원위 대퇴골의 고립성 골연골종에서 발생한 속발성 연골 육종 1례 보고

정필현,황장수,강석,김용민,오형호,채동주,김종필 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

연골육종은 비교적 서서히 자라며 늦게 전이하는 악성 연골 종양으로 알려져 있다. 골 연골종에서 발생한 속발성 연골육종은 발생빈도는 드물며 타부위로의 전이가 적고 악성도가 낮은 경우가 많아 적합한 수술적 치료로서 좋은 예후를 보이는 것으로 보고되고 있다. 본 동국대학교 정형외과학 교실에서는 우측 대퇴골 원위부 골간단부에 생긴 고립성 골 연골종에서 이차적으로 발생한 연골육종을 치험한 바 문헌고찰과 함께 보고하는 바이다. A case of Secondary Chondrosarcoma Arising from Solitary Osteochondroma of the Distal Femur Department of Orthopaedic Surgery, College of Medicine, DongGuk University Phil Hyun Chung M.D., Jung Su Hwang M.D., Suk Kang M.D., Yang Mln Kim M.D., Hyung Ho Oh M.D., Dong Ju Chae M.D., Jong Pil Kim M.D. Chondrpsarcoma is a malignant cartilage-forming tumor that grows slowly and metastasis of this tumor occurs in late stage. Secondary chondrosarcomas arising from a solitary osteocartilaginous exostosis are rare and those have a better prognosis than other chondrosarcomas, and they rarely metastasize. We present our experience with a case of secondary chondrpsarcoma arising in solitary osteochondroma of distal metaphysis of right femur with clinical details.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

용수철을 이용한 자기력 측정 장치 개발

오광택,박종호 이화여자대학교 교과교육연구소 2008 교과교육학연구 Vol.12 No.3

전자기적 현상에 있어서 자기력은 가장 기초적인 개념 중의 하나이다. 현행교육과정은 자기력을 설명하는데 있어 단일 물리량을 통해 현상에 대한 법칙을 설명함으로써 단편적이고 관찰자 위주의 자료를 제시되어지고 있다. 현행교육과정에서의 자기력 측정방법은 클립이 자석에 붙는 거리비교를 통해 측정하거나 자석에 붙는 클립의 개수 비교를 통해 알아보고 있다. 이는 자기력 세기측정과 관찰에 있어 현행 시행하고 있는 실험방법이 자기력의 세기에 대한 학생들의 이해에 있어서 고려되어야할 물리적 현상이 다중적이며 복잡하고 할 수 있다. 현실적인 관점에서 본다면 중력,마찰력 등과 같이 자기력에 영향을 미치는 물리량을 고려하지 못하여 자기력의 차이가 미세하면 그 차이를 알 수 없는 경우가 발생하고 있다. 따라서 보다 미세한 자기력의 세기를 측정할 수 있는 것과 자기력에 영향을 미치는 두 가지 이상의 물리적 법칙이 복합된 현상의 관찰을 통해 현상의관계성을 설명하는 것이 더 좋을 수 있다. 따라서 자기력에 영향을 미치는 물리량의 관계를 통한보다 정량적인 자료의 형태로 제시되어 자기력에 대한 학생들의 개념형성에 보다 효과적인 방법을 모색할 필요가 있다. 본 연구에서는 초등학교 교육과정에 있는 에너지 영역의 실험 중 자기력을 측정하는 방법에 대하여 서로 다른 물리량, 즉 자기력의 세기를 질량과 거리의 복합적인 관계를 통해 설명하는 방법에 대하여 알아보았다. 현행교육과정에서 제시하고 있는 자기력 측정 방법인 클립이 자석에 붙는 거리 비교, 클립이 붙는 개수를 통해 자기력을 비교하여 자기력의 세기를 비교하는 방법과는 달리교육과정에 함께 제시되어 있는 용수철의 성질을 이용해 용수철의 길이 변화에 따른 자기력의 세기 측정방법으로 장치를 구성하여 자기력 세기를 측정하도록 실험기구를 제작하여 자기력의 세기가 용수철의 늘어난 길이에 구분가능 한을 알아보았다. 실험 결과에 따르면 자기력은 용수철의 탄성계수에 대응하여 그 힘을 나타내고 있었으며, 현행교육과정에 제시되어 있는 측정방법보다는 자석들 간의 자기력 세기의 차이를 더 세분화하여 보여 주고 있다. 이는 용수철을 이용한 자기력 측정 방법이 현행교육과정의 방법보다 더 세밀한 수치로 나타냄으로써 자석들 자기력의 세기를 효과적으로 구분할 수 있는 기준이 될 수 있음을 보여준다. In the science curriculum of Elementary School, the Magnetic force is very basic and important concept. In the science curriculum of elementary school, Magnetic force provided single physical parameter. The experimental method of the magnetic force in the text of elementary school use a magnet attracts clips. This method can be said as a error result of the experiment method by reciprocal action of magnet and other physical parameters. So, for the method of magnetic force measurement need provide physical parameters have an effect on the magnetic force. It can be provide as a quantitative and qualitative rather then the experimental method of the magnetic force in the text of elementary school. Therefore, we developed the Magnetic Force Measurement Device a new method to observe the magnetic force using lengthen of spring depending on a magnet attracts clips. As a result of the experiment of new 'Magnetic Force measurement Device', it showed 'Magnetic force' that the correspondence ofthe 'Magnetic Force' with Spring's modulus of elasticity. And it showed sub·di·vi·sion of difference of the magnetics force. So, this new method can be said as a effectively of explain the Magnetic Force rather then the experimental method of the magnetic force in the text of elementary.

