청소년기 태권도 수련생들의 체격 및 체력 요인별 발달 비교

김동제,권창기,가경환 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

This study was intended to investigate changes in the physique and fitness by age in adolescence. For this purpose, it attempted to make the first measurement in June, 2001 and the second measurement in 2002 for a total of 15 persons(seven middle school students aged 13 to 14 years and 8 high school students aged 16 to 17 years) practicing Taekwondo at 'S' and 'C' Drill Centers located in South Kyungsang Province. Both measures were conducted over the 2-day period. An attempt was made to compare and analyze the growth rate of physique and fitness factors by age based on data from measurement. As a result, the following conclusion was drawn: First, it was found that there was a statistically significant difference in the change of height, weight and body fat percent before and after measurement in order to investigate the change of physique(P<.05). Among other things, it was found that there was a statistically significant difference in the change of height, weight between the period of middle school days(13 to 14 years old) and the period of high school days(16 to 17 years old)(P<.05). It was found that Taekwondo trainees grew more over the period of middle school days(13 to 14 years old) than over the period of high school days(16 to 17 years old). But it was found that there was not a statistically significant difference in body fat percent between both groups(P<.05). But body fat percent reduced over the period of middle school days{13 to 14 years old) but did remain almost unchanged. Second, an attempt was made to measure power(high jump test), agility(side step test), muscular endurance(sit-up) and cardiopulmonary endurance(1500-meter run) to investigate the change of physique. It was found that there was not a statistically significant difference in the change of power(high jump test) and muscular endurance(sit-up) before and after measurement(P<.05). But it was found that there was a statistically significant difference on agility(side-step test) and cardiopulmonary(1500-meter run)(P<.05). It was found that there was a statistically significant difference in agility(side-step test), muscular endurance(sit-up) and cardiopulmonary endurance(1500-meter run) except power(high jump test) between he period of middle school days(13 to 14 years old) and the period of high school days(16 to 17 years old)(P<.05). The high jump test was conducted to investigate the change of power. As a result, it was found that power increase the period of middle school days(13 to 14 years old), whereas it decrease over the period of high school days(16 to 17 years old). On the other hand, the side-step test was conducted to investigate the change of agility. It was found that agility increased in Tawekwondo trainees over both the period of middle school days(13 to 14 years old) and the period of high school daysd(16 to 17 years old), the latter of which it was more or less improved. This study conducted the sit-up test to investigate the change of muscular endurance and the 1500-meter run test to investigate the change of cardiopulmonary endurance. In case of the 1500-meter run, cardiopulmonary endurance decreased over the period of middle school days(13 to 14 years old) but increased over the period of high school days(16 to 17 years old).

중부지역 옥수수 파종기에 따른 생육단계 및 수량성 변화

서종호, 문중경, 정건호, 서민정, 구자환, 박장환, 배환희, 신성휴, 권영업 忠北大學校 農業科學硏究所 2014 農業科學硏究 Vol.30 No.2

Maize hybrids were planted on April 1, April 25, May 20 and June 15 in 2012, 2013 at the experimental paddy and upland fields in Suwon city , respectively to know changes of growth stage and yield according to different planting time. Maize planting on April 1 was not recommended because total growing days at planting on April 1 was not different with that at planting on April 25 due to many days from planting to emergence over 20 days at planting on April 1. Total growing days were not much different among three planting time after April 25 because days from silking to maturity was lengthened though days from planting to silking was shortened at later planting time. Stalk weight was decreased as planting time was delayed, particularly at planting times after May 20 at paddy field by excess water injury during early growth stage. But, grain yield was not low as in May and June. It is needed to introduce early maturity maize variety as Yanganok at late planting for higher grain yield and enough time for soil preparation for next winter crops

Ischemia-Related Changes in Galanin Expression in the Dentate Hilar Region after Transient Forebrain Ischemia in Gerbils

LEE, Hyeon Yong,HWANG, In Koo,KIM, Dae Ho,KIM, Jung Hwa,KIM, Chang Ho,LIM, Beong Ou,KANG, Tae-Cheon,BANG, Kyung Hwan,SEONG, Nak Sul,LEE, Hak Ju,KIM, Jong Dai,WON, Moo Ho Japanese Association for Laboratory Animal Science 2005 EXPERIMENTAL ANIMALS Vol.54 No.1

