels a partir de celles-la, en prenant en compte l'approche communicative, selon la consigne du ministere de l'education. Bien que les instructions officielles leur offrent des invormations (objectifis, contenu a delimiter, methodologies a mettre en oeuvre, et) pour leur elaboration, et qu'on possede des grilles d'evaluation ou d'elaboration des ensembles didactiques par rapport a l'approche communicative, il n'est point toujours facile de les adapter a l'elaboration des manuels des secondes langues etrangeres (l'allemand, le francais, l'espagnol, le chinois, le japonais, le russe, l'arabe). Par consequent, nous avons essaye de proposer une orientation, en presentant des grilles concretes adaptees a la situation des lycees coreens. En ce qui concerne l'organisation de cet article, nous avons d'abord essaye de degager le statut des manuels dans l'action diactique en consideration de la situation coreenne, puis d'examiner les grilles d'elaboration du point de vue de l'approche communicative, enfin de proposer des criteres concret selon les articles des Insturctions Officielles. Voici les sous-titres de notre proposition.

뇌졸중과 동반된 병원감염

한범기,이지용,이성수,김헌주 연세대학교 원주의과대학 2000 원주의대논문집 Vol.13 No.1

하시모토 갑상선염과 동반된 갑상선 유두암에서 BRAFV600E의 발현과 임상적 특징

남성진,최영식,박요한,김정훈 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Background: An association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) is still controversial. Studies to date established the coexistence of HT in 11% to 36% of PTC patients. BRAFV600E mutation was presented 90% with no HT, 64% with HT in PTC patients. Therefore, BRAFV600E mutation is associated with the pathogenesis of PTC arising in HT. The purpose of this study was to identify predictive factors for the coexistence of PTC and HT and to evaluate the association of the BRAFV600E mutation with the clinicopathological features of coexistence of PTC and HT. Methods: A total of 247 patients underwent surgery for thyroid disorders between January 2007 and April 2009. In all, 212 patients was diagnosed as thyroid papillary carcinoma only (PTC group), 33 had coexistence of PTC and HT (PTC+HT group), and 2 had been diagnosed with HT. DNA was extracted from paraffin embedded thyroid tumor specimens taken from 99 patients with PTC, 13 coexistence of PTC and HT, and 2 was HT. The presence of the BRAFV600E mutation was determined by polymerase chain reaction amplification of exon 15 followed by direct sequencing. Results: Among clinicopathological features sex, age, tumor size and capsule invasion was not significant between PTC group and PTC+HT group. Lymph node metastasis and stage was significantly lower in PTC+HT group than PTC group (p=0.044). BRAFV600E mutation was found in 34 of the 99 PTC group (34.3%), 1 of the 13 PTC+HT group and 2 HT show no BRAFV600E mutation. Conclusion: These data demonstrated that the coexistence of PTC and HT was less aggressive than PTC only.

정신증상을 수반한 급성 간헐성 폴피리아의 1예 보고

한상엽,오민웅,김헌석,최수호 大韓神經精神醫學會 1972 신경정신의학 Vol.11 No.2

This is a brief report on a case Acute Intermittent Porphyria observed in the St. Mary's Hospital, Catholic Medical College, Seoul, Korea. The case was originally admitted to the internal medicine department where initial diagnostic workup was made. The case, however, showed various psychoneurotic signs which impressed both internists as well a psychiatrists who saw the case upon consultation that the patient might as well be suffered from hysteria. Consequently the Patient was transfered to the psychiatric free-ward where further observation, family study as well as various laboratory tests thought to necessary, were done. While family study revealed(see pedigree) that one of the patient's aunt and her mother had suffered from the illness which seemed similar with the patient's present illness, and two of her siblings were also found to have suffered from the almost identical illness in the past. Examination of urine also revealed excess in amount of porphobilinogen and uroporphyrin in the urine. Authors stressed the importance 1) interdepartmental consultation, and also of 2) the needs of careful review and evaluation of the results of the basic and further laboratory tests for which paychiatrists tend to pay less attention to those cases with neurotic manifestations.