그룹 이용자의 원문서비스를 위한 게이트웨이 시스템 설계 및 구현

오인수,신영호,임종태 公州大學校 工學硏究院 生産技術硏究所 2003 論文集 Vol.11 No.-

최근 인터넷 사용의 확산과 네트워크 기술의 발달로 정보의 양이 폭증하고 있으며, 정보의 접근가능성을 확대할 수 있는 기반이 마련되고, 이에 따른 이용자들의 요구는 더욱 다양해지고 있다. 이에따른 원문서비스에 대한 이용자의 욕구는 증가하고 있으나, 아직까지 대학, 기업과 같은 기관에 속한 그룹 이용자들은 자신이 속한 도서관을 통해 제한된 자료만을 임수하고 있는 실정이다. 현재 원문 제공 서비스를 하고 있는 대부분의 시스템이 개별 이용자 위주의 서비스를 수행하고 있다. 따라서 다수의 내부 이용자를 가진 그룹에서는 원문 제공기관의 서비스를 이용하기 위해서 개인적으로 이용자 등록 및 인증을 거치고 서비스를 이용해야 하는 불편함이 있다. 그러므로 그룹 이용자의 등록과정을 간소화하고 그룹 이용자의 원문 신청에 대한 그룹 관리자의 체계적인 관리가 요구되고 있다. 이러한 그룹 이용자의 요구에 부합하고 편의성을 제공하기 위해 다음과 같이 게이트웨이 시스템을 설계 및 구현한다.

투스템 수직점프의 운동 역학적 분석

오정환,이종호 忠南大學校體育科學硏究所 2002 體育科學硏究誌 Vol.20 No.1

The purpose of this study was to identify kinetics factors during the two-step vertical jump. Two college students representing college were participated as the subject. The three-dimensional visual analysis and ground reaction were used for the purpose of this study. The results of this study were as follows: (1) the time spent jump took 0.13 seconds and the height of jump was 63.55cm during two-step vertical jump: (2) the speed of upper segment were appeared in order hand, forearm, upper arm, trunk and the lower segments were the thigh and crus in order during two-vertical jump: (3) the angles of shoulder joint, hip joint, knee joint, and ankle were 94.1°, 105.2°, 116.4°, and 84.2°, respectively during taking arms back: (4) the speeds of shoulder joint, knee joint, ankle joint, hip joint were 1926.9deg/sec, 626.6deg/sec, 546.4deg/sec, and 368.4deg/sec, respectively: (5) the vertical speed of the central gravity on body was 362.1cm/sec and the force that was applied to vertical was 1154.2N/sec during the two-step vertical jump: (7) hands, forearms, upper arms, trunk, and head were going down and feet, lower limbs, and thigh were going up vertically during the two-step vertical jump.

複合組織鋼의 母相粒徑이 乾式로링 磨耗特性에 미치는 影響

吳世旭,姜鎬珉,金時綜 동아대학교 공과대학 부설 한국자원개발연구소 1985 硏究報告 Vol.9 No.2

The wear specimens of M.E.F. steel were conducted by Amsler type abrasive test machine under sliding ratio 9 09%. The relationship between weight loss ratio of wear, rolling life and scanning electron microscope investigation of micro wear surface was investigated during the test. The results of the experiment are summarized as follows. The amount and the weight loss ratio of the rolling wear are decreased when tensile strength is high and the amount of rolling wear of M E F. steel is lower than that of raw materials. As the ferrite grain size of M E F. steel is small, the amount and the weight loss ratio of the rolling wear are decreased. The amount of rolling wear is increased with increasing rolling revolution and wear of dual phase steel under dry rolling condition is characterized by three modes, initial, stationary wear and abnormal wear. Abnormal wear is caused by pitting occurrence on the exfoliation of sub-surface layer because of compression, shear, sliding of this wear surface. The wear surface condition is getting better as the ferrite grain size is getting smaller, which is caused by the promotion of the second phase sketetal strength.

기초과학 실험에 관한 학습자료 개발 : 4·5·6학년 새 자연과 교육 과정 4th·5th·6th grade new elementary school science curri culum

오상철,김영호,현종익 濟州敎育大學 科學敎育硏究所 1983 科學敎育硏究誌 Vol.7 No.-

This is a study to develop the obervations and experimental materials for the elementary school 4th.5th.6th grade science curriculum that are carried on effect from this year. The materials which teachers do and the teachers and students can make, by themselves, are as follows: 1) In the field of biology for 4th.5th and 6th grade, 11 kinds of plant observating materials were cultivated. 2) In physics field of sixth units in the text book for 4th.5th and 6th grade, 10 kinds of implements were developed: electric circuit, moving of heat, expansion of heat and body, solute, movement of Earth and Moon, eaergy of Water and Wind.