<P>Although galanin (GAL) protects hippocampal neurons from ischemic damage, no study has examined ischemia-related changes in endogenous GAL in the hippocampal dentate gyrus. We investigated the chronological changes of GAL, well-known as the potassium channel opener, expression in the dentate gyrus at various times after 5 min of transient forebrain ischemia in gerbils. A few GAL-immunoreactive (IR) neurons were found in the polymorphic layer of the sham-operated group. Three hours after ischemia-reperfusion, the pattern of GAL immunoreactivity was similar to that of the sham-operated group and the number of GAL-IR neurons and immunoreactivity were highest 12 h after ischemic insult. At this time, GAL-IR neurons in the polymorphic layer showed strong GAL immunoreactivity. Thereafter, GAL-IR neurons and immunoreactivity significantly decreased in the dentate hilar region. Four days after ischemic insult, GAL-IR neurons were not detectable. In addition, the results of a Western blot study showed a pattern of GAL expression similar to the immunohistochemical changes. GAL protein content also was highest 12 h after ischemia. In conclusion, the increased expression of endogenous GAL in the dentate gyrus after ischemia is related to response to the ischemic damage.</P>

울형성 심부전증에서 심혈관계 보상기전의 지표로서 저나트륨혈증의 의의에 관한 연구

김경환,김미경,이우형,홍사석,신길자,장일중 대한내과학회 1986 대한내과학회지 Vol.31 No.3

In patient with congestive heart failure, it is well known that the sympatho-adrenal system and the renin angiotensin system are activated to compensate for the reduction of cardiac output and the redistribution of blood flow. Although Lilly, et al. (1984) and Francis, et al. (1985) have insisted that the induction of these circulatory compensation mechanism by pastura1 changes is closely related to the concentration of plama sodium in congestive heart failure, it is still controversial. Thus, in an effort to clarify this hypothesis, present study was designed to determine the relationship between the existing sodium concentration in plasma and the changes of the plasma catecholamine concentration and renin activity during postural alterations in patients with congestive heart fai1ure and normal subjects. Ten patients with congestive heart failure who had been admitted to the Ewha Womans University Hospital from May, 1985 to July, 1985 and five normal volunteers were chosen. Patients with more than one year history of congestive heart failure belonging to class 3 or 4 as the criteria set by the New York Heart Association have been selected for this study. Among these ten patients, 5(3 males and 2 females) had low plasma sodium concentration(below 135mEq/l) and 5(3 males and 2 females) had normal plasma sodium concentration(above 135mEq/l). The observed results are as follows: 1) In the normal subjects, the observed plasma renin activity was 1,2±0.4ng/ml/hr and the concentrations of norepinephrine and epinephrine were 177.5±27 and 150.0±8pg/ml, respectively, at supine position. However, these values were increased by about 2 times by changing to upright position. 2) In patients with hyponatremic congestive heart failure, the values of plasma renin activity and catecholamine levels were significantly higher than those patients having normonatremia. 3) The increase in the plasma renin activity and catecholamin levels induced by upright position were minimal in patients with congestive heart failure having normonatremia. 4) However, in patients with hyponatremic congestive heart failure, the plasma renin activity and the levels of plasma catecholamines were not altered, or rather decreased, by the same postural changes. Based on the results, the levels of plasma sodium concentration in patients with congestive heart failure could provide an index for the induction of circulatory compensation mechaniams and may have important significance in determining the severity and prognosis of the disease. Particularly in the congestive heart failure patients with hyponatremia, as the circulatory compensation mechanism appear to be operating at maximum already, they would not be able to utilize the reflex compensation mechanism inducible with the changes of body position.

A case of erosive vitreoretinopathy

Seong Eun Kyung,Moo Hwan Chang,Jun Young Ji 대한안과학회 2002 Korean Journal of Ophthalmology Vol.16 No.1

Hereditary vitreoretinopathies are potentially blinding inherited disorders characterized by an abnormal-appearing vitreous gel and associated retinal changes. Four of these disorders, Stickler’s syndrome, Wagner’s disease, erosive vitreoretinopathy, and Goldmann-Favre syndrome, exhibit marked syneresis of the vitreous gel. Erosive vitreoretinopathy has associated retinal pigment epithelial changes, poor night vision, visual field defects, and abnormal electroretinographic findings; symptoms not found in Stickler’s syndrome. A 36-year-old man with progressive visual loss and a visual field defect had no systemic disease. His vitreous cavity was liquefied. Vitreous strands and a cataract were found in both eyes. Pronounced RPE degeneration was found superotemporally in both eyes and a bullous rhegmatogenous retinal detachment in the left eye accompanied two retinal tears. His visual field showed a ring scotoma in both eyes and the ERG finding was abnormal. We report one case of erosive vitreoretinopathy with retinal pigment epithelial changes, rhegmatogenous retinal detachment, visual field defects, abnormal electroretinographic findings, marked vitreous syneresis and cataract. These symptoms are distinct from previously described entities.

