정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

골아세포 MC₃T₃-E₁의 증식과 기능에 Insulin Like Growth Factor Ⅰ, Ⅱ 및 부갑상선 호르몬이 미치는 영향

윤현구,정호연,양인명,김성운,김진우,김광원,김영설,최영길,서광식 대한내과학회 1992 대한내과학회지 Vol.42 No.1

MC₃T₃-E₁골아세포군을 이용하여 IGF-Ⅰ과 Ⅱ를 투여하고 DNA합성과 골아세포기능을 측정하기 위해 PTH에 대한 C-AMP반응정도, alkaline phosphatase 활성도를 측정하여 다음과 같은 결과를 얻었다. 1) IGF-Ⅰ과 Ⅱ는 모두 DNA합성이 어느 농도까지는 증식효과를 나타내지만 그 이후에는 억제되는 양상을 보였다. 2) PTH에 대한 골아세포의 C-AMP반응으로 증가되었지만 IGF-Ⅰ과 Ⅱ의 투여시 농도변화에 따른 의미있는 변화는 없었다. 3) 본 실험의 조건에서 alkaline phosphatase 활성도는 증가되지 않았다. 이상의 결과로 MC₃T₃-E₁ 골아세포에 IGF-Ⅰ과 Ⅱ는 세포의 증식을 자극하여 PTH는 C-AMP생성을 촉진하는 효과가 있었다. The effect of insulin-like growth factor (IGF) Ⅰ and Ⅱ on cloned MC₃T₃-E₁ cells that had osteoblastic activity was examined by [³H] thymidine incorporation into DNA, cyclic AMP responsiveness to parathyroid hormone (PTH), and alkaline phosphatase activity. IGF Ⅰ and Ⅱ stimulated the growth and proliferation of osteoblastic cells at 20ng/㎖ and 50ng/㎖, respectively. We next examined the effect of IGF-Ⅰ and Ⅱ on the expression of osteoblastic activity. Adenylate cyclase response of PTH to IGF-Ⅰ and Ⅱ-treated cells showed maximal stimulation at 10 and 50㎚PTH, respectively, but IGF Ⅰ and Ⅱ induced limited activity of osteoblastic function. In conclusion, IGF-Ⅰ and Ⅱ were potent stimulators to the growth of osteoblastic cells but did not have an immediate effect on expression of osteoblastic function in this experiment.

불소바니쉬가 법랑질 탈회에 미치는 영향

윤명옥,이난영,이상호 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.3

이 연구의 목적은 법랑질 탈회부위에 불소 바니쉬 적용의 효과를 평가하는 것이다. 80개의 소의 법랑질 블록을 무작위로 4군으로 나누었다. 1군은 대조군으로 바니쉬 적용을 하지 않았다. 2군은 APF gel을 도포하고 4분후에 세척하였다. 3군과 4군은 Fluor Protector^(ⓡ)와 CavityShield™를 도포하고 1분 후에 세척하였다. 모든 표본을 인공우식용액 속에 넣어서 탈회시켰다. 가시광선 형광을 이용해 병소의 광밀도를 측정하고 병소의 깊이를 현미경으로 측정하고 통계적으로 비교하였다. 1. 48시간 후 광밀도 측정시 2군 광밀도는 대조군에 비해서 높았으나 바니쉬군보다 낮았고,두 가지 바니쉬 간에 유의한 차이는 없었다. 2. 72시간 후 광밀도 측정결과 3군에서만 약간의 광밀도 감소가 관찰되고,4군이 가장높았다. 3. 72시간의 탈회 후 병소의 깊이를 측정한 결과 대조군에서는 평균 205.36±42.85㎛, 2군에서 병소의 평균깊이는 21O.81±44.60㎛로 두 군간에 유의한 차이는 없었다. 4. 불소 바니쉬군의 병소 깊이는 3군이 80.03±21.66㎛, 4군이 77.46±27.72㎛로 대조군이나 2군에 비해 탈회가 억제되었음을 알 수 있었으나 두 가지 바니쉬 사이에 차이가 없었다. The aim of this study was to evaluate the effect of fluoride varnish application on enamel decalcification. Eighty bovine enamel blocks divided randomly into 4 groups. Group I is the control group. Group II was treated with the APF gel and washed after 4 minutes. Group III and IV was treated with Fluor Protector^(ⓡ) and CavityShield™ and washed after 1 minutes. Decalcification were created by placing all specimen into artificial acidic solution(pH4.0). Then the optical density of the lesions were measured by visible light fluorescence and the lesion depths were measured. The results were : 1. The optical density of group II was higher than group I but lower than group III, IV(p<0.05) and there was no difference between group III, IV(p>0.05) at 48 hours. 2. The optical density of group IV was highest at 72 hours(p<0.05). 3. Mean lesion depths were 205.36±42.85㎛ and 210.81±44.60㎛ in group I, II but no significant difference between two groups(p>0.05). 4. Mean lesion depths were 80.03±21.66㎛ and 77.46±27.72㎛ in group III, IV but no significant difference between two groups(p>0.05). Fluoride varnish treatment resulted in a significant reduction in lesion depth compared with APF gel. Fluor Protector^(?) and CavityShield™ provided the similar effect.

엘리베이터용 로프 브레이크 시스템의 설계변수 최적화에 관한 연구

윤영환,최명진,장승호 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.6

Hydraulic systems of rope brake for elevators are modelled to evaluate design parameters such as cylinder pressure, piston displacement, accumulator capacity, and so on. To assure the results, experiments were performed. The analysis results agree well with the experimental results. The scheme in this study is expected to be utilized in the design of rope brake system for elevators to get design parameters and to improve the safety.