결핵 환자의 치료 순응도 향상을 위한 자기 간호교육의 효과

오영주,전진호,손혜숙,이종태 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

Objectives : Good compliance to standard guideline might be the most important factor for success of tuberculosis treatment. This study was performed to propose the way to promote the compliance through evaluating the effect of self-care education in pulmonary tuberculosis treatment. Methods : The subjects were 100 patients(male 82, female 18) admitted in the national tuberculosis hospital, and study period was from December 1, 2000 to March 31, 2001. Study method was a direct interview survey with questionnaire that consisted of knowledges, attitudes, compliances about tuberculosis treatment, and some characteristics of subjects. The pre- and post-educational data were compared by chi-square test and paired t-test using SPSS(ver 10.0) with α-error=0.05. Results : The mean age of the subjects was 41.8±12.8years, and most of them was male. Half of them was still drinking and smoking, and the tuberculosis treatment categories of WHO was categoryⅢ 42%, categoryⅣ 22%, categoryⅡ 21%, categoryⅠ 15% when admitted. Average prevalent period was 56.8 months, and 68% of them showed positive sputum smear test. The average knowledge level was increased from 6.88±1.85 when admitted, and 8.02±1.57 when two months after(p〈0.001), that means, the effect of education was recognized. In contrast, recognition and attitudes showed no difference. And, the frequency of subjective aggravation was higher in the group of low compliance: voluntary medication stop(p=0.022). Conclusions : This study had some limitations; lack of representativeness because the subjects were limited to the patients in one tuberculosis hospital, and, not sufficient sample size etc. Nevertheless, because the effect of the education was partly recognized, to enhance the effect of tuberculosis treatment, the contents of self-care education would be changed toward the practice with a close monitoring of the patients' compliance.

Fusobacterium nucleatum의 유황화합물 생성에 영향을 미치는 인자

오인근,박은혜,양규호,오종석 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.1

Fusobacterium nucleatum, one of the bacteria causing halitosis, produces the volatile sulfur compounds (VSC) such as H2S in the media containing sulfur components, and forms FeS by binding with iron component. The various factors of oral cavity affect the concentration of sulfur compounds produced by Fusobacterium nucleatum. In this study, the effect of nutrients and pH on the production of sulfur compounds by Fusobacterium nucleatum was studied with the following results; 1. The optical density of broth was increased to 0.817±0.032 and 1.297±0.024 by adding 1.0% sodium thiosulfate and 0.05% L-cysteine hydrochloride in the media, respectively. 2. Though the optical density of broth was 0.799 ± 0.032 by adding volatile sulfur compounds (VSC) only in the media, it was increased to 1.775±0.003 and 1.648±0.022 by adding xylitol combined with glucose and fructose, respectively. 3. The concentration of VSC was above 20,000 ppb in the media above pH 5.5. The optical density of broth was still high in the media with L-cysteine hydrochloride of higher concentration, being low in the media of lower pH. 4. The concentration of VSC was high when there was distilled water or saline solution on the media, and their amount was small. These results suggest that the production of sulfur compounds by Fusobacterium nucleatum is inhibited by xylitol and acid.

유산구균 1370의 수용성 글루캔 형성에 영향을 미치는 인자

오인근,양규호,오종석 전남대학교 치과대학 2000 전남치대논문집 Vol.12 No.1

The water-soluble glucan prodeced by Lactococcus lactis 1370 affects the formation of dental plaque by Streptococcus mutans. In this study the factors affecting the formation of water-soluble glucan were assessed as the optical density of culture supernatant of Lactococcus lactis 1370 in the spectrophotometer. 1. The optical density of culture supernatant was high when Lactococcus lactis 1370 was cultured in M17 broth with 5% sucrose, while being low in culture supernatant of Streptococcus mutans. 2. The optical density of culture supernatant was higher when Lactococcus lactis 1370 was cultured in M17 broth with 10% sucrose than when being cultured without sucrose (p<0.05), and was higher at pH 7 than pH 5 (p<0.05). 3. The optical density of culture supernatant was the highest at 37℃ among 32℃, 37℃ and 42℃, and was higher in the anaerobic incubator than in the aerobic incubator (p<0.05). 4. The optical density of culture supernatant was the highest in the media containing 1.0mM CaCl2 (p<0.05), 2.5mM KCl (p<0.05), and 1.6 mM MgCl2. 5. When Streptococcus mutans was cultured in the media containing a quarter culture supernatant of Lactococcus lactis 1370 grown in M17 broth, the mean weight of produced artificial plaque was 103.0 mg on the wire, whereas being significantly reduced to 5.6mg in the media containing a quarter culture supernatant of Lactococcus lactis 1370 grown in M17 broth containing 5% sucrose (p<0.05). These results indicate that the water-soluble glucan is more formed by Lactococcus lactis 1370 in the media containing sucrose or under the adequate conditions for the growth of bacteria, and inhibits the formation of artificial plaque by Streptococcus mutans.