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골아세포 MC₃T₃-E₁의 증식과 기능에 Insulin Like Growth Factor Ⅰ, Ⅱ 및 부갑상선 호르몬이 미치는 영향
윤현구,정호연,양인명,김성운,김진우,김광원,김영설,최영길,서광식 대한내과학회 1992 대한내과학회지 Vol.42 No.1
MC₃T₃-E₁골아세포군을 이용하여 IGF-Ⅰ과 Ⅱ를 투여하고 DNA합성과 골아세포기능을 측정하기 위해 PTH에 대한 C-AMP반응정도, alkaline phosphatase 활성도를 측정하여 다음과 같은 결과를 얻었다. 1) IGF-Ⅰ과 Ⅱ는 모두 DNA합성이 어느 농도까지는 증식효과를 나타내지만 그 이후에는 억제되는 양상을 보였다. 2) PTH에 대한 골아세포의 C-AMP반응으로 증가되었지만 IGF-Ⅰ과 Ⅱ의 투여시 농도변화에 따른 의미있는 변화는 없었다. 3) 본 실험의 조건에서 alkaline phosphatase 활성도는 증가되지 않았다. 이상의 결과로 MC₃T₃-E₁ 골아세포에 IGF-Ⅰ과 Ⅱ는 세포의 증식을 자극하여 PTH는 C-AMP생성을 촉진하는 효과가 있었다. The effect of insulin-like growth factor (IGF) Ⅰ and Ⅱ on cloned MC₃T₃-E₁ cells that had osteoblastic activity was examined by [³H] thymidine incorporation into DNA, cyclic AMP responsiveness to parathyroid hormone (PTH), and alkaline phosphatase activity. IGF Ⅰ and Ⅱ stimulated the growth and proliferation of osteoblastic cells at 20ng/㎖ and 50ng/㎖, respectively. We next examined the effect of IGF-Ⅰ and Ⅱ on the expression of osteoblastic activity. Adenylate cyclase response of PTH to IGF-Ⅰ and Ⅱ-treated cells showed maximal stimulation at 10 and 50㎚PTH, respectively, but IGF Ⅰ and Ⅱ induced limited activity of osteoblastic function. In conclusion, IGF-Ⅰ and Ⅱ were potent stimulators to the growth of osteoblastic cells but did not have an immediate effect on expression of osteoblastic function in this experiment.
Incidence and Mortality Following Hip Fracture in Korea
윤현구,박찬미,장선미,장수현,이영균,하용찬 대한의학회 2011 Journal of Korean medical science Vol.26 No.8
The authors evaluated the incidence of hip fracture and subsequent mortality in Korea using nationwide data obtained from the Health Insurance Review and Assessment Service. This study was performed on patient population, aged 50-yr or older who underwent surgical procedures because of hip fracture (ICD10; S720, S721). All patients were followed using patient identification code to identify deaths. Crude hip fracture rates increased from 191.9/100,000 in 2005 to 207.0/100,000 in 2008 in women and from 94.8/100,000 in 2005 to 97.8/100,000 in 2008, in men respectively. Crude mortality within 12 months after hip fracture showed a similar trend (18.8% in 2005 and 17.8% in 2007). The mean of standardized mortality ratio of hip fracture was 6.1 at 3 months, 3.5 at 1 yr, and 2.3 at 2 yr post-fracture. The increasing incidence and the high mortality after hip fracture are likely to become serious public health problems and a public health program should begin to prevent hip fractures in Korea.
A Novel Transmit Diversity Technique for IS-2000 Systems
윤현구,육종관,박한규,Yoon, Hyun-Goo,Yook Jong-Gwan,Park, Han-Kyu The Korean Institute of Communications and Informa 2002 韓國通信學會論文誌 Vol.27 No.b1
본 논문에서는 IS-2000 시스템에 적합한 심볼 분할 OTD (orthogonal transmit diveristy)를 제안하였다. 심볼 분할 OTD는 Meyer가 제안한 심볼 분할과 OTD를 결합하여 최대 경로 다이버시티 및 시간 다이버시티 이득을 얻기에 IS-2000 순방향 성능을 개선시킬 수 있다. 이를 IS-2000 표준의 순방향 fundamental 채널에 대하여 시뮬레이션을 통해 확인하였다. 그리고, 그 결과를 기존의 IS-2000 표준에서 채택된 OTD와 STS (space-time spreading)의 성능과 비교하였다. 본 논문에서 제안한 방법을 IS-2000 시스템에 적용할 경우, 1% FER (frame error rate)을 얻기 위한 송신전력이 OTD의 경우보다 0.5-7.7dB 정도 감소되어 STS의 성능과 거의 일치하였다. 뿐만 아니라, 송신신호의 PAR(peak-to-average power ratio)가 STS보다 적으므로, 기지국 전력증폭기와 같은 RF 회로의 복잡도를 감소시킬 수 있는 장점이 있다. This paper proposes a novel transmit diversity technique, namely symbol split orthogonal transmit diversity (SS-OTD). In this technique, full path diversity and temporal diversity are achieved by combining orthogonal transmit diversity technique (OTD) technique with the symbol splitting method proposed by Meyer. Its performances is simulated for fundamental channels associated with the forward link of the IS-2000 system, and then compared with those of OTD and space-time spreading (STS). Our proposed method offers a 0.5-7.7dB performance improvement over OTD under various simulation environments and its performance is similar to STS. Moreover, compares with that of STS, the peak-to-average power ratio (PAR) of transmitted signals in SS-OTD is reduced by a maximal 1.35dB, which decreases the complexity of base station RF devices, such as power amplifiers. Thus, SS-OTD is comparable to STS in performance and superior to STS in the cost and efficiency of base station RF devices.