국산 DAF 펌프의 기포특성

안대명,이창한,최윤찬,조석호,안갑환,김성수 대한상하수도학회 2002 상하수도학회지 Vol.16 No.4

The paper introduces a domestic pump designed for dissolved air flotation (DAF). In the paper, the difference in performance between the domestic DAF pump and conventional pressure saturator is explained using the characteristics of air bubble released. The size distribution of air bubbles released from DAF pump is measured by image analyzer and particle size analyzer. And the mean diameter of bubbles is 43μm. The results are similar to that of pressure saturator. The air volume concentration in the water of domestic DAF pump and pressure saturator are 40 and 70% of theoretical amounts. In DAF system used domestic DAF pump, the removal efficiency of turbidity is 70%.

열전소자를 이용한 냉장고의 개발에 관한 연구

정용호,김명윤,김재홍 서강정보대학 1999 산업과학연구 Vol.1 No.-

The thermoelectric refrigeration technologies have no moving parts, compressor, or piping required. In this study, the basic capacity of thermoelectric devices and developement on some thermoelectric refrigerator were reviewed and basic technical concepts related with many kinds of thermoelectric materials were discussed. Especially the result of performance test on thermoelectric refrigerator whose minimum temperature of -2℃ was introduced briefly.

캔디다균이 분비하는 단백질 분해효소의 순수 분리와 특성 및 교차 항원성

이경호,신운섭,박주영,김수기,박윤선,고춘명 연세대학교 원주의과대학 1995 원주의대논문집 Vol.8 No.1

간편 퍼지와 디지털 PI+D를 이용한 제어 시스템의 설계

박윤명,권태익,박종오,임영도,최부귀 동아대학교 정보기술연구소 2000 情報通信硏究所論文誌 Vol.8 No.1

본 논문에서는 퍼지 디지털 PI+D제어기를 이용하여 외란, 잡음, 플랜트 변화 등에 강한 제어시스템을 설계한다. 퍼지제어는 간단한 4개의 규칙과 소속함수를 유도하여, 간편 퍼지를 이용한 디지털 PI+D 제어기를 설계하였으며 또한 플랜트는 2차 선형 플랜트를 적용하였다. 본 논문에서 제안한 제어 시스템과 디지털 PID 제어, 디지털 PI+D 제어 시스템을 시뮬레이션을 통해 각 시스템의 특성을 비교 하였다.

一部都市地域 靑少年의 成長發育과 最大成長發育年齡에 관한 類似縱斷的 硏究

한명호,윤태영,최중명,박순영 慶熙大學校 1991 論文集 Vol.20 No.-

This study was carried out to know physical growth and development, physical and nutritional indices, and maximum growth accelerating phenomena by semi―longitudinal method to measure body height, body weight, chest girth and sitting height of 427 of high school 3rd grade students who were living in Anyang city and born from March 1 in 1973 to February 28 in 1974. The result Were as follows : 1. Physical growth and development Body height grew one―step direct―development and body weight, chest―girth and sitting height grew two―step direct―development. Female excelled made in two―step development. Intersection phenomena of male and female showed in case of body height : 9.5 ∼ 13.5, body weight : 10.0 ∼ 14.0, chest―girth :11.5 ∼ 15.5, sitting height : 9.5 ∼ 14.0. During this periods, female excelled male but after these periods, male excelled female again. 2. Physical and nutritional indices In all cases of relative body weight, relative chest girth and relative sitting height it was found to be increasing thereafter with advancing ages. In cases of Ro¨hrer index and Kaup index it was found to be reaching to normal state thereafter with advancing ages. In either cases of Vervaeck and Pelidisi index, if was found to be increasing and teaching to normal state thereafter with advancing ages. 3. Maximum growth age of physiques M.G.A.'s were 12.31 for male and 10.42 for female which showed that M.G.A. for female appeared about 2 years earlier than that for male, in body height. M.G.A.'s were 12.73 for male and 11.65 for female which showed that M.G.A. for female appeared about 1 years earlier than that for male, in body weight. M.G.A.'s were 12.75 for male and 11.54 for female which showed that M.G.A. for female appeared about 1.2 years earlier than that for male, in chest ― girth. M.G.A.'s were 12.52 for male and 10.44 for female which showed that M.G.A. for female appeared about 2 years earlier than that for male, in sitting height.

混合 Starter Culture를 利用한 醱酵 Sausage 製造에 관한 硏究 : 分離菌株의 生育特性 및 培養條件 Growth Characteristics and Culture Conditions of Isolated Strains

고명수,윤원호 건국대학교 1989 論文集 Vol.29 No.2

Micrococcus varians, Staphylococcus carnosus, Lactobacillus plantarum and Pediococcus acidilactici were isolated from mixed smarter cultures for the fermented meat products, and then their growth characteristics and cultural conditions were investigated. The optimum temperature and pH for the growth of all the isolated strains were around 30∼ 35℃ and pH 6.0∼ 7.0, respectively, except optimum temperature (40℃) of Pediococcus acidilactici All the isolated strains were grown on the NaCl concentration of 8.0%, particularly Staphylococcus carnosus was grown on the NaCl concentration of 14.5%. Micrococcus varians and Staphylococcus carnosus grew with glucose under anaerobic condition and showed positive reaction to catalase production and nitrate reduction. Lactobacillus plantarum and Pediococcus acidilactici showed homo fermentative type which was not produced CO2 with glucose, and showed positive reaction to acetoin production, All the isolated strains produced acid with fructose, glucose and mannose. On the other hand, there was no strain that produced acid with inositol and inulin.