천연물이 간대사에 미치는 영향에 관한 연구(Ⅱ)

최기환,김순선,박윤주,안미령,서수경,신윤용,김동섭,장영섭 식품의약품안전청 1997 식품의약품안전청 연보 Vol.1 No.-

천연물이 간대사에 미치는 영향페 대한 연구의 일환으로 세계 전 지역에서 널리 사용되고 잇으며 우리나라에서도 사용빈도가 높으나 간염등 간질환 유발사레가 보고되고 있는 마황, 황금 및 샐제 임상에서 이들 생약과 복합해서 자주 사용죄고 있는 대황을 선정하여, 띠들 천연물의 투여가 간 대사에 미치는 영향을 살펴보았다. 대황,마황, 황금 수침액을 1.09/kg의 용량으로 럿드에 7일간 경구 투여하고,최종투여 24시간 후 랫드의 간을 적출하였다. 간 대사에 미치는 영향을 살펴보기 위한 모질약뿔인 7-etliokycournarin을 적출간에 과관류하면서 2시간동안 일정시간 간격으로 관류액을 채취하여 생성된 7-ethoxycoumarin의 대사체인 7-hydroxycoin, glucuronide 포합체, sulfate포합체를 대조군과 배교 관찰하였다. 또한 긴독성 지표로서 혈청 ALT, AST를 측정하였으며 적출관류간에 대해 lipid peronidation 정도를 살펴보고 ÷t직병리검사를 실시하였다. 대촹 투여군에서는 7-ethoxycoumarin의 gulcuronidation이 갛소하였고fP<0.01), 마황투여군에서는 7-ethoxycoumarin의 o-deethylation이 증가하였다(P<0.01). 이러한 7-ethoxycoumariu 대사의 변화가 대황, 마황에 의한 관련 효소의 생합성 증가/감소에 의한 것인지 여부를 살펴보고자 일착로 CYPIAI, Ct'P2Bl CDHA primer를 사용하여 적출관류간 소포체에서 mRNA level을 측정하였다.마황투옥군에서 CVPIAI mRNA level의 증가가 관찰되었지만 통계적으로 유의한 차이를 나타내지는 않았다. 또한 이들 천연물에 의한 간독성 유발여부를 비교 평가한 결과 혈청 ALT 및 AST는 대조군에 비하여 유의한 차이가 없었다. 그러나 만성 간염정도를 나타내는 지표인 ALT/AST ratio는 마황 투여군에ㅓ 대조군에 비하여 유으한 차이를 나타내었고 대황투여군에서 간소포체내 lipid Peroxidation(MDA production)이 대조군에 비해 증가하였다.반면 조직학적 관찰결과는 대조군에 비하여 유의한 차이를 나타내지 않았다. 이상의 결과를 요약하면 랫드에서 대황 투여에 의해 7-ethoxycoumarin gtucuronidation이 감소되었으며, 마황 투여에 의해서 7-ethoxycoumarin의 o-deethylation은 증가되었고 마창 투여군의 경우 이러한 효소의 활성증가는 CYPIA1 induction에 의한 것일 수도 있다는 가능성을 제시하고 있다. In recent 3rears, hepatotoxicity concerned with Ephedrae herba or Scutellariae radixadmiBistration was case reported and Rhei rhizoma is commonly used with them. Tn order to study theeffect of Rhei rhizoma, Ep]ledrae herba and Scutellariae radix on hepatic metabolism, we exalnined theeffect of those pretreatment on the metabolism of 7-ethoxycoumarin(EC). Water extracts(Ig/fg) ofRhei rhiaoma, Ephedrae tterba and Scutetlariae radix were admi3tistered orally to rats for T days,respectively. Livers were t:ten isolated and perfused with 100uM EC for 2 hours. The metabolites of EC,7-hydroxycoernarin, sulfate conjugate and glucuronide conjugate, were measured in the perfusates dur-ing perfusion. The amount of glucuronide conjvgates was decreased iB ahei rhizoma pretreated rats (p <0.01) and 7-bfdroxycournarin was increased in Ephedrae herba pretreated rats(p < 0.01). To examineTrhether the change of enByme activity is related to the induction ,or inhibition of enzymes concerned,we measured the change oif CYPIAt and CYPaBl mRNA level in the perfused rat liver, which are con-sidered to be EC specifie. However, CYPIAI and CYPEBI rnRNA ilevel were not found to be changedwith Rhei rhizoma nor I]3hedrae herba pretreatmen·t. We also assessed the hepatic toxicity of Rheirhizoma,.:phedrae herba and Scutellariae radix. The activity of ALT and AST was assayed at 34hrsafter 7 dfyt ndrninistratiofl and it was not found to be changed- Only the ratio of ALT over AST was in-creased in Epedrae herbs. pretreated rats(p < 0.05), which implies possible chronic hepatitis. Lipidperoxidation was increased in Rhei rhizoma treatment(p <0.05) , while histopathological examinationperformed after liver perfusion did not show any difference compared with vehicle treatmeut. Theseresutts suggest that Ephedrae herba pretreatment increases the o-deethylation of 7- ethoxrcoumariB inrats, which Inay be mediated by CYPIAI mRNA induction.

취장 외분기능에 대한 체내 Amines의 역할

곽정재,김예식,명창선,김경환 연세대학교 의과대학 1987 연세의대논문집 Vol.20 No.2

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Newcastle Disease Virus의 Fusion 단백 유전자의 제한효소분절형태(RELP)의 특이성

장경수,김지영,김석,김태용,송영환,허지연,김현수,송희종,전무형 충남대학교 수의과대학 동물의과학연구소 2001 動物醫科學硏究誌 Vol.9 No.-

To evaluate the specificity of restriction fragment length polymorphism (RFLP) of Newcastle disease virus (NDV) fusion (F) protein gene for various NDV strains. F protein genes of NDV CBP-1 isolate, LaSota, B1 and Kyojungwon (KJW) were amplified by reverse transcriptase-polymerase chain reaction (RT-PCR) and RFLP were examined. In RT-PCR using F primer sets for 1.7 kb F gene, the amplified products were observed in CBP-1, LaSota and B1 except KJW. However, F2 primer set for 521 bp yielded the amplified bands with all strains. The amplified F genes (1.7 kbp) were treatd with 15 different restriction enzymes to analyze RFLP and the cleavage patterns. CBP-1 showed various cleavage patterns with 8 enzymes, LaSota, with 11 enzymes and B1, with 11 enzymes. According to the cleavage patterns, the physical maps were constructed, and it was found that CBP-1, LaSota and B1 strains had specific cleavage sites with HinfI, XbaI and XhoI. These findings suggest that RFLP are worth applying in the diagnosis and molecular epidemiological studies of Newcastle disease.

상법 제4편(보험법) 개정의견

張敬煥 圓光大學校 法學硏究所 2005 法學硏究 Vol.21 No.2

In my view, first of all, the following revision of Chapter IV (Insurance Contract Law) Korean Commercial Code is needed. 1. §638-2 ② should be modified to stipulate that policy conditions may apply to insurance contract, unless the insured cancels the contract within one month from the date of receipt of a policy, although insurer did not complete the duty to deliver and explain the policy conditions. 2. In §650 ② the forfeiture clause should be inserted, which forfeits insurance contract unless the premium installments subsequent to the first one were paid during the days of grace. 3. §655 should be modified to stipulate that insurer may avoid insurance contract although he should pay insurance money, when the insurance occurrence was not caused by the non-disclosed material facts. 4. §680 ① should be modified to stipulate that the insured may recover the loss and the sue and labour charges to the extent of the sum insured. He may only recover the loss and the sue and labour charges that exceed the sum insured when he acted under the insurer' s directions. 5. In §732-2 the exception clause should be inserted, which excepts from the personal accident insurance coverages the loss occurring while the insured is doing such felonies as drunken or unlicensed driving. Or §739 should be modified to stipulate to the same effect. 6. §735-3 ③ should be modified to stipulate that the express regulation of group arrangement or the employee' s written consent is required when the employer(policyholder) will name any other person than the employee (insured) as beneficiary in group life or accident insurance.